Tryptophan degradation increases with stage in patients with rheumatoid arthritis

Clinical Rheumatology

Volumn 25, Issue 3, 2006, Pages 334-337

  Schroecksnadel, Katharina ^a,b   Winkler, Christiana ^a,b   Duftner, Christian ^c   Wirleitner, Barbara ^a,b   Schirmer, Michael ^c   Fuchs, Dietmar ^a,b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Disease activity; Indoleamine(2,3) dioxygenase; Neopterin; Rheumatoid arthritis; Stage; Tryptophan degradation

Indexed keywords

C REACTIVE PROTEIN; CYCLOSPORIN A; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE; LEFLUNOMIDE; METHOTREXATE; NEOPTERIN; SALAZOSULFAPYRIDINE; STEROID; TRYPTOPHAN;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; CALCULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ACTIVITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNE RESPONSE; MACROPHAGE; MALE; PATHOGENESIS; PHYSICIAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ARTHRITIS, RHEUMATOID; BLOOD SEDIMENTATION; C-REACTIVE PROTEIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEALTH STATUS; HUMANS; KYNURENINE; MALE; MIDDLE AGED; NEOPTERIN; SEVERITY OF ILLNESS INDEX; TRYPTOPHAN;

EID: 33645789813     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-005-0056-6     Document Type: Article

References (22)

1. Wilder RL (1993) Rheumatoid arthritis: Epidemiology, pathology and pathogenesis. In: Schumacher HR (ed) Primer on rheumatic diseases. Arthritis Foundation, Atlanta, pp 86-89
2. Malik AB, Lo SK (1996) Vascular endothelial adhesion molecules and tissue inflammation. Pharmacol Rev 48:213-229
3. Steiner G, Studnicka-Benke A, Witzmann G, Hofler E, Smolen J (1995) Soluble receptors for tumor necrosis factor and interleukin-2 in serum and synovial fluid of patients with rheumatoid arthritis, reactive arthritis and osteoarthritis. J Rheumatol 22:406-412
4. Keystone EC, Snow KM, Bombardier C, Chang CH, Nelson DL, Rubin LA (1988) Elevated soluble IL-2 receptor levels in the sera and synovial fluids of patients with rheumatoid arthritis. Arthritis Rheum 31:1358-1364
5. Reibnegger G, Egg D, Fuchs D et al (1986) Urinary neopterin reflects clinical activity in patients with rheumatoid arthritis. Arthritis Rheum 29:1063-1070
6. Kullich W (1993) Correlation of interleukin-2 receptor and neopterin secretion in rheumatoid arthritis. Clin Rheumatol 12:387-391
7. Nassonov EL, Samsonov MY, Tilz GP et al (2000) Soluble adhesion molecules in rheumatoid arthritis. Rheumatology 39:808-810
8. Wirleitner B, Neurauter G, Schröcksnadel K, Frick B, Fuchs D (2003) Interferon-γ-induced conversion of tryptophan: Immunologic and neuropsychiatric aspects. Curr Med Chem 10:1581-1591
9. Fuchs D, Möller AA, Reibnegger G, Stöckle E, Werner ER, Wachter H (1990) Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/ psychiatric symptoms. J Acquir Immune Defic Syndr 3:873-876
10. Schröcksnadel K, Kaser S, Ledochowski M et al (2003) Increased degradation of tryptophan in blood of patients with rheumatoid arthritis. J Rheumatol 30:1935-1939
11. Pfefferkorn ER (1984) Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc Natl Acad Sci U S A 81:908-912
12. Burke F, Knowles RG, East N, Balkwill FR (1995) The role of indoleamine 2,3-dioxygenase in the anti-tumour activity of human interferon-gamma in vivo. Int J Cancer 60:115-122
13. Carlin JM, Ozaki Y, Byrne GI, Brown RR, Borden EC (1989) Interferons and indoleamine 2,3-dioxygenase: Role in antimicrobial and antitumor effects. Experientia 45:535-541
14. Munn DH, Shafizadeh E, Attwood JT, Bondarev I, Pashine A, Mellor AL (1999) Inhibition of T-cell proliferation by macrophage tryptophan catabolism. J Exp Med 189:1663-1672
15. Mellor AL, Munn DH (1999) Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? Immunol Today 20:469-473
16. Widner B, Werner ER, Schennach H, Wachter H, Fuchs D (1997) Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin Chem 43:2424-2426
17. Werner ER, Werner-Felmayer G, Fuchs D, Hausen A, Reibnegger G, Wachter H (1989) Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma. Biochem J 262:861-866
18. Wirleitner B, Reider D, Ebner S et al (2002) Monocyte-derived dendritic cells release neopterin. J Leukoc Biol 72:1148-1153
19. Symons JA, Wood NC, Di Giovine FS, Duff GW (1988) Soluble IL-2 receptor in rheumatoid arthritis: Correlation with disease activity. IL-1 and IL-2 inhibition. J Immunol 141:2612-2618
20. Rubin LA, Snow KM, Kurman CC, Nelson DL, Keystone EC (1990) Serial levels of soluble interleukin 2 receptor in the peripheral blood of patients with rheumatoid arthritis: Correlations with disease activity. J Rheumatol 17:597-602
21. Diez-Ruiz A, Tilz GP, Zangerle R, Baier-Bitterlich G, Wachter H, Fuchs D (1995) Soluble receptors for tumor necrosis factor in clinical laboratory diagnosis. Eur J Haematol 54:1-8
22. Widner B, Ledochowski M, Fuchs D (2000) Interferon-gamma-induced tryptophan degradation: Neuropsychiatric and immunological consequences. Curr Drug Metab 1:193-204