HIV accessory proteins versus host restriction factors

Current Opinion in Virology

Volumn 3, Issue 6, 2013, Pages 692-699

  Strebel, Klaus ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; BONE MARROW STROMAL CELL ANTIGEN 2; CD4 ANTIGEN; CELL ANTIGEN; HOST FACTOR; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; NEF PROTEIN; RESTRICTION FACTOR; STERILE ALPHA MOTIF AND HD DOMAIN PROTEIN 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VIF PROTEIN; VIRUS ENVELOPE PROTEIN; VPR PROTEIN; VPU PROTEIN; VPX PROTEIN;

CELL SURFACE; HOST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; REVIEW; VIRION; VIRUS INHIBITION; VIRUS MUTATION; VIRUS RELEASE; VIRUS REPLICATION; VIRUS TRANSMISSION;

ANTIGENS, CD; CYTIDINE DEAMINASE; GPI-LINKED PROTEINS; HIV; HOST-PATHOGEN INTERACTIONS; HUMAN IMMUNODEFICIENCY VIRUS PROTEINS; HUMANS; IMMUNE EVASION; LENTIVIRUSES, PRIMATE; MONOMERIC GTP-BINDING PROTEINS; VIF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; VIRAL REGULATORY AND ACCESSORY PROTEINS;

EID: 84890125460     PISSN: 18796257     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coviro.2013.08.004     Document Type: Review

References (82)

1. B. Walker, and A. McMichael The T-cell response to HIV Cold Spring Harb Perspect Med 2012 2
2. M. Perreau, Y. Levy, and G. Pantaleo Immune response to HIV Curr Opin HIV AIDS 8 2013 333 340
3. K. Strebel, J. Luban, and K.T. Jeang Human cellular restriction factors that target HIV-1 replication BMC Med 7 2009 48
4. N. Laguette, B. Sobhian, N. Casartelli, M. Ringeard, C. Chable-Bessia, E. Segeral, A. Yatim, S. Emiliani, O. Schwartz, and M. Benkirane SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx Nature 474 2011 654 657
5. K. Hrecka, C. Hao, M. Gierszewska, S.K. Swanson, M. Kesik-Brodacka, S. Srivastava, L. Florens, M.P. Washburn, and J. Skowronski Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein Nature 474 2011 658 661
6. B. Beer, J. Denner, C.R. Brown, S. Norley, J. zur Megede, C. Coulibaly, R. Plesker, S. Holzammer, M. Baier, and V.M. Hirsch Simian immunodeficiency virus of African green monkeys is apathogenic in the newborn natural host J Acquir Immune Defic Syndr Hum Retrovirol 18 1998 210 220
7. F. Gao, E. Bailes, D.L. Robertson, Y. Chen, C.M. Rodenburg, S.F. Michael, L.B. Cummins, L.O. Arthur, M. Peeters, and G.M. Shaw Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes Nature 397 1999 436 441
8. K. Bozek, and T. Lengauer Positive selection of HIV host factors and the evolution of lentivirus genes BMC Evol Biol 10 2010 186
9. A.M. Sheehy, N.C. Gaddis, J.D. Choi, and M.H. Malim Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein Nature 418 2002 646 650
10. R. Goila-Gaur, and K. Strebel HIV-1 Vif, APOBEC, and intrinsic immunity Retrovirology 5 2008 51
11. R.S. Harris, and M.T. Liddament Retroviral restriction by APOBEC proteins Nat Rev Immunol 4 2004 868 877 (Pubitemid 39490762)
12. I. Mohammed, M.K. Parai, X. Jiang, N. Sharova, G. Singh, M. Stevenson, and T.M. Rana SAR and lead optimization of an HIV-1 Vif-APOBEC3G axis inhibitor ACS Med Chem Lett 3 2012 465 469
13. T. Zuo, D. Liu, W. Lv, X. Wang, J. Wang, M. Lv, W. Huang, J. Wu, H. Zhang, and H. Jin Small-molecule inhibition of human immunodeficiency virus type 1 replication by targeting the interaction between Vif and ElonginC J Virol 86 2012 5497 5507
14. R.C. Walker Jr., M.A. Khan, S. Kao, R. Goila-Gaur, E. Miyagi, and K. Strebel Identification of dominant negative human immunodeficiency virus type 1 Vif mutants that interfere with the functional inactivation of APOBEC3G by virus-encoded Vif J Virol 84 2010 5201 5211
15. L.C. Mulder, A. Harari, and V. Simon Cytidine deamination induced HIV-1 drug resistance Proc Natl Acad Sci U S A 105 2008 5501 5506 (Pubitemid 351753892)
16. S. Wissing, N.L. Galloway, and W.C. Greene HIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factors Mol Aspects Med 31 2010 383 397
17. S. Opi, S. Kao, R. Goila-Gaur, M.A. Khan, E. Miyagi, H. Takeuchi, and K. Strebel Human immunodeficiency virus type 1 Vif inhibits packaging and antiviral activity of a degradation-resistant APOBEC3G variant J Virol 81 2007 8236 8246 (Pubitemid 47101509)
18. R. Goila-Gaur, M.A. Khan, E. Miyagi, and K. Strebel Differential sensitivity of "old" versus "new" APOBEC3G to human immunodeficiency virus type 1 vif J Virol 83 2009 1156 1160
19. E. Miyagi, F. Schwartzkopff, R. Plishka, A. Buckler-White, K.A. Clouse, and K. Strebel APOBEC3G-independent reduction in virion infectivity during long-term HIV-1 replication in terminally differentiated macrophages Virology 379 2008 266 274
20. W. Zhang, J. Du, S.L. Evans, Y. Yu, and X.F. Yu T-cell differentiation factor CBF-beta regulates HIV-1 Vif-mediated evasion of host restriction Nature 481 2012 376 379
21. S. Jager, D.Y. Kim, J.F. Hultquist, K. Shindo, R.S. LaRue, E. Kwon, M. Li, B.D. Anderson, L. Yen, and D. Stanley Vif hijacks CBF-beta to degrade APOBEC3G and promote HIV-1 infection Nature 481 2012 371 375
22. N.A. Speck, and D.G. Gilliland Core-binding factors in haematopoiesis and leukaemia Nat Rev Cancer 2 2002 502 513 (Pubitemid 37328932)
23. D.Y. Kim, E. Kwon, P.D. Hartley, D.C. Crosby, S. Mann, N.J. Krogan, and J.D. Gross CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression Mol Cell 49 2013 632 644
24. A. Andrew, and K. Strebel HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms Mol Aspects Med 31 2010 407 417
25. S.J. Neil, T. Zang, and P.D. Bieniasz Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu Nature 451 2008 425 430 (Pubitemid 351158893)
26. N. Van Damme, D. Goff, C. Katsura, R.L. Jorgenson, R. Mitchell, M.C. Johnson, E.B. Stephens, and J. Guatelli The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein Cell Host Microbe 3 2008 245 252 (Pubitemid 351494713)
27. U. Schubert, A.V. Ferrer-Montiel, M. Oblatt-Montal, P. Henklein, K. Strebel, and M. Montal Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells FEBS Lett 398 1996 12 18 (Pubitemid 26400334)
28. G.D. Ewart, T. Sutherland, P.W. Gage, and G.B. Cox The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels J Virol 70 1996 7108 7115 (Pubitemid 26307427)
29. K. Hsu, J. Seharaseyon, P. Dong, S. Bour, and E. Marban Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel Mol Cell 14 2004 259 267 (Pubitemid 38515652)
30. H. Akari, S. Bour, S. Kao, A. Adachi, and K. Strebel The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors J Exp Med 194 2001 1299 1311 (Pubitemid 33055048)
31. S. Kupzig, V. Korolchuk, R. Rollason, A. Sugden, A. Wilde, and G. Banting Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology Traffic 4 2003 694 709 (Pubitemid 37168591)
32. A.J. Andrew, S. Kao, and K. Strebel C-terminal hydrophobic region in human bone marrow stromal cell antigen 2 (BST-2)/tetherin protein functions as second transmembrane motif J Biol Chem 286 2011 39967 39981
33. A.J. Andrew, E. Miyagi, S. Kao, and K. Strebel The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu Retrovirology 6 2009 80
34. D. Perez-Caballero, T. Zang, A. Ebrahimi, M.W. McNatt, D.A. Gregory, M.C. Johnson, and P.D. Bieniasz Tetherin inhibits HIV-1 release by directly tethering virions to cells Cell 139 2009 499 511
35. A.J. Andrew, C.E. Berndsen, S. Kao, and K. Strebel The size and conservation of a coiled-coil structure in the ectodomain of human BST-2/tetherin is dispensable for inhibition of HIV-1 virion release J Biol Chem 287 2012 44278 44288
36. E. Miyagi, A.J. Andrew, S. Kao, and K. Strebel Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion Proc Natl Acad Sci U S A 106 2009 2868 2873
37. M. Dube, C. Paquay, B.B. Roy, M.G. Bego, J. Mercier, and E.A. Cohen HIV-1 Vpu antagonizes BST-2 by interfering mainly with the trafficking of newly synthesized BST-2 to the cell surface Traffic 12 2011 1714 1729
38. D. Sauter, D. Unterweger, M. Vogl, S.M. Usmani, A. Heigele, S.F. Kluge, E. Hermkes, M. Moll, E. Barker, and M. Peeters Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein PLoS Pathog 2012 8
39. M. Shingai, T. Yoshida, M.A. Martin, and K. Strebel Some human immunodeficiency virus type 1 vpu proteins are able to antagonize macaque BST-2 in vitro and in vivo: Vpu-negative simian-human immunodeficiency viruses are attenuated in vivo J Virol 85 2011 9708 9715
40. S. Bour, and K. Strebel The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses J Virol 70 1996 8285 8300 (Pubitemid 26378403)
41. H. Hauser, L.A. Lopez, S.J. Yang, J.E. Oldenburg, C.M. Exline, J.C. Guatelli, and P.M. Cannon HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment Retrovirology 7 2010 51
42. U. Schubert, S. Bour, R.L. Willey, and K. Strebel Regulation of virus release by the macrophage-tropic human immunodeficiency virus type 1 AD8 isolate is redundant and can be controlled by either Vpu or Env J Virol 73 1999 887 896 (Pubitemid 29036739)
43. D. Sauter, M. Schindler, A. Specht, W.N. Landford, J. Munch, K.A. Kim, J. Votteler, U. Schubert, F. Bibollet-Ruche, and B.F. Keele Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains Cell Host Microbe 6 2009 409 421
44. K. Nikovics, M.-C. Dazza, M. Ekwalanga, F. Mammano, F. Clavel, and S. Saragosti Counteraction of tetherin antiviral activity by two closely related SIVs differing by the presence of a Vpu gene PLoS ONE 2012 7
45. R.A. Liberatore, and P.D. Bieniasz Tetherin is a key effector of the antiretroviral activity of type I interferon in vitro and in vivo Proc Natl Acad Sci U S A 108 2011 18097 18101
46. N. Casartelli, M. Sourisseau, J. Feldmann, F. Guivel-Benhassine, A. Mallet, A.G. Marcelin, J. Guatelli, and O. Schwartz Tetherin restricts productive HIV-1 cell-to-cell transmission PLoS Pathog 6 2010 e1000955
47. K. Strebel, T. Klimkait, and M.A. Martin A novel gene of HIV-1, vpu, and its 16-kilodalton product Science 241 1988 1221 1223
48. E.F. Terwilliger, E.A. Cohen, Y.C. Lu, J.G. Sodroski, and W.A. Haseltine Functional role of human immunodeficiency virus type 1 vpu Proc Natl Acad Sci U S A 86 1989 5163 5167 (Pubitemid 19182254)
49. E.A. Cohen, E.F. Terwilliger, J.G. Sodroski, and W.A. Haseltine Identification of a protein encoded by the vpu gene of HIV-1 Nature 334 1988 532 534
50. T.S. Theodore, G. Englund, A. Buckler-White, C.E. Buckler, M.A. Martin, and K.W. Peden Construction and characterization of a stable full-length macrophage-tropic HIV type 1 molecular clone that directs the production of high titers of progeny virions AIDS Res Hum Retroviruses 12 1996 191 194
51. S. Bour, H. Akari, E. Miyagi, and K. Strebel Naturally occurring amino acid substitutions in the HIV-2 ROD envelope glycoprotein regulate its ability to augment viral particle release Virology 309 2003 85 98 (Pubitemid 36506592)
52. M. Tristem, C. Marshall, A. Karpas, J. Petrik, and F. Hill Origin of vpx in lentiviruses Nature 347 1990 341 342 (Pubitemid 20332301)
53. V. Planelles, and E. Barker Roles of Vpr and Vpx in modulating the virus-host cell relationship Mol Aspects Med 31 2010 398 406
54. M. Fujita, M. Otsuka, M. Nomaguchi, and A. Adachi Multifaceted activity of HIV Vpr/Vpx proteins: the current view of their virological functions Rev Med Virol 20 2010 68 76
55. S. Srivastava, S.K. Swanson, N. Manel, L. Florens, M.P. Washburn, and J. Skowronski Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection PLoS Pathog 4 2008 e1000059
56. C. Goujon, J.L. Darlix, and A. Cimarelli The Vpx protein of HIV-2 Virologie 13 2009 259 269
57. A. Berger, A.F. Sommer, J. Zwarg, M. Hamdorf, K. Welzel, N. Esly, S. Panitz, A. Reuter, I. Ramos, and A. Jatiani SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutieres syndrome are highly susceptible to HIV-1 infection PLoS Pathog 7 2011 e1002425
58. C. Goujon, V. Arfi, T. Pertel, J. Luban, J. Lienard, D. Rigal, J.L. Darlix, and A. Cimarelli Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells J Virol 82 2008 12335 12345
59. C. Goujon, L. Riviere, L. Jarrosson-Wuilleme, J. Bernaud, D. Rigal, J.-L. Darlix, and A. Cimarelli SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells Retrovirology 4 2007 2 2
60. N. Sharova, Y. Wu, X. Zhu, R. Stranska, R. Kaushik, M. Sharkey, and M. Stevenson Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction PLoS Pathog 4 2008 e1000057
61. T. Gramberg, N. Sunseri, and N.R. Landau Evidence for an activation domain at the amino terminus of simian immunodeficiency virus Vpx J Virol 84 2010 1387 1396
62. H.-M. Baldauf, X. Pan, E. Erikson, S. Schmidt, W. Daddacha, M. Burggraf, K. Schenkova, I. Ambiel, G. Wabnitz, and T. Gramberg SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells Nat Med 18 2012 1682 1687
63. B. Descours, A. Cribier, C. Chable-Bessia, D. Ayinde, G. Rice, Y. Crow, A. Yatim, O. Schwartz, N. Laguette, and M. Benkirane SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+ T-cells Retrovirology 9 2012 87
64. J. Ahn, C. Hao, J. Yan, M. Delucia, J. Mehrens, C. Wang, A.M. Gronenborn, and J. Skowronski HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1 J Biol Chem 287 2012 12550 12558
65. S. Welbourn, E. Miyagi, T.E. White, F. Diaz-Griffero, and K. Strebel Identification and characterization of naturally occurring splice variants of SAMHD1 Retrovirology 9 2012 86
66. T.E. White, A. Brandariz-Nunez, J. Carlos Valle-Casuso, S. Amie, L. Nguyen, B. Kim, J. Brojatsch, and F. Diaz-Griffero Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1 Virology 436 2013 81 90
67. A. Goncalves, E. Karayel, G.I. Rice, K.L. Bennett, Y.J. Crow, G. Superti-Furga, and T. Burckstummer SAMHD1 is a nucleic-acid binding protein that is mislocalized due to Aicardi-Goutieres syndrome-associated mutations Hum Mutat 33 2012 1116 1122
68. N. Beloglazova, R. Flick, A. Tchigvintsev, G. Brown, A. Popovic, B. Nocek, and A.F. Yakunin Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction J Biol Chem 288 2013 8101 8110
69. D.C. Goldstone, V. Ennis-Adeniran, J.J. Hedden, H.C. Groom, G.I. Rice, E. Christodoulou, P.A. Walker, G. Kelly, L.F. Haire, and M.W. Yap HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase Nature 480 2011 379 382
70. R.D. Powell, P.J. Holland, T. Hollis, and F.W. Perrino Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase J Biol Chem 286 2011 43596 43600
71. H. Lahouassa, W. Daddacha, H. Hofmann, D. Ayinde, E.C. Logue, L. Dragin, N. Bloch, C. Maudet, M. Bertrand, and T. Gramberg SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates Nat Immunol 13 2012 223 228
72. B. Kim, L.A. Nguyen, W. Daddacha, and J.A. Hollenbaugh Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages J Biol Chem 287 2012 21570 21574
73. C. St Gelais, S. de Silva, S.M. Amie, C.M. Coleman, H. Hoy, J.A. Hollenbaugh, B. Kim, and L. Wu SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons Retrovirology 9 2012 105 105
74. T.E. White, A. Brandariz-Nunez, J.C. Valle-Casuso, S. Amie, L.A. Nguyen, B. Kim, M. Tuzova, and F. Diaz-Griffero The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation Cell Host Microbe 13 2013 441 451
75. A. Cribier, B. Descours, A.L.C. Valadao, N. Laguette, and M. Benkirane Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1 Cell Rep 3 2013 1036 1043
76. J.A. Endicott, M.E. Noble, and J.A. Tucker Cyclin-dependent kinases: inhibition and substrate recognition Curr Opin Struct Biol 9 1999 738 744
77. E.A. Nigg Cellular substrates of p34(cdc2) and its companion cyclin-dependent kinases Trends Cell Biol 3 1993 296 301 (Pubitemid 23242670)
78. A. Landi, V. Iannucci, A.V. Nuffel, P. Meuwissen, and B. Verhasselt One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef Curr HIV Res 9 2011 496 504
79. M. Doria Role of the CD4 down-modulation activity of Nef in HIV-1 infectivity Curr HIV Res 9 2011 490 495
80. L. Abraham, and O.T. Fackler HIV-1 Nef: a multifaceted modulator of T cell receptor signaling Cell Commun Signal 10 2012 39
81. B. Romani, and E.A. Cohen Lentivirus Vpr and Vpx accessory proteins usurp the cullin4-DDB1 (DCAF1) E3 ubiquitin ligase Curr Opin Virol 2 2012 755 763
82. S. Welbourn, S.M. Dutta, O.J. Semmes, and K. Strebel Restriction of virus infection but not catalytic dNTPase activity are regulated by phosphorylation of SAMHD1 J Virol 87 2013 11516 11524