Il-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults

Age and Ageing

Volumn 40, Issue 4, 2011, Pages 475-481

  Leng, Sean X ^a   Tian, Xinping ^a,b   Matteini, Amy ^a   Li, Huifen ^a   Hughes, Jennifer ^a   Jain, Alka ^a   Walston, Jeremy D ^a   Fedarko, Neal S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

Elderly; Frailty; IL 6; Monocyte macrophage mediated immune activation; Neopterin

Indexed keywords

INTERLEUKIN 6; NEOPTERIN;

AGED; AGING; ARTICLE; BLOOD LEVEL; CASE CONTROL STUDY; CELL FUNCTION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FRAIL ELDERLY; HUMAN; MACROPHAGE ACTIVATION; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; SCREENING TEST; SEX RATIO; VALIDATION PROCESS;

AGED; AGED, 80 AND OVER; AGING; ANALYSIS OF VARIANCE; BALTIMORE; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FRAIL ELDERLY; HUMANS; INDEPENDENT LIVING; INFLAMMATION MEDIATORS; INTERLEUKIN-6; LINEAR MODELS; LOGISTIC MODELS; NEOPTERIN; ODDS RATIO; RISK ASSESSMENT; RISK FACTORS; UP-REGULATION;

EID: 79959544003     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afr047     Document Type: Article

References (29)

1. Fried LP, Tangen C, Walston J et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56A: M1-11.
2. Lipsitz LA. Dynamics of stability: the physiologic basis of functional health and frailty. J Gerontol A Biol Sci Med Sci 2002; 57: 115-25.
3. Fried LP, Xue QL, Cappola AR et al. Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci 2009; 64: 1049-57.
4. Fried LP, Ferrucci L, Darer J et al. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 2004; 59: 255-63.
5. Leng S, Chaves P, Koenig K et al. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study. J Am Geriatr Soc 2002; 50: 1268-71.
6. Leng SX, Cappola AR, Andersen RE et al. Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty. Aging Clin Exp Res 2004; 16: 153-7.
7. Leng SX, Xue QL, Tian J et al. Inflammation and frailty in older women. J Am Geriatr Soc 2007; 55: 864-71.
8. Leng S, Xue Q, Tian J. Association of neutrophil and monocyte counts with fraily in community-dwelling older women. Exp Gerontol 2009; 44: 511-6.
9. Qu T, Yang H, Walston JD et al. Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty. Cytokine 2009; 46: 319-24.
10. Qu T, Walston JD, Yang H et al. Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14(+) monocytes in frail older adults. Mech Ageing Dev 2009; 130: 161-6.
11. Murr C, Widner B, Wirleitner B et al. Neopterin as a marker for immune system activation. Curr Drug Metab 2002; 3: 175-87.
12. Prof Dietmar Fuchs. Immune Activation Marker Neopterin. scitopoics com Available at (accessed 7 August 2008).
13. Spencer ME, Jain A, Matteini A et al. Serum levels of the immune activation marker neopterin change with age and gender and are modified by race, BMI and percentage body fat. J Gerontol A Biol Sci Med Sci 2010; 65: 858-65. doi:10.1093/gerona/glq066.
14. Reibnegger G, Huber LA, Jurgens G et al. Approach to define 'normal aging' in man. Immune function, serum lipids, lipoproteins and neopterin levels. Mech Ageing Dev 1988; 46: 67-82.
15. Frick B, Schroecksnadel K, Neurauter G et al. Increasing production of homocysteine and neopterin and degradation of tryptophan with older age. Clin Biochem 2004; 37: 684-7.
16. Fahey JL, Schnelle JF, Boscardin J et al. Distinct categories of immunologic changes in frail elderly. Mech Ageing Dev 2000; 115: 1-20.
17. Solichova D, Melichar B, Blaha V et al. Biochemical profile and survival in nonagenarians. Clin Biochem 2001; 34: 563-9.
18. Murr C, Hainz U, Asch E et al. Association of increased neopterin production with decreased humoral immunity in the elderly. Exp Gerontol 2003; 38: 583-7.
19. Nubling CM, Chudy M, Volkers P et al. Neopterin levels during the early phase of human immunodeficiency virus, hepatitis C virus, or hepatitis B virus infection. Transfusion 2006; 46: 1886-91.
20. Nasonov EL, Samsonov MI, Tilz G et al. [Neopterin: new immunological marker of autoimmune rheumatic disease]. Klin Med (Mosk) 2000; 78: 43-6.
21. von Ingersleben G, Souchon R, Fitzner R. Serum neopterin levels in lung and breast cancer patients undergoing 480 radiotherapy and/or chemotherapy. Int J Biol Markers 1988; 3: 135-9.
22. Punjabi NM, Beamer BA, Jain A et al. Elevated levels of neopterin in sleep-disordered breathing. Chest 2007; 132: 1124-30.
23. Avanzas P, rroyo-Espliguero R, Cosin-Sales J et al. Markers of inflammation and multiple complex stenoses (pancoronary plaque vulnerability) in patients with non-ST segment elevation acute coronary syndromes. Heart 2004; 90: 847-52.
24. Takabatake N, Sata M, Abe S et al. Impaired systemic cellmediated immunity and increased susceptibility to acute respiratory tract infections in patients with COPD. Respir Med 2005; 99: 485-92.
25. Schennach H, Hessenberger G, Mayersbach P et al. Acute cytomegalovirus infections in blood donors are indicated by increased serum neopterin concentrations. Med Microbiol Immunol 2002; 191: 115-8.
26. Mildvan D, Spritzler J, Grossberg SE et al. Serum neopterin, an immune activation marker, independently predicts disease progression in advanced HIV-1 infection. Clin Infect Dis 2005; 40: 853-8.
27. Samsonov MY, Tilz GP, Egorova O et al. Serum soluble markers of immune activation and disease activity in systemic lupus erythematosus. Lupus 1995; 4: 29-32.
28. Schmaltz HN, Fried LP, Xue QL et al. Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. J Am Geriatr Soc 2005; 53: 747-54.
29. Maggio M, Guralnik JM, Longo DL et al. Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci 2006; 61: 575-84.