IL-10- and IL-20-expressing epithelial and inflammatory cells are increased in patients with ulcerative colitis

Journal of Clinical Immunology

Volumn 33, Issue 3, 2013, Pages 640-648

  Fonseca Camarillo, Gabriela ^a,b   Furuzawa Carballeda, Janette ^b   Llorente, Luis ^b   Yamamoto Furusho, Jesús K ^b  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

Author keywords

Colitis; IL 10; IL 10R1; IL 20R1; IL 20R2; IL10R2; Interleukin (IL) 20; U.; Ulcerative

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 20; INTERLEUKIN 20 RECEPTOR; INTERLEUKIN RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLON BIOPSY; COLON MUCOSA; CONTROLLED STUDY; DISEASE ACTIVITY; EPITHELIUM CELL; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IL 10 GENE; IL 10R1 GENE; IL 10R2 GENE; IL 20 GENE; IL 20R1 GENE; IL 20R2 GENE; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULCERATIVE COLITIS; UPREGULATION;

ADOLESCENT; ADULT; AGED; COLITIS, ULCERATIVE; COLON; FEMALE; GENE EXPRESSION; HUMANS; INTERLEUKIN-10; INTERLEUKIN-10 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-10 RECEPTOR BETA SUBUNIT; INTERLEUKINS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84879880293     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-012-9843-4     Document Type: Article

References (16)

1. Podolsky DK. Inflammatory bowel disease. N England J Med. 2002;347:417-29.
2. Li MC, He SH. IL-10 and its related cytokines for treatment of inflammatory bowel disease. World J Gastroenterol. 2004;10:620-5.
3. Ouyang W, Rutz S, Crellin NK, et al. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol. 2011;23:71-109.
4. Sabat R. IL-10 family of cytokines. Cytokine Growth Factor Rev. 2010;21:315-24.
5. Blumberg H, Conklin D, Xu WF, et al. Interleukin-20: discovery, receptor identification, and role in epidermal function. Cell. 2001;104:9-19.
6. Sa SM, Valdez PA, Wu J, et al. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol. 2007;15:2229-40.
7. Kragstrup TW, Otkjaer K, Holm C, et al. The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy. Cytokine. 2008;4:16-23.
8. Chen WY, Cheng BC, Jiang MJ, et al. IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2006;26:2090-105.
9. Li HH, Cheng HH, Sun KH, et al. Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis. Clin Immunol. 2008;129:277-85.
10. Hsu YH, Chang MS. Interleukin-20 antibody is a potential therapeutic agent for experimental arthritis. Arthritis Rheum. 2010;62:3311-21.
11. Rich BE, Kupper TS. Cytokines: IL-20 - a new effector in skin inflammation. Curr Biol. 2001;11:531-4.
12. Wolk K, Witte K, Witte E, et al. Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes. J Leukoc Biol. 2008;83:1181-93.
13. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683-765.
14. Wegenka UM. IL-20: biological functions mediated through two types of receptor complexes. Cytokine Growth Factor Rev. 2010;21:353-63.
15. Camarillo GF, Furuzawa-Carballeda J, Martínez-Benítez B, et al. Role of the interleukin 24 in patients with ulcerative colitis. Inflamm Bowel Dis. 2011;17:2209-10.
16. Yamamoto-Furusho JK, Miranda-Pérez E, Fonseca-Camarillo G, et al. Colonic epithelial upregulation of Interleukin 22 in patients with ulcerative colitis. Inflamm Bowel Dis. 2010;16:1819-998.