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Volumn 1, Issue 4, 2009, Pages 645-661

Targeting the immunoregulatory indoleamine 2,3 dioxygenase pathway in immunotherapy

Author keywords

Allergy; Autoimmunity; Cancer; Dendritic cell; Immunoregulation; Indoleamine 2,3 dioxygenase; Infection; Inflammation; T cell; Tryptophan

Indexed keywords

1 METHYLTRYPTOPHAN; 5 BROMO BRISSIN; ABATACEPT; ALPHA GALACTOSYLCERAMIDE; ANTIRETROVIRUS AGENT; BETA INTERFERON; CD137 ANTIGEN; CD200 IMMUNOGLOBULIN; CD40 IMMUNOGLOBULIN; CELECOXIB; CPG OLIGODEOXYNUCLEOTIDE; DEXAMETHASONE; FC EPSILON RECEPTOR I ANTIBODY; HISTONE DEACETYLASE INHIBITOR; IMMUNOGLOBULIN ANTIBODY; IMMUNOLOGICAL ADJUVANT; INDOLEAMINE 2,3 DIOXYGENASE; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; INTERFERON; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; RESIQUIMOD; UNCLASSIFIED DRUG;

EID: 77953421676     PISSN: 1750743X     EISSN: None     Source Type: Journal    
DOI: 10.2217/IMT.09.21     Document Type: Review
Times cited : (54)

References (126)
  • 1
    • 37549061827 scopus 로고    scopus 로고
    • Creating immune privilege: Active local suppression that benefits friends, but protects foes
    • Mellor AL, Munn DH: Creating immune privilege: active local suppression that benefits friends, but protects foes. Nat. Rev. Immunol. 8, 74-80 (2008).
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 74-80
    • Mellor, A.L.1    Munn, D.H.2
  • 2
    • 0038215374 scopus 로고    scopus 로고
    • Tolerance, DCs and tryptophan: Much ado about IDO
    • Grohmann U, Fallarino F, Puccetti P: Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol. 24, 242-248 (2003).
    • (2003) Trends Immunol. , vol.24 , pp. 242-248
    • Grohmann, U.1    Fallarino, F.2    Puccetti, P.3
  • 3
    • 5044220930 scopus 로고    scopus 로고
    • IDO expression in dendritic cells: Tolerance and tryptophan catabolism
    • Mellor AL, Munn DH: IDO expression in dendritic cells: Tolerance and tryptophan catabolism. Nat. Rev. Immunol. 4, 762-774 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 762-774
    • Mellor, A.L.1    Munn, D.H.2
  • 4
    • 33748744234 scopus 로고    scopus 로고
    • Immune privilege: A recurrent theme in immunoregulation?
    • Mellor AL, Munn DH: Immune privilege: a recurrent theme in immunoregulation? Immunol. Rev. 213, 5-11 (2006).
    • (2006) Immunol. Rev. , vol.213 , pp. 5-11
    • Mellor, A.L.1    Munn, D.H.2
  • 5
    • 34248173331 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase and tumor-induced tolerance
    • Munn DH, Mellor AL: Indoleamine 2,3-dioxygenase and tumor-induced tolerance. J. Clin. Invest. 117, 1147-1154 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 1147-1154
    • Munn, D.H.1    Mellor, A.L.2
  • 8
    • 34547643025 scopus 로고    scopus 로고
    • Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan
    • DOI 10.1158/0008-5472.CAN-07-1872
    • Metz R, Duhadaway JB, Kamasani U et al.: Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Cancer Res. 67, 7082-7087 (2007). (Pubitemid 47206533)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7082-7087
    • Metz, R.1    Duhadaway, J.B.2    Kamasani, U.3    Laury-Kleintop, L.4    Muller, A.J.5    Prendergast, G.C.6
  • 9
    • 0038243535 scopus 로고    scopus 로고
    • Comparison of the sequences of Turbo and Sulculus indoleamine dioxygenase-like myoglobin genes
    • DOI 10.1016/S0378-1119(03)00467-0
    • Suzuki T, Yokouchi K, Kawamichi H et al.: Comparison of the sequences of Turbo and Sulculus indoleamine dioxygenase-like myoglobin genes. Gene 308, 89-94 (2003). (Pubitemid 36597826)
    • (2003) Gene , vol.308 , Issue.1-2 , pp. 89-94
    • Suzuki, T.1    Yokouchi, K.2    Kawamichi, H.3    Yamamoto, Y.4    Uda, K.5    Yuasa, H.J.6
  • 10
    • 4043170040 scopus 로고    scopus 로고
    • Inhibition of experimental asthma by indoleamine 2,3-dioxygenase
    • Hayashi T, Beck L, Rossetto C et al.: Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J. Clin. Invest. 114, 270-279 (2004).
    • (2004) J. Clin. Invest. , vol.114 , pp. 270-279
    • Hayashi, T.1    Beck, L.2    Rossetto, C.3
  • 11
    • 1842507884 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific
    • Baban B, Chandler P, McCool D et al.: Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific. J. Reprod. Immunol. 61, 67-77 (2004).
    • (2004) J. Reprod. Immunol. , vol.61 , pp. 67-77
    • Baban, B.1    Chandler, P.2    McCool, D.3
  • 13
    • 3242693075 scopus 로고    scopus 로고
    • Human epidermal langerhans cells express the immunoregulatory enzyme indoleamine 2,3-dioxygenase
    • von Bubnoff D, Bausinger H, Matz H et al.: Human epidermal langerhans cells express the immunoregulatory enzyme indoleamine 2,3-dioxygenase. J. Invest. Dermatol. 123, 298-304 (2004).
    • (2004) J. Invest. Dermatol. , vol.123 , pp. 298-304
    • Von Bubnoff, D.1    Bausinger, H.2    Matz, H.3
  • 14
    • 33745819629 scopus 로고    scopus 로고
    • Expression of indoleamine 2,3-dioxygenase (IDO) by endothelial cells: Implications for the control of alloresponses
    • Beutelspacher SC, Tan PH, McClure MO, Larkin DF, Lechler RI, George AJ: Expression of indoleamine 2,3-dioxygenase (IDO) by endothelial cells: implications for the control of alloresponses. Am. J. Transplant. 6, 1320-1330 (2006).
    • (2006) Am. J. Transplant. , vol.6 , pp. 1320-1330
    • Beutelspacher, S.C.1    Tan, P.H.2    McClure, M.O.3    Larkin, D.F.4    Lechler, R.I.5    George, A.J.6
  • 15
    • 49949118291 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury
    • Mohib K, Wang S, Guan Q et al.: Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury. Am. J. Physiol. Renal Physiol. 295, F226-34 (2008).
    • (2008) Am. J. Physiol. Renal Physiol. , vol.295
    • Mohib, K.1    Wang, S.2    Guan, Q.3
  • 16
    • 49149099012 scopus 로고    scopus 로고
    • Spontaneous renal allograft acceptance associated with 'regulatory' dendritic cells and IDO
    • Cook CH, Bickerstaff AA, Wang JJ et al.: Spontaneous renal allograft acceptance associated with 'regulatory' dendritic cells and IDO. J. Immunol. 180, 3103-3112 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 3103-3112
    • Cook, C.H.1    Bickerstaff, A.A.2    Wang, J.J.3
  • 17
    • 0043032808 scopus 로고    scopus 로고
    • Asp274 and His346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase
    • Littlejohn TK, Takikawa O, Truscott RJ, Walker MJ: Asp274 and His346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase. J. Biol. Chem. 278, 29525-29531 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 29525-29531
    • Littlejohn, T.K.1    Takikawa, O.2    Truscott, R.J.3    Walker, M.J.4
  • 18
    • 2142663225 scopus 로고    scopus 로고
    • Determination of the Nature of the Heme Environment in Nitrosyl Indoleamine 2,3-Dioxygenase Using Multiple-Scattering Analyses of X-ray Absorption Fine Structure
    • DOI 10.1021/bi049645s
    • Aitken JB, Thomas SE, Stocker R et al.: Determination of the nature of the heme environment in nitrosyl indoleamine 2,3-dioxygenase using multiple-scattering analyses of X-ray absorption fine structure. Biochemistry 43, 4892-4898 (2004). (Pubitemid 38552374)
    • (2004) Biochemistry , vol.43 , Issue.17 , pp. 4892-4898
    • Aitken, J.B.1    Thomas, S.E.2    Stocker, R.3    Thomas, S.R.4    Takikawa, O.5    Armstrong, R.S.6    Lay, P.A.7
  • 19
    • 38049115134 scopus 로고    scopus 로고
    • Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
    • Linked a genetic defect in NADPH oxidase activity with a biochemical defect in indoleamine 2,3-dioxygenase (IDO) functionality in a mouse model of chronic granulomatous disease. The innate defect in IDO led to increased IL-17 production and expansion of proinflammatory T cells, which increased susceptibility to Aspergillus fumigatus infection
    • Romani L, Fallarino F, De Luca A et al.: Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature 451, 211-215 (2008). •• Linked a genetic defect in NADPH oxidase activity with a biochemical defect in indoleamine 2,3-dioxygenase (IDO) functionality in a mouse model of chronic granulomatous disease. The innate defect in IDO led to increased IL-17 production and expansion of proinflammatory T cells, which increased susceptibility to Aspergillus fumigatus infection.
    • (2008) Nature , vol.451 , pp. 211-215
    • Romani, L.1    Fallarino, F.2    De Luca, A.3
  • 20
    • 4043092238 scopus 로고    scopus 로고
    • Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes
    • Munn DH, Sharma MD, Hou D et al.: Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J. Clin. Invest. 114, 280-290 (2004).
    • (2004) J. Clin. Invest. , vol.114 , pp. 280-290
    • Munn, D.H.1    Sharma, M.D.2    Hou, D.3
  • 21
    • 34848819211 scopus 로고    scopus 로고
    • Failure at the effector phase: Immune barriers at the level of the melanoma tumor microenvironment
    • Gajewski TF: Failure at the effector phase: immune barriers at the level of the melanoma tumor microenvironment. Clin. Cancer Res. 13, 5256-5261 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 5256-5261
    • Gajewski, T.F.1
  • 22
    • 0142011214 scopus 로고    scopus 로고
    • Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma
    • Lee JR, Dalton RR, Messina JL et al.: Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma. Lab. Invest. 83, 1457-1466 (2003).
    • (2003) Lab. Invest. , vol.83 , pp. 1457-1466
    • Lee, J.R.1    Dalton, R.R.2    Messina, J.L.3
  • 23
    • 0142137237 scopus 로고    scopus 로고
    • Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
    • Directly linked murine tumor expression of IDO with tumor survival, and showed that pharmacologic IDO inhibition increased antitumor immunity in IDO-expressing tumors from preimmunized mice
    • Uyttenhove C, Pilotte L, Theate I et al.: Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat. Med. 9, 1269-1274 (2003). • Directly linked murine tumor expression of IDO with tumor survival, and showed that pharmacologic IDO inhibition increased antitumor immunity in IDO-expressing tumors from preimmunized mice.
    • (2003) Nat. Med. , vol.9 , pp. 1269-1274
    • Uyttenhove, C.1    Pilotte, L.2    Theate, I.3
  • 25
    • 16244408626 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
    • Muller AJ, DuHadaway JB, Donover PS, Sutanto-Ward E, Prendergast GC: Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat. Med. 11, 312-319 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 312-319
    • Muller, A.J.1    DuHadaway, J.B.2    Donover, P.S.3    Sutanto-Ward, E.4    Prendergast, G.C.5
  • 26
    • 33846689594 scopus 로고    scopus 로고
    • Stereoisomers of 1-methyl-tryptophan as pharmacologic inhibitors of indoleamine 2,3-dioxygenase
    • Hou D, Muller AJ, Sharma M et al.: Stereoisomers of 1-methyl-tryptophan as pharmacologic inhibitors of indoleamine 2,3-dioxygenase. Cancer Res.earch 67, 792-801 (2007).
    • (2007) Cancer Res.earch , vol.67 , pp. 792-801
    • Hou, D.1    Muller, A.J.2    Sharma, M.3
  • 27
    • 55949117914 scopus 로고    scopus 로고
    • Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase
    • Revealed that chemically induced chronic inflammation created local suppression via IDO, and that IDO facilitates tumor development, since IDO1-deficient mice exhibited a robust tumor-resistant phenotype in a two-stage carcinogenesis model
    • Muller AJ, Sharma MD, Chandler PR et al.: Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase. Proc. Natl Acad. Sci. USA 105, 17073-17078 (2008). •• Revealed that chemically induced chronic inflammation created local suppression via IDO, and that IDO facilitates tumor development, since IDO1-deficient mice exhibited a robust tumor-resistant phenotype in a two-stage carcinogenesis model.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 17073-17078
    • Muller, A.J.1    Sharma, M.D.2    Chandler, P.R.3
  • 28
    • 0027230728 scopus 로고
    • Establishment of an antitoxoplasma state by stable expression of mouse indoleamine 2,3-dioxygenase
    • Habara-Ohkubo A, Shirahata T, Takikawa O, Yoshida R: Establishment of an antitoxoplasma state by stable expression of mouse indoleamine 2,3-dioxygenase. Infect. Immun. 61, 1810-1813 (1993).
    • (1993) Infect. Immun. , vol.61 , pp. 1810-1813
    • Habara-Ohkubo, A.1    Shirahata, T.2    Takikawa, O.3    Yoshida, R.4
  • 29
    • 0027324876 scopus 로고
    • IFN-γ-mediated antimicrobial response: Indolemaine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or Toxoplama growth
    • Thomas SM, Garrity LF, Brandt CR et al.: IFN-γ-mediated antimicrobial response: Indolemaine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or Toxoplama growth. J Immunol. 150, 5529-5534 (1993).
    • (1993) J Immunol. , vol.150 , pp. 5529-5534
    • Thomas, S.M.1    Garrity, L.F.2    Brandt, C.R.3
  • 30
    • 0033555723 scopus 로고    scopus 로고
    • Role of IFN-γ-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells
    • Bodaghi B, Goureau O, Zipeto D, Laurent L, Virelizier JL, Michelson S: Role of IFN-γ-induced indoleamine 2,3 dioxygenase and inducible nitric oxide syntahse in the replication of human cytomegalovirus in retinal pigment epithelial cells. J. Immunol. 162, 957-964 (1999). (Pubitemid 29035421)
    • (1999) Journal of Immunology , vol.162 , Issue.2 , pp. 957-964
    • Bodaghi, B.1    Goureau, O.2    Zipeto, D.3    Laurent, L.4    Virelizier, J.-L.5    Michelson, S.6
  • 31
    • 1242319376 scopus 로고    scopus 로고
    • Role of Indoleamine-2,3-Dioxygenase in Alpha/Beta and Gamma Interferon-Mediated Antiviral Effects against Herpes Simplex Virus Infections
    • DOI 10.1128/JVI.78.5.2632-2636.2004
    • Adams O, Besken K, Oberdorfer C et al.: Role of indoleamine-2,3- dioxygenase in α/β and γ interferon-mediated antiviral effects against herpes simplex virus infections. J. Virol. 78, 2632-2636 (2004). (Pubitemid 38228963)
    • (2004) Journal of Virology , vol.78 , Issue.5 , pp. 2632-2636
    • Adams, O.1    Besken, K.2    Oberdorfer, C.3    MacKenzie, C.R.4    Takikawa, O.5    Daubener, W.6
  • 32
    • 19944397134 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase mediates cell type-specific anti-measles virus activity of gamma interferon
    • DOI 10.1128/JVI.79.12.7768-7776.2005
    • Obojes K, Andres O, Kim KS, Daubener W, Schneider-Schaulies J: Indoleamine 2,3-dioxygenase mediates cell type-specific anti-measles virus activity of γ interferon. J. Virol. 79, 7768-7776 (2005). (Pubitemid 40756810)
    • (2005) Journal of Virology , vol.79 , Issue.12 , pp. 7768-7776
    • Obojes, K.1    Andres, O.2    Kim, K.S.3    Daubener, W.4    Schneider-Schaulies, J.5
  • 34
    • 30944440041 scopus 로고    scopus 로고
    • Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia
    • van der Sluijs KF, Nijhuis M, Levels JH et al.: Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia. J. Infect. Dis. 193, 214-222 (2006).
    • (2006) J. Infect. Dis. , vol.193 , pp. 214-222
    • Van Der Sluijs, K.F.1    Nijhuis, M.2    Levels, J.H.3
  • 35
    • 34147115208 scopus 로고    scopus 로고
    • + T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells
    • + T cells, and that increased IDO expression in HIV-infected PBMCs was due to plasmacytoid dendritic cells (pDCs), implicating IDO inhibition as potential immunotherapy for HIV patients
    • + T cells, and that increased IDO expression in HIV-infected PBMCs was due to plasmacytoid dendritic cells (pDCs), implicating IDO inhibition as potential immunotherapy for HIV patients.
    • (2007) Blood , vol.109 , pp. 3351-3359
    • Boasso, A.1    Herbeuval, J.P.2    Hardy, A.W.3
  • 37
    • 34247350014 scopus 로고    scopus 로고
    • How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation
    • Boasso A, Shearer GM: How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation. Curr. Drug Metab. 8, 217-223 (2007).
    • (2007) Curr. Drug Metab. , vol.8 , pp. 217-223
    • Boasso, A.1    Shearer, G.M.2
  • 39
    • 0042811001 scopus 로고    scopus 로고
    • Interferon-γ-induced conversion of tryptophan: Immunologic and neuropsychiatric aspects
    • Wirleitner B, Neurauter G, Schrocksnadel K, Frick B, Fuchs D: Interferon-γ-induced conversion of tryptophan: immunologic and neuropsychiatric aspects. Curr. Med. Chem. 10, 1581-1591 (2003).
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1581-1591
    • Wirleitner, B.1    Neurauter, G.2    Schrocksnadel, K.3    Frick, B.4    Fuchs, D.5
  • 40
    • 65349135346 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice
    • O'Connor JC, Lawson MA, Andre C et al.: Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol. Psychiatry 14, 511-522 (2009).
    • (2009) Mol. Psychiatry , vol.14 , pp. 511-522
    • O'Connor, J.C.1    Lawson, M.A.2    Andre, C.3
  • 41
    • 50249114538 scopus 로고    scopus 로고
    • Inoculation of bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior
    • Moreau M, Andre C, O'Connor JC et al.: Inoculation of bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior. Brain Behav. Immun. 22, 1087-1095 (2008).
    • (2008) Brain Behav. Immun. , vol.22 , pp. 1087-1095
    • Moreau, M.1    Andre, C.2    O'Connor, J.C.3
  • 42
    • 0034832968 scopus 로고    scopus 로고
    • Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase
    • Hayashi T, Rao SP, Takabayashi K et al.: Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase. Infect. Immun. 69, 6156-6164 (2001).
    • (2001) Infect. Immun. , vol.69 , pp. 6156-6164
    • Hayashi, T.1    Rao, S.P.2    Takabayashi, K.3
  • 43
    • 33845304287 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection
    • Popov A, Abdullah Z, Wickenhauser C et al.: Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection. J. Clin. Invest. 116, 3160-3170 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 3160-3170
    • Popov, A.1    Abdullah, Z.2    Wickenhauser, C.3
  • 44
    • 0036341332 scopus 로고    scopus 로고
    • Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis
    • DOI 10.1016/S0165-5728(02)00176-5, PII S0165572802001765
    • Sakurai K, Zou J, Tschetter J, Ward J, Shearer G: Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 129, 186 (2002). (Pubitemid 34874924)
    • (2002) Journal of Neuroimmunology , vol.129 , Issue.1-2 , pp. 186-196
    • Sakurai, K.1    Zou, J.-P.2    Tschetter, J.R.3    Ward, J.M.4    Shearer, G.M.5
  • 45
    • 34250349036 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice
    • Szanto S, Koreny T, Mikecz K et al.: Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice. Arthritis Res. Ther. 9, R50 (2007).
    • (2007) Arthritis Res. Ther. , vol.9
    • Szanto, S.1    Koreny, T.2    Mikecz, K.3
  • 46
    • 38449111402 scopus 로고    scopus 로고
    • The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse
    • Identified pDCs as a DC subset that inhibited murine Type 1 diabetes (T1D) progression, and IDO as an immune modulator of T1D, since pharmacologic inhibition of IDO led to increased insulitis
    • Saxena V, Ondr JK, Magnusen AF, Munn DH, Katz JD: The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. J. Immunol. 179, 5041-5053 (2007). •• Identified pDCs as a DC subset that inhibited murine Type 1 diabetes (T1D) progression, and IDO as an immune modulator of T1D, since pharmacologic inhibition of IDO led to increased insulitis.
    • (2007) J. Immunol. , vol.179 , pp. 5041-5053
    • Saxena, V.1    Ondr, J.K.2    Magnusen, A.F.3    Munn, D.H.4    Katz, J.D.5
  • 47
    • 0037815119 scopus 로고    scopus 로고
    • A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice
    • Grohmann U, Fallarino F, Bianchi R et al.: A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice. J. Exp. Med. 198, 153-160 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 153-160
    • Grohmann, U.1    Fallarino, F.2    Bianchi, R.3
  • 48
    • 7244231007 scopus 로고    scopus 로고
    • CTLA4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice
    • Fallarino F, Bianchi R, Orabona C et al.: CTLA4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. J. Exp. Med. 200, 1051-1062 (2004).
    • (2004) J. Exp. Med. , vol.200 , pp. 1051-1062
    • Fallarino, F.1    Bianchi, R.2    Orabona, C.3
  • 49
    • 34249695524 scopus 로고    scopus 로고
    • Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes
    • DOI 10.2337/db06-1727
    • Ueno A, Cho S, Cheng L et al.: Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes. Diabetes 56, 1686-1693 (2007). (Pubitemid 46842605)
    • (2007) Diabetes , vol.56 , Issue.6 , pp. 1686-1693
    • Ueno, A.1    Cho, S.2    Cheng, L.3    Wang, J.4    Hou, S.5    Nakano, H.6    Santamaria, P.7    Yang, Y.8
  • 51
    • 37749045793 scopus 로고    scopus 로고
    • Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanism
    • Matysiak M, Stasiolek M, Orlowski W et al.: Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanism. J. Neuroimmunol. 193, 12-23 (2008).
    • (2008) J. Neuroimmunol. , vol.193 , pp. 12-23
    • Matysiak, M.1    Stasiolek, M.2    Orlowski, W.3
  • 52
    • 7044261952 scopus 로고    scopus 로고
    • 4-1BB-mediated immunotherapy of rheumatoid arthritis
    • Introduced 4-1BB as an IDO inducer, and as a potential therapy for rheumatoid arthritis via an IDO-dependent mechanism
    • Seo SK, Choi JH, Kim YH et al.: 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat. Med. 10, 1088-1094 (2004). • Introduced 4-1BB as an IDO inducer, and as a potential therapy for rheumatoid arthritis via an IDO-dependent mechanism.
    • (2004) Nat. Med. , vol.10 , pp. 1088-1094
    • Seo, S.K.1    Choi, J.H.2    Kim, Y.H.3
  • 55
    • 44349184791 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation
    • Xu H, Oriss TB, Fei M et al.: Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation. Proc. Natl Acad. Sci. USA 105, 6690-6695 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 6690-6695
    • Xu, H.1    Oriss, T.B.2    Fei, M.3
  • 56
    • 0032555614 scopus 로고    scopus 로고
    • Prevention of allogeneic fetal rejection by tryptophan catabolism
    • Munn DH, Zhou M, Attwood JT et al.: Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281, 1191-1193 (1998). •• First to identify IDO as a T-cell regulatory mechanism by showing that IDO inhibitors allowed maternal T cells to reject allogeneic fetal tissues during mouse pregnancy. (Pubitemid 28406294)
    • (1998) Science , vol.281 , Issue.5380 , pp. 1191-1193
    • Munn, D.H.1    Zhou, M.2    Attwood, J.T.3    Bondarev, I.4    Conway, S.J.5    Marshall, B.6    Brown, C.7    Mellor, A.L.8
  • 57
    • 0035221101 scopus 로고    scopus 로고
    • Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy
    • Mellor AL, Sivakumar J, Chandler P et al.: Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy. Nat. Immunol. 2, 64-68 (2001).
    • (2001) Nat. Immunol. , vol.2 , pp. 64-68
    • Mellor, A.L.1    Sivakumar, J.2    Chandler, P.3
  • 58
    • 0035087335 scopus 로고    scopus 로고
    • Blockade of tryptophan catabolism prevents spontaneous tolerogenicity of liver allografts
    • Miki T, Sun H, Lee Y et al.: Blockade of tryptophan catabolism prevents spontaneous tolerogenicity of liver allografts. Transplant. Proc. 33, 129-130 (2001).
    • (2001) Transplant. Proc. , vol.33 , pp. 129-130
    • Miki, T.1    Sun, H.2    Lee, Y.3
  • 59
    • 34147112868 scopus 로고    scopus 로고
    • CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-γ, and indoleamine 2,3-dioxygenase
    • Guillonneau C, Hill M, Hubert FX et al.: CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-γ, and indoleamine 2,3-dioxygenase. J. Clin. Invest. 117, 1096-1106 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 1096-1106
    • Guillonneau, C.1    Hill, M.2    Hubert, F.X.3
  • 60
    • 46749144173 scopus 로고    scopus 로고
    • Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase- dependent DC functions and regulates experimental graft-versus-host disease in mice
    • Reddy P, Sun Y, Toubai T et al.: Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice. J. Clin. Invest. 118, 2562-2573 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 2562-2573
    • Reddy, P.1    Sun, Y.2    Toubai, T.3
  • 62
    • 33845599867 scopus 로고    scopus 로고
    • Sleeping Beauty-based gene therapy with indoleamine 2,3-dioxygenase inhibits lung allograft fibrosis
    • DOI 10.1096/fj.06-6228fje
    • Liu H, Liu L, Fletcher BS, Visner GA: Sleeping beauty-based gene therapy with indoleamine 2,3-dioxygenase inhibits lung allograft fibrosis. FASEB J. 20, 2584-2586 (2006). (Pubitemid 44953834)
    • (2006) FASEB Journal , vol.20 , Issue.13
    • Liu, H.1    Liu, L.2    Fletcher, B.S.3    Visner, G.A.4
  • 65
    • 33644775726 scopus 로고    scopus 로고
    • Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: Effect on tumor-infiltrating T cells
    • Brandacher G, Perathoner A, Ladurner R et al.: Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells. Clin. Cancer Res. 12, 1144-1151 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1144-1151
    • Brandacher, G.1    Perathoner, A.2    Ladurner, R.3
  • 66
    • 23844451052 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cells
    • Okamoto A, Nikaido T, Ochiai K et al.: Indoleamine 2,3-dioxygenase serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cells. Clin. Cancer Res. 11, 6030-6039 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 6030-6039
    • Okamoto, A.1    Nikaido, T.2    Ochiai, K.3
  • 67
    • 34548024195 scopus 로고    scopus 로고
    • Increased synthesis of indoleamine-2,3-dioxygenase protein is positively associated with impaired survival in patients with serous-type, but not with other types of, ovarian cancer
    • Takao M, Okamoto A, Nikaido T et al.: Increased synthesis of indoleamine-2,3-dioxygenase protein is positively associated with impaired survival in patients with serous-type, but not with other types of, ovarian cancer. Oncol. Rep. 17, 1333-1339 (2007).
    • (2007) Oncol. Rep. , vol.17 , pp. 1333-1339
    • Takao, M.1    Okamoto, A.2    Nikaido, T.3
  • 68
    • 53749088471 scopus 로고    scopus 로고
    • Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma
    • Pan K, Wang H, Chen MS et al.: Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 134, 1247-1253 (2008).
    • (2008) J. Cancer Res. Clin. Oncol. , vol.134 , pp. 1247-1253
    • Pan, K.1    Wang, H.2    Chen, M.S.3
  • 71
    • 25444463828 scopus 로고    scopus 로고
    • Mechanisms dependent on tryptophan catabolism regulate immune responses in primary Sjogren's syndrome
    • Pertovaara M, Raitala A, Uusitalo H et al.: Mechanisms dependent on tryptophan catabolism regulate immune responses in primary Sjogren's syndrome. Clin. Exp. Immunol. 142, 155-161 (2005).
    • (2005) Clin. Exp. Immunol. , vol.142 , pp. 155-161
    • Pertovaara, M.1    Raitala, A.2    Uusitalo, H.3
  • 72
    • 35349002824 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase activity is increased in patients with systemic lupus erythematosus and predicts disease activation in the sunny season
    • Pertovaara M, Hasan T, Raitala A et al.: Indoleamine 2,3-dioxygenase activity is increased in patients with systemic lupus erythematosus and predicts disease activation in the sunny season. Clin. Exp. Immunol. 150, 274-278 (2007).
    • (2007) Clin. Exp. Immunol. , vol.150 , pp. 274-278
    • Pertovaara, M.1    Hasan, T.2    Raitala, A.3
  • 73
    • 18544364477 scopus 로고    scopus 로고
    • Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase
    • Munn DH, Sharma MD, Lee JR et al.: Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 297, 1867-1870 (2002).
    • (2002) Science , vol.297 , pp. 1867-1870
    • Munn, D.H.1    Sharma, M.D.2    Lee, J.R.3
  • 75
    • 5044250291 scopus 로고    scopus 로고
    • Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase
    • Mellor AL, Chandler PR, Baban B et al.: Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase. Int. Immunol. 16, 1391-1401 (2004).
    • (2004) Int. Immunol. , vol.16 , pp. 1391-1401
    • Mellor, A.L.1    Chandler, P.R.2    Baban, B.3
  • 76
    • 26444489716 scopus 로고    scopus 로고
    • A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation
    • Baban B, Hansen AM, Chandler PR et al.: A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation. Int. Immunol. 17, 909-919 (2005).
    • (2005) Int. Immunol. , vol.17 , pp. 909-919
    • Baban, B.1    Hansen, A.M.2    Chandler, P.R.3
  • 77
    • 27144552597 scopus 로고    scopus 로고
    • + dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN type 1 signaling
    • + dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN type 1 signaling. J. Immunol. 175, 5601-5605 (2005). (Pubitemid 41508038)
    • (2005) Journal of Immunology , vol.175 , Issue.9 , pp. 5601-5605
    • Mellor, A.L.1    Baban, B.2    Chandler, P.R.3    Manlapat, A.4    Kahler, D.J.5    Munn, D.H.6
  • 80
    • 54049130424 scopus 로고    scopus 로고
    • Cutting edge: Autocrine TGF-β sustains default tolerogenesis by IDO-competent dendritic cells
    • Belladonna ML, Volpi C, Bianchi R et al.: Cutting edge: Autocrine TGF-β sustains default tolerogenesis by IDO-competent dendritic cells. J. Immunol. 181, 5194-5198 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 5194-5198
    • Belladonna, M.L.1    Volpi, C.2    Bianchi, R.3
  • 82
    • 27944486492 scopus 로고    scopus 로고
    • Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12
    • Orabona C, Tomasello E, Fallarino F et al.: Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12. Eur. J. Immunol. 35, 3111-3118 (2005).
    • (2005) Eur. J. Immunol. , vol.35 , pp. 3111-3118
    • Orabona, C.1    Tomasello, E.2    Fallarino, F.3
  • 83
    • 27744494470 scopus 로고    scopus 로고
    • Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells
    • Fallarino F, Orabona C, Vacca C et al.: Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells. Int. Immunol. 17, 1429-1438 (2005).
    • (2005) Int. Immunol. , vol.17 , pp. 1429-1438
    • Fallarino, F.1    Orabona, C.2    Vacca, C.3
  • 84
    • 58549107152 scopus 로고    scopus 로고
    • SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis
    • Orabona C, Pallotta MT, Volpi C et al.: SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis. Proc. Natl Acad. Sci. USA 105, 20828-20833 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 20828-20833
    • Orabona, C.1    Pallotta, M.T.2    Volpi, C.3
  • 85
    • 33645499663 scopus 로고    scopus 로고
    • Toward the identification of a tolerogenic signature in IDO-competent dendritic cells
    • Identified DAP12 and IRF-8 as signal mechanisms that regulate IDO functional competence in dendritic cells (DCs)
    • Orabona C, Puccetti P, Vacca C et al.: Toward the identification of a tolerogenic signature in IDO-competent dendritic cells. Blood 107, 2846-2854 (2006). • Identified DAP12 and IRF-8 as signal mechanisms that regulate IDO functional competence in dendritic cells (DCs).
    • (2006) Blood , vol.107 , pp. 2846-2854
    • Orabona, C.1    Puccetti, P.2    Vacca, C.3
  • 86
    • 0036856008 scopus 로고    scopus 로고
    • Translational control in the endoplasmic reticulum stress response
    • Ron D: Translational control in the endoplasmic reticulum stress response. J. Clin. Invest. 110, 1383-1388 (2002).
    • (2002) J. Clin. Invest. , vol.110 , pp. 1383-1388
    • Ron, D.1
  • 88
    • 33748749338 scopus 로고    scopus 로고
    • Immune resistance orchestrated by the tumor microenvironment
    • Gajewski TF, Meng Y, Blank C et al.: Immune resistance orchestrated by the tumor microenvironment. Immunol. Rev. 213, 131-145 (2006).
    • (2006) Immunol. Rev. , vol.213 , pp. 131-145
    • Gajewski, T.F.1    Meng, Y.2    Blank, C.3
  • 89
  • 90
    • 0346119234 scopus 로고    scopus 로고
    • Modulation of tryptophan catabolism by regulatory T cells
    • Fallarino F, Grohmann U, Hwang KW et al.: Modulation of tryptophan catabolism by regulatory T cells. Nat. Immunol. 4, 1206-1212 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 1206-1212
    • Fallarino, F.1    Grohmann, U.2    Hwang, K.W.3
  • 92
    • 36248972568 scopus 로고    scopus 로고
    • +CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells
    • +CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells. Eur. J. Immunol. 37, 3054-3062 (2007).
    • (2007) Eur. J. Immunol. , vol.37 , pp. 3054-3062
    • Hill, M.1    Tanguy-Royer, S.2    Royer, P.3
  • 93
    • 44049100797 scopus 로고    scopus 로고
    • Th17 cells: A new fate for differentiating helper T cells
    • Chen Z, O'Shea JJ: Th17 cells: a new fate for differentiating helper T cells. Immunol. Res. 41, 87-102 (2008).
    • (2008) Immunol. Res. , vol.41 , pp. 87-102
    • Chen, Z.1    O'Shea, J.J.2
  • 94
    • 0035879111 scopus 로고    scopus 로고
    • +) dendritic cells expressing indoleamine 2,3-dioxygenase
    • +) dendritic cells expressing indoleamine 2,3-dioxygenase. J. Immunol. 167, 708-714 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 708-714
    • Grohmann, U.1    Fallarino, F.2    Bianchi, R.3
  • 95
    • 0036884130 scopus 로고    scopus 로고
    • Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division
    • Lee GK, Park HJ, Macleod M et al.: Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division. Immunology 107, 1-9 (2002).
    • (2002) Immunology , vol.107 , pp. 1-9
    • Lee, G.K.1    Park, H.J.2    Macleod, M.3
  • 96
    • 19344377474 scopus 로고    scopus 로고
    • GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
    • DOI 10.1016/j.immuni.2005.03.013, PII S1074761305001081
    • Munn DH, Sharma MD, Baban B et al.: GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 22, 1-10 (2005). (Pubitemid 40719198)
    • (2005) Immunity , vol.22 , Issue.5 , pp. 633-642
    • Munn, D.H.1    Sharma, M.D.2    Baban, B.3    Harding, H.P.4    Zhang, Y.5    Ron, D.6    Mellor, A.L.7
  • 97
    • 34848915783 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes activate mature Tregs via indoleamine 2,3-dioxygenase
    • Revealed that pDCs expressing IDO directly activated Tregs to create local suppression in tumor-draining lymph nodes that was dependent on the PD-1/PD-L pathway
    • Sharma MD, Baban B, Chandler PR et al.: Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes activate mature Tregs via indoleamine 2,3-dioxygenase. J. Clin. Invest. 117, 1-13 (2007). • Revealed that pDCs expressing IDO directly activated Tregs to create local suppression in tumor-draining lymph nodes that was dependent on the PD-1/PD-L pathway.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1-13
    • Sharma, M.D.1    Baban, B.2    Chandler, P.R.3
  • 98
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • DOI 10.1126/science.1140485
    • Naugler WE, Sakurai T, Kim S et al.: Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317, 121-124 (2007). (Pubitemid 47056470)
    • (2007) Science , vol.317 , Issue.5834 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6    Karin, M.7
  • 99
    • 38649087921 scopus 로고    scopus 로고
    • Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
    • Swann JB, Vesely MD, Silva A et al.: Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc. Natl Acad. Sci. USA 105, 652-656 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 652-656
    • Swann, J.B.1    Vesely, M.D.2    Silva, A.3
  • 100
    • 0026347919 scopus 로고
    • 1-methyl-DL-tryptophan, β-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and β-[3-benzo(b)thienyl]-DL-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase
    • Cady SG, Sono M: 1-methyl-DL-tryptophan, β-(3-benzofuranyl)-DL- alanine (the oxygen analog of tryptophan), and β-[3-benzo(b)thienyl]-DL- alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase. Arch. Biochem. Biophys. 291, 326-333 (1991).
    • (1991) Arch. Biochem. Biophys. , vol.291 , pp. 326-333
    • Cady, S.G.1    Sono, M.2
  • 101
    • 36849049268 scopus 로고    scopus 로고
    • Toxicology and pharmacokinetics of 1-methyl-D-tryptophan: Absence of toxicity due to saturating absorption
    • Jia L, Schweikart K, Tomaszewski J et al.: Toxicology and pharmacokinetics of 1-methyl-D-tryptophan: absence of toxicity due to saturating absorption. Food Chem. Toxicol. 46, 203-211 (2008).
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 203-211
    • Jia, L.1    Schweikart, K.2    Tomaszewski, J.3
  • 102
    • 41349088840 scopus 로고    scopus 로고
    • Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells
    • Lob S, Konigsrainer A, Schafer R et al.: Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells. Blood 111, 2152-2154 (2008).
    • (2008) Blood , vol.111 , pp. 2152-2154
    • Lob, S.1    Konigsrainer, A.2    Schafer, R.3
  • 103
    • 54849418903 scopus 로고    scopus 로고
    • IDO1 and IDO2 are expressed in human tumors: Levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism
    • Lob S, Konigsrainer A, Zieker D et al.: IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism. Cancer Immunol. Immunother. 58, 153-157 (2009).
    • (2009) Cancer Immunol. Immunother. , vol.58 , pp. 153-157
    • Lob, S.1    Konigsrainer, A.2    Zieker, D.3
  • 104
    • 20144368637 scopus 로고    scopus 로고
    • Dendritic cells have the option to express IDO-mediated suppression or not [4]
    • DOI 10.1182/blood-2005-01-0122
    • Munn DH, Mellor AL, Rossi M, Young JW: Dendritic cells have the option to express IDO-mediated suppression or not. Blood 105, 2618 (2005). (Pubitemid 40387070)
    • (2005) Blood , vol.105 , Issue.6 , pp. 2618
    • Munn, D.H.1    Mellor, A.L.2    Rossi, M.3    Young, J.W.4
  • 105
    • 41049089064 scopus 로고    scopus 로고
    • Enhancement of dendritic cell-tumor fusion vaccine potency by indoleamine-pyrrole 2,3-dioxygenase inhibitor, 1-MT
    • Ou X, Cai S, Liu P et al.: Enhancement of dendritic cell-tumor fusion vaccine potency by indoleamine-pyrrole 2,3-dioxygenase inhibitor, 1-MT. J. Cancer Res. Clin. Oncol. 134, 525-533 (2008).
    • (2008) J. Cancer Res. Clin. Oncol. , vol.134 , pp. 525-533
    • Ou, X.1    Cai, S.2    Liu, P.3
  • 106
    • 33746912362 scopus 로고    scopus 로고
    • 1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity
    • Agaugue S, Perrin-Cocon L, Coutant F, Andre P, Lotteau V: 1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity. J. Immunol. 177, 2061-2071 (2006). (Pubitemid 44200963)
    • (2006) Journal of Immunology , vol.177 , Issue.4 , pp. 2061-2071
    • Agaugue, S.1    Perrin-Cocon, L.2    Coutant, F.3    Andre, P.4    Lotteau, V.5
  • 108
    • 33746906695 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitor enhances the efficacy of a breast cancer vaccine: Role of IDO
    • Basu GD, Tinder TL, Bradley JM et al.: Cyclooxygenase-2 inhibitor enhances the efficacy of a breast cancer vaccine: role of IDO. J. Immunol. 177, 2391-2402 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 2391-2402
    • Basu, G.D.1    Tinder, T.L.2    Bradley, J.M.3
  • 109
    • 3042767200 scopus 로고    scopus 로고
    • Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzyme
    • DOI 10.1186/1471-2091-2-1, 1
    • Marshall B, Keskin DB, Mellor AL: Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzyme. BMC Biochemistry 2, 5 (2001). (Pubitemid 38870342)
    • (2001) BMC Biochemistry , vol.2 , pp. 1-15
    • Marshall, B.1    Keskin, D.B.2    Mellor, A.L.3
  • 110
    • 30944460918 scopus 로고    scopus 로고
    • Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO
    • Wingender G, Garbi N, Schumak B et al.: Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO. Eur. J. Immunol. 36, 12-20 (2006).
    • (2006) Eur. J. Immunol. , vol.36 , pp. 12-20
    • Wingender, G.1    Garbi, N.2    Schumak, B.3
  • 111
    • 62549116236 scopus 로고    scopus 로고
    • Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity
    • Guillonneau C, Mintern JD, Hubert FX et al.: Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity. Proc. Natl Acad. Sci. USA 106, 3330-3335 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3330-3335
    • Guillonneau, C.1    Mintern, J.D.2    Hubert, F.X.3
  • 112
    • 20844459808 scopus 로고    scopus 로고
    • Modulation of human dendritic-cell function following transduction with viral vectors: Implications for gene therapy
    • Tan PH, Beutelspacher SC, Xue SA et al.: Modulation of human dendritic-cell function following transduction with viral vectors: implications for gene therapy. Blood 105, 3824-3832 (2005).
    • (2005) Blood , vol.105 , pp. 3824-3832
    • Tan, P.H.1    Beutelspacher, S.C.2    Xue, S.A.3
  • 113
    • 0036852170 scopus 로고    scopus 로고
    • CTLA4-Ig regulates tryptophan catabolism in vivo
    • First to show that DCs could be induced to acquire IDO-dependent T-cell regulatory functions, in this case using soluble cytotoxic T-lymphocyte antigen 4 as a B7 (CD80/86) ligand
    • Grohmann U, Orabona C, Fallarino F et al.: CTLA4-Ig regulates tryptophan catabolism in vivo. Nat. Immunol. 3, 1097-1101 (2002). •• First to show that DCs could be induced to acquire IDO-dependent T-cell regulatory functions, in this case using soluble cytotoxic T-lymphocyte antigen 4 as a B7 (CD80/86) ligand.
    • (2002) Nat. Immunol. , vol.3 , pp. 1097-1101
    • Grohmann, U.1    Orabona, C.2    Fallarino, F.3
  • 114
    • 0037101793 scopus 로고    scopus 로고
    • FcepsilonRI induces the tryptophan degradation pathway involved in regulating T cell responses
    • von Bubnoff D, Matz H, Frahnert C et al.: FcepsilonRI induces the tryptophan degradation pathway involved in regulating T cell responses. J. Immunol. 169, 1810-1816 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 1810-1816
    • Von Bubnoff, D.1    Matz, H.2    Frahnert, C.3
  • 118
    • 34249725559 scopus 로고    scopus 로고
    • Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy
    • Grohmann U, Volpi C, Fallarino F et al.: Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy. Nat. Med. 13, 579-586 (2007).
    • (2007) Nat. Med. , vol.13 , pp. 579-586
    • Grohmann, U.1    Volpi, C.2    Fallarino, F.3
  • 119
    • 37849028844 scopus 로고    scopus 로고
    • Impaired expression of indoleamine 2,3-dioxygenase in monocyte-derived dendritic cells in response to Toll-like receptor-7/8 ligands
    • Furset G, Floisand Y, Sioud M: Impaired expression of indoleamine 2,3-dioxygenase in monocyte-derived dendritic cells in response to Toll-like receptor-7/8 ligands. Immunology 123, 263-271 (2008).
    • (2008) Immunology , vol.123 , pp. 263-271
    • Furset, G.1    Floisand, Y.2    Sioud, M.3
  • 120
    • 33644967813 scopus 로고    scopus 로고
    • CTLA4Ig: Bridging the basic immunology with clinical application
    • Bluestone JA, St Clair EW, Turka LA: CTLA4Ig: bridging the basic immunology with clinical application. Immunity 24, 233-238 (2006).
    • (2006) Immunity , vol.24 , pp. 233-238
    • Bluestone, J.A.1    St Clair, E.W.2    Turka, L.A.3
  • 121
    • 35649027495 scopus 로고    scopus 로고
    • Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue
    • Sacre SM, Drexler SK, Andreakos E et al.: Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue. Ann. Rheum. Dis. 66(Suppl. 3), iii81-iii6 (2007).
    • (2007) Ann. Rheum. Dis. , vol.66 , Issue.SUPPL. 3
    • Sacre, S.M.1    Drexler, S.K.2    Andreakos, E.3
  • 122
    • 1642396607 scopus 로고    scopus 로고
    • +) T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells
    • +) T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells. J. Immunol. 172, 4100-4110 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 4100-4110
    • Munn, D.H.1    Sharma, M.D.2    Mellor, A.L.3
  • 123
    • 0028900297 scopus 로고
    • Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse
    • Lenschow DJ, Ho SC, Sattar H et al.: Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 181, 1145-1155 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 1145-1155
    • Lenschow, D.J.1    Ho, S.C.2    Sattar, H.3
  • 125
    • 36749044869 scopus 로고    scopus 로고
    • 3-hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis
    • Hayashi T, Mo JH, Gong X et al.: 3-hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Proc. Natl Acad. Sci. USA 104, 18619-18624 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 18619-18624
    • Hayashi, T.1    Mo, J.H.2    Gong, X.3
  • 126
    • 23644445230 scopus 로고    scopus 로고
    • Interferon-β affects the tryptophan metabolism in multiple sclerosis patients
    • Amirkhani A, Rajda C, Arvidsson B et al.: Interferon-β affects the tryptophan metabolism in multiple sclerosis patients. Eur. J. Neurol. 12, 625-631 (2005).
    • (2005) Eur. J. Neurol. , vol.12 , pp. 625-631
    • Amirkhani, A.1    Rajda, C.2    Arvidsson, B.3


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