Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis

Gastroenterology

Volumn 143, Issue 6, 2012, Pages 1670-1680

  Xue, Jing ^a   Nguyen, David T C ^a   Habtezion, Aida ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gene Expression; Immune Regulation; Inflammatory Response; T Cell Signaling

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CERULETIDE; CHOLINE; ETHIONINE; INTERLEUKIN 22; RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 22; UNCLASSIFIED DRUG;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DISEASE COURSE; EPITHELIUM CELL; LEUKOCYTE; LUNG INJURY; MOUSE; NONHUMAN; PANCREAS; PRIORITY JOURNAL;

EID: 84869754821     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.08.051     Document Type: Article

References (28)

1. G. Gravante, G. Garcea, S.L. Ong Prediction of mortality in acute pancreatitis: a systematic review of the published evidence Pancreatology 9 2009 601 614
2. H.Y. Gaisano, F.S. Gorelick New insights into the mechanisms of pancreatitis Gastroenterology 136 2009 2040 2044
3. S.C. Liang, X.Y. Tan, D.P. Luxenberg Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides J Exp Med 203 2006 2271 2279
4. L.A. Zenewicz, G.D. Yancopoulos, D.M. Valenzuela Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease Immunity 29 2008 947 957
5. M.H. Xie, S. Aggarwal, W.H. Ho Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R J Biol Chem 275 2000 31335 31339
6. D. Lejeune, L. Dumoutier, S. Constantinescu Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line Pathways that are shared with and distinct from IL-10 J Biol Chem 277 2002 33676 33682
7. A.L. Gurney IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues Int Immunopharmacol 4 2004 669 677
8. G.F. Sonnenberg, L.A. Fouser, D. Artis Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22 Nat Immunol 12 2011 383 390
9. I. Monteleone, A. Rizzo, M. Sarra Aryl hydrocarbon receptorinduced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract Gastroenterology 141 2011 237 248 e1
10. M.S. Alam, Y. Maekawa, A. Kitamura Notch signaling drives IL-22 secretion in CD4b T cells by stimulating the aryl hydrocarbon receptor Proc Natl Acad Sci U S A 107 2010 5943 5948
11. A. Habtezion, R. Kwan, E. Akhtar Panhematin provides a therapeutic benefit in experimental pancreatitis Gut 60 2011 671 679
12. I. Nakamichi, A. Habtezion, B. Zhong Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction J Clin Invest 115 2005 3007 3014
13. J. Xue, X. Li, S. Jiao Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKd independent of hydroxylase activity Gastroenterology 138 2010 606 615
14. D. Menozzi, R.T. Jensen, J.D. Gardner Dispersed pancreatic acinar cells and pancreatic acini Methods Enzymol 192 1990 271 279
15. T.A. Hawkins, R.R. Gala, J.C. Dunbar The lymphocyte and macrophage profile in the pancreas and spleen of NOD mice: percentage of interleukin-2 and prolactin receptors on immunocompetent cell subsets J Reprod Immunol 32 1996 55 71
16. S. Aggarwal, M.H. Xie, M. Maruoka Acinar cells of the pancreas are a target of interleukin-22 J Interferon Cytokine Res 21 2001 1047 1053
17. R. Graf, M. Schiesser, A. Lussi Coordinate regulation of secretory stress proteins (PSP/reg, PAP I, PAP II, and PAP III) in the rat exocrine pancreas during experimental acute pancreatitis J Surg Res 105 2002 136 144
18. M. Gironella, E. Folch-Puy, A. LeGoffic Experimental acute pancreatitis in PAP/HIP knock-out mice Gut 56 2007 1091 1097
19. Y.Y. Lin, D. Viterbo, C.M. Mueller Small-interference RNA gene knockdown of pancreatitis-associated proteins in rat acute pancreatitis Pancreas 36 2008 402 410
20. G.F. Sonnenberg, L.A. Monticelli, M.M. Elloso CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut Immunity 34 2011 122 134
21. S.H. Kim, E.C. Henry, D.K. Kim Novel compound 2-methyl-2H-pyrazole-3- carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor Mol Pharmacol 69 2006 1871 1878
22. L. Braun, T. Kardon, K. El Koulali Different induction of gulonolactone oxidase in aromatic hydrocarbon-responsive or -unresponsive mouse strains FEBS Lett 463 1999 345 349
23. D. Phelan, G.M. Winter, W.J. Rogers Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin Arch Biochem Biophys 357 1998 155 163
24. J. Mayerle A novel role for leucocytes in determining the severity of acute pancreatitis Gut 58 2009 1440 1441
25. D. Feng, O. Park, S. Radaeva Interleukin-22 ameliorates cerulein-induced pancreatitis in mice by inhibiting the autophagic pathway Int J Biol Sci 8 2012 249 257
26. L.A. Zenewicz, R.A. Flavell Recent advances in IL-22 biology Int Immunol 23 2011 159 163
27. A. Demols, O. Le Moine, F. Desalle CD4(+)T cells play an important role in acute experimental pancreatitis in mice Gastroenterology 118 2000 582 590
28. S. Radaeva, R. Sun, H.N. Pan Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation Hepatology 39 2004 1332 1342