Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22

Journal of Hepatology

Volumn 53, Issue 2, 2010, Pages 339-347

  Yang, Ling ^a   Zhang, Yixuan ^a   Wang, Lingdi ^a   Fan, Fengjuan ^a   Zhu, Lu ^a   Li, Zhigang ^a   Ruan, Xiangbo ^a   Huang, Heng ^a   Wang, Zhenzhen ^a   Huang, Zhihua ^b   Huang, Yuliang ^b   Yan, Xiaoqiang ^b   Chen, Yan ^a  

^a UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^b Generon Corporation   (China)

Author keywords

Fatty liver; IL 22; IL 22R1; Lipid metabolism; Mouse model; STAT3

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACYL COENZYME A DESATURASE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CELL NUCLEUS RECEPTOR; COMPLEMENTARY DNA; DIACYLGLYCEROL ACYLTRANSFERASE 1; DIACYLGLYCEROL ACYLTRANSFERASE 2; FAS ANTIGEN; FATTY ACID SYNTHASE; GLUCOSE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INSULIN; INTERLEUKIN 22; INTERLEUKIN 22 RECEPTOR 1; INTERLEUKIN RECEPTOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUCIFERASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 22; STAT3 PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CHOLESTEROL; FAT INTAKE; INTERLEUKIN DERIVATIVE; INTERLEUKIN-22; STAT3 PROTEIN, MOUSE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; C57BL 6 MOUSE; CELL CULTURE; CELL STRAIN HEK293; CELL STRAIN HEPG2; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ASSAY; FATTY LIVER; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; LIPID DIET; LIPID LIVER LEVEL; LIPOGENESIS; LIVER METABOLISM; LIVER PROTECTION; MALE; MOLECULAR CLONING; MOUSE; MOUSE STRAIN; NONHUMAN; OB OB MOUSE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; FAT INTAKE; LIPID METABOLISM; LIVER; METABOLISM; PHOSPHORYLATION;

ANIMALS; CHOLESTEROL; DIETARY FATS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY LIVER; INTERLEUKINS; LIPID METABOLISM; LIPOGENESIS; LIVER; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; STAT3 TRANSCRIPTION FACTOR; TRIGLYCERIDES;

EID: 77955308513     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.03.004     Document Type: Article

References (46)

1. S.J. Aujla, Y.R. Chan, M. Zheng, M. Fei, D.J. Askew, and D.A. Pociask IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia Nat Med 14 3 2008 275 281
2. K. Boniface, E. Guignouard, N. Pedretti, M. Garcia, A. Delwail, and F.X. Bernard A role for T cell-derived interleukin 22 in psoriatic skin inflammation Clin Exp Immunol 150 3 2007 407 415
3. Y. Chung, X. Yang, S.H. Chang, L. Ma, Q. Tian, and C. Dong Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes Cell Res 16 11 2006 902 907
4. D.E. Cintra, J.R. Pauli, E.P. Araujo, J.C. Moraes, C.T. de Souza, and M. Milanski Interleukin-10 is a protective factor against diet-induced insulin resistance in liver J Hepat 48 4 2008 628 637
5. B.M. De Taeye, T. Novitskaya, O.P. McGuinness, L. Gleaves, M. Medda, and J.W. Covington Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity Am J Physiol Endocrinol Metab 293 3 2007 E713 E725
6. M.A. den Boer, P.J. Voshol, J.P. Schroder-van der Elst, E. Korsheninnikova, D.M. Ouwens, and F. Kuipers Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice Endocrinology 147 10 2006 4553 4558
7. L. Dumoutier, E. Van Roost, D. Colau, and J.C. Renauld Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor Proc Natl Acad Sci USA 97 18 2000 10144 10149
8. M. Endo, T. Masaki, M. Seike, and H. Yoshimatsu TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c) Exp Biol Med (Maywood) 232 5 2007 614 621
9. J. Folch, M. Lees, and G.H. Sloane Stanley A simple method for the isolation and purification of total lipides from animal tissues J Biol Chem 226 1 1957 497 509
10. M. Goto, M. Murakawa, K. Kadoshima-Yamaoka, Y. Tanaka, K. Nagahira, and Y. Fukuda Murine NKT cells produce Th17 cytokine interleukin-22 Cell Immunol 254 2 2009 81 84
11. A.L. Gurney IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues Int Immunopharmacol 4 5 2004 669 677
12. T. Gustot, A. Lemmers, C. Moreno, N. Nagy, E. Quertinmont, and C. Nicaise Differential liver sensitization to toll-like receptor pathways in mice with alcoholic fatty liver Hepatology 43 5 2006 989 1000
13. M. Haluzik, C. Colombo, O. Gavrilova, S. Chua, N. Wolf, and M. Chen Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice Endocrinology 145 7 2004 3258 3264
14. L.E. Hammond, P.A. Gallagher, S. Wang, S. Hiller, K.D. Kluckman, and E.L. Posey-Marcos Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition Mol Cell Biol 22 23 2002 8204 8214
15. F. Hong, S. Radaeva, H.N. Pan, Z. Tian, R. Veech, and B. Gao Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease Hepatology 40 4 2004 933 941
16. H. Inoue, W. Ogawa, M. Ozaki, S. Haga, M. Matsumoto, and K. Furukawa Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo Nat Med 10 2 2004 168 174
17. S.V. Kotenko, L.S. Izotova, O.V. Mirochnitchenko, E. Esterova, H. Dickensheets, and R.P. Donnelly Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity J Immunol 166 12 2001 7096 7103
18. D. Lejeune, L. Dumoutier, S. Constantinescu, W. Kruijer, J.J. Schuringa, and J.C. Renauld Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10 J Biol Chem 277 37 2002 33676 33682
19. A.E. Leonard, S.L. Pereira, H. Sprecher, and Y.S. Huang Elongation of long-chain fatty acids Prog Lipid Res 43 1 2004 36 54
20. Z. Li, S. Yang, H. Lin, J. Huang, P.A. Watkins, and A.B. Moser Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease Hepatology 37 2 2003 343 350
21. S.C. Liang, X.Y. Tan, D.P. Luxenberg, R. Karim, K. Dunussi-Joannopoulos, and M. Collins Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides J Exp Med 203 10 2006 2271 2279
22. Y. Liu, J.S. Millar, D.A. Cromley, M. Graham, R. Crooke, and J.T. Billheimer Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice Biochim Biophys Acta 1781 3 2008 97 104
23. H.L. Ma, S. Liang, J. Li, L. Napierata, T. Brown, and S. Benoit IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation J Clin Invest 118 2 2008 597 607
24. T. Matsuzaka, H. Shimano, N. Yahagi, T. Kato, A. Atsumi, and T. Yamamoto Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance Nat Med 13 10 2007 1193 1202
25. H. Pan, F. Hong, S. Radaeva, and B. Gao Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3 Cell Mol Immunol 1 1 2004 43 49
26. S. Radaeva, R. Sun, H.N. Pan, F. Hong, and B. Gao Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation Hepatology 39 5 2004 1332 1342
27. J.J. Repa, G. Liang, J. Ou, Y. Bashmakov, J.M. Lobaccaro, and I. Shimomura Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta Gene Dev 14 22 2000 2819 2830
28. T. Shimokawa, M.V. Kumar, and M.D. Lane Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides Proc Natl Acad Sci USA 99 1 2002 66 71
29. S. Sookoian, G. Castano, T.F. Gianotti, C. Gemma, M.S. Rosselli, and C.J. Pirola Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease Cytokine 44 1 2008 201 206
30. M. Torbenson, S.Q. Yang, H.Z. Liu, J. Huang, W. Gage, and A.M. Diehl STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers Am J Pathol 161 1 2002 155 161
31. K. Uyeda, H. Yamashita, and T. Kawaguchi Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage Biochem Pharmacol 63 12 2002 2075 2080
32. S. Wada, T. Yamazaki, Y. Kawano, S. Miura, and O. Ezaki Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice J Hepat 49 3 2008 441 450
33. Q. Wang, L. Jiang, J. Wang, S. Li, Y. Yu, and J. You Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice Hepatology 49 4 2009 1166 1175
34. K. Wolk, S. Kunz, E. Witte, M. Friedrich, K. Asadullah, and R. Sabat IL-22 increases the innate immunity of tissues Immunity 21 2 2004 241 254
35. K. Wolk, and R. Sabat Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells Cytokine Growth Factor Rev 17 5 2006 367 380
36. K. Wolk, E. Witte, E. Wallace, W.D. Docke, S. Kunz, and K. Asadullah IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis Eur J Immunol 36 5 2006 1309 1323
37. P.W. Wu, J. Li, S.R. Kodangattil, D.P. Luxenberg, F. Bennett, and M. Martino IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22 J Mol Biol 382 5 2008 1168 1183
38. M.H. Xie, S. Aggarwal, W.H. Ho, J. Foster, Z. Zhang, and J. Stinson Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R J Biol Chem 275 40 2000 31335 31339
39. H. Xu, D. Wilcox, P. Nguyen, M. Voorbach, T. Suhar, and S.J. Morgan Hepatic knockdown of mitochondrial GPAT1 in ob/ob mice improves metabolic profile Biochem Biophys Res Commun 349 1 2006 439 448
40. M. Yin, M.D. Wheeler, H. Kono, B.U. Bradford, R.M. Gallucci, and M.I. Luster Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice Gastroenterology 117 4 1999 942 952
41. S. Yu, K. Matsusue, P. Kashireddy, W.Q. Cao, V. Yeldandi, and A.V. Yeldandi Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression J Biol Chem 278 1 2003 498 505
42. X.X. Yu, S.F. Murray, S.K. Pandey, S.L. Booten, D. Bao, and X.Z. Song Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice Hepatology 42 2 2005 362 371
43. L.A. Zenewicz, G.D. Yancopoulos, D.M. Valenzuela, A.J. Murphy, M. Karow, and R.A. Flavell Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation Immunity 27 4 2007 647 659
44. L.A. Zenewicz, G.D. Yancopoulos, D.M. Valenzuela, A.J. Murphy, S. Stevens, and R.A. Flavell Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease Immunity 29 6 2008 947 957
45. Y. Zheng, D.M. Danilenko, P. Valdez, I. Kasman, J. Eastham-Anderson, and J. Wu Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis Nature 445 7128 2007 648 651
46. Y. Zheng, P.A. Valdez, D.M. Danilenko, Y. Hu, S.M. Sa, and Q. Gong Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens Nat Med 14 3 2008 282 289