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Volumn 160, Issue , 1997, Pages 171-184

Primary and secondary alterations of immune reactivity in the elderly: Impact of dietary factors and disease

Author keywords

[No Author keywords available]

Indexed keywords

LIPID;

EID: 0031448878     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1997.tb01037.x     Document Type: Review
Times cited : (97)

References (113)
  • 1
    • 0001909033 scopus 로고
    • Primary immunodeficiency diseases
    • Paul WE, ed. New York: Raven Press, Ltd.
    • Buckley RH. Primary immunodeficiency diseases. In: Paul WE, ed. Fundamental immunology. New York: Raven Press, Ltd.; 1993. p. 1353-1374.
    • (1993) Fundamental Immunology , pp. 1353-1374
    • Buckley, R.H.1
  • 2
    • 0021739814 scopus 로고
    • Admission criteria for immunogerontological studies in man: The SENIEUR protocol
    • Ligthart GJ, et al. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech Ageing Dev 1984;28:47-55.
    • (1984) Mech Ageing Dev , vol.28 , pp. 47-55
    • Ligthart, G.J.1
  • 3
    • 0024206509 scopus 로고
    • Approach to define "normal aging" in man: Immune function, serum lipids, lipoproteins and neopterin levels
    • Reibnegger G, et al. Approach to define "normal aging" in man: immune function, serum lipids, lipoproteins and neopterin levels. Mech Ageing Dev 1988;46:67-82.
    • (1988) Mech Ageing Dev , vol.46 , pp. 67-82
    • Reibnegger, G.1
  • 4
    • 0022403143 scopus 로고
    • Age-related changes in lymphocyte subset proportions, surface differentiation, antigen density and plasma membrane fluidity: Application of the EURAGE SENIEUR protocol admission cirteria
    • Traill KN, et al. Age-related changes in lymphocyte subset proportions, surface differentiation, antigen density and plasma membrane fluidity: application of the EURAGE SENIEUR protocol admission cirteria. Mech Ageing Dev 1985;33:39-66.
    • (1985) Mech Ageing Dev , vol.33 , pp. 39-66
    • Traill, K.N.1
  • 5
    • 0027427524 scopus 로고
    • Immunoendocrine communication via the hypothalamo-pituitary-adrenal axis in autoimmune diseases
    • Wick G, Hu Y, Schwarz S, Kroemer G. Immunoendocrine communication via the hypothalamo-pituitary-adrenal axis in autoimmune diseases. Endocr Rev 1993;14:539-563.
    • (1993) Endocr Rev , vol.14 , pp. 539-563
    • Wick, G.1    Hu, Y.2    Schwarz, S.3    Kroemer, G.4
  • 6
    • 0022377731 scopus 로고
    • The involution of the ageing human thymic epithelium is independent of puberty: A morphometric study
    • Steinmann GG, Klaus B, Müller-Hermelink HK. The involution of the ageing human thymic epithelium is independent of puberty: a morphometric study. Scand J Immunol 1985;22:563-575.
    • (1985) Scand J Immunol , vol.22 , pp. 563-575
    • Steinmann, G.G.1    Klaus, B.2    Müller-Hermelink, H.K.3
  • 8
    • 0029895686 scopus 로고    scopus 로고
    • Thymic involution with aging: Obsolescence or good housekeeping?
    • George AJT, Ritter MA. Thymic involution with aging: obsolescence or good housekeeping? Immunol Today 1996;17:267-272.
    • (1996) Immunol Today , vol.17 , pp. 267-272
    • George, A.J.T.1    Ritter, M.A.2
  • 9
    • 0031111907 scopus 로고    scopus 로고
    • Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development
    • Aspinall R. Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development. J Immunol 1997;158:3037-3045.
    • (1997) J Immunol , vol.158 , pp. 3037-3045
    • Aspinall, R.1
  • 10
    • 0028837645 scopus 로고
    • Reference intervals for human peripheral blood lymphocyte subpopulations from "healthy" young and aged subjects
    • Stulnig T, Maczek C, Böck G, Majdic O, Wick G. Reference intervals for human peripheral blood lymphocyte subpopulations from "healthy" young and aged subjects. Int Arch Allergy Immunol 1995;108:205-210.
    • (1995) Int Arch Allergy Immunol , vol.108 , pp. 205-210
    • Stulnig, T.1    Maczek, C.2    Böck, G.3    Majdic, O.4    Wick, G.5
  • 11
    • 0028522839 scopus 로고
    • Vaccinating elderly people: Protecting from avoidable disease
    • Stein BE. Vaccinating elderly people: protecting from avoidable disease. Drug Aging 1994;5:242-253.
    • (1994) Drug Aging , vol.5 , pp. 242-253
    • Stein, B.E.1
  • 12
    • 0002466735 scopus 로고
    • Age- and sex-related changes of the lymphocyte subsets in healthy individuals: An analysis by two-dimensional flow cytometry
    • Goto M, Nishioka K. Age- and sex-related changes of the lymphocyte subsets in healthy individuals: an analysis by two-dimensional flow cytometry. J Gerontol 1989;44:M51-M56.
    • (1989) J Gerontol , vol.44
    • Goto, M.1    Nishioka, K.2
  • 13
    • 0026587436 scopus 로고
    • Differential age-change in the numbers of CD4+CD45RA+ and CD4+CD29+ T-cell subsets in human peripheral blood
    • Utusyama M, et al. Differential age-change in the numbers of CD4+CD45RA+ and CD4+CD29+ T-cell subsets in human peripheral blood. Mech Ageing Dev 1992;63:57-68.
    • (1992) Mech Ageing Dev , vol.63 , pp. 57-68
    • Utusyama, M.1
  • 14
    • 0027236505 scopus 로고
    • Age-related effects in T cell activation and proliferation
    • Song L, et al. Age-related effects in T cell activation and proliferation. Exp Gerontol 1993;28:313-321.
    • (1993) Exp Gerontol , vol.28 , pp. 313-321
    • Song, L.1
  • 15
    • 0026010132 scopus 로고
    • Correlation of lymphocyte lipid composition membrane microviscosity and mitogen response in the aged
    • Huber LA, et al. Correlation of lymphocyte lipid composition membrane microviscosity and mitogen response in the aged. Eur J Immunol 1991;21:2761-2765.
    • (1991) Eur J Immunol , vol.21 , pp. 2761-2765
    • Huber, L.A.1
  • 17
    • 0028848485 scopus 로고
    • Cellular distribution of protein kinase C isozymes in CD3-mediated stimulation of human T lymphocytes with aging
    • Fūlop T Jr, Leblanc C, Lacombe G, Dupuis G. Cellular distribution of protein kinase C isozymes in CD3-mediated stimulation of human T lymphocytes with aging. FEBS Lett 1995;375:69-74.
    • (1995) FEBS Lett , vol.375 , pp. 69-74
    • Fulop Jr., T.1    Leblanc, C.2    Lacombe, G.3    Dupuis, G.4
  • 18
    • 0028978615 scopus 로고
    • Rapid tyrosine phosphorylation of Grb2 and She in T cells exposed to anti-CD3, anti-CD4, anti-CD45 stimuli: Differential effects of aging
    • Ghosh J, Miller RA. Rapid tyrosine phosphorylation of Grb2 and She in T cells exposed to anti-CD3, anti-CD4, anti-CD45 stimuli: differential effects of aging. Mech Ageing Dev 1995;80:171-187.
    • (1995) Mech Ageing Dev , vol.80 , pp. 171-187
    • Ghosh, J.1    Miller, R.A.2
  • 19
    • 0028043586 scopus 로고
    • Decline in CD28+ T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence
    • Effros RB, et al. Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol 1994;29:601-609.
    • (1994) Exp Gerontol , vol.29 , pp. 601-609
    • Effros, R.B.1
  • 20
    • 0028832492 scopus 로고
    • Diminished cell-cell binding by lymphocytes from healthy, elderly humans: Evidence for altered activation of LFA-1 function with age
    • Jackola DR, Hallgren HM. Diminished cell-cell binding by lymphocytes from healthy, elderly humans: evidence for altered activation of LFA-1 function with age. J Gerontol A Biol Sci Med Sci 1995;50:B368-B377.
    • (1995) J Gerontol A Biol Sci Med Sci , vol.50
    • Jackola, D.R.1    Hallgren, H.M.2
  • 21
    • 0023950743 scopus 로고
    • Decreased proliferation, interleukin 2 synthesis, interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors
    • Nagel JE, et al. Decreased proliferation, interleukin 2 synthesis, interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J Clin Invest 1988;81:1096-1102.
    • (1988) J Clin Invest , vol.81 , pp. 1096-1102
    • Nagel, J.E.1
  • 22
    • 0021982128 scopus 로고
    • Immunological studies of aging. X. Impaired T lymphocytes and normal monocyte response from elderly humans to the mitogenic antibodies OKT3 and Leu 4
    • Schwab R, Hausman PB, Rinnooy-Kan E, Weksler ME. Immunological studies of aging. X. Impaired T lymphocytes and normal monocyte response from elderly humans to the mitogenic antibodies OKT3 and Leu 4. Immunology 1985;55:677-684.
    • (1985) Immunology , vol.55 , pp. 677-684
    • Schwab, R.1    Hausman, P.B.2    Rinnooy-Kan, E.3    Weksler, M.E.4
  • 23
    • 0025253398 scopus 로고
    • Decreased steady state c-myc mRNA in activated T cell cultures from old humans is caused by a smaller proportion of T cells that transcribe the c-myc gene
    • Gamble DA, Schwab R, Weksler ME, Szabo P. Decreased steady state c-myc mRNA in activated T cell cultures from old humans is caused by a smaller proportion of T cells that transcribe the c-myc gene. J Immunol 1990;144:3569-3573.
    • (1990) J Immunol , vol.144 , pp. 3569-3573
    • Gamble, D.A.1    Schwab, R.2    Weksler, M.E.3    Szabo, P.4
  • 24
    • 0022574519 scopus 로고
    • The effect of aging on the expression of interleukin 2 messenger ribonucleic acid
    • Wu W, Pahlavani M, Cheung HT, Richardson A. The effect of aging on the expression of interleukin 2 messenger ribonucleic acid. Cell Immunol 1986;100:224-231.
    • (1986) Cell Immunol , vol.100 , pp. 224-231
    • Wu, W.1    Pahlavani, M.2    Cheung, H.T.3    Richardson, A.4
  • 25
    • 0029148817 scopus 로고
    • The age-related decline in the induction of IL-2 transcription is correlated to changes in the transcription factor NFAT
    • Pahlavani MA, Harris MD, Richardson A. The age-related decline in the induction of IL-2 transcription is correlated to changes in the transcription factor NFAT. Cell Immunol 1995;165:84-91.
    • (1995) Cell Immunol , vol.165 , pp. 84-91
    • Pahlavani, M.A.1    Harris, M.D.2    Richardson, A.3
  • 26
    • 0027300829 scopus 로고
    • In vitro cellular aging in T-lymphocyte cultures: Analysis of DNA content and cell size
    • Perillo NL, Naeim F, Walford RL, Effros RB. In vitro cellular aging in T-lymphocyte cultures: analysis of DNA content and cell size. Exp Cell Res 1993;207:131-135.
    • (1993) Exp Cell Res , vol.207 , pp. 131-135
    • Perillo, N.L.1    Naeim, F.2    Walford, R.L.3    Effros, R.B.4
  • 29
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961;25:585-621.
    • (1961) Exp Cell Res , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 31
    • 8944258925 scopus 로고    scopus 로고
    • Shortened telomeres in the expanded CD28- CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis
    • Effros RB, et al. Shortened telomeres in the expanded CD28- CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 1996;10:F17-F22.
    • (1996) AIDS , vol.10
    • Effros, R.B.1
  • 32
    • 0028177371 scopus 로고
    • Long-term in vitro growth of human T cell clones: Can postmitotic "senescent" cell populations be defined?
    • Grubeck-Loebenstein B, Lechner H, Trieb K. Long-term in vitro growth of human T cell clones: can postmitotic "senescent" cell populations be defined? Int Arch Allergy Immunol 1994;104:232-239.
    • (1994) Int Arch Allergy Immunol , vol.104 , pp. 232-239
    • Grubeck-Loebenstein, B.1    Lechner, H.2    Trieb, K.3
  • 33
    • 0027281563 scopus 로고
    • The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections: The role of apoptosis in T cell memory
    • Akbar AN, et al. The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections: the role of apoptosis in T cell memory. J Exp Med 1993;178:427-438.
    • (1993) J Exp Med , vol.178 , pp. 427-438
    • Akbar, A.N.1
  • 34
    • 0029977502 scopus 로고    scopus 로고
    • Regulation of CD95 (APO-1) expression and the induction of apoptosis in human T cells: Changes in old age
    • Lechner H, Amort M, Steger MM, Maczek C, Grubeck-Loebenstein B. Regulation of CD95 (APO-1) expression and the induction of apoptosis in human T cells: changes in old age. Int Arch Allergy Immunol 1996;110:238-243.
    • (1996) Int Arch Allergy Immunol , vol.110 , pp. 238-243
    • Lechner, H.1    Amort, M.2    Steger, M.M.3    Maczek, C.4    Grubeck-Loebenstein, B.5
  • 35
    • 0030297442 scopus 로고    scopus 로고
    • Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human CD4+ TCR2+ cultured T cell clones
    • Pawelec G, Sansom D, Rehbein A, Adibzadeh M, Beckman I. Decreased proliferative capacity and increased susceptibility to activation-induced cell death in late-passage human CD4+ TCR2+ cultured T cell clones. Exp Gerontol 1996;6:655-668.
    • (1996) Exp Gerontol , vol.6 , pp. 655-668
    • Pawelec, G.1    Sansom, D.2    Rehbein, A.3    Adibzadeh, M.4    Beckman, I.5
  • 36
    • 0030823184 scopus 로고    scopus 로고
    • Replicative senescence of T cells: Does the Hayflick limit lead to immune exhaustion?
    • Effros RB, Pawelec G. Replicative senescence of T cells: does the Hayflick limit lead to immune exhaustion? Immunol Today 1997;18:450.
    • (1997) Immunol Today , vol.18 , pp. 450
    • Effros, R.B.1    Pawelec, G.2
  • 37
    • 0019480025 scopus 로고
    • Evidence for in vitro senescence of T lymphocytes cultured from normal human peripheral blood
    • Walford RL, Jawaid SW, Naeim F. Evidence for in vitro senescence of T lymphocytes cultured from normal human peripheral blood. Age 1987;4:67-71.
    • (1987) Age , vol.4 , pp. 67-71
    • Walford, R.L.1    Jawaid, S.W.2    Naeim, F.3
  • 39
    • 15844364600 scopus 로고    scopus 로고
    • CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: Implications for T cell memory
    • Cossarizza A, et al. CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory. Mech Ageing Dev 1996;86:173-195.
    • (1996) Mech Ageing Dev , vol.86 , pp. 173-195
    • Cossarizza, A.1
  • 40
    • 0027976958 scopus 로고
    • Clonal populations of T cells in normal elderly humans: The T cell equivalent to "benign monoclonal gammapathy"
    • Posnett DN, Sinha R, Kabak S, Russo C. Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy". J Exp Med 1994;179:609-618.
    • (1994) J Exp Med , vol.179 , pp. 609-618
    • Posnett, D.N.1    Sinha, R.2    Kabak, S.3    Russo, C.4
  • 41
    • 0031137735 scopus 로고    scopus 로고
    • + T cell clones in elderly humans
    • + T cell clones in elderly humans. J Immunol 1997;158:4493-4499.
    • (1997) J Immunol , vol.158 , pp. 4493-4499
    • Schwab, R.1
  • 42
    • 0037849072 scopus 로고    scopus 로고
    • Age-related impaired affinity maturation and differential D-JH gene usage in human VH6-expressing B lymphocytes from healthy individuals
    • van Dijk-Härd I, Söderström I, Feld S, Holmberg D, Lundkvist I. Age-related impaired affinity maturation and differential D-JH gene usage in human VH6-expressing B lymphocytes from healthy individuals. Eur J Immunol 1997;27:1381-1386.
    • (1997) Eur J Immunol , vol.27 , pp. 1381-1386
    • Van Dijk-Härd, I.1    Söderström, I.2    Feld, S.3    Holmberg, D.4    Lundkvist, I.5
  • 43
    • 0030035583 scopus 로고    scopus 로고
    • The aging immune system: Primer and prospectus
    • Miller RA. The aging immune system: primer and prospectus. Science 1996;273:70-74.
    • (1996) Science , vol.273 , pp. 70-74
    • Miller, R.A.1
  • 44
    • 0021871082 scopus 로고
    • Changes in the macrophage function with aging
    • De la Fuenta M. Changes in the macrophage function with aging. Comp Biochem Physiol A Physiol 1985;81:935-938.
    • (1985) Comp Biochem Physiol A Physiol , vol.81 , pp. 935-938
    • De La Fuenta, M.1
  • 45
    • 0025134053 scopus 로고
    • T cell activation in the elderly: Evidence for specific deficiencies in T cell/accessory cell interactions
    • Beckman I, et al. T cell activation in the elderly: evidence for specific deficiencies in T cell/accessory cell interactions. Mech Ageing Dev 1990;51:265-276.
    • (1990) Mech Ageing Dev , vol.51 , pp. 265-276
    • Beckman, I.1
  • 46
    • 0027190386 scopus 로고
    • Accessory function and properties of monocytes from healthy elderly humans for T lymphocyte responses to mitogen and antigen
    • Rich EA, et al. Accessory function and properties of monocytes from healthy elderly humans for T lymphocyte responses to mitogen and antigen. Gerontology 1993;39:93-108.
    • (1993) Gerontology , vol.39 , pp. 93-108
    • Rich, E.A.1
  • 48
    • 0020073049 scopus 로고
    • Effect of chronological aging on Langerhans cells in the human epidermis
    • Gilchrest BA, Murphy GF, Soter NA. Effect of chronological aging on Langerhans cells in the human epidermis. J Invest Dermatol 1982;79:85-88.
    • (1982) J Invest Dermatol , vol.79 , pp. 85-88
    • Gilchrest, B.A.1    Murphy, G.F.2    Soter, N.A.3
  • 49
    • 0023034068 scopus 로고
    • Functional competence of dendritic cells of ageing C57/BL/6 mice
    • Komatsubara S, Cinader B, Muramatsu S. Functional competence of dendritic cells of ageing C57/BL/6 mice. Scand J Immunol 1986;24:517-525.
    • (1986) Scand J Immunol , vol.24 , pp. 517-525
    • Komatsubara, S.1    Cinader, B.2    Muramatsu, S.3
  • 50
    • 0027265827 scopus 로고
    • Increased cytokine production in mononuclear cells of healthy elderly people
    • Fagiolo U, et al. Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol 1993;23:2375-2378.
    • (1993) Eur J Immunol , vol.23 , pp. 2375-2378
    • Fagiolo, U.1
  • 51
    • 0029822246 scopus 로고    scopus 로고
    • Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals
    • Steger MM, Maczek C, Grubeck-Loebenstein B. Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals. Clin Exp Immunol 1996;105:544-551.
    • (1996) Clin Exp Immunol , vol.105 , pp. 544-551
    • Steger, M.M.1    Maczek, C.2    Grubeck-Loebenstein, B.3
  • 52
    • 0026748699 scopus 로고
    • Lipid utilization by human lymphocytes is correlated with high-density lipoprotein binding site activity
    • Xu Q, Jürgens G, Huber LA, Böck G, Wolf H, Wick G. Lipid utilization by human lymphocytes is correlated with high-density lipoprotein binding site activity. Biochem J 1992;285:105-112.
    • (1992) Biochem J , vol.285 , pp. 105-112
    • Xu, Q.1    Jürgens, G.2    Huber, L.A.3    Böck, G.4    Wolf, H.5    Wick, G.6
  • 53
    • 0024395460 scopus 로고
    • Promotion of lymphocyte growth by high density lipoproteins (HDL): Physiological significance of the HDL binding site
    • Jürgens G, et al. Promotion of lymphocyte growth by high density lipoproteins (HDL): physiological significance of the HDL binding site. J Biol Chem 1989;265:8549-8556.
    • (1989) J Biol Chem , vol.265 , pp. 8549-8556
    • Jürgens, G.1
  • 54
    • 0026396730 scopus 로고
    • The decline of the immune response during aging: The role of an altered lipid metabolism
    • Wick G, Huber LA, Xu Q, Jarosch E, Schönitzer D, Jürgens G. The decline of the immune response during aging: the role of an altered lipid metabolism. Ann N Y Acad Sci 1991;621:277-290.
    • (1991) Ann N Y Acad Sci , vol.621 , pp. 277-290
    • Wick, G.1    Huber, L.A.2    Xu, Q.3    Jarosch, E.4    Schönitzer, D.5    Jürgens, G.6
  • 56
    • 0029052153 scopus 로고
    • In vivo LDL receptor and HMG-CoA reductase regulation in human lymphocytes and its alterations during aging
    • Stulnig TM, et al. In vivo LDL receptor and HMG-CoA reductase regulation in human lymphocytes and its alterations during aging. Arterioscler Thromb Vasc Biol 1995;15: 872-878.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 872-878
    • Stulnig, T.M.1
  • 57
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • McGeer PL, McGeer EG. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Brain Res Rev 1995;21:195-218.
    • (1995) Brain Res Brain Res Rev , vol.21 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 58
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner GG, Wong CW. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984;120:885-890.
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 59
    • 0024317005 scopus 로고
    • Activation of the classical complement pathway in brain tissue of Alzheimer patients
    • McGeer PL, Akiyama H, Itagaki S, McGeer EG. Activation of the classical complement pathway in brain tissue of Alzheimer patients. Neurosci Lett 1989;107:341-346.
    • (1989) Neurosci Lett , vol.107 , pp. 341-346
    • McGeer, P.L.1    Akiyama, H.2    Itagaki, S.3    McGeer, E.G.4
  • 60
    • 0028217539 scopus 로고
    • Ultrastructural localization of complement membrane attack complex (MAC)-like immuno-reactivity in brains of patients with Alzheimer's disease
    • Itagaki S, Akiyama H, Saito H, McGeer PL. Ultrastructural localization of complement membrane attack complex (MAC)-like immuno-reactivity in brains of patients with Alzheimer's disease. Brain Res 1994;645:78-84.
    • (1994) Brain Res , vol.645 , pp. 78-84
    • Itagaki, S.1    Akiyama, H.2    Saito, H.3    McGeer, P.L.4
  • 61
    • 0028178458 scopus 로고
    • Beta-amyloid activates complement by binding to a specific region of the collagen-like domain of the C1qA chain
    • Jiang H, Burdick D, Glabe CG, Cotman CW, Tenner AJ. Beta-amyloid activates complement by binding to a specific region of the collagen-like domain of the C1qA chain. J Immunol 1994;152:5050-5059.
    • (1994) J Immunol , vol.152 , pp. 5050-5059
    • Jiang, H.1    Burdick, D.2    Glabe, C.G.3    Cotman, C.W.4    Tenner, A.J.5
  • 62
    • 0026447529 scopus 로고
    • Complement activation by beta-amyloid in Alzheimer's disease
    • Rogers J, et al. Complement activation by beta-amyloid in Alzheimer's disease. Proc Natl Acad Sci USA 1992;89: 10016-10020.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10016-10020
    • Rogers, J.1
  • 63
    • 0030248270 scopus 로고    scopus 로고
    • Microglial cells internalize aggregates of the Alzheimer's disease amyloid β-protein via a scavenger receptor
    • Paresce DM, Ghosh RN, Maxfield FR. Microglial cells internalize aggregates of the Alzheimer's disease amyloid β-protein via a scavenger receptor. Neuron 1996;17:553-565.
    • (1996) Neuron , vol.17 , pp. 553-565
    • Paresce, D.M.1    Ghosh, R.N.2    Maxfield, F.R.3
  • 65
    • 0024436506 scopus 로고
    • Relationship of microglia and astrocytes to amyloid deposits in Alzheimer's disease
    • Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe DJ. Relationship of microglia and astrocytes to amyloid deposits in Alzheimer's disease. J Neuroimmunol 1989;24:173-182.
    • (1989) J Neuroimmunol , vol.24 , pp. 173-182
    • Itagaki, S.1    McGeer, P.L.2    Akiyama, H.3    Zhu, S.4    Selkoe, D.J.5
  • 67
    • 0028276177 scopus 로고
    • Cellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer's disease
    • Eikelenboom P, Zhan SS, Kamphorst W, van der Valk P, Rozemuller JM. Cellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer's disease. Virchows Arch 1994;424:421-427.
    • (1994) Virchows Arch , vol.424 , pp. 421-427
    • Eikelenboom, P.1    Zhan, S.S.2    Kamphorst, W.3    Van Der Valk, P.4    Rozemuller, J.M.5
  • 68
    • 0028923898 scopus 로고
    • Complement and cytokine gene expression in cultured microglial derived from postmortem human brains
    • Walker DG, Kim SU, McGeer PL. Complement and cytokine gene expression in cultured microglial derived from postmortem human brains. J Neurosci Res 1995;40:478-493.
    • (1995) J Neurosci Res , vol.40 , pp. 478-493
    • Walker, D.G.1    Kim, S.U.2    McGeer, P.L.3
  • 69
    • 0028953529 scopus 로고
    • Activation of microglial cells by β-amyloid protein and interferon-γ
    • Meda L, et al. Activation of microglial cells by β-amyloid protein and interferon-γ. Nature 1995;374:647-650.
    • (1995) Nature , vol.374 , pp. 647-650
    • Meda, L.1
  • 71
    • 0028832354 scopus 로고
    • Amyloid β peptide potentiates cytokine secretion by interleukin-1β-activated human astrocytoma cells
    • Gitter BD, Cox LM, Rydel RE, May PC. Amyloid β peptide potentiates cytokine secretion by interleukin-1β-activated human astrocytoma cells. Proc Natl Acad Sci USA 1995;92: 10738-10741.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10738-10741
    • Gitter, B.D.1    Cox, L.M.2    Rydel, R.E.3    May, P.C.4
  • 73
    • 0026717674 scopus 로고
    • The pathophysiology of tumor necrosis factor
    • Vassalli P. The pathophysiology of tumor necrosis factor. Annu Rev Immunol 1992;10:411-452.
    • (1992) Annu Rev Immunol , vol.10 , pp. 411-452
    • Vassalli, P.1
  • 74
    • 0028171525 scopus 로고
    • Interleukin 1β dissociates β-amyloid precursor protein and β-amyloid peptide secretion
    • Vasilakos J, Carroll R, Emmerling M. Interleukin 1β dissociates β-amyloid precursor protein and β-amyloid peptide secretion. FEBS Lett 1994;354:289-292.
    • (1994) FEBS Lett , vol.354 , pp. 289-292
    • Vasilakos, J.1    Carroll, R.2    Emmerling, M.3
  • 75
    • 0029876963 scopus 로고    scopus 로고
    • The production of an amyloidogenic metabolite of the Alzheimer amyloid β precursor protein (APP) in thyroid cells is stimulated by interleukin 1β, but inhibited by interferon gamma
    • Schmitt T, Steiner E, Klingler P, Sztankay A, Grubeck-Loebenstein B. The production of an amyloidogenic metabolite of the Alzheimer amyloid β precursor protein (APP) in thyroid cells is stimulated by interleukin 1β, but inhibited by interferon gamma. J Clin Endocrinol Metab 1996;81:1666-1669.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1666-1669
    • Schmitt, T.1    Steiner, E.2    Klingler, P.3    Sztankay, A.4    Grubeck-Loebenstein, B.5
  • 76
    • 0025332027 scopus 로고
    • Anti-inflammatory drugs and Alzheimer's disease
    • McGeer PL, McGeer EG, Rogers J, Sibley J. Anti-inflammatory drugs and Alzheimer's disease. Lancet 1990;335:1037.
    • (1990) Lancet , vol.335 , pp. 1037
    • McGeer, P.L.1    McGeer, E.G.2    Rogers, J.3    Sibley, J.4
  • 77
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
    • McGeer PL, Schulzer M, McGeer EG. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 1996;47:425-432.
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 78
    • 0027268393 scopus 로고
    • Clinical trial of indomethacin in Alzheimer's disease
    • Rogers J, et al. Clinical trial of indomethacin in Alzheimer's disease. Neurology 1993;43:1609-1611.
    • (1993) Neurology , vol.43 , pp. 1609-1611
    • Rogers, J.1
  • 79
    • 0039026601 scopus 로고
    • Peripheral biological markers as confirmatory or predictive tests for Alzheimer disease in the general population and in Down syndrome
    • Berg JM, Karlinsky H, Holland AJ, eds. Oxford, New York, Tokyo, Toronto: Oxford University Press
    • Percy ME. Peripheral biological markers as confirmatory or predictive tests for Alzheimer disease in the general population and in Down syndrome. In: Berg JM, Karlinsky H, Holland AJ, eds. Alzheimer disease. Down syndrome, and their relationship. Oxford, New York, Tokyo, Toronto: Oxford University Press; 1993. p. 199-223.
    • (1993) Alzheimer Disease. Down Syndrome, and Their Relationship , pp. 199-223
    • Percy, M.E.1
  • 80
    • 0001699385 scopus 로고
    • Alzheimer amyloid β/A4 protein-reactive antibodies in human sera and CSF
    • Iqbal K, McLachlan D, Winblad B, Wisniewski H, eds. Chichester: John Wiley & Sons;
    • Moenning U, et al. Alzheimer amyloid β/A4 protein-reactive antibodies in human sera and CSF. In: Iqbal K, McLachlan D, Winblad B, Wisniewski H, eds. Alzheimer's disease: basic mechanisms, diagnosis and therapeutic strategies. Chichester: John Wiley & Sons; 1991. p. 557-776.
    • (1991) Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies , pp. 557-776
    • Moenning, U.1
  • 81
    • 0027410894 scopus 로고
    • Human antibodies reactive with β-amyloid protein in Alzheimer's disease
    • Gaskin F, Finley J, Fang Q, Xu S, Fu SM. Human antibodies reactive with β-amyloid protein in Alzheimer's disease. J Exp Med 1993;177:1181-1186.
    • (1993) J Exp Med , vol.177 , pp. 1181-1186
    • Gaskin, F.1    Finley, J.2    Fang, Q.3    Xu, S.4    Fu, S.M.5
  • 82
    • 0026688723 scopus 로고
    • Neuroimmunology of Alzheimer's disease: A conference report
    • Dickson DW, Rogers J. Neuroimmunology of Alzheimer's disease: a conference report. Neurobiol Aging 1992;13:793-798.
    • (1992) Neurobiol Aging , vol.13 , pp. 793-798
    • Dickson, D.W.1    Rogers, J.2
  • 83
    • 0021972837 scopus 로고
    • Immunological features of nonimmunogenic hyperthyroidism
    • Grubeck-Loebenstein B, et al. Immunological features of nonimmunogenic hyperthyroidism. J Clin Endocrinol Metab 1985;60:150-155.
    • (1985) J Clin Endocrinol Metab , vol.60 , pp. 150-155
    • Grubeck-Loebenstein, B.1
  • 84
    • 0023918728 scopus 로고
    • Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic goiter and in Graves' disease
    • Grubeck-Loebenstein B, Londei M, Greenall C, Pirich K, Waldhäusl W, Feldmann M. Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic goiter and in Graves' disease. J Clin Invest 1988;81:1608-1614.
    • (1988) J Clin Invest , vol.81 , pp. 1608-1614
    • Grubeck-Loebenstein, B.1    Londei, M.2    Greenall, C.3    Pirich, K.4    Waldhäusl, W.5    Feldmann, M.6
  • 85
    • 0026584617 scopus 로고
    • Phenotypic characterization of infiltrating leukocytes in benign prostatic hyperplasia
    • Theyer G, et al. Phenotypic characterization of infiltrating leukocytes in benign prostatic hyperplasia. Lab Invest 1992;66:96-107.
    • (1992) Lab Invest , vol.66 , pp. 96-107
    • Theyer, G.1
  • 86
    • 0029830124 scopus 로고    scopus 로고
    • APP peptides stimulate lymphocyte proliferation in normals, but not in patients with Alzheimer's disease
    • Trieb K, Ransmayr G, Sgonc R, Lassmann H, Grubeck-Loebenstein B. APP peptides stimulate lymphocyte proliferation in normals, but not in patients with Alzheimer's disease. Neurobiol Aging 1996;17:541-547.
    • (1996) Neurobiol Aging , vol.17 , pp. 541-547
    • Trieb, K.1    Ransmayr, G.2    Sgonc, R.3    Lassmann, H.4    Grubeck-Loebenstein, B.5
  • 87
    • 0011104091 scopus 로고    scopus 로고
    • Interferon γ inhibits production and metabolism of amyloid precursor protein in human extraneuronal cells
    • Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM, eds. Chichester: John Wiley & Sons
    • Schmitt TL, Sztankay A, Steiner E, Klingler P, Trieb K, Grubeck-Loebenstein B. Interferon γ inhibits production and metabolism of amyloid precursor protein in human extraneuronal cells. In: Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM, eds. Alzheimer's disease: biology, diagnosis and therapeutics. Chichester: John Wiley & Sons; 1997. p. 431-437.
    • (1997) Alzheimer's Disease: Biology, Diagnosis and Therapeutics , pp. 431-437
    • Schmitt, T.L.1    Sztankay, A.2    Steiner, E.3    Klingler, P.4    Trieb, K.5    Grubeck-Loebenstein, B.6
  • 89
    • 0026761137 scopus 로고
    • An abnormality of plasma amyloid protein precursor in Alzheimer's disease
    • Bush AI, et al. An abnormality of plasma amyloid protein precursor in Alzheimer's disease. Ann Neurol 1992;32:57-65.
    • (1992) Ann Neurol , vol.32 , pp. 57-65
    • Bush, A.I.1
  • 91
    • 0030926062 scopus 로고    scopus 로고
    • Interactions of the Alzheimer β amyloid fragment (25-35) with peripheral blood dendritic cells
    • Schmitt TL, Steger M-M, Pavelka M, Grubeck-Loebenstein B. Interactions of the Alzheimer β amyloid fragment (25-35) with peripheral blood dendritic cells. Mech Ageing Dev 1997;94:223-232.
    • (1997) Mech Ageing Dev , vol.94 , pp. 223-232
    • Schmitt, T.L.1    Steger, M.-M.2    Pavelka, M.3    Grubeck-Loebenstein, B.4
  • 94
    • 0030229050 scopus 로고    scopus 로고
    • The role of heat shock proteins in protection and pathophysiology of the arterial wall
    • Xu Q, Wick G. The role of heat shock proteins in protection and pathophysiology of the arterial wall. Mol Med Today 1996;2:372-379.
    • (1996) Mol Med Today , vol.2 , pp. 372-379
    • Xu, Q.1    Wick, G.2
  • 95
    • 0025180671 scopus 로고
    • Immunology of atherosclerosis: Cellular composition and major histocompatibility complex class II antigen expression in aortic intima, fatty streaks, atherosclerotic plaques in young and aged human specimens
    • Xu Q, Oberhuber G, Gruschwitz M, Wick G. Immunology of atherosclerosis: cellular composition and major histocompatibility complex class II antigen expression in aortic intima, fatty streaks, atherosclerotic plaques in young and aged human specimens. Clin Immunol Immunopathol 1990;56: 344-359.
    • (1990) Clin Immunol Immunopathol , vol.56 , pp. 344-359
    • Xu, Q.1    Oberhuber, G.2    Gruschwitz, M.3    Wick, G.4
  • 96
    • 0027755138 scopus 로고
    • Immunology of atherosclerosis: Demonstration of heat shock protein 60 expression and T-lymphocytes bearing α/β or γ/δ receptor in human atherosclerotic lesions
    • Kleindienst R, Xu Q, Willeit J, Waldenberger F, Weimann S, Wick G. Immunology of atherosclerosis: demonstration of heat shock protein 60 expression and T-lymphocytes bearing α/β or γ/δ receptor in human atherosclerotic lesions. Am J Pathol 1993;142:1927-1937.
    • (1993) Am J Pathol , vol.142 , pp. 1927-1937
    • Kleindienst, R.1    Xu, Q.2    Willeit, J.3    Waldenberger, F.4    Weimann, S.5    Wick, G.6
  • 97
    • 0030830621 scopus 로고    scopus 로고
    • Atherosclerosis, autoimmunity and the vascular associated lymphoid tissue (VALT)
    • Wick G, et al. Atherosclerosis, autoimmunity and the vascular associated lymphoid tissue (VALT). FASEB J 1997;11:1199-1207.
    • (1997) FASEB J , vol.11 , pp. 1199-1207
    • Wick, G.1
  • 99
    • 0027233751 scopus 로고
    • Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65
    • Xu Q, Kleindienst R, Waitz W, Dietrich H, Wick G. Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65. J Clin Invest 1993;91:2693-2702.
    • (1993) J Clin Invest , vol.91 , pp. 2693-2702
    • Xu, Q.1    Kleindienst, R.2    Waitz, W.3    Dietrich, H.4    Wick, G.5
  • 100
    • 0027522356 scopus 로고
    • Cells in stress: Transcriptional activation of heat shock genes
    • Morimoto RI. Cells in stress: transcriptional activation of heat shock genes. Science 1993;259:1409-1410.
    • (1993) Science , vol.259 , pp. 1409-1410
    • Morimoto, R.I.1
  • 101
    • 0024418447 scopus 로고
    • Stress proteins, infection, and immune surveillance
    • Young RA, Elliott TJ. Stress proteins, infection, and immune surveillance. Cell 1989;59:5-8.
    • (1989) Cell , vol.59 , pp. 5-8
    • Young, R.A.1    Elliott, T.J.2
  • 102
    • 0026683392 scopus 로고
    • Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65
    • Xu Q, et al. Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65. Arterioscler Thromb 1992;12:789-799.
    • (1992) Arterioscler Thromb , vol.12 , pp. 789-799
    • Xu, Q.1
  • 103
    • 0029886232 scopus 로고    scopus 로고
    • Regression of arteriosclerotic lesions induced by immunization with heat shock protein 65-containing material in normocholesterolemic, but not hypercholesterolemic, rabbits
    • Xu Q, et al. Regression of arteriosclerotic lesions induced by immunization with heat shock protein 65-containing material in normocholesterolemic, but not hypercholesterolemic, rabbits. Atherosclerosis 1996;23:145-155.
    • (1996) Atherosclerosis , vol.23 , pp. 145-155
    • Xu, Q.1
  • 104
    • 0030031771 scopus 로고    scopus 로고
    • Coexpression of intercellular adhesion molecule-1 and heat shock protein 60 is related to increased adherent monocytes and T cells on aortic endothelium of rats in response to endotoxin
    • Seitz CS, Kleindienst R, Xu Q, Wick G. Coexpression of intercellular adhesion molecule-1 and heat shock protein 60 is related to increased adherent monocytes and T cells on aortic endothelium of rats in response to endotoxin. Lab Invest 1996;74:241-252.
    • (1996) Lab Invest , vol.74 , pp. 241-252
    • Seitz, C.S.1    Kleindienst, R.2    Xu, Q.3    Wick, G.4
  • 105
    • 0030815915 scopus 로고    scopus 로고
    • Co-expression of ICAM-1, VCAM-1, ELAM-1 and Hsp60 in human arterial venous endothelial cells in response to cytokines and oxidized low density lipoproteins
    • Amberger A, et al. Co-expression of ICAM-1, VCAM-1, ELAM-1 and Hsp60 in human arterial venous endothelial cells in response to cytokines and oxidized low density lipoproteins. Cell Stress Chaperones 1997;2:94-103.
    • (1997) Cell Stress Chaperones , vol.2 , pp. 94-103
    • Amberger, A.1
  • 106
    • 0027399854 scopus 로고
    • Association of serum antibodies to heat shock-protein 65 with carotid atherosclerosis
    • Xu Q, et al. Association of serum antibodies to heat shock-protein 65 with carotid atherosclerosis. Lancet 1993;341:255-259.
    • (1993) Lancet , vol.341 , pp. 255-259
    • Xu, Q.1
  • 107
    • 0027330902 scopus 로고
    • Staining of endothelial cells and macrophages in atherosclerotic lesions with human heat-shock protein reactive antisera
    • Xu Q, Luef G, Weimann S, Gupta RS, Wolf H, Wick G. Staining of endothelial cells and macrophages in atherosclerotic lesions with human heat-shock protein reactive antisera. Arterioscler Thromb 1993;13:1763-1769.
    • (1993) Arterioscler Thromb , vol.13 , pp. 1763-1769
    • Xu, Q.1    Luef, G.2    Weimann, S.3    Gupta, R.S.4    Wolf, H.5    Wick, G.6
  • 108
    • 0028809489 scopus 로고
    • Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity
    • Schett G, et al. Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity. J Clin Invest 1995;96:2569-2577.
    • (1995) J Clin Invest , vol.96 , pp. 2569-2577
    • Schett, G.1
  • 109
    • 0030982811 scopus 로고    scopus 로고
    • Epitope specificity of anti-heat shock protein 65/60 serum antibodies in atherosclerosis
    • Metzler B, et al. Epitope specificity of anti-heat shock protein 65/60 serum antibodies in atherosclerosis. Arterioscler Thromb Vasc Biol 1997;17: 536-541.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 536-541
    • Metzler, B.1
  • 110
    • 0028029497 scopus 로고
    • Immunoprophylaxis at extremes of age
    • Begg NT. Immunoprophylaxis at extremes of age. J Antimicrob Chemother 1994;34:121-128.
    • (1994) J Antimicrob Chemother , vol.34 , pp. 121-128
    • Begg, N.T.1
  • 111
    • 0018862048 scopus 로고
    • Selective decline in cellular immune response to varicella-zoster in the elderly
    • Miller AE. Selective decline in cellular immune response to varicella-zoster in the elderly. Neurology 1980;30:582-587.
    • (1980) Neurology , vol.30 , pp. 582-587
    • Miller, A.E.1
  • 112
    • 0026556760 scopus 로고
    • In vitro T cell activation, in vitro defective IL-2 secretion, and response to influenza vaccination in elderly women
    • Huang YP, et al. In vitro T cell activation, in vitro defective IL-2 secretion, and response to influenza vaccination in elderly women. J Immunol 1992;148:715-722.
    • (1992) J Immunol , vol.148 , pp. 715-722
    • Huang, Y.P.1
  • 113
    • 0029748272 scopus 로고    scopus 로고
    • Vaccination against tetanus in the elderly: Do recommended vaccination strategies give sufficient protection?
    • Steger MM, Maczek C, Berger P, Grubeck-Loebenstein B. Vaccination against tetanus in the elderly: do recommended vaccination strategies give sufficient protection? Lancet 1996;348ii: 762.
    • (1996) Lancet , vol.348 II , pp. 762
    • Steger, M.M.1    Maczek, C.2    Berger, P.3    Grubeck-Loebenstein, B.4


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