-
1
-
-
13344278692
-
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
-
Liston P, et al. (1996) Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379:349-353.
-
(1996)
Nature
, vol.379
, pp. 349-353
-
-
Liston, P.1
-
2
-
-
0030698127
-
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
-
Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (1997) The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J 16:6914-6925.
-
(1997)
EMBO J
, vol.16
, pp. 6914-6925
-
-
Roy, N.1
Deveraux, Q.L.2
Takahashi, R.3
Salvesen, G.S.4
Reed, J.C.5
-
3
-
-
33644853217
-
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases
-
Samuel T, et al. (2006) Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases. J Biol Chem 281:1080-1090.
-
(2006)
J Biol Chem
, vol.281
, pp. 1080-1090
-
-
Samuel, T.1
-
4
-
-
0034607655
-
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
-
Yang Y, Fang S, Jensen JP, Weissman AM, Ashwell JD (2000) Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 288:874-877.
-
(2000)
Science
, vol.288
, pp. 874-877
-
-
Yang, Y.1
Fang, S.2
Jensen, J.P.3
Weissman, A.M.4
Ashwell, J.D.5
-
5
-
-
33645640920
-
The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases
-
Eckelman BP, Salvesen GS (2006) The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J Biol Chem 281:3254-3260.
-
(2006)
J Biol Chem
, vol.281
, pp. 3254-3260
-
-
Eckelman, B.P.1
Salvesen, G.S.2
-
6
-
-
0030885421
-
Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control
-
Chu ZL, et al. (1997) Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc Natl Acad Sci USA 94:10057-10062.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 10057-10062
-
-
Chu, Z.L.1
-
7
-
-
2442559290
-
Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro
-
Park SM, Yoon JB, Lee TH (2004) Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro. FEBS Lett 566:151-156.
-
(2004)
FEBS Lett
, vol.566
, pp. 151-156
-
-
Park, S.M.1
Yoon, J.B.2
Lee, T.H.3
-
8
-
-
0030447483
-
The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex
-
Shu HB, Takeuchi M, Goeddel DV (1996) The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc Natl Acad Sci USA 93:13973-13978.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13973-13978
-
-
Shu, H.B.1
Takeuchi, M.2
Goeddel, D.V.3
-
9
-
-
0029595282
-
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
-
Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (1995) The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83:1243-1252.
-
(1995)
Cell
, vol.83
, pp. 1243-1252
-
-
Rothe, M.1
Pan, M.G.2
Henzel, W.J.3
Ayres, T.M.4
Goeddel, D.V.5
-
10
-
-
0032508414
-
NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS, Jr (1998) NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281:1680-1683.
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
Mayo, M.W.2
Korneluk, R.G.3
Goeddel, D.V.4
Baldwin Jr, A.S.5
-
11
-
-
36148954336
-
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
-
Vince JE, et al. (2007) IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 131:682-693.
-
(2007)
Cell
, vol.131
, pp. 682-693
-
-
Vince, J.E.1
-
12
-
-
36048999753
-
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
-
Varfolomeev E, et al. (2007) IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 131:669-681.
-
(2007)
Cell
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
-
14
-
-
33646034316
-
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
-
Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ (2006) Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell 22:245-257.
-
(2006)
Mol Cell
, vol.22
, pp. 245-257
-
-
Ea, C.K.1
Deng, L.2
Xia, Z.P.3
Pineda, G.4
Chen, Z.J.5
-
15
-
-
33645703930
-
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation
-
and correction 8:24
-
Wu CJ, Conze DB, Li T, Srinivasula SM, Ashwell JD (2006) Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation. Nat Cell Biol 8:398-406 and correction 8:24.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 398-406
-
-
Wu, C.J.1
Conze, D.B.2
Li, T.3
Srinivasula, S.M.4
Ashwell, J.D.5
-
16
-
-
4043136609
-
-
Lee TH, Shank J, Cusson N, KelliherMA(2001) The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2 J. Biol Chem 279:33185-33191.
-
Lee TH, Shank J, Cusson N, KelliherMA(2001) The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2 J. Biol Chem 279:33185-33191.
-
-
-
-
17
-
-
0034743199
-
NF-kappaB signals induce the expression of c-FLIP
-
Micheau O, Lens S, Gaide O, Alevizopoulos K, Tschopp J (2001) NF-kappaB signals induce the expression of c-FLIP. Mol Cell Biol 21:5299-5305.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5299-5305
-
-
Micheau, O.1
Lens, S.2
Gaide, O.3
Alevizopoulos, K.4
Tschopp, J.5
-
18
-
-
14844327760
-
Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
-
Kamata H, et al. (2005) Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120:649-661.
-
(2005)
Cell
, vol.120
, pp. 649-661
-
-
Kamata, H.1
-
19
-
-
26444605834
-
IKK/NF-kappaB signaling: Balancing life and death - a new approach to cancer therapy
-
KarinM
-
Luo JL, Kamata H, KarinM(2005) IKK/NF-kappaB signaling: Balancing life and death - a new approach to cancer therapy. J Clin Invest 115:2625-2632.
-
(2005)
J Clin Invest
, vol.115
, pp. 2625-2632
-
-
Luo, J.L.1
Kamata, H.2
-
20
-
-
30744452261
-
Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival
-
Conte D, et al. Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival. Mol Cell Biol 26:699-708.
-
Mol Cell Biol
, vol.26
, pp. 699-708
-
-
Conte, D.1
-
21
-
-
16244377737
-
Posttranscriptional down-regulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo
-
Conze DB, et al. (2005) Posttranscriptional down-regulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. Mol Cell Biol 25:3348-3356.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3348-3356
-
-
Conze, D.B.1
-
22
-
-
9144264424
-
Cloning and characterization of the rat homologues of the Inhibitor of Apoptosis protein 1, 2, and 3 genes
-
KornelukRG
-
Holcik M, Lefebvre CA, Hicks K, KornelukRG(2002) Cloning and characterization of the rat homologues of the Inhibitor of Apoptosis protein 1, 2, and 3 genes. BMC Genomics 3:5.
-
(2002)
BMC Genomics
, vol.3
, pp. 5
-
-
Holcik, M.1
Lefebvre, C.A.2
Hicks, K.3
-
23
-
-
32044447161
-
The E3 ubiquitin ligase itch couples JNK activation to TNFalphainduced cell death by inducing c-FLIP(L) turnover
-
Chang L, et al. (2006) The E3 ubiquitin ligase itch couples JNK activation to TNFalphainduced cell death by inducing c-FLIP(L) turnover Cell 124:601-613.
-
(2006)
Cell
, vol.124
, pp. 601-613
-
-
Chang, L.1
-
24
-
-
34249799878
-
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization
-
Lu M, et al. (2007) XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Mol Cell 26:689-702.
-
(2007)
Mol Cell
, vol.26
, pp. 689-702
-
-
Lu, M.1
-
25
-
-
35648935968
-
Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis
-
Santoro MM, Samuel T, Mitchell T, Reed JC, Stainier DY (2007) Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis Nat Genet 39:1397-1402.
-
(2007)
Nat Genet
, vol.39
, pp. 1397-1402
-
-
Santoro, M.M.1
Samuel, T.2
Mitchell, T.3
Reed, J.C.4
Stainier, D.Y.5
-
26
-
-
37749037799
-
Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs
-
Zobel K, et al. (2006) Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol 1:525-533.
-
(2006)
ACS Chem Biol
, vol.1
, pp. 525-533
-
-
Zobel, K.1
-
27
-
-
37549000486
-
A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling
-
Gaither A, et al. (2007) A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling. Cancer Res 67:11493-11498.
-
(2007)
Cancer Res
, vol.67
, pp. 11493-11498
-
-
Gaither, A.1
-
28
-
-
35948994157
-
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
-
Petersen SL, et al. Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 12:445-456.
-
Cancer Cell
, vol.12
, pp. 445-456
-
-
Petersen, S.L.1
|