Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: A gene-marking and neuropathological study

Journal of Neurosurgery

Volumn 92, Issue 5, 2000, Pages 804-811

  Harsh, Griffith R ^a   Deisboeck, Thomas S ^b   Louis, David N ^b   Hilton, John ^b   Colvin, Michael ^b   Silver, Jonathan S ^b   Qureshi, Nazer H ^b   Kracher, Jean ^b   Finkelstein, Diane ^b   Chiocca, Ennino A ^b   Hochberg, Fred H ^b  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

Brain neoplasm; Ganciclovir; Gene therapy; Glioblastoma multiforme

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE; VIRUS VECTOR;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN ABSCESS; CANCER REGRESSION; CLINICAL ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSDUCTION; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MALE; MARKER GENE; NEUROPATHOLOGY; PRIORITY JOURNAL; RETROVIRUS; STEREOTAXIC SURGERY;

EID: 0034095219     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.2000.92.5.0804     Document Type: Article

References (20)

1. Barba D, Hardin J, Ray J, et al: Thymidine kinase-mediated killing of rat brain tumors. J Neurosurg 79:729-735, 1993
2. Barba D, Hardin J, Sadelain M, et al: Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc Natl Acad Sci USA 91: 4348-4352, 1994
3. Black PM: Brain tumors (second of two parts). N Engl J Med 324:1555-1564, 1991
4. Chen CY, Chang YN, Ryan P, et al: Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the "bystander effect." Hum Gene Ther 6: 467-1476, 1995
5. Culver KW, Ram Z, Wallbridge S, et al: In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain rumors. Science 256:1550-1552, 1992
6. Ezzeddine ZD, Martuza RL, Platika D, et al: Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene. New Biol 3: 608-614, 1991
7. Fine HA, Dear KBG, Loeffler JS, et al: Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 71:2585-2597, 1993
8. Harsh GR IV, Levin VA, Gutin PH, et al: Reoperation for recurrent glioblastoma and anaplastic astrocytoma. Neurosurgery 21:615-621, 1987
9. Izquierdo M, Martin V, de Felipe P, et al: Human malignant brain tumor response to herpes simplex thymidine kinase (HSVtk)/ganciclovir gene therapy. Gene Ther 3:491-495, 1996
10. Kramm CM, Sena-Esteves M, Barnett FH, et al: Gene therapy for brain tumors. Brain Pathol 5:345-381, 1995
11. Namba H, Tagawa M, Iwadate Y, et al: Bystander effect-mediated therapy of experimental brain tumor by genetically engineered tumor cells. Hum Gene Ther 9:5-11, 1998
12. Qureshi NH, Bankiewicz KS, Louis DN, et al: Multi-column infusion of gene therapy cells into human brain tumor: technical report. Neurosurgery 46:663-669, 2000
13. Ram Z, Culver KW, Oshiro EM, et al: Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nat Med 3:1354-1361, 1997
14. Ram Z, Culver KW, Walbridge S, et al: In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res 53:83-88, 1993
15. Ram Z, Culver KW, Walbridge S, et al: Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors. J Neurosurg 79:400-407, 1993
16. Takamiya Y, Short MP, Ezzedine ZD, et al: Gene therapy of malignant brain tumors: a rat glioma line bearing the herpes simplex virus type 1-thymidine kinase gene and wild type retrovirus kills other tumor cells. J Neurosci Res 33:493-503, 1992
17. Takamiya Y, Short P, Moolten FL, et al: An experimental model of retrovirus gene therapy for malignant brain tumors. J Neurosurg 79:104-110, 1993
18. Tamiya T, Wei MX, Chase M, et al: Transgene inheritance and retroviral infection contribute to the efficiency of gene expression in solid tumors inoculated with retroviral vector producer cells. Gene Ther 2:531-538, 1995
19. Vincent AJPE, Vogels R, Someren GV, et al: Herpes simplex virus thymidine kinase gene therapy for rat malignant brain tumors. Hum Gene Ther 7:197-205, 1996
20. Whittle IR: Management of primary malignant brain tumours. J Neurol Neurosurg Psychiatry 60:2-5, 1996