Local immunotherapy with interleukin-2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: A novel treatment for experimental malignant glioma

Neurosurgery

Volumn 52, Issue 4, 2003, Pages 872-880

  Rhines, Laurence D ^a   Sampath, Prakash ^b   DiMeco, Francesco ^c   Christopher Lawson, H ^d   Tyler, Betty M ^d   Hanes, Justin ^d   Olivi, Alessandro ^d   Brem, Henry ^d   Raffel, Corey ^e   Westphal, Manfred ^e   Dietrich, Pierre Yves ^e   De Tribolet, Nicolas ^e   Kaye, Andrew H ^e   Berger, Mitchel S ^e  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b BROWN UNIVERSITY   (United States)

^c DEPARTMENT OF NEUROSURGERY   (Italy)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NONE

Author keywords

Biodegradable polymer; Brain tumors; Cytokine; Interleukin 2; Interstitial chemotherapy; Microspheres

Indexed keywords

CARMUSTINE; DRUG VEHICLE; INTERLEUKIN 2; MICROSPHERE; POLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; CANCER COMBINATION CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CANCER LOCALIZATION; CANCER SURVIVAL; CANCER TRANSPLANTATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG POTENTIATION; DRUG RESPONSE; EXPERIMENTAL MODEL; FEMALE; GLIOBLASTOMA; GLIOSARCOMA; HISTOLOGY; INFLAMMATION; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZATION; RAT; SURVIVAL TIME; TREATMENT OUTCOME;

EID: 0037386047     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/01.NEU.0000053211.39087.D1     Document Type: Article

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