Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: Effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions

Cancer Gene Therapy

Volumn 7, Issue 3, 2000, Pages 413-421

  Sandmair, Anu Maaria ^a,b   Turunen, Marita ^a,b   Tyynelä, Kristiina ^a,b   Loimas, Sami ^a   Vainio, Pauli ^b   Vanninen, Ritva ^b   Vapalahti, Matti ^b   Bjerkvig, Rolf ^c   Jänne, Juhani ^a,b   Ylä Herttuala, Seppo ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

Apoptosis; Astroglia; Bystander effect; Gene transfer; Glial fibrillary acid protein; Glioma; Microgila; Nuclear magnetic resonance imaging; Thyroidine kinase

Indexed keywords

ANTIVIRUS AGENT; COMPLEMENTARY DNA; CONTRAST MEDIUM; GADOLINIUM PENTETATE; GANCICLOVIR; GLIAL FIBRILLARY ACIDIC PROTEIN; THYMIDINE KINASE; VIMENTIN; VIRUS VECTOR;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN TUMOR; CONTRAST ENHANCEMENT; CONTROLLED STUDY; GENE THERAPY; GENE TRANSFER; GLIOMA; GLIOMA CELL; HERPES SIMPLEX VIRUS; MACROGLIA; MALE; MICROGLIA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT;

ANIMALIA; HERPES; PAPOVAVIRIDAE; SIMPLEXVIRUS;

EID: 0034128036     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700132     Document Type: Article

References (38)

1. Salcman M. Epidemiology and factors affecting survival. In: Apuzzo MLJ, ed. Malignant Cerebral Glioma. Park Ridge, Ill: American Association of Neurological Surgeons; 1990:95-109.
2. Ammirati M, Galicich JH, Arbit E, Liao Y. Reoperation in the treatment of recurrent intracranial malignant gliomas. Neurosurgery. 1987;21:607-614.
3. Shapiro WR, Green SB, Burger PC, et al. Randomized trial of three chemotherapy regimens and two radiotherapy regimens in postoperative treatment of malignant glioma. J Neurosurg. 1989;71:1-9.
4. Moolten FL. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res. 1986;46: 5276-5281.
5. Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH, Blaese RM. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science. 1992;256:1550-1552.
6. Vile R, Russell SJ. Gene transfer technologies for the gene therapy of cancer. Gene Ther. 1994;1:88-98.
7. Ram Z, Culver KW, Oshiro EM, et al. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nat Med. 1998;3:1354-1361.
8. Boviatsis EJ, Chase M, Wei MX, et al. Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors. Hum Gene Ther. 1994;5:183-191.
9. Ylä-Herttuala S. Gene therapy and brain tumors. Mikkelsen T, Bjerkvig R, Laerum OD, Rosenblum ML, eds. In: Brain Tumor Invasion: Biological, Clinical, and Therapeutic Considerations. New York: Wiley-Liss, Inc.; 1998:435-445.
10. Morgan RA, Anderson WF. Human gene therapy. Annu Rev Biochem. 1993;62:191-217.
11. Chen S-H, Shine HD, Goodman JC, Grossman RG, Woo SLC. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci USA. 1994;91:3054-3057.
12. Perez-Cruet MJ, Trask TW, Chen S-H, et al. Adenovirus-mediated gene therapy of experimental gliomas. J Neurosci Res. 1994;39:506-511.
13. Oldfield EH, Ram Z, Culver KW, Blaese RM, DeVroom HL, Anreson WF. Gene therapy for the treatment of brain tumors using intratumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther. 1993;4:39-69.
14. Bi WI, Parusek LM, Warwick R, Stambrook PJ. In vitro evidence that metabolic co-operation is responsible for the bystander effect observed with HSVtk retroviral gene therapy. Hum Gene Ther. 1993;4:725-731.
15. Barth RF. Rat brain tumor models in experimental neurooncology: the 9L, C6, T9, F98, RG2 (D74), RT-2, and CNS-1 gliomas. J Neurooncol. 1998;36:91-102.
16. Laerum OD, Rajewsky MF, Schachner M, Stavrou D, Haglid KG, Haugen A. Phenotypic properties of neoplastic cell lines developed from fetal rat brain cells in culture after exposure to ethylnitrosourea in vivo. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;89:273-295.
17. McKnight SL. The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene. Nucleic Acids Res. 1980;8:5949-5964.
18. Miller AD, Buttimore C. Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol. 1986;6:2985-2902.
19. Ylä-Herttuala S, Luoma J, Viita H, Hiltunen T, Sisto T, Nikkari T. Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low-density lipoprotein. J Clin Invest. 1995;95:2692-2698.
20. Puumalainen AM, Vapalahti M, Agrawal RS, et al. β-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses. Hum Gene Ther. 1998;9:1769-1774.
21. Laerum OD, Rajewsky MF. Neoplastic transformation of fetal rat brain cells in culture following exposure to ethylnitrosourea in vivo. J Natl Cancer Inst. 1975;55:1177-1187.
22. Paxinos G, Watson C. The Rat Brain in Stereotactic Coordinates. San Diego: Academic Press; 1986:Plate 22.
23. Ylä-Herttuala S, Rosenfeld ME, Parthasarathy S, et al. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low-density lipoprotein in macrophage-rich areas of atherosclerotic lesions. Proc Natl Acad Sci USA. 1990;87:6959-6963.
24. Mato M, Ookawara S, Sakamoto A, et al. Involvement of specific macrophage lineage cells surrounding arterioles in barrier and scavenger function in brain cortex. Proc Natl Acad Sci USA. 1996;93:3269-3274.
25. Poptani H, Puumalainen AM, Gröhn O, et al. Monitoring thymidine kinase and ganciclovir-induced changes in rat malignant glioma in vivo by nuclear magnetic resonance imaging. Cancer Gene Ther. 1998;5:101-109.
26. Moolten FL, Wells JM. Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J Natl Cancer Inst. 1990;82:297-300.
27. Short MP, Choi BC, Lee JK, Malick A, Breakefield XO, Martuza RL. Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line. J Neurosci Res. 1990;27:427-439.
28. Ram Z, Culver KW, Wallbridge S, Blaese RM, Oldfield EH. In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res. 1993;53:83-88.
29. Stegman LD, Ben-Yoseph O, Freyer JP, Ross BD. In vivo 31P MRS evaluation of ganciclovir toxicity in C6 gliomas stably expressing the herpes simplex thymidine kinase gene. NMR Biomed. 1996;9:364-368.
30. Di Meco F, Benedetti S, Colombo MP, Finocchiaro G. Perspectives for the gene therapy of malignant gliomas by suicide gene transfer. J Neurosurg Sci. 1997;41:227-234.
31. Wu JK, Cano WG, Meylearts SAG, Peimin Q, Vrionis F, Cherington V. Bystander tumoricidal effect in the treatment of experimental brain tumors. Neurosurgery. 1994;35: 1094-1103.
32. Tapscott SJ, Miller AD, Olson JM, Berger MS, Groudine M, Spence AM. Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection. Proc Natl Acad Sci USA. 1994;91: 8185-8189.
33. Cool V, Pirotte B, Gerard C, et al. Curative potential of herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma. Hum Gene Ther. 1996;7:627-635.
34. Barba D, Hardin J, Ray J, Gage FH. Thymidine kinase-mediated killing of rat brain tumors. J Neurosurg. 1993;79: 729-735.
35. Freeman SM, Abbound CN, Whartenby KA, et al. The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 1993;53: 5274-5283.
36. Colombo BM, Benedetti S, Ottolenghi S, et al. The "bystander effect": association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice. Hum Gene Ther. 1995;6:763-772.
37. Samejima Y, Meruelo D. "Bystander killing" induces apoptosis and is inhibited by forskolin. Gene Ther. 1995;2: 50-58.
38. Hamel W, Magnelli L, Chiarugi VP, Israel MA. Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res. 1996;56:2697-2702.