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Volumn 5, Issue APR, 2014, Pages

DNA damage repair machinery and HIV escape from innate immune sensing

Author keywords

DNA damage response; G2 M arrest; HIV; Innate immunity; SLX4 complex; Vpr

Indexed keywords

CYCLIN B1; CYCLIN DEPENDENT KINASE 1; ENDONUCLEASE; ENDONUCLEASE SLX4; FANCONI ANEMIA GROUP D2 PROTEIN; FANCONI ANEMIA PROTEIN; INTERFERON; NUCLEAR PROTEIN; PATTERN RECOGNITION RECEPTOR; SAM DOMAIN AND HD DOMAIN 1; TRIPARTITE MOTIF PROTEIN 5; UNCLASSIFIED DRUG; VPR PROTEIN;

EID: 84899682448     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2014.00176     Document Type: Article
Times cited : (42)

References (110)
  • 1
    • 77950646448 scopus 로고    scopus 로고
    • Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr
    • doi: 10.1186/1742-4690-7-35
    • Ayinde, D., Maudet, C., Transy, C., and Margottin-Goguet, F. (2010). Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr? Retrovirology 7, 35. doi: 10.1186/1742-4690-7-35
    • (2010) Retrovirology , vol.7 , pp. 35
    • Ayinde, D.1    Maudet, C.2    Transy, C.3    Margottin-Goguet, F.4
  • 2
    • 27644513772 scopus 로고    scopus 로고
    • Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions
    • doi: 10.1172/JCI26032
    • Beignon, A. S., McKenna, K., Skoberne, M., Manches, O., Dasilva, I., Kavanagh, D. G., et al. (2005). Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. J. Clin. Invest. 115, 3265-3275. doi: 10.1172/JCI26032
    • (2005) J. Clin. Invest. , vol.115 , pp. 3265-3275
    • Beignon, A.S.1    McKenna, K.2    Skoberne, M.3    Manches, O.4    Dasilva, I.5    Kavanagh, D.G.6
  • 3
    • 84874959500 scopus 로고    scopus 로고
    • Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction
    • doi: 10.1074/jbc.M112.431148
    • Beloglazova, N., Flick, R., Tchigvintsev, A., Brown, G., Popovic, A., Nocek, B., et al. (2013). Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction. J. Biol. Chem. 288, 8101-8110. doi: 10.1074/jbc.M112.431148
    • (2013) J. Biol. Chem. , vol.288 , pp. 8101-8110
    • Beloglazova, N.1    Flick, R.2    Tchigvintsev, A.3    Brown, G.4    Popovic, A.5    Nocek, B.6
  • 4
    • 34547639932 scopus 로고    scopus 로고
    • HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase
    • doi: 10.1371/journal.ppat.0030085
    • Belzile, J. P., Duisit, G., Rougeau, N., Mercier, J., Finzi, A., and Cohen, E. A. (2007). HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase. PLoS Pathog. 3:e85. doi: 10.1371/journal.ppat.0030085
    • (2007) PLoS Pathog. , vol.3
    • Belzile, J.P.1    Duisit, G.2    Rougeau, N.3    Mercier, J.4    Finzi, A.5    Cohen, E.A.6
  • 5
    • 0742305344 scopus 로고    scopus 로고
    • RNA interference inhibition of Mus81 reduces mitotic recombination in human cells
    • doi: 10.1091/mbc.E03-08-0580
    • Blais, V., Gao, H., Elwell, C. A., Boddy, M. N., Gaillard, P. H., Russell, P., et al. (2004). RNA interference inhibition of Mus81 reduces mitotic recombination in human cells. Mol. Biol. Cell 15, 552-562. doi: 10.1091/mbc.E03-08-0580
    • (2004) Mol. Biol. Cell , vol.15 , pp. 552-562
    • Blais, V.1    Gao, H.2    Elwell, C.A.3    Boddy, M.N.4    Gaillard, P.H.5    Russell, P.6
  • 6
    • 0035900652 scopus 로고    scopus 로고
    • Mus81-Eme1 are essential components of a Holliday junction resolvase
    • doi: 10.1016/S0092-8674(01)00536-0
    • Boddy, M. N., Gaillard, P. H., McDonald, W. H., Shanahan, P., Yates, J. R. III, and Russell, P. (2001). Mus81-Eme1 are essential components of a Holliday junction resolvase. Cell 107, 537-548. doi: 10.1016/S0092-8674(01)00536-0
    • (2001) Cell , vol.107 , pp. 537-548
    • Boddy, M.N.1    Gaillard, P.H.2    McDonald, W.H.3    Shanahan, P.4    Yates, J.R.5    Russell, P.6
  • 7
    • 41349110877 scopus 로고    scopus 로고
    • Aberrant activation of stress-response pathways leads to TNF-alpha oversecretion in Fanconi anemia
    • doi: 10.1182/blood-2007-07-099218
    • Briot, D., Mace-Aime, G., Subra, F., and Rosselli, F. (2008). Aberrant activation of stress-response pathways leads to TNF-alpha oversecretion in Fanconi anemia. Blood 111, 1913-1923. doi: 10.1182/blood-2007-07-099218
    • (2008) Blood , vol.111 , pp. 1913-1923
    • Briot, D.1    Mace-Aime, G.2    Subra, F.3    Rosselli, F.4
  • 8
    • 84880923978 scopus 로고    scopus 로고
    • Newly described pattern recognition receptors team up against intracellular pathogens
    • doi: 10.1038/nri3479
    • Broz, P., and Monack, D. M. (2013). Newly described pattern recognition receptors team up against intracellular pathogens. Nat. Rev. Immunol. 13, 551-565. doi: 10.1038/nri3479
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 551-565
    • Broz, P.1    Monack, D.M.2
  • 9
    • 84886251421 scopus 로고    scopus 로고
    • Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases
    • doi: 10.1016/j.molcel.2013.08.036
    • Castor, D., Nair, N., Declais, A. C., Lachaud, C., Toth, R., Macartney, T. J., et al. (2013). Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases. Mol. Cell 52, 221-233. doi: 10.1016/j.molcel.2013.08.036
    • (2013) Mol. Cell , vol.52 , pp. 221-233
    • Castor, D.1    Nair, N.2    Declais, A.C.3    Lachaud, C.4    Toth, R.5    Macartney, T.J.6
  • 10
    • 81955161162 scopus 로고    scopus 로고
    • New insights into the formation and resolution of ultra-fine anaphase bridges
    • doi: 10.1016/j.semcdb.2011.07.001
    • Chan, K. L., and Hickson, I. D. (2011). New insights into the formation and resolution of ultra-fine anaphase bridges. Semin. Cell Dev. Biol. 22, 906-912. doi: 10.1016/j.semcdb.2011.07.001
    • (2011) Semin. Cell Dev. Biol. , vol.22 , pp. 906-912
    • Chan, K.L.1    Hickson, I.D.2
  • 11
    • 67349227137 scopus 로고    scopus 로고
    • Replication stress induces sister-chromatid bridging at fragile site loci in mitosis
    • doi: 10.1038/ncb1882
    • Chan, K. L., Palmai-Pallag, T., Ying, S., and Hickson, I. D. (2009). Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nat. Cell Biol. 11, 753-760. doi: 10.1038/ncb1882
    • (2009) Nat. Cell Biol. , vol.11 , pp. 753-760
    • Chan, K.L.1    Palmai-Pallag, T.2    Ying, S.3    Hickson, I.D.4
  • 12
    • 0043092025 scopus 로고    scopus 로고
    • Identification and characterization of the human mus81-eme1 endonuclease
    • doi: 10.1074/jbc.M302882200
    • Ciccia, A., Constantinou, A., and West, S. C. (2003). Identification and characterization of the human mus81-eme1 endonuclease. J. Biol. Chem. 278, 25172-25178. doi: 10.1074/jbc.M302882200
    • (2003) J. Biol. Chem. , vol.278 , pp. 25172-25178
    • Ciccia, A.1    Constantinou, A.2    West, S.C.3
  • 13
    • 84897585594 scopus 로고    scopus 로고
    • SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage
    • doi: 10.1182/blood-2013-04-490847
    • Clifford, R., Louis, T., Robbe, P., Ackroyd, S., Burns, A., Timbs, A. T., et al. (2014). SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage. Blood 123, 1021-1031. doi: 10.1182/blood-2013-04-490847
    • (2014) Blood , vol.123 , pp. 1021-1031
    • Clifford, R.1    Louis, T.2    Robbe, P.3    Ackroyd, S.4    Burns, A.5    Timbs, A.T.6
  • 14
    • 0028842207 scopus 로고
    • Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes
    • doi: 10.1006/viro.1995.1016
    • Connor, R. I., Chen, B. K., Choe, S., and Landau, N. R. (1995). Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes. Virology 206, 935-944. doi: 10.1006/viro.1995.1016
    • (1995) Virology , vol.206 , pp. 935-944
    • Connor, R.I.1    Chen, B.K.2    Choe, S.3    Landau, N.R.4
  • 15
    • 84859747536 scopus 로고    scopus 로고
    • Rescue of replication failure by Fanconi anaemia proteins
    • doi: 10.1007/s00412-011-0349-2
    • Constantinou, A. (2012). Rescue of replication failure by Fanconi anaemia proteins. Chromosoma 121, 21-36. doi: 10.1007/s00412-011-0349-2
    • (2012) Chromosoma , vol.121 , pp. 21-36
    • Constantinou, A.1
  • 16
    • 84964063204 scopus 로고    scopus 로고
    • DNA double strand break repair via non-homologous end-joining
    • doi: 10.3978/j.issn.2218-676X.2013.04.02
    • Davis, A. J., and Chen, D. J. (2013). DNA double strand break repair via non-homologous end-joining. Transl. Cancer Res. 2, 130-143. doi: 10.3978/j.issn.2218-676X.2013.04.02
    • (2013) Transl. Cancer Res. , vol.2 , pp. 130-143
    • Davis, A.J.1    Chen, D.J.2
  • 17
    • 35548929728 scopus 로고    scopus 로고
    • G2/M cell cycle arrest in the life cycle of viruses
    • doi: 10.1016/j.virol.2007.05.043
    • Davy, C., and Doorbar, J. (2007). G2/M cell cycle arrest in the life cycle of viruses. Virology 368, 219-226. doi: 10.1016/j.virol.2007.05.043
    • (2007) Virology , vol.368 , pp. 219-226
    • Davy, C.1    Doorbar, J.2
  • 18
    • 34347376505 scopus 로고    scopus 로고
    • HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system
    • doi: 10.1186/1743-422X-4-57
    • DeHart, J. L., Zimmerman, E. S., Ardon, O., Monteiro-Filho, C. M., Arganaraz, E. R., and Planelles, V. (2007). HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system. Virol. J. 4, 57. doi: 10.1186/1743-422X-4-57
    • (2007) Virol. J. , vol.4 , pp. 57
    • DeHart, J.L.1    Zimmerman, E.S.2    Ardon, O.3    Monteiro-Filho, C.M.4    Arganaraz, E.R.5    Planelles, V.6
  • 19
    • 85027953032 scopus 로고    scopus 로고
    • Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage
    • doi: 10.1038/nsmb.2550nsmb.2550
    • Dehe, P. M., Coulon, S., Scaglione, S., Shanahan, P., Takedachi, A., Wohlschlegel, J. A., et al. (2013). Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage. Nat. Struct. Mol. Biol. 20, 598-603. doi: 10.1038/nsmb.2550nsmb.2550
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 598-603
    • Dehe, P.M.1    Coulon, S.2    Scaglione, S.3    Shanahan, P.4    Takedachi, A.5    Wohlschlegel, J.A.6
  • 20
    • 0028824894 scopus 로고
    • Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr
    • Di Marzio, P., Choe, S., Ebright, M., Knoblauch, R., and Landau, N. R. (1995). Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. J. Virol. 69, 7909-7916.
    • (1995) J. Virol. , vol.69 , pp. 7909-7916
    • Di Marzio, P.1    Choe, S.2    Ebright, M.3    Knoblauch, R.4    Landau, N.R.5
  • 21
    • 0037031837 scopus 로고    scopus 로고
    • Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks
    • doi: 10.1074/jbc.M202120200
    • Doe, C. L., Ahn, J. S., Dixon, J., and Whitby, M. C. (2002). Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks. J. Biol. Chem. 277, 32753-32759. doi: 10.1074/jbc.M202120200
    • (2002) J. Biol. Chem. , vol.277 , pp. 32753-32759
    • Doe, C.L.1    Ahn, J.S.2    Dixon, J.3    Whitby, M.C.4
  • 22
    • 70349748582 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 mediates global disruption of innate antiviral signaling and immune defenses within infected cells
    • doi: 10.1128/JVI.00849-09
    • Doehle, B. P., Hladik, F., McNevin, J. P., McElrath, M. J., and Gale, M. (2009). Human immunodeficiency virus type 1 mediates global disruption of innate antiviral signaling and immune defenses within infected cells. J. Virol. 83, 10395-10405. doi: 10.1128/JVI.00849-09
    • (2009) J. Virol. , vol.83 , pp. 10395-10405
    • Doehle, B.P.1    Hladik, F.2    McNevin, J.P.3    McElrath, M.J.4    Gale, M.5
  • 23
    • 0141567661 scopus 로고    scopus 로고
    • TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro
    • doi: 10.1182/blood-2003-01-0114
    • Dufour, C., Corcione, A., Svahn, J., Haupt, R., Poggi, V., Beka'ssy, A. N., et al. (2003). TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro. Blood 102, 2053-2059. doi: 10.1182/blood-2003-01-0114
    • (2003) Blood , vol.102 , pp. 2053-2059
    • Dufour, C.1    Corcione, A.2    Svahn, J.3    Haupt, R.4    Poggi, V.5    Beka'ssy, A.N.6
  • 24
    • 33645529880 scopus 로고    scopus 로고
    • Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses
    • doi: 10.1093/nar/gkl054
    • Esnault, C., Millet, J., Schwartz, O., and Heidmann, T. (2006). Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses. Nucleic Acids Res. 34, 1522-1531. doi: 10.1093/nar/gkl054
    • (2006) Nucleic Acids Res. , vol.34 , pp. 1522-1531
    • Esnault, C.1    Millet, J.2    Schwartz, O.3    Heidmann, T.4
  • 25
    • 84890084535 scopus 로고    scopus 로고
    • A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes
    • doi: 10.1093/nar/gkt760
    • Fadden, A. J., Schalbetter, S., Bowles, M., Harris, R., Lally, J., Carr, A. M., et al. (2013). A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes. Nucleic Acids Res. 41, 9741-9752. doi: 10.1093/nar/gkt760
    • (2013) Nucleic Acids Res. , vol.41 , pp. 9741-9752
    • Fadden, A.J.1    Schalbetter, S.2    Bowles, M.3    Harris, R.4    Lally, J.5    Carr, A.M.6
  • 26
    • 67649655402 scopus 로고    scopus 로고
    • Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases
    • doi: 10.1016/j.cell.2009.06.029
    • Fekairi, S., Scaglione, S., Chahwan, C., Taylor, E. R., Tissier, A., Coulon, S., et al. (2009). Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. Cell 138, 78-89. doi: 10.1016/j.cell.2009.06.029
    • (2009) Cell , vol.138 , pp. 78-89
    • Fekairi, S.1    Scaglione, S.2    Chahwan, C.3    Taylor, E.R.4    Tissier, A.5    Coulon, S.6
  • 27
    • 0032574712 scopus 로고    scopus 로고
    • HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator
    • doi: 10.1073/pnas.95.9.5281
    • Felzien, L. K., Woffendin, C., Hottiger, M. O., Subbramanian, R. A., Cohen, E. A., and Nabel, G. J. (1998). HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator. Proc. Natl. Acad. Sci. U.S.A. 95, 5281-5286. doi: 10.1073/pnas.95.9.5281
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 5281-5286
    • Felzien, L.K.1    Woffendin, C.2    Hottiger, M.O.3    Subbramanian, R.A.4    Cohen, E.A.5    Nabel, G.J.6
  • 28
    • 84875224757 scopus 로고    scopus 로고
    • DNA-PK is a DNA sensor for IRF-3-dependent innate immunity
    • doi: 10.7554/eLife.00047
    • Ferguson, B. J., Mansur, D. S., Peters, N. E., Ren, H., and Smith, G. L. (2012). DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. Elife 1, e00047. doi: 10.7554/eLife.00047
    • (2012) Elife , vol.1
    • Ferguson, B.J.1    Mansur, D.S.2    Peters, N.E.3    Ren, H.4    Smith, G.L.5
  • 29
    • 0141707818 scopus 로고    scopus 로고
    • The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism
    • doi: 10.1016/S1097-2765(03)00342-3
    • Gaillard, P. H., Noguchi, E., Shanahan, P., and Russell, P. (2003). The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanism. Mol. Cell 12, 747-759. doi: 10.1016/S1097-2765(03)00342-3
    • (2003) Mol. Cell , vol.12 , pp. 747-759
    • Gaillard, P.H.1    Noguchi, E.2    Shanahan, P.3    Russell, P.4
  • 30
    • 84866912764 scopus 로고    scopus 로고
    • Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4
    • doi: 10.1093/nar/gks599
    • Gallo-Fernandez, M., Saugar, I., Ortiz-Bazan, M. A., Vazquez, M. V., and Tercero, J. A. (2012). Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4. Nucleic Acids Res. 40, 8325-8335. doi: 10.1093/nar/gks599
    • (2012) Nucleic Acids Res. , vol.40 , pp. 8325-8335
    • Gallo-Fernandez, M.1    Saugar, I.2    Ortiz-Bazan, M.A.3    Vazquez, M.V.4    Tercero, J.A.5
  • 31
    • 84882896267 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses
    • doi: 10.1126/science.1240933
    • Gao, D., Wu, J., Wu, Y. T., Du, F., Aroh, C., Yan, N., et al. (2013). Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 341, 903-906. doi: 10.1126/science.1240933
    • (2013) Science , vol.341 , pp. 903-906
    • Gao, D.1    Wu, J.2    Wu, Y.T.3    Du, F.4    Aroh, C.5    Yan, N.6
  • 32
    • 0035105291 scopus 로고    scopus 로고
    • Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway
    • doi: 10.1016/S1097-2765(01)00173-3
    • Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., et al. (2001). Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol. Cell 7, 249-262. doi: 10.1016/S1097-2765(01)00173-3
    • (2001) Mol. Cell , vol.7 , pp. 249-262
    • Garcia-Higuera, I.1    Taniguchi, T.2    Ganesan, S.3    Meyn, M.S.4    Timmers, C.5    Hejna, J.6
  • 33
    • 84885855405 scopus 로고    scopus 로고
    • Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions
    • doi: 10.1016/j.celrep.2013.08.041
    • Garner, E., Kim, Y., Lach, F. P., Kottemann, M. C., and Smogorzewska, A. (2013). Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions. Cell Rep. 5, 207-215. doi: 10.1016/j.celrep.2013.08.041
    • (2013) Cell Rep. , vol.5 , pp. 207-215
    • Garner, E.1    Kim, Y.2    Lach, F.P.3    Kottemann, M.C.4    Smogorzewska, A.5
  • 34
    • 80052717417 scopus 로고    scopus 로고
    • Ubiquitylation and the Fanconi anemia pathway
    • doi: 10.1016/j.febslet.2011.04.078
    • Garner, E., and Smogorzewska, A. (2011). Ubiquitylation and the Fanconi anemia pathway. FEBS Lett. 585, 2853-2860. doi: 10.1016/j.febslet.2011.04.078
    • (2011) FEBS Lett. , vol.585 , pp. 2853-2860
    • Garner, E.1    Smogorzewska, A.2
  • 35
    • 0042467680 scopus 로고    scopus 로고
    • Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades
    • doi: 10.1038/sj.onc.1206549
    • Gatza, M. L., Watt, J. C., and Marriott, S. J. (2003). Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades. Oncogene 22, 5141-5149. doi: 10.1038/sj.onc.1206549
    • (2003) Oncogene , vol.22 , pp. 5141-5149
    • Gatza, M.L.1    Watt, J.C.2    Marriott, S.J.3
  • 36
    • 84884333427 scopus 로고    scopus 로고
    • Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing
    • doi: 10.1016/j.immuni.2013.08.004
    • Gehrke, N., Mertens, C., Zillinger, T., Wenzel, J., Bald, T., Zahn, S., et al. (2013). Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. Immunity 39, 482-495. doi: 10.1016/j.immuni.2013.08.004
    • (2013) Immunity , vol.39 , pp. 482-495
    • Gehrke, N.1    Mertens, C.2    Zillinger, T.3    Wenzel, J.4    Bald, T.5    Zahn, S.6
  • 37
    • 80053490751 scopus 로고    scopus 로고
    • Automated genome-wide visual profiling of cellular proteins involved in HIV infection
    • doi: 10.1177/1087057111415521
    • Genovesio, A., Kwon, Y. J., Windisch, M. P., Kim, N. Y., Choi, S. Y., Kim, H. C., et al. (2011). Automated genome-wide visual profiling of cellular proteins involved in HIV infection. J. Biomol. Screen. 16, 945-958. doi: 10.1177/1087057111415521
    • (2011) J. Biomol. Screen. , vol.16 , pp. 945-958
    • Genovesio, A.1    Kwon, Y.J.2    Windisch, M.P.3    Kim, N.Y.4    Choi, S.Y.5    Kim, H.C.6
  • 38
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • doi: 10.1016/j.cell.2010.01.025
    • Grivennikov, S. I., Greten, F. R., and Karin, M. (2010). Immunity, inflammation, and cancer. Cell 140, 883-899. doi: 10.1016/j.cell.2010.01.025
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 39
    • 17444373533 scopus 로고    scopus 로고
    • Cell cycle arrest in G2/M promotes early steps of infection by human immunodeficiency virus
    • doi: 10.1128/JVI.79.9.5695-5704.2005
    • Groschel, B., and Bushman, F. (2005). Cell cycle arrest in G2/M promotes early steps of infection by human immunodeficiency virus. J. Virol. 79, 5695-5704. doi: 10.1128/JVI.79.9.5695-5704.2005
    • (2005) J. Virol. , vol.79 , pp. 5695-5704
    • Groschel, B.1    Bushman, F.2
  • 40
    • 0037032428 scopus 로고    scopus 로고
    • Cleavage of a DNA-RNA-DNA/DNA chimeric substrate containing a single ribonucleotide at the DNA-RNA junction with prokaryotic RNases HII
    • doi: 10.1016/S0014-5793(02)03503-2
    • Haruki, M., Tsunaka, Y., Morikawa, M., and Kanaya, S. (2002). Cleavage of a DNA-RNA-DNA/DNA chimeric substrate containing a single ribonucleotide at the DNA-RNA junction with prokaryotic RNases HII. FEBS Lett. 531, 204-208. doi: 10.1016/S0014-5793(02)03503-2
    • (2002) FEBS Lett. , vol.531 , pp. 204-208
    • Haruki, M.1    Tsunaka, Y.2    Morikawa, M.3    Kanaya, S.4
  • 41
    • 0028853961 scopus 로고
    • Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity
    • He, J., Choe, S., Walker, R., Di Marzio, P., Morgan, D. O., and Landau, N. R. (1995). Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. J. Virol. 69, 6705-6711.
    • (1995) J. Virol. , vol.69 , pp. 6705-6711
    • He, J.1    Choe, S.2    Walker, R.3    Di Marzio, P.4    Morgan, D.O.5    Landau, N.R.6
  • 42
    • 0028239060 scopus 로고
    • The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells
    • doi: 10.1073/pnas.91.15.7311
    • Heinzinger, N. K., Bukinsky, M. I., Haggerty, S. A., Ragland, A. M., Kewalramani, V., Lee, M. A., et al. (1994). The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. Proc. Natl. Acad. Sci. U.S.A. 91, 7311-7315. doi: 10.1073/pnas.91.15.7311
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 7311-7315
    • Heinzinger, N.K.1    Bukinsky, M.I.2    Haggerty, S.A.3    Ragland, A.M.4    Kewalramani, V.5    Lee, M.A.6
  • 43
    • 59349088766 scopus 로고    scopus 로고
    • Small DNA tumor viruses: large contributors to biomedical sciences
    • doi: 10.1016/j.virol.2008.12.006
    • Howley, P. M., and Livingston, D. M. (2009). Small DNA tumor viruses: large contributors to biomedical sciences. Virology 384, 256-259. doi: 10.1016/j.virol.2008.12.006
    • (2009) Virology , vol.384 , pp. 256-259
    • Howley, P.M.1    Livingston, D.M.2
  • 45
    • 0029165291 scopus 로고
    • The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle
    • Jowett, J. B., Planelles, V., Poon, B., Shah, N. P., Chen, M. L., and Chen, I. S. (1995). The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle. J. Virol. 69, 6304-6313.
    • (1995) J. Virol. , vol.69 , pp. 6304-6313
    • Jowett, J.B.1    Planelles, V.2    Poon, B.3    Shah, N.P.4    Chen, M.L.5    Chen, I.S.6
  • 46
    • 31344461659 scopus 로고    scopus 로고
    • Innate immune recognition of viral infection
    • doi: 10.1038/ni1303
    • Kawai, T., and Akira, S. (2006). Innate immune recognition of viral infection. Nat. Immunol. 7, 131-137. doi: 10.1038/ni1303
    • (2006) Nat. Immunol. , vol.7 , pp. 131-137
    • Kawai, T.1    Akira, S.2
  • 47
    • 0025907983 scopus 로고
    • HBx gene of hepatitis B virus induces liver cancer in transgenic mice
    • doi: 10.1038/351317a0
    • Kim, C. M., Koike, K., Saito, I., Miyamura, T., and Jay, G. (1991). HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351, 317-320. doi: 10.1038/351317a0
    • (1991) Nature , vol.351 , pp. 317-320
    • Kim, C.M.1    Koike, K.2    Saito, I.3    Miyamura, T.4    Jay, G.5
  • 48
    • 46749106037 scopus 로고    scopus 로고
    • Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24
    • doi: 10.1182/blood-2007-09-113092
    • Kim, J. M., Kee, Y., Gurtan, A., and D'Andrea, A. D. (2008). Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood 111, 5215-5222. doi: 10.1182/blood-2007-09-113092
    • (2008) Blood , vol.111 , pp. 5215-5222
    • Kim, J.M.1    Kee, Y.2    Gurtan, A.3    D'Andrea, A.D.4
  • 50
    • 84926665256 scopus 로고    scopus 로고
    • SAMHD1 prevents autoimmunity by maintaining genome stability
    • doi: 10.1136/annrheumdis-2013-204845
    • Kretschmer, S., Wolf, C., Konig, N., Staroske, W., Guck, J., Hausler, M., et al. (2014). SAMHD1 prevents autoimmunity by maintaining genome stability. Ann. Rheum. Dis. doi: 10.1136/annrheumdis-2013-204845
    • (2014) Ann. Rheum. Dis.
    • Kretschmer, S.1    Wolf, C.2    Konig, N.3    Staroske, W.4    Guck, J.5    Hausler, M.6
  • 51
    • 33645745240 scopus 로고    scopus 로고
    • Spectrum of Epstein-Barr virus-associated diseases
    • doi: 10.1146/annurev.pathol.1.110304.100209
    • Kutok, J. L., and Wang, F. (2006). Spectrum of Epstein-Barr virus-associated diseases. Annu. Rev. Pathol. 1, 375-404. doi: 10.1146/annurev.pathol.1.110304.100209
    • (2006) Annu. Rev. Pathol. , vol.1 , pp. 375-404
    • Kutok, J.L.1    Wang, F.2
  • 52
    • 84892799863 scopus 로고    scopus 로고
    • Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing
    • doi: 10.1016/j.cell.2013.12.011
    • Laguette, N., Bregnard, C., Hue, P., Basbous, J., Yatim, A., Larroque, M., et al. (2014). Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing. Cell 156, 134-145. doi: 10.1016/j.cell.2013.12.011
    • (2014) Cell , vol.156 , pp. 134-145
    • Laguette, N.1    Bregnard, C.2    Hue, P.3    Basbous, J.4    Yatim, A.5    Larroque, M.6
  • 53
    • 84862777555 scopus 로고    scopus 로고
    • SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
    • doi: 10.1038/ni.2236
    • Lahouassa, H., Daddacha, W., Hofmann, H., Ayinde, D., Logue, E. C., Dragin, L., et al. (2012). SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat. Immunol. 13, 223-228. doi: 10.1038/ni.2236
    • (2012) Nat. Immunol. , vol.13 , pp. 223-228
    • Lahouassa, H.1    Daddacha, W.2    Hofmann, H.3    Ayinde, D.4    Logue, E.C.5    Dragin, L.6
  • 54
    • 33846899500 scopus 로고    scopus 로고
    • HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase
    • doi: 10.4161/cc.6.2.3732
    • Le Rouzic, E., Belaidouni, N., Estrabaud, E., Morel, M., Rain, J. C., Transy, C., et al. (2007). HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase. Cell Cycle 6, 182-188. doi: 10.4161/cc.6.2.3732
    • (2007) Cell Cycle , vol.6 , pp. 182-188
    • Le Rouzic, E.1    Belaidouni, N.2    Estrabaud, E.3    Morel, M.4    Rain, J.C.5    Transy, C.6
  • 55
    • 0023873028 scopus 로고
    • Intrathecal synthesis of interferon-alpha in infants with progressive familial encephalopathy
    • doi: 10.1016/0022-510X(88)90125-6
    • Lebon, P., Badoual, J., Ponsot, G., Goutieres, F., Hemeury-Cukier, F., and Aicardi, J. (1988). Intrathecal synthesis of interferon-alpha in infants with progressive familial encephalopathy. J. Neurol. Sci. 84, 201-208. doi: 10.1016/0022-510X(88)90125-6
    • (1988) J. Neurol. Sci. , vol.84 , pp. 201-208
    • Lebon, P.1    Badoual, J.2    Ponsot, G.3    Goutieres, F.4    Hemeury-Cukier, F.5    Aicardi, J.6
  • 56
    • 0014818347 scopus 로고
    • Variation of interferon production during the cell cycle
    • Lee, S. H., and Rozee, K. R. (1970). Variation of interferon production during the cell cycle. Appl. Microbiol. 20, 11-15.
    • (1970) Appl. Microbiol. , vol.20 , pp. 11-15
    • Lee, S.H.1    Rozee, K.R.2
  • 57
    • 84891276148 scopus 로고    scopus 로고
    • APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma
    • doi: 10.1158/0008-5472.CAN-13-1753
    • Leonard, B., Hart, S. N., Burns, M. B., Carpenter, M. A., Temiz, N. A., Rathore, A., et al. (2013). APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma. Cancer Res. 73, 7222-7231. doi: 10.1158/0008-5472.CAN-13-1753
    • (2013) Cancer Res. , vol.73 , pp. 7222-7231
    • Leonard, B.1    Hart, S.N.2    Burns, M.B.3    Carpenter, M.A.4    Temiz, N.A.5    Rathore, A.6
  • 58
    • 77954251074 scopus 로고    scopus 로고
    • Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R
    • doi: 10.1186/1742-4690-7-59
    • Li, G., Park, H. U., Liang, D., and Zhao, R. Y. (2010). Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R. Retrovirology 7, 59. doi: 10.1186/1742-4690-7-59
    • (2010) Retrovirology , vol.7 , pp. 59
    • Li, G.1    Park, H.U.2    Liang, D.3    Zhao, R.Y.4
  • 59
    • 35548978945 scopus 로고    scopus 로고
    • The impact of a negligent G2/M checkpoint on genomic instability and cancer induction
    • doi: 10.1038/nrc2248
    • Lobrich, M., and Jeggo, P. A. (2007). The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat. Rev. Cancer 7, 861-869. doi: 10.1038/nrc2248
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 861-869
    • Lobrich, M.1    Jeggo, P.A.2
  • 60
    • 0033552943 scopus 로고    scopus 로고
    • Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
    • doi: 10.1038/16488
    • Lopez-Girona, A., Furnari, B., Mondesert, O., and Russell, P. (1999). Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature 397, 172-175. doi: 10.1038/16488
    • (1999) Nature , vol.397 , pp. 172-175
    • Lopez-Girona, A.1    Furnari, B.2    Mondesert, O.3    Russell, P.4
  • 61
    • 84878956988 scopus 로고    scopus 로고
    • HIV restriction factors and mechanisms of evasion
    • doi: 10.1101/cshperspect.a006940
    • Malim, M. H., and Bieniasz, P. D. (2012). HIV restriction factors and mechanisms of evasion. Cold Spring Harb. Perspect. Med. 2, a006940. doi: 10.1101/cshperspect.a006940
    • (2012) Cold Spring Harb. Perspect. Med. , vol.2
    • Malim, M.H.1    Bieniasz, P.D.2
  • 62
    • 33746539166 scopus 로고    scopus 로고
    • DNA precursor metabolism and genomic stability
    • doi: 10.1096/fj.06-5730rev
    • Mathews, C. K. (2006). DNA precursor metabolism and genomic stability. FASEB J. 20, 1300-1314. doi: 10.1096/fj.06-5730rev
    • (2006) FASEB J. , vol.20 , pp. 1300-1314
    • Mathews, C.K.1
  • 63
    • 80053544629 scopus 로고    scopus 로고
    • Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis
    • doi: 10.1016/j.cell.2011.08.032
    • Matos, J., Blanco, M. G., Maslen, S., Skehel, J. M., and West, S. C. (2011). Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis. Cell 147, 158-172. doi: 10.1016/j.cell.2011.08.032
    • (2011) Cell , vol.147 , pp. 158-172
    • Matos, J.1    Blanco, M.G.2    Maslen, S.3    Skehel, J.M.4    West, S.C.5
  • 64
    • 84892432014 scopus 로고    scopus 로고
    • Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregation
    • doi: 10.1016/j.celrep.2013.05.039
    • Matos, J., Blanco, M. G., and West, S. C. (2013). Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregation. Cell Rep. 4, 76-86. doi: 10.1016/j.celrep.2013.05.039
    • (2013) Cell Rep. , vol.4 , pp. 76-86
    • Matos, J.1    Blanco, M.G.2    West, S.C.3
  • 65
    • 34249947699 scopus 로고    scopus 로고
    • ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    • doi: 10.1126/science.1140321
    • Matsuoka, S., Ballif, B. A., Smogorzewska, A., Mcdonald, E. R. III, Hurov, K. E., Luo, J., et al. (2007). ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166. doi: 10.1126/science.1140321
    • (2007) Science , vol.316 , pp. 1160-1166
    • Matsuoka, S.1    Ballif, B.A.2    Smogorzewska, A.3    Mcdonald, E.R.4    Hurov, K.E.5    Luo, J.6
  • 66
    • 0035805548 scopus 로고    scopus 로고
    • Structure and expression of the TREX1 and TREX2 3'→ 5' exonuclease genes
    • doi: 10.1074/jbc.M010051200
    • Mazur, D. J., and Perrino, F. W. (2001). Structure and expression of the TREX1 and TREX2 3' → 5' exonuclease genes. J. Biol. Chem. 276, 14718-14727. doi: 10.1074/jbc.M010051200
    • (2001) J. Biol. Chem. , vol.276 , pp. 14718-14727
    • Mazur, D.J.1    Perrino, F.W.2
  • 67
    • 2942746374 scopus 로고    scopus 로고
    • Involvement of mammalian Mus81 in genome integrity and tumor suppression
    • doi: 10.1126/science.1094557304/5678/1822
    • McPherson, J. P., Lemmers, B., Chahwan, R., Pamidi, A., Migon, E., Matysiak-Zablocki, E., et al. (2004). Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science 304, 1822-1826. doi: 10.1126/science.1094557304/5678/1822
    • (2004) Science , vol.304 , pp. 1822-1826
    • McPherson, J.P.1    Lemmers, B.2    Chahwan, R.3    Pamidi, A.4    Migon, E.5    Matysiak-Zablocki, E.6
  • 68
    • 84892946076 scopus 로고    scopus 로고
    • IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV
    • doi: 10.1126/science.1243640
    • Monroe, K. M., Yang, Z., Johnson, J. R., Geng, X., Doitsh, G., Krogan, N. J., et al. (2013). IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science 343, 428-432. doi: 10.1126/science.1243640
    • (2013) Science , vol.343 , pp. 428-432
    • Monroe, K.M.1    Yang, Z.2    Johnson, J.R.3    Geng, X.4    Doitsh, G.5    Krogan, N.J.6
  • 69
    • 34547107878 scopus 로고    scopus 로고
    • A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints
    • doi: 10.1074/jbc.C700079200
    • Mu, J. J., Wang, Y., Luo, H., Leng, M., Zhang, J., Yang, T., et al. (2007). A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J. Biol. Chem. 282, 17330-17334. doi: 10.1074/jbc.C700079200
    • (2007) J. Biol. Chem. , vol.282 , pp. 17330-17334
    • Mu, J.J.1    Wang, Y.2    Luo, H.3    Leng, M.4    Zhang, J.5    Yang, T.6
  • 70
    • 67649641641 scopus 로고    scopus 로고
    • Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair
    • doi: 10.1016/j.molcel.2009.06.020
    • Munoz, I. M., Hain, K., Declais, A. C., Gardiner, M., Toh, G. W., Sanchez-Pulido, L., et al. (2009). Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol. Cell 35, 116-127. doi: 10.1016/j.molcel.2009.06.020
    • (2009) Mol. Cell , vol.35 , pp. 116-127
    • Munoz, I.M.1    Hain, K.2    Declais, A.C.3    Gardiner, M.4    Toh, G.W.5    Sanchez-Pulido, L.6
  • 71
    • 67349187702 scopus 로고    scopus 로고
    • The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities
    • doi: 10.1038/ncb1883ncb1883
    • Naim, V., and Rosselli, F. (2009). The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities. Nat. Cell Biol. 11, 761-768. doi: 10.1038/ncb1883ncb1883
    • (2009) Nat. Cell Biol. , vol.11 , pp. 761-768
    • Naim, V.1    Rosselli, F.2
  • 72
    • 84881471113 scopus 로고    scopus 로고
    • ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis
    • doi: 10.1038/ncb2793ncb2793
    • Naim, V., Wilhelm, T., Debatisse, M., and Rosselli, F. (2013). ERCC1 and MUS81-EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis. Nat. Cell Biol. 15, 1008-1015. doi: 10.1038/ncb2793ncb2793
    • (2013) Nat. Cell Biol. , vol.15 , pp. 1008-1015
    • Naim, V.1    Wilhelm, T.2    Debatisse, M.3    Rosselli, F.4
  • 73
    • 40649114040 scopus 로고    scopus 로고
    • HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation
    • doi: 10.1016/j.virol.2007.10.042
    • Okumura, A., Alce, T., Lubyova, B., Ezelle, H., Strebel, K., and Pitha, P. M. (2008). HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation. Virology 373, 85-97. doi: 10.1016/j.virol.2007.10.042
    • (2008) Virology , vol.373 , pp. 85-97
    • Okumura, A.1    Alce, T.2    Lubyova, B.3    Ezelle, H.4    Strebel, K.5    Pitha, P.M.6
  • 74
    • 0030951420 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard
    • Poon, B., Jowett, J. B., Stewart, S. A., Armstrong, R. W., Rishton, G. M., and Chen, I. S. (1997). Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard. J. Virol. 71, 3961-3971.
    • (1997) J. Virol. , vol.71 , pp. 3961-3971
    • Poon, B.1    Jowett, J.B.2    Stewart, S.A.3    Armstrong, R.W.4    Rishton, G.M.5    Chen, I.S.6
  • 75
    • 0030845529 scopus 로고    scopus 로고
    • Inactivation of the Fanconi anemia group C gene augments interferon-gamma-induced apoptotic responses in hematopoietic cells
    • Rathbun, R. K., Faulkner, G. R., Ostroski, M. H., Christianson, T. A., Hughes, G., Jones, G., et al. (1997). Inactivation of the Fanconi anemia group C gene augments interferon-gamma-induced apoptotic responses in hematopoietic cells. Blood 90, 974-985.
    • (1997) Blood , vol.90 , pp. 974-985
    • Rathbun, R.K.1    Faulkner, G.R.2    Ostroski, M.H.3    Christianson, T.A.4    Hughes, G.5    Jones, G.6
  • 76
    • 0028801303 scopus 로고
    • Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B
    • Re, F., Braaten, D., Franke, E. K., and Luban, J. (1995). Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. J. Virol. 69, 6859-6864.
    • (1995) J. Virol. , vol.69 , pp. 6859-6864
    • Re, F.1    Braaten, D.2    Franke, E.K.3    Luban, J.4
  • 77
    • 35349019691 scopus 로고    scopus 로고
    • Clinical and molecular phenotype of Aicardi-Goutieres syndrome
    • doi: 10.1086/521373
    • Rice, G., Patrick, T., Parmar, R., Taylor, C. F., Aeby, A., Aicardi, J., et al. (2007). Clinical and molecular phenotype of Aicardi-Goutieres syndrome. Am. J. Hum. Genet. 81, 713-725. doi: 10.1086/521373
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 713-725
    • Rice, G.1    Patrick, T.2    Parmar, R.3    Taylor, C.F.4    Aeby, A.5    Aicardi, J.6
  • 78
    • 84883432724 scopus 로고    scopus 로고
    • An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers
    • doi: 10.1038/ng.2702ng.2702
    • Roberts, S. A., Lawrence, M. S., Klimczak, L. J., Grimm, S. A., Fargo, D., Stojanov, P., et al. (2013). An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat. Genet. 45, 970-976. doi: 10.1038/ng.2702ng.2702
    • (2013) Nat. Genet. , vol.45 , pp. 970-976
    • Roberts, S.A.1    Lawrence, M.S.2    Klimczak, L.J.3    Grimm, S.A.4    Fargo, D.5    Stojanov, P.6
  • 79
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    • doi: 10.1038/ncb1909ncb1909
    • Rodier, F., Coppe, J. P., Patil, C. K., Hoeijmakers, W. A., Munoz, D. P., Raza, S. R., et al. (2009). Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol. 11, 973-979. doi: 10.1038/ncb1909ncb1909
    • (2009) Nat. Cell Biol. , vol.11 , pp. 973-979
    • Rodier, F.1    Coppe, J.P.2    Patil, C.K.3    Hoeijmakers, W.A.4    Munoz, D.P.5    Raza, S.R.6
  • 80
    • 0028813107 scopus 로고
    • The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection
    • Rogel, M. E., Wu, L. I., and Emerman, M. (1995). The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection. J. Virol. 69, 882-888.
    • (1995) J. Virol. , vol.69 , pp. 882-888
    • Rogel, M.E.1    Wu, L.I.2    Emerman, M.3
  • 81
    • 0037830710 scopus 로고    scopus 로고
    • Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R
    • doi: 10.1074/jbc.M303948200M303948200
    • Roshal, M., Kim, B., Zhu, Y., Nghiem, P., and Planelles, V. (2003). Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R. J. Biol. Chem. 278, 25879-25886. doi: 10.1074/jbc.M303948200M303948200
    • (2003) J. Biol. Chem. , vol.278 , pp. 25879-25886
    • Roshal, M.1    Kim, B.2    Zhu, Y.3    Nghiem, P.4    Planelles, V.5
  • 82
    • 0030867582 scopus 로고    scopus 로고
    • Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25
    • doi: 10.1126/science.277.5331.1497
    • Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., et al. (1997). Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277, 1497-1501. doi: 10.1126/science.277.5331.1497
    • (1997) Science , vol.277 , pp. 1497-1501
    • Sanchez, Y.1    Wong, C.2    Thoma, R.S.3    Richman, R.4    Wu, Z.5    Piwnica-Worms, H.6
  • 83
    • 0015891353 scopus 로고
    • A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents
    • Sasaki, M. S., and Tonomura, A. (1973). A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents. Cancer Res. 33, 1829-1836.
    • (1973) Cancer Res. , vol.33 , pp. 1829-1836
    • Sasaki, M.S.1    Tonomura, A.2
  • 84
    • 84885968281 scopus 로고    scopus 로고
    • Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage
    • doi: 10.1093/nar/gkt645
    • Saugar, I., Vazquez, M. V., Gallo-Fernandez, M., Ortiz-Bazan, M. A., Segurado, M., Calzada, A., et al. (2013). Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage. Nucleic Acids Res. 41, 8943-8958. doi: 10.1093/nar/gkt645
    • (2013) Nucleic Acids Res. , vol.41 , pp. 8943-8958
    • Saugar, I.1    Vazquez, M.V.2    Gallo-Fernandez, M.3    Ortiz-Bazan, M.A.4    Segurado, M.5    Calzada, A.6
  • 85
    • 79955522790 scopus 로고    scopus 로고
    • Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes
    • doi: 10.1007/s00412-010-0304-7
    • Schwartz, E. K., and Heyer, W. D. (2011). Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes. Chromosoma 120, 109-127. doi: 10.1007/s00412-010-0304-7
    • (2011) Chromosoma , vol.120 , pp. 109-127
    • Schwartz, E.K.1    Heyer, W.D.2
  • 86
    • 0033603819 scopus 로고    scopus 로고
    • Roles of p53 and caspases in the induction of cell cycle arrest and apoptosis by HIV-1 Vpr
    • doi: 10.1006/excr.1999.4568
    • Shostak, L. D., Ludlow, J., Fisk, J., Pursell, S., Rimel, B. J., Nguyen, D., et al. (1999). Roles of p53 and caspases in the induction of cell cycle arrest and apoptosis by HIV-1 Vpr. Exp. Cell Res. 251, 156-165. doi: 10.1006/excr.1999.4568
    • (1999) Exp. Cell Res. , vol.251 , pp. 156-165
    • Shostak, L.D.1    Ludlow, J.2    Fisk, J.3    Pursell, S.4    Rimel, B.J.5    Nguyen, D.6
  • 87
    • 84894353718 scopus 로고    scopus 로고
    • DNA damage response: three levels of DNA repair regulation
    • doi: 10.1101/cshperspect.a012724a012724
    • Sirbu, B. M., and Cortez, D. (2013). DNA damage response: three levels of DNA repair regulation. Cold Spring Harb. Perspect. Biol. 5, a012724. doi: 10.1101/cshperspect.a012724a012724
    • (2013) Cold Spring Harb. Perspect. Biol. , vol.5
    • Sirbu, B.M.1    Cortez, D.2
  • 88
    • 77958498222 scopus 로고    scopus 로고
    • The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    • doi: 10.1016/B978-0-12-380888-2.00003-0
    • Smith, J., Tho, L. M., Xu, N., and Gillespie, D. A. (2010). The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv. Cancer Res. 108, 73-112. doi: 10.1016/B978-0-12-380888-2.00003-0
    • (2010) Adv. Cancer Res. , vol.108 , pp. 73-112
    • Smith, J.1    Tho, L.M.2    Xu, N.3    Gillespie, D.A.4
  • 89
    • 33646907207 scopus 로고    scopus 로고
    • Control of the G2/M transition
    • doi: 10.1385/MB:32:3:227
    • Stark, G. R., and Taylor, W. R. (2006). Control of the G2/M transition. Mol. Biotechnol. 32, 227-248. doi: 10.1385/MB:32:3:227
    • (2006) Mol. Biotechnol. , vol.32 , pp. 227-248
    • Stark, G.R.1    Taylor, W.R.2
  • 90
    • 0031901250 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription
    • Stark, L. A., and Hay, R. T. (1998). Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA synthetase: implications for priming of HIV-1 reverse transcription. J. Virol. 72, 3037-3044.
    • (1998) J. Virol. , vol.72 , pp. 3037-3044
    • Stark, L.A.1    Hay, R.T.2
  • 91
    • 33746895106 scopus 로고    scopus 로고
    • Antiviral defense: interferons and beyond
    • doi: 10.1084/jem.20061377
    • Stetson, D. B., and Medzhitov, R. (2006). Antiviral defense: interferons and beyond. J. Exp. Med. 203, 1837-1841. doi: 10.1084/jem.20061377
    • (2006) J. Exp. Med. , vol.203 , pp. 1837-1841
    • Stetson, D.B.1    Medzhitov, R.2
  • 92
    • 0030920243 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest
    • Stewart, S. A., Poon, B., Jowett, J. B., and Chen, I. S. (1997). Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest. J. Virol. 71, 5579-5592.
    • (1997) J. Virol. , vol.71 , pp. 5579-5592
    • Stewart, S.A.1    Poon, B.2    Jowett, J.B.3    Chen, I.S.4
  • 93
    • 79251632658 scopus 로고    scopus 로고
    • SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype
    • doi: 10.1038/ng.751
    • Stoepker, C., Hain, K., Schuster, B., Hilhorst-Hofstee, Y., Rooimans, M. A., Steltenpool, J., et al. (2011). SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat. Genet. 43, 138-141. doi: 10.1038/ng.751
    • (2011) Nat. Genet. , vol.43 , pp. 138-141
    • Stoepker, C.1    Hain, K.2    Schuster, B.3    Hilhorst-Hofstee, Y.4    Rooimans, M.A.5    Steltenpool, J.6
  • 94
    • 80955155438 scopus 로고    scopus 로고
    • The Fanconi anemia pathway and DNA interstrand cross-link repair
    • doi: 10.1007/s13238-011-1098-y
    • Su, X., and Huang, J. (2011). The Fanconi anemia pathway and DNA interstrand cross-link repair. Protein Cell 2, 704-711. doi: 10.1007/s13238-011-1098-y
    • (2011) Protein Cell , vol.2 , pp. 704-711
    • Su, X.1    Huang, J.2
  • 95
    • 67649662604 scopus 로고    scopus 로고
    • Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
    • doi: 10.1016/j.cell.2009.06.030
    • Svendsen, J. M., Smogorzewska, A., Sowa, M. E., O'Connell, B. C., Gygi, S. P., Elledge, S. J., et al. (2009). Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell 138, 63-77. doi: 10.1016/j.cell.2009.06.030
    • (2009) Cell , vol.138 , pp. 63-77
    • Svendsen, J.M.1    Smogorzewska, A.2    Sowa, M.E.3    O'Connell, B.C.4    Gygi, S.P.5    Elledge, S.J.6
  • 96
    • 84876407519 scopus 로고    scopus 로고
    • Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover
    • doi: 10.1038/emboj.2013.67
    • Szakal, B., and Branzei, D. (2013). Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover. EMBO J. 32, 1155-1167. doi: 10.1038/emboj.2013.67
    • (2013) EMBO J. , vol.32 , pp. 1155-1167
    • Szakal, B.1    Branzei, D.2
  • 97
    • 34648833229 scopus 로고    scopus 로고
    • DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
    • doi: 10.1128/JVI.01380-07
    • Tan, L., Ehrlich, E., and Yu, X. F. (2007). DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest. J. Virol. 81, 10822-10830. doi: 10.1128/JVI.01380-07
    • (2007) J. Virol. , vol.81 , pp. 10822-10830
    • Tan, L.1    Ehrlich, E.2    Yu, X.F.3
  • 98
    • 79953239469 scopus 로고    scopus 로고
    • Aberrant chromosome morphology in human cells defective for Holliday junction resolution
    • doi: 10.1038/nature09790nature09790
    • Wechsler, T., Newman, S., and West, S. C. (2011). Aberrant chromosome morphology in human cells defective for Holliday junction resolution. Nature 471, 642-646. doi: 10.1038/nature09790nature09790
    • (2011) Nature , vol.471 , pp. 642-646
    • Wechsler, T.1    Newman, S.2    West, S.C.3
  • 99
    • 77957951602 scopus 로고    scopus 로고
    • Genomes in conflict: maintaining genome integrity during virus infection
    • doi: 10.1146/annurev.micro.112408.134016
    • Weitzman, M. D., Lilley, C. E., and Chaurushiya, M. S. (2010). Genomes in conflict: maintaining genome integrity during virus infection. Annu. Rev. Microbiol. 64, 61-81. doi: 10.1146/annurev.micro.112408.134016
    • (2010) Annu. Rev. Microbiol. , vol.64 , pp. 61-81
    • Weitzman, M.D.1    Lilley, C.E.2    Chaurushiya, M.S.3
  • 100
    • 34848911347 scopus 로고    scopus 로고
    • The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor
    • doi: 10.1074/jbc.M703955200
    • Wen, X., Duus, K. M., Friedrich, T. D., and De Noronha, C. M. (2007). The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor. J. Biol. Chem. 282, 27046-27057. doi: 10.1074/jbc.M703955200
    • (2007) J. Biol. Chem. , vol.282 , pp. 27046-27057
    • Wen, X.1    Duus, K.M.2    Friedrich, T.D.3    De Noronha, C.M.4
  • 101
    • 8944258558 scopus 로고    scopus 로고
    • Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene
    • Whitney, M. A., Royle, G., Low, M. J., Kelly, M. A., Axthelm, M. K., Reifsteck, C., et al. (1996). Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene. Blood 88, 49-58.
    • (1996) Blood , vol.88 , pp. 49-58
    • Whitney, M.A.1    Royle, G.2    Low, M.J.3    Kelly, M.A.4    Axthelm, M.K.5    Reifsteck, C.6
  • 102
    • 0347987856 scopus 로고    scopus 로고
    • The Bloom's syndrome helicase suppresses crossing over during homologous recombination
    • doi: 10.1038/nature02253nature02253
    • Wu, L., and Hickson, I. D. (2003). The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature 426, 870-874. doi: 10.1038/nature02253nature02253
    • (2003) Nature , vol.426 , pp. 870-874
    • Wu, L.1    Hickson, I.D.2
  • 103
    • 84886241606 scopus 로고    scopus 로고
    • Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells
    • doi: 10.1016/j.molcel.2013.08.035
    • Wyatt, H. D., Sarbajna, S., Matos, J., and West, S. C. (2013). Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells. Mol. Cell 52, 234-247. doi: 10.1016/j.molcel.2013.08.035
    • (2013) Mol. Cell , vol.52 , pp. 234-247
    • Wyatt, H.D.1    Sarbajna, S.2    Matos, J.3    West, S.C.4
  • 104
    • 79955580794 scopus 로고    scopus 로고
    • Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway
    • doi: 10.1073/pnas.1018487108
    • Yamamoto, K. N., Kobayashi, S., Tsuda, M., Kurumizaka, H., Takata, M., Kono, K., et al. (2011). Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc. Natl. Acad. Sci. U.S.A. 108, 6492-6496. doi: 10.1073/pnas.1018487108
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 6492-6496
    • Yamamoto, K.N.1    Kobayashi, S.2    Tsuda, M.3    Kurumizaka, H.4    Takata, M.5    Kono, K.6
  • 105
    • 77958114725 scopus 로고    scopus 로고
    • The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
    • doi: 10.1038/ni.1941
    • Yan, N., Regalado-Magdos, A. D., Stiggelbout, B., Lee-Kirsch, M. A., and Lieberman, J. (2010). The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat. Immunol. 11, 1005-1013. doi: 10.1038/ni.1941
    • (2010) Nat. Immunol. , vol.11 , pp. 1005-1013
    • Yan, N.1    Regalado-Magdos, A.D.2    Stiggelbout, B.3    Lee-Kirsch, M.A.4    Lieberman, J.5
  • 106
    • 36248988008 scopus 로고    scopus 로고
    • Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
    • doi: 10.1016/j.cell.2007.10.017
    • Yang, Y. G., Lindahl, T., and Barnes, D. E. (2007). Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 131, 873-886. doi: 10.1016/j.cell.2007.10.017
    • (2007) Cell , vol.131 , pp. 873-886
    • Yang, Y.G.1    Lindahl, T.2    Barnes, D.E.3
  • 108
    • 79955004696 scopus 로고    scopus 로고
    • Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN
    • doi: 10.4049/jimmunol.1003389
    • Zhang, X., Brann, T. W., Zhou, M., Yang, J., Oguariri, R. M., Lidie, K. B., et al. (2011). Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN. J. Immunol. 186, 4541-4545. doi: 10.4049/jimmunol.1003389
    • (2011) J. Immunol. , vol.186 , pp. 4541-4545
    • Zhang, X.1    Brann, T.W.2    Zhou, M.3    Yang, J.4    Oguariri, R.M.5    Lidie, K.B.6
  • 109
    • 84884590112 scopus 로고    scopus 로고
    • Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutieres syndrome-related SAMHD1
    • doi: 10.1016/j.celrep.2013.08.019
    • Zhao, K., Du, J., Han, X., Goodier, J. L., Li, P., Zhou, X., et al. (2013). Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutieres syndrome-related SAMHD1. Cell Rep. 4, 1108-1115. doi: 10.1016/j.celrep.2013.08.019
    • (2013) Cell Rep. , vol.4 , pp. 1108-1115
    • Zhao, K.1    Du, J.2    Han, X.3    Goodier, J.L.4    Li, P.5    Zhou, X.6
  • 110
    • 34447132813 scopus 로고    scopus 로고
    • Fen1 mutations result in autoimmunity, chronic inflammation and cancers
    • doi: 10.1038/nm1599
    • Zheng, L., Dai, H., Zhou, M., Li, M., Singh, P., Qiu, J., et al. (2007). Fen1 mutations result in autoimmunity, chronic inflammation and cancers. Nat. Med. 13, 812-819. doi: 10.1038/nm1599
    • (2007) Nat. Med. , vol.13 , pp. 812-819
    • Zheng, L.1    Dai, H.2    Zhou, M.3    Li, M.4    Singh, P.5    Qiu, J.6


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