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Volumn 20, Issue 38, 2014, Pages 6048-6057

Activated immune system and inflammation in healthy ageing: Relevance for tryptophan and neopterin metabolism

Author keywords

Aging; Antioxidants; Inflammation; Neopterin; Tryptophan breakdown; Vitamins

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CYANOCOBALAMIN; FOLIC ACID; GAMMA INTERFERON; HOMOCYSTEINE; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE; NEOPTERIN; PHENYLALANINE; PYRIDOXINE; REACTIVE OXYGEN METABOLITE; TRYPTOPHAN; VITAMIN D;

EID: 84922971289     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612820666140317110217     Document Type: Article
Times cited : (55)

References (136)
  • 1
    • 0031448878 scopus 로고    scopus 로고
    • Primary and secondary alterations of immune reactivity in the elderly: Impact of dietary factors and disease
    • Wick G, Grubeck-Loebenstein B. Primary and secondary alterations of immune reactivity in the elderly: impact of dietary factors and disease. Immunol Rev 1997; 160: 171-84.
    • (1997) Immunol Rev , vol.160 , pp. 171-184
    • Wick, G.1    Grubeck-Loebenstein, B.2
  • 2
    • 0034565044 scopus 로고    scopus 로고
    • The biochemistry of aging
    • Knight JA. The biochemistry of aging. Adv Clin Chem 2000; 35: 1-62.
    • (2000) Adv Clin Chem , vol.35 , pp. 1-62
    • Knight, J.A.1
  • 3
    • 0024206509 scopus 로고
    • Approach to define "normal aging" in man. Immune function, serum lipids, lipoproteins and neopterin levels
    • Reibnegger G, Huber LA, Jürgens G, et al. Approach to define "normal aging" in man. Immune function, serum lipids, lipoproteins and neopterin levels. Mech Ageing Dev 1988; 46: 67-82.
    • (1988) Mech Ageing Dev , vol.46 , pp. 67-82
    • Reibnegger, G.1    Huber, L.A.2    Jürgens, G.3
  • 4
    • 0028572409 scopus 로고
    • Factors influencing serum neopterin and beta 2-microglobulin levels in a healthy diverse population
    • Diamondstone LS, Tollerud DJ, Fuchs D, et al. Factors influencing serum neopterin and beta 2-microglobulin levels in a healthy diverse population. J Clin Immunol 1994; 14: 368-4.
    • (1994) J Clin Immunol , vol.14 , pp. 368-464
    • Diamondstone, L.S.1    Tollerud, D.J.2    Fuchs, D.3
  • 5
    • 0034679070 scopus 로고    scopus 로고
    • Distinct categories of immunologic changes in frail elderly
    • Fahey JL, Schnelle JF, Boscardin J, et al. Distinct categories of immunologic changes in frail elderly. Mech Ageing Dev 2000; 115: 1-20.
    • (2000) Mech Ageing Dev , vol.115 , pp. 1-20
    • Fahey, J.L.1    Schnelle, J.F.2    Boscardin, J.3
  • 6
    • 77954851565 scopus 로고    scopus 로고
    • Serum levels of the immune activation marker neopterin change with age and gender and are modified by race, BMI, and percentage of body fat
    • Spencer ME, Jain A, Matteini A, et al. Serum levels of the immune activation marker neopterin change with age and gender and are modified by race, BMI, and percentage of body fat. J Gerontol A Biol Sci Med Sci 2010; 65: 858-65.
    • (2010) J Gerontol A Biol Sci Med Sci , vol.65 , pp. 858-865
    • Spencer, M.E.1    Jain, A.2    Matteini, A.3
  • 7
    • 0030907213 scopus 로고    scopus 로고
    • Cytokine antagonists in aged subjects and their relation with cellular immunity
    • Catania A, Airaghi L, Motta P, et al. Cytokine antagonists in aged subjects and their relation with cellular immunity. J Gerontol A Biol Sci Med Sci 1997; 52: B93-7.
    • (1997) J Gerontol A Biol Sci Med Sci , vol.52 , pp. 93-97
    • Catania, A.1    Airaghi, L.2    Motta, P.3
  • 8
    • 0035667444 scopus 로고    scopus 로고
    • Biochemical profile and survival in nonagenarians
    • Solichova D, Melichar B, Blaha V, et al. Biochemical profile and survival in nonagenarians. Clin Biochem 2001; 134: 563-9.
    • (2001) Clin Biochem , vol.134 , pp. 563-569
    • Solichova, D.1    Melichar, B.2    Blaha, V.3
  • 9
    • 77954851565 scopus 로고    scopus 로고
    • Serum levels of the immune activation marker neopterin change with age and gender and are modified by race, BMI, and percentage of body fat
    • Spencer ME, Jain A, Matteini A, et al. Serum levels of the immune activation marker neopterin change with age and gender and are modified by race, BMI, and percentage of body fat. J Gerontol A Biol Sci Med Sci 2010; 65: 858-65.
    • (2010) J Gerontol A Biol Sci Med Sci , Issue.65 , pp. 858-865
    • Spencer, M.E.1    Jain, A.2    Matteini, A.3
  • 10
    • 4043180519 scopus 로고    scopus 로고
    • Increasing production of homocysteine and neopterin and degradation of tryptophan with older age
    • Frick B, Schroecksnadel K, Neurauter G, Leblhuber F, Fuchs D. Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. Clin Biochem 2004; 37: 684-7.
    • (2004) Clin Biochem , vol.37 , pp. 684-687
    • Frick, B.1    Schroecksnadel, K.2    Neurauter, G.3    Leblhuber, F.4    Fuchs, D.5
  • 11
    • 33646468351 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality
    • Pertovaara M, Raitala A, Lehtimäki T, et al. Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality. Mech Ageing Dev 2006; 127: 497-9.
    • (2006) Mech Ageing Dev , vol.127 , pp. 497-499
    • Pertovaara, M.1    Raitala, A.2    Lehtimäki, T.3
  • 12
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison DE, Strong R, Sharp ZD, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460: 392-5.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3
  • 13
    • 76549104638 scopus 로고    scopus 로고
    • Resveratrol and rapamycin: Are they anti-aging drugs?
    • Kaeberlein M. Resveratrol and rapamycin: are they anti-aging drugs? BioEssays 2010; 32: 96-9.
    • (2010) BioEssays , vol.32 , pp. 96-99
    • Kaeberlein, M.1
  • 14
    • 24344502320 scopus 로고    scopus 로고
    • Resveratrol suppresses interferon-gamma-induced biochemical pathways in human peripheral blood mononuclear cells in vitro
    • Wirleitner B, Schroecksnadel K, Winkler C, Schennach H, Fuchs D. Resveratrol suppresses interferon-gamma-induced biochemical pathways in human peripheral blood mononuclear cells in vitro. Immunol Lett 2005; 100: 159-63.
    • (2005) Immunol Lett , vol.100 , pp. 159-163
    • Wirleitner, B.1    Schroecksnadel, K.2    Winkler, C.3    Schennach, H.4    Fuchs, D.5
  • 15
    • 80052325862 scopus 로고    scopus 로고
    • Influence of immunosuppressive agents on tryptophan degradation and neopterin production in human peripheral blood mononuclear cells
    • Schroecksnadel S, Sucher R, Kurz K, Fuchs, Brandacher G. Influence of immunosuppressive agents on tryptophan degradation and neopterin production in human peripheral blood mononuclear cells. Transplant Immunol 2011; 25: 119-23.
    • (2011) Transplant Immunol , vol.25 , pp. 119-123
    • Schroecksnadel, S.1    Sucher, R.2    Kurz, K.3    Fuchs, B.G.4
  • 16
    • 0021264311 scopus 로고
    • Immune responseassociated production of neopterin-Release from macrophages primarily under control of interferon-gamma
    • Huber C, Batchelor JR, Fuchs D, et al. Immune responseassociated production of neopterin-Release from macrophages primarily under control of interferon-gamma. J Exp Med 1984; 160: 310-6.
    • (1984) J Exp Med , vol.160 , pp. 310-316
    • Huber, C.1    Batchelor, J.R.2    Fuchs, D.3
  • 17
    • 0036917842 scopus 로고    scopus 로고
    • Monocyte-derived dendritic cells release neopterin
    • Wirleitner B, Reider D, Ebner S, et al. Monocyte-derived dendritic cells release neopterin. J Leukocyte Biol 2002; 72: 1148-53.
    • (2002) J Leukocyte Biol , vol.72 , pp. 1148-1153
    • Wirleitner, B.1    Reider, D.2    Ebner, S.3
  • 18
    • 0027066967 scopus 로고
    • The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious and malignant diseases
    • Fuchs D, Weiss G, Reibegger G, Wachter H. The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious and malignant diseases. Crit Rev Clin Lab Sci 1992; 29: 307-41.
    • (1992) Crit Rev Clin Lab Sci , vol.29 , pp. 307-341
    • Fuchs, D.1    Weiss, G.2    Reibegger, G.3    Wachter, H.4
  • 19
    • 0031660353 scopus 로고    scopus 로고
    • Neopterin: Indicator of oxidative stress and part of the cytotoxic armature of activated macrophages in humans
    • Widner B, Baier-Bitterlich G, Wede I, Wirleitner B, Wachter H, Fuchs D. Neopterin: indicator of oxidative stress and part of the cytotoxic armature of activated macrophages in humans. Pteridines 1998; 9: 91-102.
    • (1998) Pteridines , vol.9 , pp. 91-102
    • Widner, B.1    Baier-Bitterlich, G.2    Wede, I.3    Wirleitner, B.4    Wachter, H.5    Fuchs, D.6
  • 21
    • 80051675515 scopus 로고    scopus 로고
    • Tetrahydrobiopterin: Biochemistry and pathophysiology
    • Werner ER, Blau N, Thöny B. Tetrahydrobiopterin: biochemistry and pathophysiology. Biochem J 2011; 438: 397-414.
    • (2011) Biochem J , vol.438 , pp. 397-414
    • Werner, E.R.1    Blau, N.2    Thöny, B.3
  • 22
    • 77956385426 scopus 로고    scopus 로고
    • Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes
    • Watschinger K, Keller MA, Golderer G, et al. Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. Proc Natl Acad Sci USA 2010; 107: 13672-77.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 13672-13677
    • Watschinger, K.1    Keller, M.A.2    Golderer, G.3
  • 23
    • 0024351625 scopus 로고
    • Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages
    • Kwon NS, Nathan CF, Stuehr DJ. Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J Biol Chem 1989; 264: 20496-501.
    • (1989) J Biol Chem , vol.264 , pp. 20496-20501
    • Kwon, N.S.1    Nathan, C.F.2    Stuehr, D.J.3
  • 24
    • 0024317795 scopus 로고
    • Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma
    • Werner ER, Werner-Felmayer G, Fuchs D, Hausen A, Reibnegger G, Wachter H. Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma. Biochem J 1989; 262: 861-6.
    • (1989) Biochem J , vol.262 , pp. 861-866
    • Werner, E.R.1    Werner-Felmayer, G.2    Fuchs, D.3    Hausen, A.4    Reibnegger, G.5    Wachter, H.6
  • 25
    • 0023276687 scopus 로고
    • Human macrophages degrade tryptophan upon induction by interferon-gamma
    • Werner ER, Bitterlich G, Fuchs D, et al. Human macrophages degrade tryptophan upon induction by interferon-gamma. Life Sci 1987; 41: 273-80.
    • (1987) Life Sci , vol.41 , pp. 273-280
    • Werner, E.R.1    Bitterlich, G.2    Fuchs, D.3
  • 26
    • 0024390957 scopus 로고
    • Interferons and indoleamine 2,3-dioxygenase: Role in antimicrobial and antitumor effects
    • Carlin JM, Ozaki Y, Byrne GI, Brown RR, Borden EC. Interferons and indoleamine 2,3-dioxygenase: role in antimicrobial and antitumor effects. Experientia 1989; 45: 535-41.
    • (1989) Experientia , vol.45 , pp. 535-541
    • Carlin, J.M.1    Ozaki, Y.2    Byrne, G.I.3    Brown, R.R.4    Borden, E.C.5
  • 27
    • 0025949160 scopus 로고
    • Implications of interferon-induced tryptophan catabolism in cancer, auto-immune diseases and AIDS
    • Brown RR, Ozaki Y, Datta SP, Borden EC, Sondel PM, Malone DG. Implications of interferon-induced tryptophan catabolism in cancer, auto-immune diseases and AIDS. Adv Exp Med Biol 1991; 294: 425-35.
    • (1991) Adv Exp Med Biol , vol.294 , pp. 425-435
    • Brown, R.R.1    Ozaki, Y.2    Datta, S.P.3    Borden, E.C.4    Sondel, P.M.5    Malone, D.G.6
  • 28
    • 0025944659 scopus 로고
    • Relationship between interferon-indoleamine 2,3-dioxygenase, and tryptophan catabolism
    • Taylor MW, Feng, GS. Relationship between interferon-[, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J 1991; 5: 2516-22.
    • (1991) FASEB J , vol.5 , pp. 2516-2522
    • Taylor, M.W.1    Feng, G.S.2
  • 30
    • 0024994054 scopus 로고
    • Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms
    • Fuchs D, Möller AA, Reibnegger G, Stöckle E, Werner ER, Wachter H. Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms. J Acquir Immune Defic Syndr 1990; 3: 873-6.
    • (1990) J Acquir Immune Defic Syndr , vol.3 , pp. 873-876
    • Fuchs, D.1    Möller, A.A.2    Reibnegger, G.3    Stöckle, E.4    Werner, E.R.5    Wachter, H.6
  • 31
    • 79851514132 scopus 로고    scopus 로고
    • Association between increased tryptophan degradation and depression in cancer patients
    • Kurz K, Schroecksnadel S, Weiss G, Fuchs D. Association between increased tryptophan degradation and depression in cancer patients. Curr Opin Clin Nutr Metabol Care 2011; 14: 49-56.
    • (2011) Curr Opin Clin Nutr Metabol Care , vol.14 , pp. 49-56
    • Kurz, K.1    Schroecksnadel, S.2    Weiss, G.3    Fuchs, D.4
  • 32
    • 0026507973 scopus 로고
    • Human macrophages convert Ltryptophan into the neurotoxin quinolinic acid
    • Heyes MP, Saito K, Markey SP. Human macrophages convert Ltryptophan into the neurotoxin quinolinic acid. Biochem J 1992; 283: 633-5.
    • (1992) Biochem J , vol.283 , pp. 633-635
    • Heyes, M.P.1    Saito, K.2    Markey, S.P.3
  • 33
    • 0026539659 scopus 로고
    • Quinolinic acid and kynurenine pathway metabolism in inflammatory and noninflammatory neurological disease
    • Heyes MP, Saito K, Crowley JS, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and noninflammatory neurological disease. Brain 1992;115: 1249-73.
    • (1992) Brain , vol.115 , pp. 1249-1273
    • Heyes, M.P.1    Saito, K.2    Crowley, J.S.3
  • 34
    • 0027486072 scopus 로고
    • Neuropharmacology of quinolinic and kynurenic acids
    • Stone TW. Neuropharmacology of quinolinic and kynurenic acids. Pharmacol Rev 1993; 45: 309-79.
    • (1993) Pharmacol Rev , vol.45 , pp. 309-379
    • Stone, T.W.1
  • 35
    • 33845920042 scopus 로고    scopus 로고
    • Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients
    • Weinlich G, Murr C, Richardsen L, Winkler C, Fuchs D. Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients. Dermatology 2007; 214: 8-14.
    • (2007) Dermatology , vol.214 , pp. 8-14
    • Weinlich, G.1    Murr, C.2    Richardsen, L.3    Winkler, C.4    Fuchs, D.5
  • 37
    • 73249121300 scopus 로고    scopus 로고
    • Kynurenine pathway metabolites in humans: Disease and healthy states
    • Chen Y, Guillemin GJ. Kynurenine pathway metabolites in humans: disease and healthy states. Int J Tryptophan Res 2009; 2: 1-19.
    • (2009) Int J Tryptophan Res , vol.2 , pp. 1-19
    • Chen, Y.1    Guillemin, G.J.2
  • 38
    • 0031451315 scopus 로고    scopus 로고
    • Simultaneous measurement of serum tryptophan and kynurenine by HPLC
    • Widner B, Werner ER, Schennach H, Wachter H, Fuchs D. Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin Chem 1997; 43: 2424-6.
    • (1997) Clin Chem , vol.43 , pp. 2424-2426
    • Widner, B.1    Werner, E.R.2    Schennach, H.3    Wachter, H.4    Fuchs, D.5
  • 39
    • 79952194201 scopus 로고    scopus 로고
    • Systemic markers of interferon-α-mediated immune activation and long-term prognosis in patients with stable coronary artery disease
    • Pedersen ER, Midttun Ø, Ueland PM, et al. Systemic markers of interferon-α-mediated immune activation and long-term prognosis in patients with stable coronary artery disease. Arterioscler Thromb Vasc Biol 2011; 31: 698-704.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 698-704
    • Pedersen, E.R.1    Midttun, Ø.2    Ueland, P.M.3
  • 40
    • 34548204420 scopus 로고    scopus 로고
    • Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide
    • Thomas SR, Terentis AC, Cai H, et al. Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide. J Biol Chem 2007; 282: 23778-87.
    • (2007) J Biol Chem , vol.282 , pp. 23778-23787
    • Thomas, S.R.1    Terentis, A.C.2    Cai, H.3
  • 41
    • 0036229901 scopus 로고    scopus 로고
    • Disorders of tetrahydrobiopterin metabolism and their treatment
    • Shintaku, H. Disorders of tetrahydrobiopterin metabolism and their treatment. Curr Drug Metab 2002; 3: 123-31.
    • (2002) Curr Drug Metab , vol.3 , pp. 123-131
    • Shintaku, H.1
  • 42
    • 52449126348 scopus 로고    scopus 로고
    • Chronic immune stimulation correlates with reduced phenylalanine turnover
    • Neurauter G, Schröcksnadel K, Scholl-Bürgi S, et al. Chronic immune stimulation correlates with reduced phenylalanine turnover. Curr Drug Metabol 2008; 9: 622-7.
    • (2008) Curr Drug Metabol , vol.9 , pp. 622-627
    • Neurauter, G.1    Schröcksnadel, K.2    Scholl-Bürgi, S.3
  • 43
    • 0022209426 scopus 로고
    • Amino acid concentrations in plasma and skeletal muscle of patients with acute hemorrhagic necrotizing pancreatitis
    • Roth E, Zöch G, Schulz F, et al. Amino acid concentrations in plasma and skeletal muscle of patients with acute hemorrhagic necrotizing pancreatitis. Clin Chem 1985; 31: 1305-9.
    • (1985) Clin Chem , vol.31 , pp. 1305-1309
    • Roth, E.1    Zöch, G.2    Schulz, F.3
  • 46
    • 49749136662 scopus 로고    scopus 로고
    • Serum phenylalanine in patients post trauma and with sepsis correlate to neopterin concentrations
    • Ploder M, Neurauter G, Spittler A, Schroecksnadel K, Roth E, Fuchs D. Serum phenylalanine in patients post trauma and with sepsis correlate to neopterin concentrations. Amino Acids 2008; 35: 303-7.
    • (2008) Amino Acids , vol.35 , pp. 303-307
    • Ploder, M.1    Neurauter, G.2    Spittler, A.3    Schroecksnadel, K.4    Roth, E.5    Fuchs, D.6
  • 47
    • 53949089621 scopus 로고    scopus 로고
    • Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with concentrations of immune activation markers and of isoprostane-8
    • Neurauter G, Grahmann AV, Klieber M, et al. Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with concentrations of immune activation markers and of isoprostane-8. Cancer Lett 2008; 272: 141-7.
    • (2008) Cancer Lett , vol.272 , pp. 141-147
    • Neurauter, G.1    Grahmann, A.V.2    Klieber, M.3
  • 48
    • 77951620507 scopus 로고    scopus 로고
    • Increased blood phenylalanine to tyrosine ratio in HIV-1 infection and correction following effective antiretroviral therapy
    • Zangerle R, Kurz K, Neurauter G, Kitchen M, Sarcletti M, Fuchs D. Increased blood phenylalanine to tyrosine ratio in HIV-1 infection and correction following effective antiretroviral therapy. Brain Behav Immun 2010; 24: 403-8.
    • (2010) Brain Behav Immun , vol.24 , pp. 403-408
    • Zangerle, R.1    Kurz, K.2    Neurauter, G.3    Kitchen, M.4    Sarcletti, M.5    Fuchs, D.6
  • 49
    • 0037966344 scopus 로고    scopus 로고
    • Serum amino acids, biopterin and neopterin during long-term immunotherapy with interferon-alpha in high-risk melanoma patients
    • Van Gool AR, Fekkes D, Kruit WH, et al. Serum amino acids, biopterin and neopterin during long-term immunotherapy with interferon-alpha in high-risk melanoma patients. Psychiatry Res 2003; 15: 125-32.
    • (2003) Psychiatry Res , vol.15 , pp. 125-132
    • Van Gool, A.R.1    Fekkes, D.2    Kruit, W.H.3
  • 50
    • 84861392303 scopus 로고    scopus 로고
    • Influence of interferon-ootherapy on phenylalanine hydroxylase activity in patients with HCV infection
    • Zoller H, Schloegl A, Schroecksnadel S, Vogel W, Fuchs D. Influence of interferon-ootherapy on phenylalanine hydroxylase activity in patients with HCV infection. J Interferon Cytokine Res 2012; 32: 216-20.
    • (2012) J Interferon Cytokine Res , vol.32 , pp. 216-220
    • Zoller, H.1    Schloegl, A.2    Schroecksnadel, S.3    Vogel, W.4    Fuchs, D.5
  • 51
    • 84878160653 scopus 로고    scopus 로고
    • Tyrosine metabolism during interferon-alpha administration: Association with fatigue and CSF dopamine concentrations
    • Felger JC, Li L, Marvar PJ, et al. Tyrosine metabolism during interferon-alpha administration: Association with fatigue and CSF dopamine concentrations. Brain Behav Immun 2013; 31: 153-60.
    • (2013) Brain Behav Immun , vol.31 , pp. 153-160
    • Felger, J.C.1    Li, L.2    Marvar, P.J.3
  • 52
    • 79959740393 scopus 로고    scopus 로고
    • Chronic low grade immune activation in the elderly is associated with increased tryptophan catabolism and altered phenylalanine turnover: Role in neuropsychiatric symptomatology
    • Capuron L, Schroecksnadel S, Féart C, et al. Chronic low grade immune activation in the elderly is associated with increased tryptophan catabolism and altered phenylalanine turnover: role in neuropsychiatric symptomatology. Biol Psych 2011; 70: 175-82.
    • (2011) Biol Psych , vol.70 , pp. 175-182
    • Capuron, L.1    Schroecksnadel, S.2    Féart, C.3
  • 53
    • 84856111463 scopus 로고    scopus 로고
    • Psychoneuroimmunology meets neuropsychopharmacology: Translational implications of the impact of inflammation on behavior
    • Haroon E, Raison CL, Miller AH. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 2012; 37: 137-62.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 137-162
    • Haroon, E.1    Raison, C.L.2    Miller, A.H.3
  • 54
    • 0033533505 scopus 로고    scopus 로고
    • Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): Population reference ranges and contribution of vitamin status to high serum concentrations
    • Selhub J, Jacques PF, Rosenberg IH, et al. Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Ann Intern Med 1999; 131: 331-9.
    • (1999) Ann Intern Med , vol.131 , pp. 331-339
    • Selhub, J.1    Jacques, P.F.2    Rosenberg, I.H.3
  • 55
    • 33846021288 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia: A critical review of old and new aspects
    • Herrmann W, Herrmann M, Obeid R. Hyperhomocysteinaemia: a critical review of old and new aspects. Curr Drug Metab 2007; 8: 17-31.
    • (2007) Curr Drug Metab , vol.8 , pp. 17-31
    • Herrmann, W.1    Herrmann, M.2    Obeid, R.3
  • 56
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. J Am Med Aassoc 1995; 274: 1049-57.
    • (1995) J Am Med Aassoc , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 57
    • 0029939676 scopus 로고    scopus 로고
    • Homocysteine and vascular disease
    • McCully KS. Homocysteine and vascular disease. Nat Med 1996; 2: 386-9.
    • (1996) Nat Med , vol.2 , pp. 386-389
    • McCully, K.S.1
  • 58
    • 0030994488 scopus 로고    scopus 로고
    • Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis
    • Verhoef P, Kok FJ, Kruyssen DA, et al. Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis. Arterioscler Thromb Vasc Biol 1997; 17: 989-95.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 989-995
    • Verhoef, P.1    Kok, F.J.2    Kruyssen, D.A.3
  • 59
    • 0035078770 scopus 로고    scopus 로고
    • Does disturbed homocysteine and folate metabolism in depression result from enhanced oxidative stress?
    • Widner B, Fuchs D, Leblhuber F, Sperner-Unterweger B. Does disturbed homocysteine and folate metabolism in depression result from enhanced oxidative stress? J Neurol Neurosurg Psychiatry 2001; 70: 419.
    • (2001) J Neurol Neurosurg Psychiatry , vol.70 , pp. 419
    • Widner, B.1    Fuchs, D.2    Leblhuber, F.3    Sperner-Unterweger, B.4
  • 60
    • 0034819473 scopus 로고    scopus 로고
    • Is hyperhomocysteinaemia due to oxidative depletion of folate rather than to insufficient dietary intake?
    • Fuchs D, Jaeger M, Widner B, Wirleitner B, Artner-Dworzak E, Leblhuber F. Is hyperhomocysteinaemia due to oxidative depletion of folate rather than to insufficient dietary intake? Clin Chem Med 2001; 39: 691-4.
    • (2001) Clin Chem Med , vol.39 , pp. 691-694
    • Fuchs, D.1    Jaeger, M.2    Widner, B.3    Wirleitner, B.4    Artner-Dworzak, E.5    Leblhuber, F.6
  • 62
    • 0034449999 scopus 로고    scopus 로고
    • Impairment of lipid metabolism due to deficiency of pyridoxal-5-phosphate and/or activated immune system: Its interpretation
    • Rudzite V, Jurika E, Jäger M, Fuchs D. Impairment of lipid metabolism due to deficiency of pyridoxal-5-phosphate and/or activated immune system: its interpretation. Pteridines 2000; 11: 107-20.
    • (2000) Pteridines , vol.11 , pp. 107-120
    • Rudzite, V.1    Jurika, E.2    Jäger, M.3    Fuchs, D.4
  • 63
    • 0141427874 scopus 로고    scopus 로고
    • Homocysteine accumulates in supernatants of stimulated human peripheral blood mononuclear cells
    • Schröcksnadel K, Frick B, Wirleitner B, Schennach H, Fuchs D. Homocysteine accumulates in supernatants of stimulated human peripheral blood mononuclear cells. Clin Exp Immunol 2003; 134: 53-56.
    • (2003) Clin Exp Immunol , vol.134 , pp. 53-56
    • Schröcksnadel, K.1    Frick, B.2    Wirleitner, B.3    Schennach, H.4    Fuchs, D.5
  • 64
    • 78149278761 scopus 로고    scopus 로고
    • Moderate hyperhomocysteinemia in patients with multiple trauma and with sepsis predicts poor survival
    • Ploder M, Schroecksnadel K, Spittler A, Neurauter G, Roth E, Fuchs D. Moderate hyperhomocysteinemia in patients with multiple trauma and with sepsis predicts poor survival. Mol Med 2010; 16: 498-504.
    • (2010) Mol Med , vol.16 , pp. 498-504
    • Ploder, M.1    Schroecksnadel, K.2    Spittler, A.3    Neurauter, G.4    Roth, E.5    Fuchs, D.6
  • 65
    • 0020502358 scopus 로고
    • Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity
    • Nathan CF, Murray HW, Wiebe ME, Rubin BY. Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med 1983; 158: 670-89.
    • (1983) J Exp Med , vol.158 , pp. 670-689
    • Nathan, C.F.1    Murray, H.W.2    Wiebe, M.E.3    Rubin, B.Y.4
  • 66
    • 0027129517 scopus 로고
    • The effects of vitamins B12, B6, and folate on blood homocysteine levels
    • Mason JB, Miller JW. The effects of vitamins B12, B6, and folate on blood homocysteine levels. Ann N-Y Acad Sci 1992; 30: 197-204.
    • (1992) Ann N-Y Acad Sci , vol.30 , pp. 197-204
    • Mason, J.B.1    Miller, J.W.2
  • 67
    • 33645796222 scopus 로고    scopus 로고
    • NORVIT Trial Investigators. Homocysteine lowering and cardiovascular events after acute myocardial infarction
    • Bønaa KH, Njølstad I, Ueland PM, et al. NORVIT Trial Investigators. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 2006; 354: 1578-88.
    • (2006) N Engl J Med , vol.354 , pp. 1578-1588
    • Bønaa, K.H.1    Njølstad, I.2    Ueland, P.M.3
  • 68
    • 1842527939 scopus 로고    scopus 로고
    • Folic acid and vitamin B12 are more effective than vitamin B6 in lowering fasting plasma homocysteine concentration in patients with coronary artery disease
    • Lee BJ, Huang MC, Chung LJ, et al. Folic acid and vitamin B12 are more effective than vitamin B6 in lowering fasting plasma homocysteine concentration in patients with coronary artery disease. Eur J Clin Nutr 2004; 58: 481-7.
    • (2004) Eur J Clin Nutr , vol.58 , pp. 481-487
    • Lee, B.J.1    Huang, M.C.2    Chung, L.J.3
  • 69
  • 70
    • 34447626134 scopus 로고    scopus 로고
    • Homocysteine-lowering therapy does not affect inflammatory markers of atherosclerosis in patients with stable coronary artery disease
    • Bleie Ø, Semb AG, Grundt H, et al. Homocysteine-lowering therapy does not affect inflammatory markers of atherosclerosis in patients with stable coronary artery disease. J Intern Med 2007; 262: 244-53.
    • (2007) J Intern Med , vol.262 , pp. 244-253
    • Bleie, Ø.1    Semb, A.G.2    Grundt, H.3
  • 71
    • 0032501963 scopus 로고    scopus 로고
    • Low circulating folate and vitamin B6 concentrations: Risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group
    • Robinson K, Arheart K, Refsum H, et al. Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group. Circulation 1998; 97: 437-43.
    • (1998) Circulation , vol.97 , pp. 437-443
    • Robinson, K.1    Arheart, K.2    Refsum, H.3
  • 72
    • 0035714220 scopus 로고    scopus 로고
    • Association between increased serum neopterin and homocysteine concentrations as well as pyridoxal phosphate deficiency in patients with coronary heart disease
    • Rudzite V, Saliva A, Kalnins U, et al. Association between increased serum neopterin and homocysteine concentrations as well as pyridoxal phosphate deficiency in patients with coronary heart disease. Pteridines 2001; 12; 130-4.
    • (2001) Pteridines , vol.12 , pp. 130-134
    • Rudzite, V.1    Saliva, A.2    Kalnins, U.3
  • 73
    • 17644411729 scopus 로고    scopus 로고
    • Usefulness of neopterin, C-reactive protein, homocysteine, pyridoxal-5-phosphate, and phospholipid determination in coronary artery disease
    • Rudzite V, Jurika E, Schroecksnadel K, et al. Usefulness of neopterin, C-reactive protein, homocysteine, pyridoxal-5-phosphate, and phospholipid determination in coronary artery disease. Pteridines 2005; 16: 15-21.
    • (2005) Pteridines , vol.16 , pp. 15-21
    • Rudzite, V.1    Jurika, E.2    Schroecksnadel, K.3
  • 74
    • 84860304272 scopus 로고    scopus 로고
    • Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectoris
    • Ulvik A, Midttun Ø, Pedersen ER, Nygård O, Ueland PM. Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectoris. Am J Clin Nutr 2012; 95: 1072-8.
    • (2012) Am J Clin Nutr , vol.95 , pp. 1072-1078
    • Ulvik, A.1    Midttun, Ø.2    Pedersen, E.R.3    Nygård, O.4    Ueland, P.M.5
  • 75
    • 84863550129 scopus 로고    scopus 로고
    • Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults
    • Sakakeeny L, Roubenoff R, Obin M, et al. Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U. S. adults. J Nutr 2012; 142: 1280-5.
    • (2012) J Nutr , vol.142 , pp. 1280-1285
    • Sakakeeny, L.1    Roubenoff, R.2    Obin, M.3
  • 76
    • 84869874509 scopus 로고    scopus 로고
    • Vitamin B6 status and interferon-α-mediated immune activation in primary hyperparathyroidism
    • Christensen MH, Pedersen EK, Nordbø Y, et al. Vitamin B6 status and interferon-α-mediated immune activation in primary hyperparathyroidism. J Intern Med 2012; 272: 583-91.
    • (2012) J Intern Med , vol.272 , pp. 583-591
    • Christensen, M.H.1    Pedersen, E.K.2    Nordbø, Y.3
  • 77
    • 84875410545 scopus 로고    scopus 로고
    • Neopterin, a marker of interferon-gamma-inducible inflammation, correlates with pyridoxal-5'-phosphate, waist circumference, HDLcholesterol, insulin resistance and mortality risk in adult Boston community dwellers of Puertorican origin
    • Oxenkrug G, Tucker KL, Requintina P, Summergrad P. Neopterin, a marker of interferon-gamma-inducible inflammation, correlates with pyridoxal-5'-phosphate, waist circumference, HDLcholesterol, insulin resistance and mortality risk in adult Boston community dwellers of Puertorican origin. Am J Neuroprot Neuroregen 2011; 3: 48-52.
    • (2011) Am J Neuroprot Neuroregen , vol.3 , pp. 48-52
    • Oxenkrug, G.1    Tucker, K.L.2    Requintina, P.3    Summergrad, P.4
  • 78
    • 84872875428 scopus 로고    scopus 로고
    • Vitamin D deficiency parallels inflammation and immune activation, the Ludwigshafen Risk and Cardiovascular Health (LURIC) study
    • Murr C, Pilz S, Grammer T, et al. Vitamin D deficiency parallels inflammation and immune activation, the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Clin Chem Lab Med 2012; 20: 2205-12.
    • (2012) Clin Chem Lab Med , vol.20 , pp. 2205-2212
    • Murr, C.1    Pilz, S.2    Grammer, T.3
  • 79
    • 0023186976 scopus 로고
    • Determination of neopterin in serum and urine
    • Werner ER, Bichler A, Daxenbichler G, et al. Determination of neopterin in serum and urine. Clin Chem 1987; 33: 62-6.
    • (1987) Clin Chem , vol.33 , pp. 62-66
    • Werner, E.R.1    Bichler, A.2    Daxenbichler, G.3
  • 80
    • 0028178876 scopus 로고
    • Commercial enzyme-linked immunosorbent assay for neopterin detection in blood donations compared with RIA and HPLC
    • Mayersbach P, Augustin R, Schennach H, et al. Commercial enzyme-linked immunosorbent assay for neopterin detection in blood donations compared with RIA and HPLC. Clin Chem 1994; 40: 265-6.
    • (1994) Clin Chem , vol.40 , pp. 265-266
    • Mayersbach, P.1    Augustin, R.2    Schennach, H.3
  • 82
    • 0024849614 scopus 로고
    • Urinary neopterin concentrations vs total neopterins for clinical utility
    • Fuchs D, Milstien S, Krämer A, et al. Urinary neopterin concentrations vs total neopterins for clinical utility. Clin Chem 1989; 35: 2305-7.
    • (1989) Clin Chem , vol.35 , pp. 2305-2307
    • Fuchs, D.1    Milstien, S.2    Krämer, A.3
  • 83
    • 40649122573 scopus 로고    scopus 로고
    • Diazotization of kynurenine by acidified nitrite secreted from indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells
    • Hara T, Yamakura F, Takikawa O, et al. Diazotization of kynurenine by acidified nitrite secreted from indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells. J Immunol Methods 2008; 332: 162-9.
    • (2008) J Immunol Methods , vol.332 , pp. 162-169
    • Hara, T.1    Yamakura, F.2    Takikawa, O.3
  • 84
    • 84882381120 scopus 로고    scopus 로고
    • Immune activation and inflammation in patients with cardiovascular disease are associated with elevated phenylalanine to tyrosine ratios
    • Mangge H, Schnedl WJ, Schroecksnadel S, Geisler S, Murr C, Fuchs D. Immune activation and inflammation in patients with cardiovascular disease are associated with elevated phenylalanine to tyrosine ratios. Pteridines 2013; 24: 51-5.
    • (2013) Pteridines , vol.24 , pp. 51-55
    • Mangge, H.1    Schnedl, W.J.2    Schroecksnadel, S.3    Geisler, S.4    Murr, C.5    Fuchs, D.6
  • 85
    • 58549116694 scopus 로고    scopus 로고
    • Inverse association between serum concentrations of neopterin and antioxidants in patients with and without angiographic coronary artery disease
    • Murr C, Schroecksnadel K, Winklhofer-Roob BM, Mangge H, Böhm BO, Winkelmann BR, Maerz W, Fuchs D. Inverse association between serum concentrations of neopterin and antioxidants in patients with and without angiographic coronary artery disease. Atherosclerosis 2009; 202: 543-9.
    • (2009) Atherosclerosis , vol.202 , pp. 543-549
    • Murr, C.1    Schroecksnadel, K.2    Winklhofer-Roob, B.M.3    Mangge, H.4    Böhm, B.O.5    Winkelmann, B.R.6    Maerz, W.7    Fuchs, D.8
  • 88
    • 0034972564 scopus 로고    scopus 로고
    • Association between homocysteine and neopterin in healthy subjects measured by a simple HPLC-fluorometric method
    • Turgan N, Habif S, Parildar Z, et al. Association between homocysteine and neopterin in healthy subjects measured by a simple HPLC-fluorometric method. Clin Biochem 2001; 34: 271-5.
    • (2001) Clin Biochem , vol.34 , pp. 271-275
    • Turgan, N.1    Habif, S.2    Parildar, Z.3
  • 90
    • 76449091049 scopus 로고    scopus 로고
    • Haemostatic system, biochemical profiles, kynurenines and the prevalence of cardiovascular disease in peritoneally dialyzed patients
    • Pawlak K, Mysliwiec M, Pawlak D. Haemostatic system, biochemical profiles, kynurenines and the prevalence of cardiovascular disease in peritoneally dialyzed patients. Thromb Res 2010; 125: e40-5.
    • (2010) Thromb Res , vol.125 , pp. 40-45
    • Pawlak, K.1    Mysliwiec, M.2    Pawlak, D.3
  • 93
    • 77952026024 scopus 로고    scopus 로고
    • Total homocysteine in patients with angiographic coronary artery disease correlates with inflammation markers
    • Schroecksnadel K, Grammer TB, Boehm BO, März W, Fuchs D. Total homocysteine in patients with angiographic coronary artery disease correlates with inflammation markers. Thromb Haemost 2010; 103: 926-35.
    • (2010) Thromb Haemost , vol.103 , pp. 926-935
    • Schroecksnadel, K.1    Grammer, T.B.2    Boehm, B.O.3    März, W.4    Fuchs, D.5
  • 97
    • 0033215041 scopus 로고    scopus 로고
    • Tryptophan catabolism and T-cell tolerance: Immunosuppression by starvation?
    • Mellor AL, Munn DH. Tryptophan catabolism and T-cell tolerance: Immunosuppression by starvation? Immunol Today 1999; 20: 469-73.
    • (1999) Immunol Today , vol.20 , pp. 469-473
    • Mellor, A.L.1    Munn, D.H.2
  • 98
    • 0032555614 scopus 로고    scopus 로고
    • Inhibition of T cell proliferation by macrophage tryptophan catabolism
    • Munn DH, Zhou M, Attwood JT, et al. Inhibition of T cell proliferation by macrophage tryptophan catabolism. Science 1998, 281: 1191-3.
    • (1998) Science , vol.281 , pp. 1191-1193
    • Munn, D.H.1    Zhou, M.2    Attwood, J.T.3
  • 99
  • 100
    • 36248972568 scopus 로고    scopus 로고
    • IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells
    • Hill M, Tanguy-Royer S, Royer P, et al. IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells. Eur J Immunol 2007, 37: 3054-62.
    • (2007) Eur J Immunol , vol.37 , pp. 3054-3062
    • Hill, M.1    Tanguy-Royer, S.2    Royer, P.3
  • 101
    • 77953421676 scopus 로고    scopus 로고
    • Targeting the immunoregulatory indoleamine 2,3 dioxygenase pathway in immunotherapy
    • Johnson BA, Baban B, Mellor AL. Targeting the immunoregulatory indoleamine 2,3 dioxygenase pathway in immunotherapy. Immunotherapy 2009, 1: 645-61.
    • (2009) Immunotherapy , vol.1 , pp. 645-661
    • Johnson, B.A.1    Baban, B.2    Mellor, A.L.3
  • 102
    • 0027532121 scopus 로고
    • Association between immune activation, changes of iron metabolism and anaemia in patients with HIV-infection
    • Fuchs D, Zangerle R, Artner-Dworzak E, et al. Association between immune activation, changes of iron metabolism and anaemia in patients with HIV-infection. Eur J Haematol 1993; 50: 90-4.
    • (1993) Eur J Haematol , vol.50 , pp. 90-94
    • Fuchs, D.1    Zangerle, R.2    Artner-Dworzak, E.3
  • 104
    • 0027402767 scopus 로고
    • Weight loss in patients with hematological neoplasias is associated with immune system stimulation
    • Denz H, Orth B, Weiss G, et al. Weight loss in patients with hematological neoplasias is associated with immune system stimulation. Clin Investig 1993; 71: 37-41.
    • (1993) Clin Investig , vol.71 , pp. 37-41
    • Denz, H.1    Orth, B.2    Weiss, G.3
  • 105
    • 0028932245 scopus 로고
    • Decreased serum tryptophan in patients with cancer cachexia correlates with increased serum neopterin
    • Iwagaki H, Hizuta A, Tanaka N, Orita K. Decreased serum tryptophan in patients with cancer cachexia correlates with increased serum neopterin. Immunol Invest 1995; 24: 467-78.
    • (1995) Immunol Invest , vol.24 , pp. 467-478
    • Iwagaki, H.1    Hizuta, A.2    Tanaka, N.3    Orita, K.4
  • 106
    • 79959544003 scopus 로고    scopus 로고
    • IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults
    • Leng SX, Tian X, Matteini A, et al. IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults. Age Ageing 2011; 40: 475-81.
    • (2011) Age Ageing , vol.40 , pp. 475-481
    • Leng, S.X.1    Tian, X.2    Matteini, A.3
  • 107
    • 33747179266 scopus 로고    scopus 로고
    • Antitumoral activity of interferon-DDinvolved in impaired immune function in cancer patients
    • Brandacher G, Schroecksnadel K, Winkler C, Margreiter R, Fuchs D. Antitumoral activity of interferon-DDinvolved in impaired immune function in cancer patients. Curr Drug Metabol 2006; 7: 599-612.
    • (2006) Curr Drug Metabol , vol.7 , pp. 599-612
    • Brandacher, G.1    Schroecksnadel, K.2    Winkler, C.3    Margreiter, R.4    Fuchs, D.5
  • 109
    • 0034053304 scopus 로고    scopus 로고
    • Enhanced tryptophan degradation in systemic lupus erythematosus
    • Widner B, Sepp N, Kowald E, et al. Enhanced tryptophan degradation in systemic lupus erythematosus. Immunobiology 2000; 201: 621-30.
    • (2000) Immunobiology , vol.201 , pp. 621-630
    • Widner, B.1    Sepp, N.2    Kowald, E.3
  • 110
    • 0029903084 scopus 로고    scopus 로고
    • Quinolinic acid in patients with systemic lupus erythematosus and neuropsychiatric manifestations
    • Vogelgesang SA, Heyes MP, West SG, et al. Quinolinic acid in patients with systemic lupus erythematosus and neuropsychiatric manifestations. J Rheumatol 1996; 23: 850-5.
    • (1996) J Rheumatol , vol.23 , pp. 850-855
    • Vogelgesang, S.A.1    Heyes, M.P.2    West, S.G.3
  • 111
    • 35349002824 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase activity is increased in patients with systemic lupus erythematosus and predicts disease activation in the sunny season
    • Pertovaara M, Hasan T, Raitala A, et al. Indoleamine 2,3-dioxygenase activity is increased in patients with systemic lupus erythematosus and predicts disease activation in the sunny season. Clin Exp Immunol 2007; 150: 274-8.
    • (2007) Clin Exp Immunol , vol.150 , pp. 274-278
    • Pertovaara, M.1    Hasan, T.2    Raitala, A.3
  • 113
    • 78650477632 scopus 로고    scopus 로고
    • Kynurenine and its metabolites in Alzheimer's disease patients
    • Gulaj E, Pawlak K, Bien B, Pawlak D. Kynurenine and its metabolites in Alzheimer's disease patients. Adv Med Sci 2010; 55: 204-11.
    • (2010) Adv Med Sci , vol.55 , pp. 204-211
    • Gulaj, E.1    Pawlak, K.2    Bien, B.3    Pawlak, D.4
  • 114
    • 14644425246 scopus 로고    scopus 로고
    • Elevated serum neopterin predicts future adverse cardiac events in patients with chronic stable angina pectoris
    • Avanzas P, Arroyo-Espliguero R, Quiles J, Roy D, Kaski JC. Elevated serum neopterin predicts future adverse cardiac events in patients with chronic stable angina pectoris. Eur Heart J 2005; 26: 457-63.
    • (2005) Eur Heart J , vol.26 , pp. 457-463
    • Avanzas, P.1    Arroyo-Espliguero, R.2    Quiles, J.3    Roy, D.4    Kaski, J.C.5
  • 115
    • 33847616039 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase enzyme activity correlates with risk factors for atherosclerosis: The Cardiovascular Risk in Young Finns Study
    • Pertovaara M, Raitala A, Juonala M, et al. Indoleamine 2,3-dioxygenase enzyme activity correlates with risk factors for atherosclerosis: the Cardiovascular Risk in Young Finns Study. Clin Exp Immunol 2007; 148: 106-11.
    • (2007) Clin Exp Immunol , vol.148 , pp. 106-111
    • Pertovaara, M.1    Raitala, A.2    Juonala, M.3
  • 116
    • 57349088307 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase activity associates with cardiovascular risk factors: The Health 2000 study
    • Niinisalo P, Raitala A, Pertovaara M, et al. Indoleamine 2,3-dioxygenase activity associates with cardiovascular risk factors: the Health 2000 study. Scand J Clin Lab Invest 2008; 68: 767-70.
    • (2008) Scand J Clin Lab Invest , vol.68 , pp. 767-770
    • Niinisalo, P.1    Raitala, A.2    Pertovaara, M.3
  • 117
    • 80052099574 scopus 로고    scopus 로고
    • Moderating effect of indoleamine 2,3-dioxygenase (IDO) activation in the association between depressive symptoms and carotid atherosclerosis: Evidence from the Young Finns study
    • Elovainio M, Hurme M, Jokela M, et al. Moderating effect of indoleamine 2,3-dioxygenase (IDO) activation in the association between depressive symptoms and carotid atherosclerosis: evidence from the Young Finns study. J Affect Disord 2011; 133: 611-4.
    • (2011) J Affect Disord , vol.133 , pp. 611-614
    • Elovainio, M.1    Hurme, M.2    Jokela, M.3
  • 118
    • 18344389175 scopus 로고    scopus 로고
    • Association of interferon-gamma +874(T/A) single nucleotide polymorphism with the rate of tryptophan catabolism in healthy individuals
    • Raitala A, Pertovaara M, Karjalainen J, Oja SS, Hurme M. Association of interferon-gamma +874(T/A) single nucleotide polymorphism with the rate of tryptophan catabolism in healthy individuals. Scand J Immunol 2005; 61: 387-90.
    • (2005) Scand J Immunol , vol.61 , pp. 387-390
    • Raitala, A.1    Pertovaara, M.2    Karjalainen, J.3    Oja, S.S.4    Hurme, M.5
  • 119
    • 79955929537 scopus 로고    scopus 로고
    • Interferongamma (+874) T/A genotypes and risk of IFN-alpha-induced depression
    • Oxenkrug G, Perianayagam M, Mikolich D, et al. Interferongamma (+874) T/A genotypes and risk of IFN-alpha-induced depression. J Neural Transm 2011; 118: 271-4.
    • (2011) J Neural Transm , vol.118 , pp. 271-274
    • Oxenkrug, G.1    Perianayagam, M.2    Mikolich, D.3
  • 120
    • 67349241663 scopus 로고    scopus 로고
    • The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease
    • Pawlak K, Domaniewski T, Mysliwiec M, Pawlak D. The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease. Atherosclerosis 2009; 204: 309-14.
    • (2009) Atherosclerosis , vol.204 , pp. 309-314
    • Pawlak, K.1    Domaniewski, T.2    Mysliwiec, M.3    Pawlak, D.4
  • 121
    • 84885311364 scopus 로고    scopus 로고
    • Neopterin and kynureninetryptophan ratio as predictors of coronary events in older adults, the Hordaland Health Study
    • Sulo G, Vollset SE, Nygård O, et al. Neopterin and kynureninetryptophan ratio as predictors of coronary events in older adults, the Hordaland Health Study. Int J Cardiol 2013; 168: 1435-40.
    • (2013) Int J Cardiol , vol.168 , pp. 1435-1440
    • Sulo, G.1    Vollset, S.E.2    Nygård, O.3
  • 122
    • 84876688834 scopus 로고    scopus 로고
    • Immune activation in patients with Alzheimer's disease is associated with higher serum phenylalanine concentrations
    • Wissmann P, Geisler S, Leblhuber F, Fuchs D. Immune activation in patients with Alzheimer's disease is associated with higher serum phenylalanine concentrations. J Neurol Sci 2013; 329: 29-33.
    • (2013) J Neurol Sci , vol.329 , pp. 29-33
    • Wissmann, P.1    Geisler, S.2    Leblhuber, F.3    Fuchs, D.4
  • 123
    • 0035101295 scopus 로고    scopus 로고
    • Nutritional factors in cerebral aging and dementia: Epidemiological arguments for a role of oxidative stress
    • Deschamps V, Barberger-Gateau P, Peuchant E, Orgogozo JM. Nutritional factors in cerebral aging and dementia: epidemiological arguments for a role of oxidative stress. Neuroepidemiology 2001; 20: 7-15.
    • (2001) Neuroepidemiology , vol.20 , pp. 7-15
    • Deschamps, V.1    Barberger-Gateau, P.2    Peuchant, E.3    Orgogozo, J.M.4
  • 124
    • 54249130383 scopus 로고    scopus 로고
    • Age-associated changes in immune and inflammatory responses: Impact of vitamin E intervention
    • Wu D, Meydani SN. Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. J Leukoc Biol 2008; 84: 900-14.
    • (2008) J Leukoc Biol , vol.84 , pp. 900-914
    • Wu, D.1    Meydani, S.N.2
  • 125
    • 79951725595 scopus 로고    scopus 로고
    • In vitro testing for antiinflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors
    • Jenny M, Klieber M, Zaknun D, et al. In vitro testing for antiinflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors. Inflamm Res 2011; 60: 127-35.
    • (2011) Inflamm Res , vol.60 , pp. 127-135
    • Jenny, M.1    Klieber, M.2    Zaknun, D.3
  • 126
    • 80053514753 scopus 로고    scopus 로고
    • Potential role of antioxidant food supplements, preservatives and colorants in the pathogenesis of allergy and asthma
    • Zaknun D, Schroecksnadel S, Kurz K, Fuchs D. Potential role of antioxidant food supplements, preservatives and colorants in the pathogenesis of allergy and asthma. Int Arch Allergy Immunol 2012, 157: 113-24.
    • (2012) Int Arch Allergy Immunol , vol.157 , pp. 113-124
    • Zaknun, D.1    Schroecksnadel, S.2    Kurz, K.3    Fuchs, D.4
  • 127
    • 16244393385 scopus 로고    scopus 로고
    • Aspirin down-regulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro
    • Schroecksnadel K, Winkler C, Wirleitner B, Schennach H, Fuchs D. Aspirin down-regulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro. Clin Exp Immunol 2005; 140: 41-5.
    • (2005) Clin Exp Immunol , vol.140 , pp. 41-45
    • Schroecksnadel, K.1    Winkler, C.2    Wirleitner, B.3    Schennach, H.4    Fuchs, D.5
  • 128
    • 77956264421 scopus 로고    scopus 로고
    • LPS-induced NFkappaB expression in THP-1Blue cells correlates with neopterin production and activity of indoleamine 2,3-dioxygenase
    • Schroecksnadel S, Jenny M, Kurz K, et al. LPS-induced NFkappaB expression in THP-1Blue cells correlates with neopterin production and activity of indoleamine 2,3-dioxygenase. Biochem Biophys Res Com 2010; 399: 642-6.
    • (2010) Biochem Biophys Res Com , vol.399 , pp. 642-646
    • Schroecksnadel, S.1    Jenny, M.2    Kurz, K.3
  • 129
    • 80052325862 scopus 로고    scopus 로고
    • Influence of immunosuppressive agents on tryptophan degradation and neopterin production in human peripheral blood mononuclear cells
    • Schroecksnadel S, Sucher R, Kurz K, Fuchs, Brandacher G. Influence of immunosuppressive agents on tryptophan degradation and neopterin production in human peripheral blood mononuclear cells. Transplant Immunol 2011; 25: 119-23.
    • (2011) Transplant Immunol , vol.25 , pp. 119-123
    • Schroecksnadel, S.1    Sucher, R.2    Kurz, K.3    Fuchs, B.G.4
  • 130
    • 20444426900 scopus 로고    scopus 로고
    • Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells
    • Tan PH, Sagoo P, Chan C, et al. Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. J Immunol 2005; 174: 7633-44.
    • (2005) J Immunol , vol.174 , pp. 7633-7644
    • Tan, P.H.1    Sagoo, P.2    Chan, C.3
  • 131
    • 82855167178 scopus 로고    scopus 로고
    • Extension of life span of Drosophila melanogaster by the inhibitors of tryptophan-kynurenine metabolism
    • Oxenkrug GF, Navrotskaya V, Voroboyva L, Summergrad P. Extension of life span of Drosophila melanogaster by the inhibitors of tryptophan-kynurenine metabolism. Fly (Austin) 2011; 5: 307-9.
    • (2011) Fly (Austin) , vol.5 , pp. 307-309
    • Oxenkrug, G.F.1    Navrotskaya, V.2    Voroboyva, L.3    Summergrad, P.4
  • 132
    • 84873992070 scopus 로고    scopus 로고
    • Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: A meta-analysis
    • Long SJ, Benton D. Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: a meta-analysis. Psychosom Med. 2013; 75: 144-53.
    • (2013) Psychosom Med , vol.75 , pp. 144-153
    • Long, S.J.1    Benton, D.2
  • 133
    • 85027958539 scopus 로고    scopus 로고
    • Depressive symptoms are associated with food insufficiency and nutritional deficiencies in poor community-dwelling elderly people
    • German L, Kahana C, Rosenfeld V, et al. Depressive symptoms are associated with food insufficiency and nutritional deficiencies in poor community-dwelling elderly people. J Nutr Health Aging 2011; 15: 3-8.
    • (2011) J Nutr Health Aging , vol.15 , pp. 3-8
    • German, L.1    Kahana, C.2    Rosenfeld, V.3
  • 134
    • 0037316358 scopus 로고    scopus 로고
    • Atorvastatin suppresses interferon-D-induced neopterin formation and tryptophan degradation in human peripheral blood mononuclear cells and in monocytic cell lines
    • Neurauter G, Wirleitner B, Laich A, Schennach H, Weiss G, Fuchs D. Atorvastatin suppresses interferon-D-induced neopterin formation and tryptophan degradation in human peripheral blood mononuclear cells and in monocytic cell lines. Clin Exp Immunol 2003; 131: 264-7.
    • (2003) Clin Exp Immunol , vol.131 , pp. 264-267
    • Neurauter, G.1    Wirleitner, B.2    Laich, A.3    Schennach, H.4    Weiss, G.5    Fuchs, D.6
  • 135
    • 77955684288 scopus 로고    scopus 로고
    • Resveratrol and red wine, healthy heart and longevity
    • Das DK, Mukherjee S, Ray D. Resveratrol and red wine, healthy heart and longevity. Heart Fail Rev 2010; 15: 467-77.
    • (2010) Heart Fail Rev , vol.15 , pp. 467-477
    • Das, D.K.1    Mukherjee, S.2    Ray, D.3
  • 136
    • 80955163668 scopus 로고    scopus 로고
    • Effects of high adherence to Mediterranean or low-fat diets in medicated secondary prevention patients
    • Thomazella MC, Góes MF, Andrade CR, et al. Effects of high adherence to Mediterranean or low-fat diets in medicated secondary prevention patients. Am J Cardiol 2011; 108: 1523-9.
    • (2011) Am J Cardiol , vol.108 , pp. 1523-1529
    • Thomazella, M.C.1    Góes, M.F.2    Andrade, C.R.3


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