Immune activation and inflammation in patients with cardiovascular disease are associated with elevated phenylalanine-to-tyrosine ratios

Pteridines

Volumn 24, Issue 1, 2013, Pages 51-55

  Mangge, Harald ^b   Schnedl, Wolfgang J ^c   Schröcksnadel, Sebastian ^a   Geisler, Simon ^a   Murr, Christian ^a   Fuchs, Dietmar ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c Practice for General Internal Medicine   (Austria)

Author keywords

Coronary artery disease; Neopterin; Phenylalanine; Phenylalanine hydroxylase; Tetrahydrobiopterin

Indexed keywords

KYNURENINE; NEOPTERIN; NITRITE; PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE; TRYPTOPHAN; TYROSINE;

AGED; ARTICLE; CLINICAL ARTICLE; COLORIMETRY; CONCENTRATION (PARAMETERS); CORONARY ARTERY DISEASE; CORRELATION ANALYSIS; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOREACTIVITY; INFLAMMATION; MALE; PILOT STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

EID: 84882381120     PISSN: 09334807     EISSN: 21954720     Source Type: Journal    
DOI: 10.1515/pterid-2013-0002     Document Type: Article

References (34)

1. Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature 2011;473:317-25.
2. Huber C, Batchelor JR, Fuchs D, Hausen A, Lang A, Niederwieser D, et al. Immune response-Associated production of neopterin-release from macrophages primarily under control of interferon-Ã. J Exp Med 1984;160:310-6.
3. Wirleitner B, Reider D, Ebner S, Böck G, Widner B, Jaeger M, et al. Monocyte-derived dendritic cells release neopterin. J Leukocyte Biol 2002;2:1148-53.
4. Werner ER, Werner-Felmayer G, Fuchs D, Hausen A, Reibnegger G, Yim JJ, et al. Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP.-1 and T 24 cells. GTP.-cyclohydrolase I is stimulated by interferon-Ã, 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present. J Biol Chem 1990;265:3189-92.
5. Schroecksnadel K, Wirleitner B, Winkler C, Fuchs D. Monitoring tryptophan metabolism in chronic immune activation. Clin Chim Acta 2006;364:82-90.
6. Wirleitner B, Rudzite V, Neurauter G, Murr C, Kalnins U, Erglis A, et al. Immune activation and degradation of tryptophan in coronary heart disease. Eur J Clin Invest 2003;33:550-4.
7. Niinisalo P, Raitala A, Pertovaara M, Oja SS, Lehtimäki T, Kähönen M, et al. Indoleamine 2,3-dioxygenase activity associates with cardiovascular risk factors: the Health 2000 study. Scand J Clin Lab Invest 2008;68:767-70.
8. Fuchs D, Avanzas P, Arroyo-Espliguero R, Jenny M, Consuegra Sanchez L, Kaski JC. The role of neopterin in atherogenesis and cardiovascular risk stratification. Curr Med Chem 2009;16: 4644-53.
9. Grammer TB, Fuchs D, Böhm BO, Winkelmann BR, Maerz W. Neopterin as a predictor of total and cardiovascular mortality in individuals undergoing angiography (The Ludwigshafen Risk and Cardiovascular Health Study). Clin Chem 2009;55:115-46.
10. Pedersen ER, Midttun O, Ueland PM, Schartum-Hansen H, Seifert R, Igland J, et al. Systemic markers of interferon-Ã-mediated immune activation and long-Term prognosis in patients with stable coronary artery disease. Arterioscler Thromb Vasc Biol 2011;31:698-704.
11. Neurauter G, Schröcksnadel K, Scholl-Bürgi S, Sperner-Unterweger B, Schubert C, Ledochowski M, et al. Chronic immune stimulation correlates with reduced phenylalanine turnover. Curr Drug Metab 2008;9:622-7.
12. Ploder M, Neurauter G, Spittler A, Schroecksnadel K, Roth E, Fuchs D. Serum phenylalanine in patients post trauma and with sepsis correlates to neopterin concentrations. Amino Acids 2008;35:303-7.
13. Zangerle R, Kurz K, Neurauter G, Kitchen M, Sarcletti M, Fuchs D. Increased blood phenylalanine to tyrosine ratio in HIV.-1 infection and correction following effective antiretroviral therapy. Brain Behav Immun 2010;24:403-8.
14. Capuron L, Schroecksnadel S, Féart C, Aubert A, Higueret D, Barberger-Gateau P, et al. Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms. Biol Psychiatry 2011;70:175-82.
15. Gotto AM Jr, Moon JE. Management of cardiovascular risk: the importance of meeting lipid targets. Am J Cardiol 2012;110(Suppl 1):3A.-14A.
16. Widner B, Werner ER, Schennach H, Wachter H, Fuchs D. Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin Chem 1997;43:2424-6.
17. Neurauter G, Grahmann AV, Klieber M, Zeimet A, Ledochowski M, Sperner-Unterweger B, et al. Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with concentrations of immune activation markers and of isoprostane-8. Cancer Lett 2008;272:141-7.
18. Rosenblatt D, Scriver CR. Heterogeneity in genetic control of phenylalanine metabolism in man. Nature 1968;218:677-8.
19. Anderson DN, Wilkinson AM, Abou-Saleh MT, Blair JA. Recovery from depression after electroconvulsive therapy is accompanied by evidence of increased tetrahydrobiopterin-dependent hydroxylation. Acta Psychiatr Scand 1994;90:10-3.
20. Giustarini D, Dalle-Donne I, Colombo R, Milzani A, Rossi R. Adaptation of the Griess reaction for detection of nitrite in human plasma. Free Radic Res 2004;38:1235-40.
21. Shih VE. Amino acid analysis. In: Blau N, Duran M, Blaskovic ME, Gibson KM, editors. Physician's guide to the laboratory diagnosis of metabolic diseases, 2nd ed. Berlin: Springer, 2003:11-26.
22. Scholl-Bürgi S, Schroecksnadel S, Jenny M, Karall D, Fuchs D. Chronic immune stimulation may cause moderate impairment of phenylalanine 4-hydroxylase. Pteridines 2011;22:120-5.
23. Haroon E, Raison CL, Miller AH. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 2012;37:137-62.
24. Felger JC, Li L, Marvar PJ, Woolwine BJ, Harrison DG, Raison CL, et al. Tyrosine metabolism during interferon-Áadministration: association with fatigue and CSF dopamine concentrations. Brain Behav Immun 2012;pii:S0889- 1591(12)00472-2.
25. Van Gool AR, Fekkes D, Kruit WH, Mulder PG, Ten Hagen TL, Bannink M, et al. Serum amino acids, biopterin and neopterin during long-Term immunotherapy with interferon-Áin high-risk melanoma patients. Psychiatry Res 2003;119:125-32.
26. Zoller H, Schloegl A, Schroecksnadel S, Vogel W, Fuchs D. Influence of interferon-Átherapy on phenylalanine hydroxylase activity in patients with HCV infection. J Interferon Cytokine Res 2012;32:216-20.
27. Murr C, Widner B, Wirleitner B, Fuchs D. Neopterin as a marker for immune system activation. Curr Drug Metabol 2002;3: 175-87.
28. Kaufman S. Hepatic phenylalanine hydroxylase and PKU. UCLA Forum Med Sci 1975;18:445-58.
29. Fitzpatrick PF. The tetrahydropterin-dependent amino acid hydroxylases. Annu Rev Biochem 1999;68:355-81.
30. Watschinger K, Keller MA, Golderer G, Hermann M, Maglione M, Sarg B, et al. Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterindependent enzymes. Proc Natl Acad Sci USA 2010;107:13672-7.
31. Crabtree MJ, Channon KM. Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric Oxide 2011;25:81-8.
32. Cunnington C, Van Assche T, Shirodaria C, Kylintireas I, Lindsay AC, Lee JM, et al. Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease. Circulation 2012;125:1356-66.
33. Biondi R, Ambrosio G, De Pascali F, Tritto I, Capodicasa E, Druhan LJ, et al. HPLC analysis of tetrahydrobiopterin and its pteridine derivatives using sequential electrochemical and fluorimetric detection: application to tetrahydrobiopterin autoxidation and chemical oxidation. Arch Biochem Biophys 2012;520:7-16.
34. Kwon NS, Nathan CF, Stuehr DJ. Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J Biol Chem 1989;264:20496-501.