New insights from structural biology into the druggability of G protein-coupled receptors

Trends in Pharmacological Sciences

Volumn 33, Issue 5, 2012, Pages 249-260

  Mason, Jonathan S ^a   Bortolato, Andrea ^a   Congreve, Miles ^a   Marshall, Fiona H ^a  

^a Heptares Therapeutics Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; AMPRENAVIR; BACLOFEN; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA SECRETASE 1; BI 167107; CARAZOLOL; CHEMOKINE RECEPTOR CXCR4; CLOPIDOGREL; CYANOPINDOLOL; DOPAMINE 3 RECEPTOR; FINGOLIMOD; G PROTEIN COUPLED RECEPTOR; HISTAMINE H1 RECEPTOR; IMATINIB; ISOPRENALINE; LOPINAVIR; MORPHINE; MUSCARINIC M2 RECEPTOR; NELFINAVIR; OSELTAMIVIR; PLERIXAFOR; PROTEIN TYROSINE KINASE INHIBITOR; SGX 523; TICAGRELOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZANAMIVIR;

BINDING SITE; COMPLEX FORMATION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; LIPOPHILICITY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; REVIEW;

BINDING SITES; DRUG DESIGN; PROTEIN CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84860505658     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2012.02.005     Document Type: Review

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