Increased neopterin concentration in older age coincides with decline of CD28+CD45RA+ T-cells

Pteridines

Volumn 15, Issue 4, 2004, Pages 170-174

  Murr, Christian ^a   Hainz, Ursula ^c   Asch, Ester ^c   Berger, Peter ^c   Jenewein, Brigitte ^c   Saurwein Teissl, Maria ^c   Grubeck Loebenstein, Beatrix ^c   Fuchs, Dietmar ^a,b,d  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^d Institute of Biochemistry   (Austria)

Author keywords

Aging; CD28; Neopterin; T lymphocyte surface antigen expression

Indexed keywords

CD28 ANTIGEN; CD45 ANTIGEN; CD45RA ANTIGEN; CD45RO ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; NEOPTERIN; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; AGING; ARTICLE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; LYMPHOCYTE DIFFERENTIATION; MACROPHAGE; MULTIVARIATE ANALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REFERENCE VALUE; T LYMPHOCYTE;

EID: 14344265471     PISSN: 09334807     EISSN: 21954720     Source Type: Journal    
DOI: 10.1515/pteridines.2004.15.4.170     Document Type: Article

References (24)

1. Huber C, Batchelor JR, Fuchs D, Hausen A, Lang A, Niederwieser D, Reibnegger G, Swetly P, Troppmair J, Wachter H. Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon gamma. J Exp Med 1984;160:310-316.
2. Fuchs D, Hausen A, Reibnegger G, Werner ER, Dierich MP, Wachter H. Neopterin as a marker for activated cell-mediated immunity: application in HIV infection. Immunol Today 1988;9:150-155.
3. Fuchs D, Weiss G, Reibnegger G Wachter H. The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious and malignant diseases. Crit Rev Clin Lab Sci 1992;29:307-341.
4. Fahey JL, Taylor JMG, Detels R, Hofmann B, Melmed R, Nishanian P, Giorgi JV. The prognostic value of cellular and prognostic markers in infections with human immunodeficiency virus type I infection. N Engl J Med 1990;322:166-172.
5. Reibnegger G, Fuchs D, Fuith LC, Hausen A, Werner ER, Werner-Felmayer G, Wachter H. Neopterin as a marker for activated cell-mediated immunity: application in malignant disease. Cancer Detect Prev 1991;15:483-490.
6. Murr C, Bergant A, Widschwendter M, Heim K, Schröcksnadel H, Fuchs D. Neopterin is an independent prognostic variable in females with breast cancer. Clin Chem 1999;45:1998-2004.
7. Samsonov MY, Tilz GP, Egorova O, Reibnegger G, Balabanova RM, Nassonov EL, Nassonova VA, Wachter H, Fuchs D. Serum soluble markers of immune activation and disease activity in systemic lupus erythematosus. Lupus 1995;4:29-32.
8. Reibnegger G, Aichberger C, Fuchs D, Hausen A, Spielberger M, Werner ER, Margreiter R, Wachter H. Posttransplant neopterin excretion in renal allograft recipients-A reliable diagnostic aid for acute rejection and a predictive marker of long-term graft survival. Tranplantation 1991;52:58-63.
9. Reibnegger G, Huber LA, Jürgens G, Schönitzer D, Werner ER, Wächter H, Wick G, Traill KN. Approach to define "normal ageing" in man immune function, serum lipids, lipoproteins and neopterin levels. Mech Ageing Dev 1988;46:67-82.
10. Diamondstone LS, Tollerud DJ, Fuchs D, Wachter H, Brown LM, Maloney E, Kurman CC, Nelson DL, Blattner WA. Factors influencing serum neopterin and β2-microglobulin levels in healthy diverse population. J Clin Immunol 1994;14:368-374.
11. Ledochowski M, Murr C, Widner B, Fuchs D. Association between insulin resistance, body mass and neopterin concentrations. Clin Chim Acta 1999;282:115-123.
12. Ledochowski M, Murr C, Widner B, Fuchs D. Inverse relationship between neopterin and immunoglobulin. E Clin Immunol 2001;98:104-108.
13. Ledochowski M, Murr C, Jäger M, Fuchs D. Dehydroepiandrosterone, ageing and immune activation. Exp Gerontol 2001;36:1739-1747.
14. Schennach H, Murr C, Gächter E, Mayersbach P, Schönitzer D, Fuchs, D. Factors influencing serum neopterin levels in a population of blood donors Clin Chem 2002;48:643-645.
15. Weiss G, Willeit J, Kiechl S, Fuchs D, Jarosch E, Oberhollenzer F, Reibnegger G, Tilz GP, Gerstenbrand F, Wachter H. Increased concentrations of neopterin in carotid atherosclerosis. Atherosclerosis 1994;106:263-271.
16. Leblhuber F, Walli J, Demel U, Tilz GP, Widner B, Fuchs D. Increased serum neopterin concentrations in patients with Alzheimer's disease. Clin Chem Lab Med 1999;37:429-431.
17. Wick G, Grubeck-Loebenstein B. Primary and secondary alterations of the immune system in the elderly: impact of dietary factors and disease. Immunol Rev 1997;160:171-184.
18. Vallejo AN, Brandes JC, Weyand CM, Goronzy JJ. Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence. J Immunol 1999;162:6572-5729.
19. Saurwein-Teissl M, Lung TL, Marx F, Gschösser C, Asch E, Blasko I, Parson W, Böck G, Schönitzer D, Trannoy E, Grubeck-Loebenstein B. Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J Immunol 2002;168: 5893-5899.
20. Hainz U, Aigner K, Asch E, Berger P, Böhmer F, Feldkircher B, Horwath B, Jenewein B, Kassal H, Kistner O, Mack H, Pfeiffer K-P, Pils K, Plank J, Renner D, Saurwein-Teissl M, Schwanzer E, Trieb K, Grubeck-Loebenstein B. Do recommended vaccination strategies give sufficient protection in the elderly? An Austrian-wide evaluation. Wien Klin Wochenschr 2002;114:187-193.
21. Murr C, Hainz U, Asch E, Berger P, Jenewein B, Saurwein-Teissl M, Grubeck-Loebenstein B, Fuchs D. Association of increased neopterin production with decreased humoral immunity in the elderly. Exp Gerontol 2003;38:583-587.
22. Fahey JL, Schnelle JF, Boscardin J, Thomas JK, Gorre ME, Aziz N, Sadeghi H, Nishanian P. Distinct categories of immunologic changes in frail elderly. Mech Ageing Dev 2000;115:1-20.
23. Tarazona R, DelaRosa O, Alonso C, Ostos B, Espejo J, Pena J, Solana R. Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T-cells. Mech Ageing Dev 2000;121:77-88.
24. Russell GJ. CD28 signaling and T cell death. Mod Asp Immunobiol 2003;3:4.