Immune activation in patients with Alzheimer's disease is associated with high serum phenylalanine concentrations

Journal of the Neurological Sciences

Volumn 329, Issue 1-2, 2013, Pages 29-33

  Wissmann, Philipp ^a   Geisler, Simon ^a   Leblhuber, Friedrich ^b   Fuchs, Dietmar ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b Landesnervenklinik Wagner Jauregg Linz ^*  (Austria)

Author keywords

Alzheimer's disease; Immune activation; Kyn Trp; Neopterin; Phenylalanine; Phenylalanine 4 hydroxylase; Phenylalanine to tyrosine ratio; Tyrosine

Indexed keywords

KYNURENINE; NEOPTERIN; PHENYLALANINE; TYROSINE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; COGNITIVE DEFECT; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNITY; MALE; MINI MENTAL STATE EXAMINATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN METABOLISM;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; COGNITION DISORDERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; KYNURENINE; MALE; MIDDLE AGED; NEOPTERIN; NEUROPSYCHOLOGICAL TESTS; PHENYLALANINE; PSYCHIATRIC STATUS RATING SCALES; SINGLE-BLIND METHOD; STATISTICS, NONPARAMETRIC; TYROSINE;

EID: 84876688834     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2013.03.007     Document Type: Article

References (41)

1. D.J. Selkoe Alzheimer's disease is a synaptic failure Science 298 2002 789 791
2. M.T. Heneka, M.K. O'Banion, D. Terwel, and M.P. Kummer Neuroinflammatory processes in Alzheimer's disease J Neural Transm 117 2010 919 947
3. T. Wyss-Coray, and J. Rogers Inflammation in Alzheimer disease - a brief review of the basic science and clinical literature Cold Spring Harb Perspect Med 2 2012 a006346
4. W. Swardfager, K. Lanctôt, L. Rothenburg, A. Wong, J. Cappell, and N. Herrmann A meta-analysis of cytokines in Alzheimeŕs disease Biol Psychiatry 68 2010 930 941
5. C. Holmes, C. Cunningham, E. Zotova, D. Culliford, and V.H. Perry Profinflammatory cytokines, sickness behaviour and Alzheimeŕs disease Neurology 77 2011 212 218
6. K. Schroecksnadel, F. Leblhuber, B. Frick, B. Wirleitner, and D. Fuchs Association of hyperhomocysteinemia in Alzheimer's disease with elevated neopterin levels Alzheimer's Dis Assoc Disord 18 2004 129 133
7. D.C. Parker, M.M. Mielke, O. Yu, P.B. Rosenberg, A. Jain, and C.G. Lyketsos Plasma neopterin level as a marker of peripheral immune activation in amnestic mild cognitive impairment and Alzheimer's disease Int J Geriatr Psychiatry 28 2013 149 154
8. C. Huber, J.R. Batchelor, and D. Fuchs Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma J Exp Med 160 1984 310 316
9. B. Wirleitner, D. Reider, and S. Ebner Monocyte-derived dendritic cells release neopterin J Leukoc Biol 72 2002 1148 1153
10. O.D. Cano, G. Neurauter, D. Fuchs, G.M. Shearer, and A. Boasso Differential effect of type I and type II interferons on neopterin production and amino acid metabolism in human astrocyte-derived cells Neurosci Lett 438 2008 22 25
11. B. Wirleitner, G. Neurauter, K. Schröcksnadel, B. Frick, and D. Fuchs Interferon-gamma-induced conversion of tryptophan: immunologic and neuropsychiatric aspects Curr Med Chem 10 2003 1581 1591
12. F. Leblhuber, J. Walli, U. Demel, G.P. Tilz, B. Widner, and D. Fuchs Increased serum neopterin concentrations in patients with Alzheimer's disease Clin Chem Lab Med 37 1999 429 431
13. M. Hull, G.M. Pasinetti, and P.S. Aisen Elevated plasma neopterin levels in Alzheimer disease Alzheimer Dis Assoc Disord 2000 14228 14230
14. B. Widner, F. Leblhuber, J. Walli, G.P. Tilz, U. Demel, and D. Fuchs Tryptophan degradation and immune activation in Alzheimer's disease J Neural Transm 107 2000 343 353
15. I. Blasko, G. Knaus, and E. Weiss Cognitive deterioration in Alzheimer's disease is accompanied by increase of plasma neopterin J Psychiatr Res 41 2007 694 701
16. G. Neurauter, K. Schröcksnadel, S. Scholl-Bürgi, B. Sperner-Unterweger, C. Schubert, and M. Ledochowski Chronic immune stimulation correlates with reduced phenylalanine turnover Curr Drug Metab 9 2008 622 627
17. H. Shintaku Disorders of tetrahydrobiopterin metabolism and their treatment Curr Drug Metab 3 2002 123 131
18. G. Neurauter, A.V. Grahmann, and M. Klieber Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with concentrations of immune activation markers and of isoprostane-8 Cancer Lett 272 2008 141 147
19. G. McKhann, D. Drachmann, M. Folstein, R. Katzmann, D. Price, and E.M. Stadlan Clinical diagnosis of Alzheimer's disease. Report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force of Alzheimer's disease Neurology 34 1984 934 944
20. B. Widner, E.R. Werner, H. Schennach, H. Wachter, and D. Fuchs Simultaneous measurement of serum tryptophan and kynurenine by HPLC Clin Chem 43 1997 2424 2426
21. V.E. Shih Amino acid analysis N. Blau, M. Duran, M.E. Blaskovic, K.M. Gibson, Physician's guide to the laboratory diagnosis of metabolic diseases 2nd ed 2003 Springer Berlin Heidelberg New York 11 26
22. S. Scholl-Bürgi, S. Schroecksnadel, M. Jenny, D. Karall, and D. Fuchs Chronic immune stimulation may cause moderate impairment of phenylalanine 4-hydroxylase Pteridines 22 2011 120 125
23. L. Capuron, S. Schroecksnadel, and C. Féart Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms Biol Psychiatry 70 2011 175 182
24. H. Zoller, A. Schloegl, S. Schroecksnadel, W. Vogel, and D. Fuchs Interferon-alpha therapy in patients with hepatitis C virus infection increases plasma phenylalanine and the phenylalanine to tyrosine ratio J Interferon Cytokine Res 32 2012 216 220
25. A.R. Van Gool, D. Fekkes, and W.H. Kruit Serum amino acids, biopterin and neopterin during long-term immunotherapy with interferon-alpha in high-risk melanoma patients Psychiatry Res 15 2003 125 132
26. Felger JC, Marwar PJ, Woolwine BJ, et al. Tyrosine metabolism during interferon-alpha administration: association 3 with fatigue and CSF dopamine concentrations. Brain Behav Immun in press. http://dx.doi.org/10.1016/j.bbi. 2012.10.010 (pii: S0889-1591(12)00472-2).
27. A.A. Aziz, R.J. Leeming, and J.A. Blair Tetrahydrobiopterin metabolism in senile dementia of Alzheimer type J Neurol Neurosurg Psychiatry 46 1983 410 413
28. I. Smith Significantly lower mean plasma total biopterin in 18 patients with senile dementia of Alzheimer type J Neurol Neurosurg Psychiatry 47 1984 1057
29. R.H. Foxton, J.M. Land, and S.J. Heales Tetrahydrobiopterin availability in Parkinson's and Alzheimer's disease; potential pathogenic mechanisms Neurochem Res 32 2007 751 756
30. B. Widner, C. Enzinger, A. Laich, B. Wirleitner, and D. Fuchs Hyperhomocysteinemia, pteridines and oxidative stress Curr Drug Metab 3 2002 225 232
31. D. Fuchs, M. Jaeger, B. Widner, B. Wirleitner, E. Artner-Dworzak, and F. Leblhuber Is hyperhomocysteinemia due to oxidative depletion of folate rather than insufficient dietary intake? Clin Chem Lab Med 39 2001 691 694
32. M.J. Connor, A.E. Pheasant, and J.A. Blair The identification of p-acetamiobenzoate as a folate degradation product in rat urine Biochem J 178 1979 795 797
33. J.E. Fuchs, R.G. Huber, and H.G. Wallnoefer Conformational changes of phenylalanine hydroxylase upon simulated oxidative stress Pteridines 23 2012 57 58
34. C.W. Zhu, and M. Sano Economic considerations in the management of Alzheimer's disease Clin Interv Aging 1 2006 143 154
35. H. Bruunsgaard, M. Pedersen, and B.K. Pedersen Aging and proinflammatory cytokines Curr Opin Hematol 8 2001 131 136
36. C. Franceschi, M. Bonafè, and S. Valensin Inflamm-aging. An evolutionary perspective on immunosenescence Ann N Y Acad Sci 908 2000 244 254
37. T.W. Stone Neuropharmacology of quinolinic and kynurenic acids Pharmacol Rev 45 1993 309 379
38. G.F. Oxenkrug Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders J Neural Transm 118 2011 75 85
39. E. Haroon, C.L. Raison, and A.H. Miller Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior Neuropsychopharmacology 37 2012 137 162
40. J.L. Cummings The neuropsychiatric inventory: assessing psychopathology in dementia patients Neurology 48 1997 S10 S16
41. L.M. Bekris, C.E. Yu, T.D. Bird, and D.W. Tsuang Genetics of Alzheimer disease J Geriatr Psychiatry Neurol 23 2010 213 227