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Volumn 11, Issue 1, 2014, Pages

How SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest

Author keywords

Cell cycle; DNA repair; Endonucleases; HIV; Innate immune response; SLX4; Vpr

Indexed keywords

ENDONUCLEASE; MULTIPROTEIN COMPLEX; PEPTIDES AND PROTEINS; PROTEIN DCAF1; PROTEIN EME1; PROTEIN MUS81; PROTEIN SAMHD1; SLX4 ENDONUCLEASE COMPLEX; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN; VPR PROTEIN; RECOMBINASE; SLX4 PROTEIN, HUMAN; VPR PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84924200883     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/s12977-014-0117-5     Document Type: Review
Times cited : (13)

References (99)
  • 1
    • 44649139364 scopus 로고    scopus 로고
    • HIV-1 accessory proteins-ensuring viral survival in a hostile environment
    • Malim MH, Emerman M: HIV-1 accessory proteins-ensuring viral survival in a hostile environment. Cell Host Microbe 2008, 3:388-398.
    • (2008) Cell Host Microbe , vol.3 , pp. 388-398
    • Malim, M.H.1    Emerman, M.2
  • 2
    • 84890125460 scopus 로고    scopus 로고
    • HIV accessory proteins versus host restriction factors
    • Strebel K: HIV accessory proteins versus host restriction factors. Curr Opin Virol 2013, 3:692-699.
    • (2013) Curr Opin Virol , vol.3 , pp. 692-699
    • Strebel, K.1
  • 3
    • 77950646448 scopus 로고    scopus 로고
    • Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr?
    • Ayinde D, Maudet C, Transy C, Margottin-Goguet F: Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr? Retrovirology 2010, 7:35.
    • (2010) Retrovirology , vol.7 , pp. 35
    • Ayinde, D.1    Maudet, C.2    Transy, C.3    Margottin-Goguet, F.4
  • 4
    • 0028853961 scopus 로고
    • Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity
    • He J, Choe S, Walker R, Di Marzio P, Morgan DO, Landau NR: Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. J Virol 1995, 69:6705-6711.
    • (1995) J Virol , vol.69 , pp. 6705-6711
    • He, J.1    Choe, S.2    Walker, R.3    Marzio, P.4    Morgan, D.O.5    Landau, N.R.6
  • 5
    • 0029165291 scopus 로고
    • The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2+M phase of the cell cycle
    • Jowett JB, Planelles V, Poon B, Shah NP, Chen ML, Chen IS: The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2+M phase of the cell cycle. J Virol 1995, 69:6304-6313.
    • (1995) J Virol , vol.69 , pp. 6304-6313
    • Jowett, J.B.1    Planelles, V.2    Poon, B.3    Shah, N.P.4    Chen, M.L.5    Chen, I.S.6
  • 7
    • 0028801303 scopus 로고
    • Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B
    • Re F, Braaten D, Franke EK, Luban J: Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. J Virol 1995, 69:6859-6864.
    • (1995) J Virol , vol.69 , pp. 6859-6864
    • Re, F.1    Braaten, D.2    Franke, E.K.3    Luban, J.4
  • 8
    • 0028813107 scopus 로고
    • The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection
    • Rogel ME, Wu LI, Emerman M: The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection. J Virol 1995, 69:882-888.
    • (1995) J Virol , vol.69 , pp. 882-888
    • Rogel, M.E.1    Wu, L.I.2    Emerman, M.3
  • 9
    • 0028297360 scopus 로고
    • Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate
    • Balliet JW, Kolson DL, Eiger G, Kim FM, McGann KA, Srinivasan A, Collman R: Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate. Virology 1994, 200:623-631.
    • (1994) Virology , vol.200 , pp. 623-631
    • Balliet, J.W.1    Kolson, D.L.2    Eiger, G.3    Kim, F.M.4    McGann, K.A.5    Srinivasan, A.6    Collman, R.7
  • 10
    • 0028842207 scopus 로고
    • Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes
    • Connor RI, Chen BK, Choe S, Landau NR: Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes. Virology 1995, 206:935-944.
    • (1995) Virology , vol.206 , pp. 935-944
    • Connor, R.I.1    Chen, B.K.2    Choe, S.3    Landau, N.R.4
  • 11
    • 0035914839 scopus 로고    scopus 로고
    • HIV-1 Vpr enhances viral burden by facilitating infection of tissue macrophages but not nondividing CD4+ T cells
    • Eckstein DA, Sherman MP, Penn ML, Chin PS, De Noronha CM, Greene WC, Goldsmith MA: HIV-1 Vpr enhances viral burden by facilitating infection of tissue macrophages but not nondividing CD4+ T cells. J Exp Med 2001, 194:1407-1419.
    • (2001) J Exp Med , vol.194 , pp. 1407-1419
    • Eckstein, D.A.1    Sherman, M.P.2    Penn, M.L.3    Chin, P.S.4    Noronha, C.M.5    Greene, W.C.6    Goldsmith, M.A.7
  • 14
    • 11444257728 scopus 로고    scopus 로고
    • The role of Vpr in HIV-1 pathogenesis
    • Andersen JL, Planelles V: The role of Vpr in HIV-1 pathogenesis. Curr HIV Res 2005, 3:43-51.
    • (2005) Curr HIV Res , vol.3 , pp. 43-51
    • Andersen, J.L.1    Planelles, V.2
  • 15
    • 29744464493 scopus 로고    scopus 로고
    • Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo
    • Lai M, Zimmerman ES, Planelles V, Chen J: Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo. J Virol 2005, 79:15443-15451.
    • (2005) J Virol , vol.79 , pp. 15443-15451
    • Lai, M.1    Zimmerman, E.S.2    Planelles, V.3    Chen, J.4
  • 16
    • 0037830710 scopus 로고    scopus 로고
    • Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R
    • Roshal M, Kim B, Zhu Y, Nghiem P, Planelles V: Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R. J Biol Chem 2003, 278:25879-25886.
    • (2003) J Biol Chem , vol.278 , pp. 25879-25886
    • Roshal, M.1    Kim, B.2    Zhu, Y.3    Nghiem, P.4    Planelles, V.5
  • 17
  • 20
    • 84891301320 scopus 로고    scopus 로고
    • Causes and consequences of replication stress
    • Zeman MK, Cimprich KA: Causes and consequences of replication stress. Nat Cell Biol 2014, 16:2-9.
    • (2014) Nat Cell Biol , vol.16 , pp. 2-9
    • Zeman, M.K.1    Cimprich, K.A.2
  • 23
    • 77954251074 scopus 로고    scopus 로고
    • Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R
    • Li G, Park HU, Liang D, Zhao RY: Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R. Retrovirology 2010, 7:59.
    • (2010) Retrovirology , vol.7 , pp. 59
    • Li, G.1    Park, H.U.2    Liang, D.3    Zhao, R.Y.4
  • 27
    • 34247187942 scopus 로고    scopus 로고
    • HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1
    • Schrofelbauer B, Hakata Y, Landau NR: HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1. Proc Natl Acad Sci U S A 2007, 104:4130-4135.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 4130-4135
    • Schrofelbauer, B.1    Hakata, Y.2    Landau, N.R.3
  • 28
    • 34648833229 scopus 로고    scopus 로고
    • DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
    • Tan L, Ehrlich E, Yu XF: DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest. J Virol 2007, 81:10822-10830.
    • (2007) J Virol , vol.81 , pp. 10822-10830
    • Tan, L.1    Ehrlich, E.2    Yu, X.F.3
  • 29
    • 34848911347 scopus 로고    scopus 로고
    • The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor
    • Wen X, Duus KM, Friedrich TD, de Noronha CM: The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor. J Biol Chem 2007, 282:27046-27057.
    • (2007) J Biol Chem , vol.282 , pp. 27046-27057
    • Wen, X.1    Duus, K.M.2    Friedrich, T.D.3    Noronha, C.M.4
  • 30
    • 0028318421 scopus 로고
    • Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein
    • Zhao LJ, Mukherjee S, Narayan O: Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein. J Biol Chem 1994, 269:15577-15582.
    • (1994) J Biol Chem , vol.269 , pp. 15577-15582
    • Zhao, L.J.1    Mukherjee, S.2    Narayan, O.3
  • 31
    • 33749535905 scopus 로고    scopus 로고
    • Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery
    • Angers S, Li T, Yi X, MacCoss MJ, Moon RT, Zheng N: Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature 2006, 443:590-593.
    • (2006) Nature , vol.443 , pp. 590-593
    • Angers, S.1    Li, T.2    Yi, X.3    MacCoss, M.J.4    Moon, R.T.5    Zheng, N.6
  • 32
    • 33751112293 scopus 로고    scopus 로고
    • DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases
    • He YJ, McCall CM, Hu J, Zeng Y, Xiong Y: DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev 2006, 20:2949-2954.
    • (2006) Genes Dev , vol.20 , pp. 2949-2954
    • He, Y.J.1    McCall, C.M.2    Hu, J.3    Zeng, Y.4    Xiong, Y.5
  • 33
    • 34248209547 scopus 로고    scopus 로고
    • Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy
    • Higa LA, Zhang H: Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy. Cell Div 2007, 2:5.
    • (2007) Cell Div , vol.2 , pp. 5
    • Higa, L.A.1    Zhang, H.2
  • 34
    • 33747873322 scopus 로고    scopus 로고
    • A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
    • Jin J, Arias EE, Chen J, Harper JW, Walter JC: A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell 2006, 23:709-721.
    • (2006) Mol Cell , vol.23 , pp. 709-721
    • Jin, J.1    Arias, E.E.2    Chen, J.3    Harper, J.W.4    Walter, J.C.5
  • 41
    • 84886241606 scopus 로고    scopus 로고
    • Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells
    • Wyatt HD, Sarbajna S, Matos J, West SC: Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells. Mol Cell 2013, 52:234-247.
    • (2013) Mol Cell , vol.52 , pp. 234-247
    • Wyatt, H.D.1    Sarbajna, S.2    Matos, J.3    West, S.C.4
  • 42
    • 84885855405 scopus 로고    scopus 로고
    • Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions
    • Garner E, Kim Y, Lach FP, Kottemann MC, Smogorzewska A: Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions. Cell Rep 2013, 5:207-215.
    • (2013) Cell Rep , vol.5 , pp. 207-215
    • Garner, E.1    Kim, Y.2    Lach, F.P.3    Kottemann, M.C.4    Smogorzewska, A.5
  • 46
    • 80053544629 scopus 로고    scopus 로고
    • Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis
    • Matos J, Blanco MG, Maslen S, Skehel JM, West SC: Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis. Cell 2011, 147:158-172.
    • (2011) Cell , vol.147 , pp. 158-172
    • Matos, J.1    Blanco, M.G.2    Maslen, S.3    Skehel, J.M.4    West, S.C.5
  • 47
    • 84892432014 scopus 로고    scopus 로고
    • Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregation
    • Matos J, Blanco MG, West SC: Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregation. Cell Rep 2013, 4:76-86.
    • (2013) Cell Rep , vol.4 , pp. 76-86
    • Matos, J.1    Blanco, M.G.2    West, S.C.3
  • 49
    • 84924171368 scopus 로고    scopus 로고
    • G2/M cell cycle arrest correlates with primate lentiviral Vpr interaction with the SLX4 complex
    • Berger G, Lawrence M, Hue S, Neil SJ
    • (2014) J Virol
  • 50
    • 84863670930 scopus 로고    scopus 로고
    • Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway
    • Kim H, D'Andrea AD: Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev 2012, 26:1393-1408.
    • (2012) Genes Dev , vol.26 , pp. 1393-1408
    • Kim, H.1    D'Andrea, A.D.2
  • 53
    • 59649123419 scopus 로고    scopus 로고
    • Modulation of dendritic cell function by persistent viruses
    • Liu B, Woltman AM, Janssen HL, Boonstra A: Modulation of dendritic cell function by persistent viruses. J Leukoc Biol 2009, 85:205-214.
    • (2009) J Leukoc Biol , vol.85 , pp. 205-214
    • Liu, B.1    Woltman, A.M.2    Janssen, H.L.3    Boonstra, A.4
  • 54
    • 70349748582 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 mediates global disruption of innate antiviral signaling and immune defenses within infected cells
    • Doehle BP, Hladik F, McNevin JP, McElrath MJ, Gale M Jr: Human immunodeficiency virus type 1 mediates global disruption of innate antiviral signaling and immune defenses within infected cells. J Virol 2009, 83:10395-10405.
    • (2009) J Virol , vol.83 , pp. 10395-10405
    • Doehle, B.P.1    Hladik, F.2    McNevin, J.P.3    McElrath, M.J.4    Gale, M.5
  • 55
    • 40649114040 scopus 로고    scopus 로고
    • HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation
    • Okumura A, Alce T, Lubyova B, Ezelle H, Strebel K, Pitha PM: HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation. Virology 2008, 373:85-97.
    • (2008) Virology , vol.373 , pp. 85-97
    • Okumura, A.1    Alce, T.2    Lubyova, B.3    Ezelle, H.4    Strebel, K.5    Pitha, P.M.6
  • 56
    • 64749100822 scopus 로고    scopus 로고
    • HIV-1 mediated immune pathogenesis: spotlight on the role of viral protein R (Vpr)
    • Majumder B, Venkatachari NJ, Srinivasan A, Ayyavoo V: HIV-1 mediated immune pathogenesis: spotlight on the role of viral protein R (Vpr). Curr HIV Res 2009, 7:169-177.
    • (2009) Curr HIV Res , vol.7 , pp. 169-177
    • Majumder, B.1    Venkatachari, N.J.2    Srinivasan, A.3    Ayyavoo, V.4
  • 58
    • 0035025888 scopus 로고    scopus 로고
    • A quantitative assay for HIV DNA integration in vivo
    • Butler SL, Hansen MS, Bushman FD: A quantitative assay for HIV DNA integration in vivo. Nat Med 2001, 7:631-634.
    • (2001) Nat Med , vol.7 , pp. 631-634
    • Butler, S.L.1    Hansen, M.S.2    Bushman, F.D.3
  • 59
    • 77958114725 scopus 로고    scopus 로고
    • The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    • Yan N, Regalado-Magdos AD, Stiggelbout B, Lee-Kirsch MA, Lieberman J: The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol 2010, 11:1005-1013.
    • (2010) Nat Immunol , vol.11 , pp. 1005-1013
    • Yan, N.1    Regalado-Magdos, A.D.2    Stiggelbout, B.3    Lee-Kirsch, M.A.4    Lieberman, J.5
  • 60
    • 84906919951 scopus 로고    scopus 로고
    • HIV-1 Vpr Induces Interferon-Stimulated Genes in Human Monocyte-Derived Macrophages
    • Zahoor MA, Xue G, Sato H, Murakami T, Takeshima SN, Aida Y: HIV-1 Vpr Induces Interferon-Stimulated Genes in Human Monocyte-Derived Macrophages. PLoS One 2014, 9:e106418.
    • (2014) PLoS One , vol.9
    • Zahoor, M.A.1    Xue, G.2    Sato, H.3    Murakami, T.4    Takeshima, S.N.5    Aida, Y.6
  • 61
    • 84857347109 scopus 로고    scopus 로고
    • The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx
    • Lim ES, Fregoso OI, McCoy CO, Matsen FA, Malik HS, Emerman M: The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. Cell Host Microbe 2012, 11:194-204.
    • (2012) Cell Host Microbe , vol.11 , pp. 194-204
    • Lim, E.S.1    Fregoso, O.I.2    McCoy, C.O.3    Matsen, F.A.4    Malik, H.S.5    Emerman, M.6
  • 67
    • 77956497003 scopus 로고    scopus 로고
    • A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
    • Manel N, Hogstad B, Wang Y, Levy DE, Unutmaz D, Littman DR: A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010, 467:214-217.
    • (2010) Nature , vol.467 , pp. 214-217
    • Manel, N.1    Hogstad, B.2    Wang, Y.3    Levy, D.E.4    Unutmaz, D.5    Littman, D.R.6
  • 68
    • 79959353247 scopus 로고    scopus 로고
    • Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon
    • Pertel T, Reinhard C, Luban J: Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon. Retrovirology 2011, 8:49.
    • (2011) Retrovirology , vol.8 , pp. 49
    • Pertel, T.1    Reinhard, C.2    Luban, J.3
  • 69
    • 84874716238 scopus 로고    scopus 로고
    • SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells
    • Puigdomenech I, Casartelli N, Porrot F, Schwartz O: SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells. J Virol 2013, 87:2846-2856.
    • (2013) J Virol , vol.87 , pp. 2846-2856
    • Puigdomenech, I.1    Casartelli, N.2    Porrot, F.3    Schwartz, O.4
  • 70
    • 84882896267 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
    • Gao D, Wu J, Wu YT, Du F, Aroh C, Yan N, Sun L, Chen ZJ: Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 2013, 341:903-906.
    • (2013) Science , vol.341 , pp. 903-906
    • Gao, D.1    Wu, J.2    Wu, Y.T.3    Du, F.4    Aroh, C.5    Yan, N.6    Sun, L.7    Chen, Z.J.8
  • 72
    • 84874959500 scopus 로고    scopus 로고
    • Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutieres Syndrome and HIV-1 Restriction
    • Beloglazova N, Flick R, Tchigvintsev A, Brown G, Popovic A, Nocek B, Yakunin AF: Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutieres Syndrome and HIV-1 Restriction. J Biol Chem 2013, 288:8101-8110.
    • (2013) J Biol Chem , vol.288 , pp. 8101-8110
    • Beloglazova, N.1    Flick, R.2    Tchigvintsev, A.3    Brown, G.4    Popovic, A.5    Nocek, B.6    Yakunin, A.F.7
  • 76
    • 83755162644 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase
    • Powell RD, Holland PJ, Hollis T, Perrino FW: Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase. J Biol Chem 2011, 286:43596-43600.
    • (2011) J Biol Chem , vol.286 , pp. 43596-43600
    • Powell, R.D.1    Holland, P.J.2    Hollis, T.3    Perrino, F.W.4
  • 80
    • 84899769393 scopus 로고    scopus 로고
    • The innate immune response to HIV-1: to sense or not to sense
    • Landau NR: The innate immune response to HIV-1: to sense or not to sense. DNA Cell Biol 2014, 33:271-274.
    • (2014) DNA Cell Biol , vol.33 , pp. 271-274
    • Landau, N.R.1
  • 81
    • 34248579519 scopus 로고    scopus 로고
    • Out of Africa: what can we learn from HIV-2 about protective immunity to HIV-1?
    • Rowland-Jones SL, Whittle HC: Out of Africa: what can we learn from HIV-2 about protective immunity to HIV-1? Nat Immunol 2007, 8:329-331.
    • (2007) Nat Immunol , vol.8 , pp. 329-331
    • Rowland-Jones, S.L.1    Whittle, H.C.2
  • 82
    • 84899682448 scopus 로고    scopus 로고
    • DNA damage repair machinery and HIV escape from innate immune sensing
    • Bregnard C, Benkirane M, Laguette N: DNA damage repair machinery and HIV escape from innate immune sensing. Front Microbiol 2014, 5:176.
    • (2014) Front Microbiol , vol.5 , pp. 176
    • Bregnard, C.1    Benkirane, M.2    Laguette, N.3
  • 83
    • 84884333427 scopus 로고    scopus 로고
    • Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing
    • Gehrke N, Mertens C, Zillinger T, Wenzel J, Bald T, Zahn S, Tuting T, Hartmann G, Barchet W: Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. Immunity 2013, 39:482-495.
    • (2013) Immunity , vol.39 , pp. 482-495
    • Gehrke, N.1    Mertens, C.2    Zillinger, T.3    Wenzel, J.4    Bald, T.5    Zahn, S.6    Tuting, T.7    Hartmann, G.8    Barchet, W.9
  • 84
    • 0037032428 scopus 로고    scopus 로고
    • Cleavage of a DNA-RNA-DNA/DNA chimeric substrate containing a single ribonucleotide at the DNA-RNA junction with prokaryotic RNases HII
    • Haruki M, Tsunaka Y, Morikawa M, Kanaya S: Cleavage of a DNA-RNA-DNA/DNA chimeric substrate containing a single ribonucleotide at the DNA-RNA junction with prokaryotic RNases HII. FEBS Lett 2002, 531:204-208.
    • (2002) FEBS Lett , vol.531 , pp. 204-208
    • Haruki, M.1    Tsunaka, Y.2    Morikawa, M.3    Kanaya, S.4
  • 85
    • 36248988008 scopus 로고    scopus 로고
    • Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
    • Yang YG, Lindahl T, Barnes DE: Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 2007, 131:873-886.
    • (2007) Cell , vol.131 , pp. 873-886
    • Yang, Y.G.1    Lindahl, T.2    Barnes, D.E.3
  • 89
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson DB, Ko JS, Heidmann T, Medzhitov R: Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 2008, 134:587-598.
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 90
    • 33645529880 scopus 로고    scopus 로고
    • Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses
    • Esnault C, Millet J, Schwartz O, Heidmann T: Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses. Nucleic Acids Res 2006, 34:1522-1531.
    • (2006) Nucleic Acids Res , vol.34 , pp. 1522-1531
    • Esnault, C.1    Millet, J.2    Schwartz, O.3    Heidmann, T.4
  • 92
    • 84899685774 scopus 로고    scopus 로고
    • Safeguard against DNA sensing: the role of TREX1 in HIV-1 infection and autoimmune diseases
    • Hasan M, Yan N: Safeguard against DNA sensing: the role of TREX1 in HIV-1 infection and autoimmune diseases. Front Microbiol 2014, 5:193.
    • (2014) Front Microbiol , vol.5 , pp. 193
    • Hasan, M.1    Yan, N.2
  • 94
    • 0034855639 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1N-terminal capsid mutants that exhibit aberrant core morphology and are blocked in initiation of reverse transcription in infected cells
    • Tang S, Murakami T, Agresta BE, Campbell S, Freed EO, Levin JG: Human immunodeficiency virus type 1N-terminal capsid mutants that exhibit aberrant core morphology and are blocked in initiation of reverse transcription in infected cells. J Virol 2001, 75:9357-9366.
    • (2001) J Virol , vol.75 , pp. 9357-9366
    • Tang, S.1    Murakami, T.2    Agresta, B.E.3    Campbell, S.4    Freed, E.O.5    Levin, J.G.6
  • 95
    • 84871985539 scopus 로고    scopus 로고
    • Inhibition of reverse transcriptase activity increases stability of the HIV-1 core
    • Yang Y, Fricke T, Diaz-Griffero F: Inhibition of reverse transcriptase activity increases stability of the HIV-1 core. J Virol 2013, 87:683-687.
    • (2013) J Virol , vol.87 , pp. 683-687
    • Yang, Y.1    Fricke, T.2    Diaz-Griffero, F.3
  • 96
    • 84892946076 scopus 로고    scopus 로고
    • IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV
    • Monroe KM, Yang Z, Johnson JR, Geng X, Doitsh G, Krogan NJ, Greene WC: IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science 2014, 343:428-432.
    • (2014) Science , vol.343 , pp. 428-432
    • Monroe, K.M.1    Yang, Z.2    Johnson, J.R.3    Geng, X.4    Doitsh, G.5    Krogan, N.J.6    Greene, W.C.7
  • 98
    • 84866740475 scopus 로고    scopus 로고
    • Evolutionary conflicts between viruses and restriction factors shape immunity
    • Duggal NK, Emerman M: Evolutionary conflicts between viruses and restriction factors shape immunity. Nat Rev Immunol 2012, 12:687-695.
    • (2012) Nat Rev Immunol , vol.12 , pp. 687-695
    • Duggal, N.K.1    Emerman, M.2
  • 99
    • 84860534449 scopus 로고    scopus 로고
    • Differential effects of Vpr on single-cycle and spreading HIV-1 infections in CD4+ T-cells and dendritic cells
    • de Silva S, Planelles V, Wu L: Differential effects of Vpr on single-cycle and spreading HIV-1 infections in CD4+ T-cells and dendritic cells. PLoS One 2012, 7:e35385.
    • (2012) PLoS One , vol.7
    • Silva, S.1    Planelles, V.2    Wu, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.