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Angewandte Chemie - International Edition

Volumn 54, Issue 2, 2015, Pages 556-559

W2466.48 opens a gate for a continuous intrinsic water pathway during activation of the adenosine A2A receptor

(4) Yuan, Shuguang a Hu, Zhenquan b Filipek, Slawomir c Vogel, Horst a

a EPFL (Switzerland)

b UNIVERSITY OF BASEL (Switzerland)

c UNIVERSITY OF WARSAW (Poland)

Author keywords

G protein coupled receptor; Molecular dynamics simulations; Molecular switches; Signal transduction; Water channel

Indexed keywords

BIOLOGICAL MEMBRANES; ENZYME ACTIVITY; LIPID BILAYERS; MOLECULAR DYNAMICS; MOLECULES; PROTEINS; SIGNAL TRANSDUCTION;

CONFORMATIONAL TRANSITIONS; EXTRACELLULAR SIGNALS; G PROTEIN COUPLED RECEPTORS; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR SWITCHES; ROTAMER TOGGLE SWITCHES; TRANSMEMBRANE HELICES; WATER CHANNELS;

CONFORMATIONS;

ADENOSINE A2A RECEPTOR; WATER;

CHEMISTRY; MOLECULAR DYNAMICS;

MOLECULAR DYNAMICS SIMULATION; RECEPTOR, ADENOSINE A2A; WATER;

EID: 84922789503 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201409679 Document Type: Article

Times cited : (60)

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