Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo

ACS Nano

Volumn 9, Issue 2, 2015, Pages 1236-1249

  Mangraviti, Antonella ^a   Tzeng, Stephany Yi ^a   Kozielski, Kristen Lynn ^a   Wang, Yuan ^a,c   Jin, Yike ^a   Gullotti, David ^a   Pedone, Mariangela ^a   Buaron, Nitsa ^a,d   Liu, Ann ^a   Wilson, David R ^a   Hansen, Sarah K ^a   Rodriguez, Fausto J ^a   Gao, Guo Dong ^c   Dimeco, Francesco ^a,e   Brem, Henry ^a   Olivi, Alessandro ^a   Tyler, Betty ^a   Green, Jordan J ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^e DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

brain tumor; DNA; gene therapy; nanomedicine; nonviral gene delivery; polymer

Indexed keywords

ANTIVIRAL AGENTS; BIODEGRADABLE POLYMERS; BRAIN; CELL CULTURE; DNA; DRUG THERAPY; GENE THERAPY; GENE TRANSFER; LIPOSOMES; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; POLYMERS; TUMORS; VIRUSES;

1 ,4-BUTANEDIOL DIACRYLATE; BIODEGRADABLE POLYMERIC NANOPARTICLES; BRAIN TUMORS; CONVECTION ENHANCED DELIVERIES (CED); NANOPARTICLE FORMULATION; NON-VIRAL GENE DELIVERY; POLIES (BETA AMINO ESTER); POLYMERIC NANOPARTICLES;

SYNTHESIS (CHEMICAL);

DNA; GANCICLOVIR; NANOPARTICLE; POLY(BETA-AMINO ESTER); POLYMER; PRODRUG; THYMIDINE KINASE;

ANIMAL; BRAIN NEOPLASMS; CELL DEATH; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; GLIOMA; HERPES SIMPLEX VIRUS 1; METABOLISM; NANOMEDICINE; PATHOLOGY; PROCEDURES; RAT; SAFETY; SURVIVAL ANALYSIS; TUMOR CELL LINE;

ANIMALS; BRAIN NEOPLASMS; CELL DEATH; CELL LINE, TUMOR; DNA; FEMALE; GANCICLOVIR; GENETIC THERAPY; GLIOMA; HERPESVIRUS 1, HUMAN; NANOMEDICINE; NANOPARTICLES; POLYMERS; PRODRUGS; RATS; SAFETY; SURVIVAL ANALYSIS; THYMIDINE KINASE; TRANSFECTION;

EID: 84923410987     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn504905q     Document Type: Article

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