Biodegradable polymeric nanoparticles show high efficacy and specificity at DNA delivery to human glioblastoma in vitro and in vivo

ACS Nano

Volumn 8, Issue 5, 2014, Pages 5141-5153

  Guerrero Cázares, Hugo ^a   Tzeng, Stephany Y ^a,b   Young, Noah P ^a,b   Abutaleb, Ameer O ^a   Quiñones Hinojosa, Alfredo ^a   Green, Jordan J ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Johns Hopkins University   (United States)

Author keywords

glioblastoma; nanomedicine; nonviral gene delivery; targeted delivery

Indexed keywords

BRAIN; CELL CULTURE; CELL PROLIFERATION; CELLS; DRUG THERAPY; GENE EXPRESSION; GENE TRANSFER; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; TUMORS;

BIODEGRADABLE POLYMERIC NANOPARTICLES; GLIOBLASTOMAS; INTRATUMORAL INJECTION; NEURAL PROGENITOR CELLS; NON-VIRAL GENE DELIVERY; NON-VIRAL TRANSFECTIONS; POLYMERIC NANOPARTICLES; TARGETED DELIVERY;

MOLECULAR BIOLOGY;

ANTINEOPLASTIC AGENT; BIOMATERIAL; DNA; GREEN FLUORESCENT PROTEIN; NANOPARTICLE; POLYMER;

ANIMAL; BIOTECHNOLOGY; BRAIN NEOPLASMS; CANCER TRANSPLANTATION; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG DELIVERY SYSTEM; FREEZE DRYING; GENE EXPRESSION REGULATION; GENE TRANSFER; GENE VECTOR; GENETIC TRANSFECTION; GLIOBLASTOMA; HUMAN; METABOLISM; MOUSE; NANOTECHNOLOGY; NERVE CELL; PATHOLOGY; PROCEDURES; STEM CELL; TRANSGENE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOCOMPATIBLE MATERIALS; BIOTECHNOLOGY; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DNA; DRUG DELIVERY SYSTEMS; FREEZE DRYING; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLIOBLASTOMA; GREEN FLUORESCENT PROTEINS; HUMANS; MICE; NANOPARTICLES; NANOTECHNOLOGY; NEOPLASM TRANSPLANTATION; NEURONS; POLYMERS; STEM CELLS; TRANSFECTION; TRANSGENES;

EID: 84901675777     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn501197v     Document Type: Article

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