Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies

Journal of Medicinal Chemistry

Volumn 57, Issue 9, 2014, Pages 3666-3677

  Condon, Stephen M ^a   Mitsuuchi, Yasuhiro ^a   Deng, Yijun ^a   Laporte, Matthew G ^a,g   Rippin, Susan R ^a   Haimowitz, Thomas ^a   Alexander, Matthew D ^a,h   Kumar, Pavan Tirunahari ^a   Hendi, Mukta S ^a   Lee, Yu Hua ^a   Benetatos, Christopher A ^a   Yu, Guangyao ^a   Kapoor, Gurpreet Singh ^a   Neiman, Eric ^a   Seipel, Martin E ^a   Burns, Jennifer M ^a   Graham, Martin A ^a   McKinlay, Mark A ^a,i   Li, Xiaochun ^b   Wang, Jiawei ^b   Shi, Yigong ^b   Feltham, Rebecca ^c,j   Bettjeman, Bodhi ^d   Cumming, Mathew H ^d   Vince, James E ^e,f   Khan, Nufail ^e,f   Silke, John ^c,e,f   Day, Catherine L ^d   Chunduru, Srinivas K ^a   more..

^a TetraLogic Pharmaceuticals   (United States)

^b TSINGHUA UNIVERSITY   (China)

^c LA TROBE UNIVERSITY   (Australia)

^d UNIVERSITY OF OTAGO   (New Zealand)

^e WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^f UNIVERSITY OF MELBOURNE   (Australia)

^g UNIVERSITY OF PITTSBURGH   (United States)

^h CELGENE CORPORATION   (United States)

ⁱ Task Force for Global Health   (United States)

^j INSTITUTE OF CANCER RESEARCH   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BIRINAPANT; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG INDICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; HEMATOLOGIC MALIGNANCY; MOUSE; NONHUMAN; SOLID TUMOR;

ANIMALS; ANTINEOPLASTIC AGENTS; CARRIER PROTEINS; DIPEPTIDES; DRUG DISCOVERY; HEMATOLOGIC NEOPLASMS; INDOLES; MICE; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; MOLECULAR MIMICRY; NEOPLASMS, EXPERIMENTAL;

EID: 84900308237     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500176w     Document Type: Article

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