메뉴 건너뛰기




Volumn 40, Issue 12, 2014, Pages 1565-1575

Physicochemical characterization techniques for solid lipid nanoparticles: Principles and limitations

Author keywords

Lipid polymorphism; Particle size; Physico chemical characterization; Poorly soluble drugs; Protein delivery; SLN; Zeta potential

Indexed keywords

LIPID; SOLID LIPID NANOPARTICLE; SURFACTANT; NANOPARTICLE;

EID: 84922226591     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2014.909840     Document Type: Article
Times cited : (94)

References (141)
  • 3
    • 0030602783 scopus 로고    scopus 로고
    • Stability of lipid emulsions for drug delivery
    • Washington C. Stability of lipid emulsions for drug delivery. Adv Drug Deliv Rev 1996;20:131-45.
    • (1996) Adv Drug Deliv Rev , vol.20 , pp. 131-145
    • Washington, C.1
  • 4
    • 0025344957 scopus 로고
    • The use of oil-in-water emulsions as a vehicle for parenteral drug administration
    • Prankerd RJ, Stella VJ. The use of oil-in-water emulsions as a vehicle for parenteral drug administration. J Parenter Sci Technol 1990;44:139-49.
    • (1990) J Parenter Sci Technol , vol.44 , pp. 139-149
    • Prankerd, R.J.1    Stella, V.J.2
  • 5
    • 35048842305 scopus 로고    scopus 로고
    • Liposomal drug delivery systems: An update review
    • Samad A, Sultana Y, Aqil M. Liposomal drug delivery systems: an update review. Curr Drug Deliv 2007;4:297-305.
    • (2007) Curr Drug Deliv , vol.4 , pp. 297-305
    • Samad, A.1    Sultana, Y.2    Aqil, M.3
  • 6
    • 0028939209 scopus 로고
    • Controlled drug delivery with nanoparticles: Current possibilities and future trends
    • Couvreur P, Dubernet C, Puisieux F. Controlled drug delivery with nanoparticles: current possibilities and future trends. Eur J Pharm Biopharm 1995;41:2-13.
    • (1995) Eur J Pharm Biopharm , vol.41 , pp. 2-13
    • Couvreur, P.1    Dubernet, C.2    Puisieux, F.3
  • 8
    • 84922219365 scopus 로고    scopus 로고
    • Functionalized polymeric nanoparticles
    • Cambridge, UK: Cambridge University Press
    • Sussman E, Clark M, Shastri VP. Functionalized polymeric nanoparticles. MRS Proceedings. Cambridge, UK: Cambridge University Press; 2004:M12-19.
    • (2004) MRS Proceedings , pp. M12-19
    • Sussman, E.1    Clark, M.2    Shastri, V.P.3
  • 9
    • 0022496987 scopus 로고
    • Evaluation of poly (lactic acid) as a biodegradable drug delivery system for parenteral administration
    • Smith A. Evaluation of poly (lactic acid) as a biodegradable drug delivery system for parenteral administration. Int J Pharm 1986;30: 215-20.
    • (1986) Int J Pharm , vol.30 , pp. 215-220
    • Smith, A.1
  • 10
    • 34447259574 scopus 로고    scopus 로고
    • Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: Preparation and characterization
    • Liu J, Gong T, Wang C, et al. Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: preparation and characterization. Int J Pharm 2007;340: 153-62.
    • (2007) Int J Pharm , vol.340 , pp. 153-162
    • Liu, J.1    Gong, T.2    Wang, C.3
  • 12
    • 0033800767 scopus 로고    scopus 로고
    • Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: Pharmacokinetics and tissue distribution after iv administration to rats
    • Fundaro A, Cavalli R, Bargoni A, et al. Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: pharmacokinetics and tissue distribution after i.v. administration to rats. Pharmacol Res 2000;42:337-43.
    • (2000) Pharmacol Res , vol.42 , pp. 337-343
    • Fundaro, A.1    Cavalli, R.2    Bargoni, A.3
  • 13
    • 84922217804 scopus 로고
    • Method for producing solid lipid microspheres having a narrow size distribution
    • US 5250236 A
    • Gasco M, Antonelli PL. Method for producing solid lipid microspheres having a narrow size distribution. Maria R. Gasco, Torino, Italy; US 5250236 A;1993:1-4.
    • (1993) Maria R. Gasco Torino Italy , pp. 1-4
    • Gasco, M.1    Antonelli, P.L.2
  • 14
    • 0031960962 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery-Drug release and release mechanism
    • Zur Mühlen A, Schwarz C, Mehnert W. Solid lipid nanoparticles (SLN) for controlled drug delivery-drug release and release mechanism. Eur J Pharm Biopharm 1998;45:149-55.
    • (1998) Eur J Pharm Biopharm , vol.45 , pp. 149-155
    • Zur Mühlen, A.1    Schwarz, C.2    Mehnert, W.3
  • 16
    • 0027738620 scopus 로고
    • Electrophoretic light scattering
    • Takagi T. Electrophoretic light scattering. Electrophoresis 1993;14: 1255-6.
    • (1993) Electrophoresis , vol.14 , pp. 1255-1256
    • Takagi, T.1
  • 17
    • 0038032150 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery-A review of the state of the art
    • Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery-A review of the state of the art. Eur J Pharm Biopharm 2000;50:161-77.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 161-177
    • Müller, R.H.1    Mäder, K.2    Gohla, S.3
  • 18
    • 0032950389 scopus 로고    scopus 로고
    • Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain
    • Yang SC, Lu LF, Cai Y, et al. Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. J Control Release 1999;59:299-307.
    • (1999) J Control Release , vol.59 , pp. 299-307
    • Yang, S.C.1    Lu, L.F.2    Cai, Y.3
  • 19
    • 84863445857 scopus 로고    scopus 로고
    • Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases g-Tocotrienol oral bioavailability
    • Abuasal B, Lucas C, Peyton B, et al. Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases g-Tocotrienol oral bioavailability. Lipids 2012;47:461-9.
    • (2012) Lipids , vol.47 , pp. 461-469
    • Abuasal, B.1    Lucas, C.2    Peyton, B.3
  • 20
    • 10044223246 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs
    • Hu L, Tang X, Cui F. Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs. J Pharm Pharmacol 2004;56:1527-35.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 1527-1535
    • Hu, L.1    Tang, X.2    Cui, F.3
  • 21
    • 77956161610 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for ocular drug delivery
    • Seyfoddin A, Shaw J, Al-Kassas R. Solid lipid nanoparticles for ocular drug delivery. Drug Deliv 2010;17:467-89.
    • (2010) Drug Deliv , vol.17 , pp. 467-489
    • Seyfoddin, A.1    Shaw, J.2    Al-Kassas, R.3
  • 22
    • 34547905035 scopus 로고    scopus 로고
    • Lipid nanoparticles for improved topical application of drugs for skin diseases
    • Schäfer-Korting M, Mehnert W, Korting H-C. Lipid nanoparticles for improved topical application of drugs for skin diseases. Adv Drug Deliv Rev 2007;59:427-43.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 427-443
    • Schäfer-Korting, M.1    Mehnert, W.2    Korting, H.-C.3
  • 23
    • 0028954379 scopus 로고
    • Solid lipid nanoparticles (SLN): An alternative colloidal carrier system for controlled drug delivery
    • Same T, Müller RH, Mehnert W, et al. Solid lipid nanoparticles (SLN): an alternative colloidal carrier system for controlled drug delivery. Eur J Pharm Biopharm 1995;41:62-9.
    • (1995) Eur J Pharm Biopharm , vol.41 , pp. 62-69
    • Same, T.1    Müller, R.H.2    Mehnert, W.3
  • 24
    • 0028285718 scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery i Production, characterization and sterilization
    • Schwarz C, Mehnert W, Lucks JS, Miiller RH. Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization. J Control Release 1994;30:83-96.
    • (1994) J Control Release , vol.30 , pp. 83-96
    • Schwarz, C.1    Mehnert, W.2    Lucks, J.S.3    Miiller, R.H.4
  • 25
    • 0035946615 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: Production, characterization and applications
    • Mehnert W, Mäder K. Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev 2001;47: 165-96.
    • (2001) Adv Drug Deliv Rev , vol.47 , pp. 165-196
    • Mehnert, W.1    Mäder, K.2
  • 26
    • 78649648145 scopus 로고    scopus 로고
    • Lipid nanoparticles for the delivery of poorly watersoluble drugs
    • Bunjes H. Lipid nanoparticles for the delivery of poorly watersoluble drugs. J Pharm Pharmacol 2010;62:1637-45.
    • (2010) J Pharm Pharmacol , vol.62 , pp. 1637-1645
    • Bunjes, H.1
  • 27
    • 84875911854 scopus 로고    scopus 로고
    • Preparation, characterization, cellular uptake and evaluation in vivo of solid lipid nanoparticles loaded with cucurbitacin B
    • Hu H, Liu D, Zhao X, et al. Preparation, characterization, cellular uptake and evaluation in vivo of solid lipid nanoparticles loaded with cucurbitacin B. Drug Dev Ind Pharm 2013;39:770-9.
    • (2013) Drug Dev Ind Pharm , vol.39 , pp. 770-779
    • Hu, H.1    Liu, D.2    Zhao, X.3
  • 28
    • 84886062230 scopus 로고    scopus 로고
    • 6 Emulsions, nanoemulsions and solid lipid nanoparticles as delivery systems in foods
    • Yucel U, Elias RJ, Coupland JN. 6 Emulsions, nanoemulsions and solid lipid nanoparticles as delivery systems in foods. Food Ind Bioprod Bioprocess 2012;167:146-54.
    • (2012) Food Ind Bioprod Bioprocess , vol.167 , pp. 146-154
    • Yucel, U.1    Elias, R.J.2    Coupland, J.N.3
  • 29
    • 33947711751 scopus 로고    scopus 로고
    • Employment of cationic solid-lipid nanoparticles as RNA carriers
    • Montana G, Bondi ML, Carrotta R, et al. Employment of cationic solid-lipid nanoparticles as RNA carriers. Bioconjug Chem 2007;18: 302-8.
    • (2007) Bioconjug Chem , vol.18 , pp. 302-308
    • Montana, G.1    Bondi, M.L.2    Carrotta, R.3
  • 30
    • 84857040855 scopus 로고    scopus 로고
    • Dextranprotamine-solid lipid nanoparticles as a non-viral vector for gene therapy: In vitro characterization and in vivo transfection after intravenous administration to mice
    • Delgado D, Gascon AR, Del Pozo-Rodriguez A, et al. Dextranprotamine-solid lipid nanoparticles as a non-viral vector for gene therapy: in vitro characterization and in vivo transfection after intravenous administration to mice. Int J Pharm 2012;425: 35-43.
    • (2012) Int J Pharm , vol.425 , pp. 35-43
    • Delgado, D.1    Gascon, A.R.2    Del Pozo-Rodriguez, A.3
  • 31
    • 35548968849 scopus 로고    scopus 로고
    • Lipoplex morphologies and their influences on transfection efficiency in gene delivery
    • Ma B, Zhang S, Jiang H, et al. Lipoplex morphologies and their influences on transfection efficiency in gene delivery. J Control Release 2007;123:184-94.
    • (2007) J Control Release , vol.123 , pp. 184-194
    • Ma, B.1    Zhang, S.2    Jiang, H.3
  • 32
    • 57149108667 scopus 로고    scopus 로고
    • A proline-rich peptide improves cell transfection of solid lipid nanoparticle-based non-viral vectors
    • Del Pozo-Rodriguez A, Pujals S, Delgado D, et al. A proline-rich peptide improves cell transfection of solid lipid nanoparticle-based non-viral vectors. J Control Release 2009;133:52-9.
    • (2009) J Control Release , vol.133 , pp. 52-59
    • Del Pozo-Rodriguez, A.1    Pujals, S.2    Delgado, D.3
  • 33
    • 79952920907 scopus 로고    scopus 로고
    • The influence of lipid characteristics on the formation, in vitro release, and in vivo absorption of proteinloaded SLN prepared by the double emulsion process
    • Yang R, Gao R, Li F, et al. The influence of lipid characteristics on the formation, in vitro release, and in vivo absorption of proteinloaded SLN prepared by the double emulsion process. Drug Dev Ind Pharm 2011;37:139-48.
    • (2011) Drug Dev Ind Pharm , vol.37 , pp. 139-148
    • Yang, R.1    Gao, R.2    Li, F.3
  • 34
    • 33750501785 scopus 로고    scopus 로고
    • Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin
    • Zhang N, Ping Q, Huang G, et al. Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin. Int J Pharm 2006;327:153-9.
    • (2006) Int J Pharm , vol.327 , pp. 153-159
    • Zhang, N.1    Ping, Q.2    Huang, G.3
  • 35
    • 0030944482 scopus 로고    scopus 로고
    • Peptide-loaded solid lipid nanoparticles (SLN): Influence of production parameters
    • Almeida AJ, Runge S, Müller RH. Peptide-loaded solid lipid nanoparticles (SLN): influence of production parameters. Int J Pharm 1997;149:255-65.
    • (1997) Int J Pharm , vol.149 , pp. 255-265
    • Almeida, A.J.1    Runge, S.2    Müller, R.H.3
  • 36
    • 84866875931 scopus 로고    scopus 로고
    • Oral delivery of peptides and proteins using lipid-based drug delivery systems
    • Li P, Nielsen HM, Müllertz A. Oral delivery of peptides and proteins using lipid-based drug delivery systems. Exp Opinion Drug Deliv 2012;9:1289-304.
    • (2012) Exp Opinion Drug Deliv , vol.9 , pp. 1289-1304
    • Li, P.1    Nielsen, H.M.2    Müllertz, A.3
  • 37
    • 79958735219 scopus 로고    scopus 로고
    • Physicochemical properties of lipid nanoparticles: Effect of lipid and surfactant composition
    • Martins S, Tho I, Ferreira DC, et al. Physicochemical properties of lipid nanoparticles: effect of lipid and surfactant composition. Drug Dev Ind Pharm 2011;37:815-24.
    • (2011) Drug Dev Ind Pharm , vol.37 , pp. 815-824
    • Martins, S.1    Tho, I.2    Ferreira, D.C.3
  • 38
    • 34547913461 scopus 로고    scopus 로고
    • Stability of lipid excipients in solid lipid nanoparticles
    • Radomska-Soukharev A. Stability of lipid excipients in solid lipid nanoparticles. Adv Drug Deliv Rev 2007;59:411-18.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 411-418
    • Radomska-Soukharev, A.1
  • 39
    • 84885015322 scopus 로고    scopus 로고
    • Direct comparison of fatty acid ratios in single cellular lipid droplets as determined by comparative Raman spectroscopy and gas chromatography
    • Schie IW, Nolte L, Pedersen TL, et al. Direct comparison of fatty acid ratios in single cellular lipid droplets as determined by comparative Raman spectroscopy and gas chromatography. Analyst 2013;138:6662-70.
    • (2013) Analyst , vol.138 , pp. 6662-6670
    • Schie, I.W.1    Nolte, L.2    Pedersen, T.L.3
  • 40
    • 84866241046 scopus 로고    scopus 로고
    • In vitro digestion kinetics of excipients for lipid-based drug delivery and introduction of a relative lipolysis half life
    • Arnold YE, Imanidis G, Kuentz M. In vitro digestion kinetics of excipients for lipid-based drug delivery and introduction of a relative lipolysis half life. Drug Dev Ind Pharm 2012;38:1262-9.
    • (2012) Drug Dev Ind Pharm , vol.38 , pp. 1262-1269
    • Arnold, Y.E.1    Imanidis, G.2    Kuentz, M.3
  • 41
    • 79953234715 scopus 로고    scopus 로고
    • Preparation and evaluation of solid lipid nanoparticles of baicalin for ocular drug delivery system in vitro and in vivo
    • Liu Z, Zhang X, Wu H, et al. Preparation and evaluation of solid lipid nanoparticles of baicalin for ocular drug delivery system in vitro and in vivo. Drug Dev Ind Pharm 2011;37:475-81.
    • (2011) Drug Dev Ind Pharm , vol.37 , pp. 475-481
    • Liu, Z.1    Zhang, X.2    Wu, H.3
  • 42
    • 84875911854 scopus 로고    scopus 로고
    • Preparation, characterization, cellular uptake and evaluation in vivo of solid lipid nanoparticles loaded with cucurbitacin B
    • Hu H, Liu D, Zhao X, et al. Preparation, characterization, cellular uptake and evaluation in vivo of solid lipid nanoparticles loaded with cucurbitacin B. Drug Dev Ind Pharm 2013;39:770-9.
    • (2013) Drug Dev Ind Pharm , vol.39 , pp. 770-779
    • Hu, H.1    Liu, D.2    Zhao, X.3
  • 43
    • 80052099308 scopus 로고    scopus 로고
    • Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: Effects of process variables
    • Das S, Ng WK, Kanaujia P, et al. Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: effects of process variables. Colloids Surf B Biointerfaces 2011;88:483-9.
    • (2011) Colloids Surf B Biointerfaces , vol.88 , pp. 483-489
    • Das, S.1    Ng, W.K.2    Kanaujia, P.3
  • 44
    • 0034042912 scopus 로고    scopus 로고
    • The stability of enzymes after sonication
    • Özbek B, Ülgen KO. The stability of enzymes after sonication. Process Biochem 2000;35:1037-43.
    • (2000) Process Biochem , vol.35 , pp. 1037-1043
    • Özbek, B.1    Ülgen, K.O.2
  • 45
    • 0035994314 scopus 로고    scopus 로고
    • Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturate
    • Olbrich C, Gessner A, Kayser O, Müller RH. Lipid-drug-conjugate (LDC) nanoparticles as novel carrier system for the hydrophilic antitrypanosomal drug diminazenediaceturate. J Drug Target 2002; 10:387-96.
    • (2002) J Drug Target , vol.10 , pp. 387-396
    • Olbrich, C.1    Gessner, A.2    Kayser, O.3    Müller, R.H.4
  • 46
    • 2142812902 scopus 로고    scopus 로고
    • Lipid-drug conjugate nanoparticles of the hydrophilic drug diminazene-cytotoxicity testing and mouse serum adsorption
    • Olbrich C, Gessner A, Schröder W, et al. Lipid-drug conjugate nanoparticles of the hydrophilic drug diminazene-cytotoxicity testing and mouse serum adsorption. J Control Release 2004;96: 425-35.
    • (2004) J Control Release , vol.96 , pp. 425-435
    • Olbrich, C.1    Gessner, A.2    Schröder, W.3
  • 47
    • 84864115348 scopus 로고    scopus 로고
    • Targeted lipid based drug conjugates: A novel strategy for drug delivery
    • Vadlapudi AD, Vadlapatla RK, Kwatra D, et al. Targeted lipid based drug conjugates: a novel strategy for drug delivery. Int J Pharm 2012;434:315-24.
    • (2012) Int J Pharm , vol.434 , pp. 315-324
    • Vadlapudi, A.D.1    Vadlapatla, R.K.2    Kwatra, D.3
  • 48
    • 84884648001 scopus 로고    scopus 로고
    • Lipid drug conjugate nanoparticle as a novel lipid nanocarrier for the oral delivery of decitabine: Ex vivo gut permeation studies
    • doi: 10.1088/0957-4484/24/41/415102
    • Neupane YR, Sabir MD, Ahmad N, et al. Lipid drug conjugate nanoparticle as a novel lipid nanocarrier for the oral delivery of decitabine: ex vivo gut permeation studies. Nanotechnology 2013; 24:415102. doi: 10.1088/0957-4484/24/41/415102.
    • (2013) Nanotechnology , vol.24 , pp. 415102
    • Neupane, Y.R.1    Sabir, M.D.2    Ahmad, N.3
  • 49
    • 79951578183 scopus 로고    scopus 로고
    • Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): Effects on size, physical stability and particle matrix structure
    • Kovacevic A, Savic S, Vuleta G, et al. Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): effects on size, physical stability and particle matrix structure. Int J Pharm 2011;406:163-72.
    • (2011) Int J Pharm , vol.406 , pp. 163-172
    • Kovacevic, A.1    Savic, S.2    Vuleta, G.3
  • 50
    • 10644257823 scopus 로고    scopus 로고
    • Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions
    • Li P, Ghosh A, Wagner RF, et al. Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions. Int J Pharm 2005;288:27-34.
    • (2005) Int J Pharm , vol.288 , pp. 27-34
    • Li, P.1    Ghosh, A.2    Wagner, R.F.3
  • 51
    • 84878333039 scopus 로고    scopus 로고
    • Edible lipid nanoparticles: Digestion, absorption, and potential toxicity
    • McClements DJ. Edible lipid nanoparticles: digestion, absorption, and potential toxicity. Prog Lipid Res 2013;52:409-23.
    • (2013) Prog Lipid Res , vol.52 , pp. 409-423
    • McClements, D.J.1
  • 52
    • 1942453805 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for parenteral drug delivery
    • Wissing SA, Kayser O, Müller RH. Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev 2004;56:1257-72.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1257-1272
    • Wissing, S.A.1    Kayser, O.2    Müller, R.H.3
  • 53
    • 84864438970 scopus 로고    scopus 로고
    • Influence of electrolyte and poloxamer 188 on the aggregation kinetics of solid lipid nanoparticles (SLNs)
    • Wei C-C, Ge Z-Q. Influence of electrolyte and poloxamer 188 on the aggregation kinetics of solid lipid nanoparticles (SLNs). Drug Dev Ind Pharm 2012;38:1084-9.
    • (2012) Drug Dev Ind Pharm , vol.38 , pp. 1084-1089
    • Wei, C.-C.1    Ge, Z.-Q.2
  • 54
    • 84855236495 scopus 로고    scopus 로고
    • Preparation and cytotoxicity of 2-methoxyestradiol-loaded solid lipid nanoparticles
    • Guo X, Xing Y, Mei Q, et al. Preparation and cytotoxicity of 2-methoxyestradiol-loaded solid lipid nanoparticles. Anticancer Drugs 2012;23:185-90.
    • (2012) Anticancer Drugs , vol.23 , pp. 185-190
    • Guo, X.1    Xing, Y.2    Mei, Q.3
  • 55
    • 0036153211 scopus 로고    scopus 로고
    • Medium scale production of solid lipid nanoparticles (SLN) by high pressure homogenization
    • Jenning V, Lippacher A, Gohla SH. Medium scale production of solid lipid nanoparticles (SLN) by high pressure homogenization. J Microencapsul 2002;19:1-10.
    • (2002) J Microencapsul , vol.19 , pp. 1-10
    • Jenning, V.1    Lippacher, A.2    Gohla, S.H.3
  • 57
    • 24444443072 scopus 로고
    • Incorporation in lipospheres of [D-Trp-6] LHRH
    • Morel S, Rosa Gasco M, Cavalli R. Incorporation in lipospheres of [D-Trp-6] LHRH. Int J Pharm 1994;105:R1-3.
    • (1994) Int J Pharm , vol.105 , pp. R1-R3
    • Morel, S.1    Rosa Gasco, M.2    Cavalli, R.3
  • 58
    • 78651449676 scopus 로고    scopus 로고
    • Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: Influences of fatty acids
    • Xie S, Zhu L, Dong Z, et al. Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: influences of fatty acids. Colloids Surfaces B Biointerfaces 2011;83: 382-7.
    • (2011) Colloids Surfaces B Biointerfaces , vol.83 , pp. 382-387
    • Xie, S.1    Zhu, L.2    Dong, Z.3
  • 59
    • 84856287868 scopus 로고    scopus 로고
    • Lipid nanoparticles containing oryzalin for the treatment of leishmaniasis
    • Lopes R, Eleuterio C V, Gonçalves LMD, et al. Lipid nanoparticles containing oryzalin for the treatment of leishmaniasis. Eur J Pharm Sci 2012;45:442-50.
    • (2012) Eur J Pharm Sci , vol.45 , pp. 442-450
    • Lopes, R.1    Eleuterio, C.V.2    Gonçalves, L.M.D.3
  • 60
    • 84875034773 scopus 로고    scopus 로고
    • Indomethacinloaded solid lipid nanoparticles for ocular delivery: Development, characterization, and in vitro evaluation
    • Hippalgaonkar K, Adelli GR, Hippalgaonkar K, et al. Indomethacinloaded solid lipid nanoparticles for ocular delivery: development, characterization, and in vitro evaluation. J Ocul Pharmacol Ther 2013;29:216-28.
    • (2013) J Ocul Pharmacol Ther , vol.29 , pp. 216-228
    • Hippalgaonkar, K.1    Adelli, G.R.2    Hippalgaonkar, K.3
  • 61
    • 35348842195 scopus 로고    scopus 로고
    • Influence of preparation conditions and heat treatment on the properties of supercooled smectic cholesteryl myristate nanoparticles
    • Kuntsche J, Bunjes H. Influence of preparation conditions and heat treatment on the properties of supercooled smectic cholesteryl myristate nanoparticles. Eur J Pharm Biopharm 2007;67:612-20.
    • (2007) Eur J Pharm Biopharm , vol.67 , pp. 612-620
    • Kuntsche, J.1    Bunjes, H.2
  • 62
    • 84874502028 scopus 로고    scopus 로고
    • Development of solid lipid nanoparticles and nanostructured lipid carriers for improving ocular delivery of acyclovir
    • Seyfoddin A, Al-Kassas R. Development of solid lipid nanoparticles and nanostructured lipid carriers for improving ocular delivery of acyclovir. Drug Dev Ind Pharm 2013;39:508-19.
    • (2013) Drug Dev Ind Pharm , vol.39 , pp. 508-519
    • Seyfoddin, A.1    Al-Kassas, R.2
  • 63
    • 84867051502 scopus 로고    scopus 로고
    • Solid lipid nanoparticles of ondansetron HCl for intranasal delivery: Development, optimization and evaluation
    • Joshi AS, Patel HS, Belgamwar VS, et al. Solid lipid nanoparticles of ondansetron HCl for intranasal delivery: development, optimization and evaluation. J Mater Sci Mater Med 2012;23:2163-75.
    • (2012) J Mater Sci Mater Med , vol.23 , pp. 2163-2175
    • Joshi, A.S.1    Patel, H.S.2    Belgamwar, V.S.3
  • 64
    • 0027264830 scopus 로고
    • Investigations on the physical state of lipid nanoparticles by synchrotron radiation X-ray diffraction
    • Westesen K, Siekmann B, Koch MHJ. Investigations on the physical state of lipid nanoparticles by synchrotron radiation X-ray diffraction. Int J Pharm 1993;93:189-99.
    • (1993) Int J Pharm , vol.93 , pp. 189-199
    • Westesen, K.1    Siekmann, B.2    Koch, M.H.J.3
  • 65
    • 0028882123 scopus 로고
    • Study by X-ray powder diffraction and differential scanning calorimetry of two model drugs, phenothiazine and nifedipine, incorporated into lipid nanoparticles
    • Cavalli R, Aquilano D, Carlotti ME, Gasco MR. Study by X-ray powder diffraction and differential scanning calorimetry of two model drugs, phenothiazine and nifedipine, incorporated into lipid nanoparticles. Eur J Pharm Biopharm 1995;41:329-33.
    • (1995) Eur J Pharm Biopharm , vol.41 , pp. 329-333
    • Cavalli, R.1    Aquilano, D.2    Carlotti, M.E.3    Gasco, M.R.4
  • 66
    • 0028548631 scopus 로고
    • Thermoanalysis of the recrystallization process of melt-homogenized glyceride nanoparticles
    • Siekmann B, Westesen K. Thermoanalysis of the recrystallization process of melt-homogenized glyceride nanoparticles. Colloids Surfaces B Biointerfaces 1994;3:159-75.
    • (1994) Colloids Surfaces B Biointerfaces , vol.3 , pp. 159-175
    • Siekmann, B.1    Westesen, K.2
  • 67
    • 0029876015 scopus 로고    scopus 로고
    • Crystallization tendency and polymorphic transitions in triglyceride nanoparticles
    • Bunjes H, Westesen K, Koch MHJ, Michel HJ. Crystallization tendency and polymorphic transitions in triglyceride nanoparticles. Int J Pharm 1996;129:159-73.
    • (1996) Int J Pharm , vol.129 , pp. 159-173
    • Bunjes, H.1    Westesen, K.2    Koch, M.H.J.3    Michel, H.J.4
  • 68
    • 0343618485 scopus 로고    scopus 로고
    • Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids
    • Jenning V, Thünemann AF, Gohla SH. Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids. Int J Pharm 2000;199:167-77.
    • (2000) Int J Pharm , vol.199 , pp. 167-177
    • Jenning, V.1    Thünemann, A.F.2    Gohla, S.H.3
  • 69
    • 47049100427 scopus 로고    scopus 로고
    • Nanoparticles target distinct dendritic cell populations according to their size
    • Manolova V, Flace A, Bauer M, et al. Nanoparticles target distinct dendritic cell populations according to their size. Eur J Immunol 2008;38:1404-13.
    • (2008) Eur J Immunol , vol.38 , pp. 1404-1413
    • Manolova, V.1    Flace, A.2    Bauer, M.3
  • 71
    • 77955515323 scopus 로고
    • Dynamic light scattering: With applications to chemistry biology and physics
    • New York Wiley
    • Berne B, Pecora R. Dynamic light scattering: with applications to chemistry, biology, and physics. Biology and Physics. New York: Wiley; 1976.
    • (1976) Biology and Physics
    • Berne, B.1    Pecora, R.2
  • 72
    • 37249041394 scopus 로고    scopus 로고
    • Nimodipine loaded lipid nanospheres prepared by solvent diffusion method in a drug saturated aqueous system
    • Hu F-Q, Zhang Y, Du Y-Z, Yuan H. Nimodipine loaded lipid nanospheres prepared by solvent diffusion method in a drug saturated aqueous system. Int J Pharm 2008;348:146-52.
    • (2008) Int J Pharm , vol.348 , pp. 146-152
    • Hu, F.-Q.1    Zhang, Y.2    Du, Y.-Z.3    Yuan, H.4
  • 73
    • 0037180882 scopus 로고    scopus 로고
    • Distinguishing heteroaggregation from homoaggregation in mixed binary particle suspensions by multiangle static and dynamic light scattering
    • Yu WL, Borkovec M. Distinguishing heteroaggregation from homoaggregation in mixed binary particle suspensions by multiangle static and dynamic light scattering. J Phys Chem B 2002;106: 13106-10.
    • (2002) J Phys Chem B , vol.106 , pp. 13106-13110
    • Yu, W.L.1    Borkovec, M.2
  • 74
    • 35448977211 scopus 로고    scopus 로고
    • Investigations of the effect of the lipid matrix on drug entrapment, in vitro release, and physical stability of olanzapine-loaded solid lipid nanoparticles
    • doi: 10.1208/pt0804083
    • Vivek K, Reddy H, Murthy RSR. Investigations of the effect of the lipid matrix on drug entrapment, in vitro release, and physical stability of olanzapine-loaded solid lipid nanoparticles. AAPS Pharm Sci Tech 2007;8:E83. doi: 10.1208/pt0804083.
    • (2007) AAPS Pharm Sci Tech , vol.8 , pp. E83
    • Vivek, K.1    Reddy, H.2    Murthy, R.S.R.3
  • 75
    • 84867590653 scopus 로고    scopus 로고
    • Formation of a physical stable delivery system by simply autoclaving nanostructured lipid carriers (NLC)
    • Pardeike J, Weber S, Matsko N, Zimmer A. Formation of a physical stable delivery system by simply autoclaving nanostructured lipid carriers (NLC). Int J Pharm 2012;439:22-7.
    • (2012) Int J Pharm , vol.439 , pp. 22-27
    • Pardeike, J.1    Weber, S.2    Matsko, N.3    Zimmer, A.4
  • 76
    • 41549123975 scopus 로고    scopus 로고
    • Nanoparticles for drug delivery: The need for precision in reporting particle size parameters
    • Gaumet M, Vargas A, Gurny R, Delie F. Nanoparticles for drug delivery: the need for precision in reporting particle size parameters. Eur J Pharm Biopharm 2008;69:1-9.
    • (2008) Eur J Pharm Biopharm , vol.69 , pp. 1-9
    • Gaumet, M.1    Vargas, A.2    Gurny, R.3    Delie, F.4
  • 77
    • 1242338847 scopus 로고    scopus 로고
    • Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy
    • Jores K, Mehnert W, Drechsler M, et al. Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy. J Control Release 2004;95:217-27.
    • (2004) J Control Release , vol.95 , pp. 217-227
    • Jores, K.1    Mehnert, W.2    Drechsler, M.3
  • 78
    • 0037027882 scopus 로고    scopus 로고
    • Biodegradable poly(epsilon-caprolactone) nanoparticles for tumor-Targeted delivery of tamoxifen
    • Chawla JS, Amiji MM. Biodegradable poly(epsilon-caprolactone) nanoparticles for tumor-Targeted delivery of tamoxifen. Int J Pharm 2002;249:127-38.
    • (2002) Int J Pharm , vol.249 , pp. 127-138
    • Chawla, J.S.1    Amiji, M.M.2
  • 79
    • 33846061644 scopus 로고    scopus 로고
    • Particle size analysis in pharmaceutics: Principles, methods and applications
    • Shekunov BY, Chattopadhyay P, Tong HHY, Chow AHL. Particle size analysis in pharmaceutics: principles, methods and applications. Pharm Res 2007;24:203-27.
    • (2007) Pharm Res , vol.24 , pp. 203-227
    • Shekunov, B.Y.1    Chattopadhyay, P.2    Tong, H.H.Y.3    Chow, A.H.L.4
  • 80
    • 84866721319 scopus 로고    scopus 로고
    • Characterization of a nanoparticulate drug delivery system using scanning ion occlusion sensing
    • Yang L, Broom MF, Tucker IG. Characterization of a nanoparticulate drug delivery system using scanning ion occlusion sensing. Pharm Res 2012;29:2578-86.
    • (2012) Pharm Res , vol.29 , pp. 2578-2586
    • Yang, L.1    Broom, M.F.2    Tucker, I.G.3
  • 81
    • 0032526787 scopus 로고    scopus 로고
    • Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLNTM) dispersions
    • Freitas C, Müller RH. Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLNTM) dispersions. Int J Pharm 1998;168:221-9.
    • (1998) Int J Pharm , vol.168 , pp. 221-229
    • Freitas, C.1    Müller, R.H.2
  • 82
    • 79955570813 scopus 로고    scopus 로고
    • Quantitative sizing of nano/ microparticles with a tunable elastomeric pore sensor
    • Vogel R, Willmott G, Kozak D, et al. Quantitative sizing of nano/ microparticles with a tunable elastomeric pore sensor. Anal Chem 2011;83:3499-506.
    • (2011) Anal Chem , vol.83 , pp. 3499-3506
    • Vogel, R.1    Willmott, G.2    Kozak, D.3
  • 83
    • 0344959598 scopus 로고    scopus 로고
    • Stability determination of solid lipid nanoparticles (SLN TM) in aqueous dispersion after addition of electrolyte
    • Freitas C, Müller R. Stability determination of solid lipid nanoparticles (SLN TM) in aqueous dispersion after addition of electrolyte. J Microencapsul 1999;16:59-71.
    • (1999) J Microencapsul , vol.16 , pp. 59-71
    • Freitas, C.1    Müller, R.2
  • 84
    • 0034880490 scopus 로고    scopus 로고
    • Electrolyte-And pH-stabilities of aqueous solid lipid nanoparticle (SLNTM) dispersions in artificial gastrointestinal media
    • Zimmermann E, Müller RH. Electrolyte-And pH-stabilities of aqueous solid lipid nanoparticle (SLNTM) dispersions in artificial gastrointestinal media. Eur J Pharm Biopharm 2001;52:203-10.
    • (2001) Eur J Pharm Biopharm , vol.52 , pp. 203-210
    • Zimmermann, E.1    Müller, R.H.2
  • 85
    • 77955175216 scopus 로고    scopus 로고
    • Strategies in the design of nanoparticles for therapeutic applications
    • Petros RA, DeSimone JM. Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov 2010;9:615-27.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 615-627
    • Petros, R.A.1    Desimone, J.M.2
  • 87
    • 84856032652 scopus 로고    scopus 로고
    • Characterization of ergocalciferol loaded solid lipid nanoparticles
    • Patel MR, San Martin-Gonzalez MF. Characterization of ergocalciferol loaded solid lipid nanoparticles. J Food Sci 2012; 77:N8-13.
    • (2012) J Food Sci , vol.77 , pp. N8-N13
    • Patel, M.R.1    San Martin-Gonzalez, M.F.2
  • 88
    • 10044225776 scopus 로고    scopus 로고
    • Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs
    • Yin Win K, Feng S-S. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials 2005;26:2713-22.
    • (2005) Biomaterials , vol.26 , pp. 2713-2722
    • Yin Win, K.1    Feng, S.-S.2
  • 89
    • 84875231772 scopus 로고    scopus 로고
    • High melting lipid based approach for drug delivery: Solid lipid nanoparticles
    • Kumar S, Randhawa JK. High melting lipid based approach for drug delivery: solid lipid nanoparticles. Mater Sci Eng C Mater Biol Appl 2013;33:1842-52.
    • (2013) Mater Sci Eng C Mater Biol Appl , vol.33 , pp. 1842-1852
    • Kumar, S.1    Randhawa, J.K.2
  • 90
    • 0035051499 scopus 로고    scopus 로고
    • Surface damage formation during ion-beam thinning of samples for transmission electron microscopy
    • McCaffrey JP, Phaneuf MW, Madsen LD. Surface damage formation during ion-beam thinning of samples for transmission electron microscopy. Ultramicroscopy 2001;87:97-104.
    • (2001) Ultramicroscopy , vol.87 , pp. 97-104
    • McCaffrey, J.P.1    Phaneuf, M.W.2    Madsen, L.D.3
  • 91
    • 0015009897 scopus 로고
    • Damage to biological samples caused by the electron beam during electron microscopy
    • Thach RE, Thach SS. Damage to biological samples caused by the electron beam during electron microscopy. Biophys J 1971;11: 204-10.
    • (1971) Biophys J , vol.11 , pp. 204-210
    • Thach, R.E.1    Thach, S.S.2
  • 94
    • 0037723990 scopus 로고    scopus 로고
    • Scanning electron microscopy and atomic force microscopy imaging of solid lipid nanoparticles derived from amphiphilic cyclodextrins
    • Dubes A, Parrot-Lopez H, Abdelwahed W, et al. Scanning electron microscopy and atomic force microscopy imaging of solid lipid nanoparticles derived from amphiphilic cyclodextrins. Eur J Pharm Biopharm 2003;55:279-82.
    • (2003) Eur J Pharm Biopharm , vol.55 , pp. 279-282
    • Dubes, A.1    Parrot-Lopez, H.2    Abdelwahed, W.3
  • 95
    • 0034889869 scopus 로고    scopus 로고
    • Cryo field emission scanning electron microscopy
    • Erlandsen SLOF, Chris C, Chen Y. Cryo field emission scanning electron microscopy. BioTechniques 2001;31:300-5.
    • (2001) Bio Techniques , vol.31 , pp. 300-305
    • Erlandsen, S.L.O.F.1    Chris, C.2    Chen, Y.3
  • 100
    • 41949118305 scopus 로고    scopus 로고
    • Progress in nanoparticles characterization: Sizing and zeta potential measurement
    • Xu R. Progress in nanoparticles characterization: sizing and zeta potential measurement. Particuology 2008;6:112-15.
    • (2008) Particuology , vol.6 , pp. 112-115
    • Xu, R.1
  • 102
    • 79951679560 scopus 로고    scopus 로고
    • Effect of chitosan coating in overcoming the phagocytosis of insulin loaded solid lipid nanoparticles by mononuclear phagocyte system
    • Sarmento B, Mazzaglia D, Bonferoni MC, et al. Effect of chitosan coating in overcoming the phagocytosis of insulin loaded solid lipid nanoparticles by mononuclear phagocyte system. Carbohydr Polym 2011;84:919-25.
    • (2011) Carbohydr Polym , vol.84 , pp. 919-925
    • Sarmento, B.1    Mazzaglia, D.2    Bonferoni, M.C.3
  • 103
    • 13944281688 scopus 로고    scopus 로고
    • Cytotoxic activities of chitosan nanoparticles and copper-loaded nanoparticles
    • Qi L, Xu Z, Jiang X, et al. Cytotoxic activities of chitosan nanoparticles and copper-loaded nanoparticles. Bioorg Med Chem Lett 2005;15:1397-9.
    • (2005) Bioorg Med Chem Lett , vol.15 , pp. 1397-1399
    • Qi, L.1    Xu, Z.2    Jiang, X.3
  • 104
    • 33748344520 scopus 로고    scopus 로고
    • Nanotechnology in cancer therapeutics: Bioconjugated nanoparticles for drug delivery
    • Sinha R, Kim GJ, Nie S, Shin DM. Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery. Mol Cancer Ther 2006;5:1909-17.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1909-1917
    • Sinha, R.1    Kim, G.J.2    Nie, S.3    Shin, D.M.4
  • 105
    • 84880265244 scopus 로고    scopus 로고
    • Polymorphism in the pharmaceutical industry
    • doi: 10.1002/anie.200685424
    • Harris RK. Polymorphism in the pharmaceutical industry. Angew Chemie Int Ed 2006;45:6609. doi: 10.1002/anie.200685424.
    • (2006) Angew Chemie Int Ed , vol.45 , pp. 6609
    • Harris, R.K.1
  • 106
    • 4244117912 scopus 로고
    • The polymorphism of glycerides
    • Chapman D. The polymorphism of glycerides. Chem Rev 1962;62: 433-56.
    • (1962) Chem Rev , vol.62 , pp. 433-456
    • Chapman, D.1
  • 107
    • 0345390953 scopus 로고    scopus 로고
    • Correlation between long-Term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase
    • Freitas C, Müller RH. Correlation between long-Term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase. Eur J Pharm Biopharm 1999;47:125-32.
    • (1999) Eur J Pharm Biopharm , vol.47 , pp. 125-132
    • Freitas, C.1    Müller, R.H.2
  • 108
    • 17344391922 scopus 로고    scopus 로고
    • Vitamin A-loaded solid lipid nanoparticles for topical use: Drug release properties
    • Jenning V, Schäfer-Korting M, Gohla S. Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J Control Release 2000;66:115-26.
    • (2000) J Control Release , vol.66 , pp. 115-126
    • Jenning, V.1    Schäfer-Korting, M.2    Gohla, S.3
  • 109
    • 0028917883 scopus 로고
    • Do nanoparticles prepared from lipids solid at room temperature always possess a solid lipid matrix?
    • Westesen K, Bunjes H. Do nanoparticles prepared from lipids solid at room temperature always possess a solid lipid matrix? Int J Pharm 1995;115:129-31.
    • (1995) Int J Pharm , vol.115 , pp. 129-131
    • Westesen, K.1    Bunjes, H.2
  • 110
    • 0035456233 scopus 로고    scopus 로고
    • Effect of temperature on recrystallization behavior of cocoa butter
    • Langevelde A, Malssen K, Peschar R, Schenk H. Effect of temperature on recrystallization behavior of cocoa butter. J Am Oil Chem Soc 2001;78:919-25.
    • (2001) J Am Oil Chem Soc , vol.78 , pp. 919-925
    • Langevelde, A.1    Malssen, K.2    Peschar, R.3    Schenk, H.4
  • 111
    • 0033699886 scopus 로고    scopus 로고
    • Effect of particle size on colloidal solid triglycerides
    • Bunjes H, Koch MHJ, Westesen K. Effect of particle size on colloidal solid triglycerides. Langmuir 2000;16:5234-41.
    • (2000) Langmuir , vol.16 , pp. 5234-5241
    • Bunjes, H.1    Koch, M.H.J.2    Westesen, K.3
  • 112
    • 84881474298 scopus 로고    scopus 로고
    • Characterization of silver sulfadiazine-loaded solid lipid nanoparticles by thermal analysis
    • Laura C, Milena S, Giovanna B, et al. Characterization of silver sulfadiazine-loaded solid lipid nanoparticles by thermal analysis. J Therm Anal Calorim 2012;111:2149-55.
    • (2012) J Therm Anal Calorim , vol.111 , pp. 2149-2155
    • Laura, C.1    Milena, S.2    Giovanna, B.3
  • 113
    • 77949419485 scopus 로고    scopus 로고
    • Preparation, characterization, and evaluation of gatifloxacin loaded solid lipid nanoparticles as colloidal ocular drug delivery system
    • Khan M, Sultana Y, Ali A, et al. Preparation, characterization, and evaluation of gatifloxacin loaded solid lipid nanoparticles as colloidal ocular drug delivery system. J Drug Target 2009;18: 191-204.
    • (2009) J Drug Target , vol.18 , pp. 191-204
    • Khan, M.1    Sultana, Y.2    Ali, A.3
  • 114
    • 0031185424 scopus 로고    scopus 로고
    • Properties of fatty-Acid esters of starch and their blends with LDPE
    • Thiebaud S, Aburto J, Alric I, et al. Properties of fatty-Acid esters of starch and their blends with LDPE. J Appl Polym Sci 1997;65: 705-21.
    • (1997) J Appl Polym Sci , vol.65 , pp. 705-721
    • Thiebaud, S.1    Aburto, J.2    Alric, I.3
  • 115
    • 29244436380 scopus 로고    scopus 로고
    • Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting
    • Chen H, Chang X, Du D, et al. Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting. J Control Release 2006;110: 296-306.
    • (2006) J Control Release , vol.110 , pp. 296-306
    • Chen, H.1    Chang, X.2    Du, D.3
  • 116
    • 65349085507 scopus 로고    scopus 로고
    • No Minoxidil-loaded nanostructured lipid carriers (NLC): Characterization and rheological behaviour of topical formulations
    • Silva A, Santos D, Ferreira D, Souto E. No Minoxidil-loaded nanostructured lipid carriers (NLC): characterization and rheological behaviour of topical formulations. PHARMAZIE 2009;64: 177-82.
    • (2009) Pharmazie , vol.64 , pp. 177-182
    • Silva, A.1    Santos, D.2    Ferreira, D.3    Souto, E.4
  • 117
    • 33646106067 scopus 로고    scopus 로고
    • Structural investigations on nanoemulsions, solid lipid nanoparticles and nanostructured lipid carriers by cryo-field emission scanning electron microscopy and Raman spectroscopy
    • Saupe A, Gordon KC, Rades T. Structural investigations on nanoemulsions, solid lipid nanoparticles and nanostructured lipid carriers by cryo-field emission scanning electron microscopy and Raman spectroscopy. Int J Pharm 2006;314:56-62.
    • (2006) Int J Pharm , vol.314 , pp. 56-62
    • Saupe, A.1    Gordon, K.C.2    Rades, T.3
  • 118
    • 84856557172 scopus 로고    scopus 로고
    • Physicochemical characterization of curcuminoid-loaded solid lipid nanoparticles
    • Noack A, Hause G, Mäder K. Physicochemical characterization of curcuminoid-loaded solid lipid nanoparticles. Int J Pharm 2012; 423:440-51.
    • (2012) Int J Pharm , vol.423 , pp. 440-451
    • Noack, A.1    Hause, G.2    Mäder, K.3
  • 119
    • 0342350239 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) based on binary mixtures of liquid and solid lipids: A (1)H-NMR study
    • Jenning V, Mäder K, Gohla SH. Solid lipid nanoparticles (SLN) based on binary mixtures of liquid and solid lipids: a (1)H-NMR study. Int J Pharm 2000;205:15-21.
    • (2000) Int J Pharm , vol.205 , pp. 15-21
    • Jenning, V.1    Mäder, K.2    Gohla, S.H.3
  • 120
    • 33746626869 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability
    • Luo Y, Chen D, Ren L, et al. Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability. J Control Release 2006;114:53-9.
    • (2006) J Control Release , vol.114 , pp. 53-59
    • Luo, Y.1    Chen, D.2    Ren, L.3
  • 121
    • 84891530845 scopus 로고    scopus 로고
    • Formulation and invitro characterization of domperidone loaded solid lipid nanoparticles
    • Kotikalapudi LS, Adepu L, Vijayaratna J, Diwan PV. Formulation and invitro characterization of domperidone loaded solid lipid nanoparticles. Int J Pharm 2012;3:22-9.
    • (2012) Int J Pharm , vol.3 , pp. 22-29
    • Kotikalapudi, L.S.1    Adepu, L.2    Vijayaratna, J.3    Diwan, P.V.4
  • 122
    • 33746584827 scopus 로고    scopus 로고
    • Histidine-conjugated poly(amino acid) derivatives for the novel endosomolytic delivery carrier of doxorubicin
    • Yang SR, Lee HJ, Kim J-D. Histidine-conjugated poly(amino acid) derivatives for the novel endosomolytic delivery carrier of doxorubicin. J Control Release 2006;114:60-8.
    • (2006) J Control Release , vol.114 , pp. 60-68
    • Yang, S.R.1    Lee, H.J.2    Kim, J.-D.3
  • 123
    • 33645105885 scopus 로고    scopus 로고
    • Quantitative determination of insulin entrapment efficiency in triblock copolymeric nanoparticles by high-performance liquid chromatography
    • Xu X, Fu Y, Hu H, et al. Quantitative determination of insulin entrapment efficiency in triblock copolymeric nanoparticles by high-performance liquid chromatography. J Pharm Biomed Anal 2006;41:266-73.
    • (2006) J Pharm Biomed Anal , vol.41 , pp. 266-273
    • Xu, X.1    Fu, Y.2    Hu, H.3
  • 124
    • 78650678527 scopus 로고    scopus 로고
    • Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting
    • Aji Alex MR, Chacko AJ, Jose S, Souto EB. Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting. Eur J Pharm Sci 2011;42:11-18.
    • (2011) Eur J Pharm Sci , vol.42 , pp. 11-18
    • Aji Alex, M.R.1    Chacko, A.J.2    Jose, S.3    Souto, E.B.4
  • 125
    • 75449109191 scopus 로고    scopus 로고
    • Cyclosporine-A incorporated cationic solid lipid nanoparticles for ocular delivery
    • Bąsaran E, Demirel M, Sirmagül B, Yazan Y. Cyclosporine-A incorporated cationic solid lipid nanoparticles for ocular delivery. J Microencapsul 2010;27:37-47.
    • (2010) J Microencapsul , vol.27 , pp. 37-47
    • Bąsaran, E.1    Demirel, M.2    Sirmagül, B.3    Yazan, Y.4
  • 126
    • 84856681528 scopus 로고    scopus 로고
    • Preparation and characterization of catalase-loaded solid lipid nanoparticles based on soybean phosphatidylcholine
    • Qi C, Chen Y, Huang J-H, et al. Preparation and characterization of catalase-loaded solid lipid nanoparticles based on soybean phosphatidylcholine. J Sci Food Agric 2012;92:787-93.
    • (2012) J Sci Food Agric , vol.92 , pp. 787-793
    • Qi, C.1    Chen, Y.2    Huang, J.-H.3
  • 127
    • 34347217899 scopus 로고    scopus 로고
    • Development of a new solid lipid nanoparticle formulation containing retinoic acid for topical treatment of acne
    • Castro GA, Orefice RL, Vilela JMC, et al. Development of a new solid lipid nanoparticle formulation containing retinoic acid for topical treatment of acne. J Microencapsul 2007;24: 395-407.
    • (2007) J Microencapsul , vol.24 , pp. 395-407
    • Castro, G.A.1    Orefice, R.L.2    Vilela, J.M.C.3
  • 129
    • 33846677328 scopus 로고    scopus 로고
    • Preparation, characterization and in vitro cytotoxicity of paclitaxel-loaded sterically stabilized solid lipid nanoparticles
    • Lee M-K, Lim S-J, Kim C-K. Preparation, characterization and in vitro cytotoxicity of paclitaxel-loaded sterically stabilized solid lipid nanoparticles. Biomaterials 2007;28:2137-46.
    • (2007) Biomaterials , vol.28 , pp. 2137-2146
    • Lee, M.-K.1    Lim, S.-J.2    Kim, C.-K.3
  • 130
    • 79960686477 scopus 로고    scopus 로고
    • Preparation and in vitro, in vivo evaluations of norfloxacin-loaded solid lipid nanopartices for oral delivery
    • Dong Z, Xie S, Zhu L, et al. Preparation and in vitro, in vivo evaluations of norfloxacin-loaded solid lipid nanopartices for oral delivery. Drug Deliv 2011;18:441-50.
    • (2011) Drug Deliv , vol.18 , pp. 441-450
    • Dong, Z.1    Xie, S.2    Zhu, L.3
  • 131
    • 42649135116 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for pulmonary delivery of insulin
    • Liu J, Gong T, Fu H, et al. Solid lipid nanoparticles for pulmonary delivery of insulin. Int J Pharm 2008;356:333-44.
    • (2008) Int J Pharm , vol.356 , pp. 333-344
    • Liu, J.1    Gong, T.2    Fu, H.3
  • 132
    • 0000815976 scopus 로고
    • Determination of the effective hydrodynamic radii of small molecules by viscometry
    • Schultz SG. Determination of the effective hydrodynamic radii of small molecules by viscometry. J Gen Physiol 1961;44:1189-99.
    • (1961) J Gen Physiol , vol.44 , pp. 1189-1199
    • Schultz, S.G.1
  • 134
    • 78649939261 scopus 로고    scopus 로고
    • Tunable nano/micropores for particle detection and discrimination: Scanning ion occlusion spectroscopy
    • Roberts GS, Kozak D, Anderson W, et al. Tunable nano/micropores for particle detection and discrimination: scanning ion occlusion spectroscopy. Small 2010;6:2653-8.
    • (2010) Small , vol.6 , pp. 2653-2658
    • Roberts, G.S.1    Kozak, D.2    Anderson, W.3
  • 135
    • 0037173520 scopus 로고    scopus 로고
    • Incorporation of cyclosporin A in solid lipid nanoparticles (SLN)
    • Ugazio E, Cavalli R, Gasco MR. Incorporation of cyclosporin A in solid lipid nanoparticles (SLN). Int J Pharm 2002;241:341-4.
    • (2002) Int J Pharm , vol.241 , pp. 341-344
    • Ugazio, E.1    Cavalli, R.2    Gasco, M.R.3
  • 136
    • 0037404980 scopus 로고    scopus 로고
    • The production and characteristics of solid lipid nanoparticles (SLNs)
    • Hou D, Xie C, Huang K, Zhu C. The production and characteristics of solid lipid nanoparticles (SLNs). Biomaterials 2003;24: 1781-5.
    • (2003) Biomaterials , vol.24 , pp. 1781-1785
    • Hou, D.1    Xie, C.2    Huang, K.3    Zhu, C.4
  • 137
    • 0035997341 scopus 로고    scopus 로고
    • Long-circulating poly(ethylene glycol)-modified gelatin nanoparticles for intracellular delivery
    • Kaul G, Amiji M. Long-circulating poly(ethylene glycol)-modified gelatin nanoparticles for intracellular delivery. Pharm Res 2002;19: 1061-7.
    • (2002) Pharm Res , vol.19 , pp. 1061-1067
    • Kaul, G.1    Amiji, M.2
  • 138
    • 17144374563 scopus 로고    scopus 로고
    • Effects of three nickel salts on germinating seeds of Grevillea exul var rubiginosa, an endemic serpentine Proteaceae
    • Leon V, Rabier J, Notonier R, et al. Effects of three nickel salts on germinating seeds of Grevillea exul var. rubiginosa, an endemic serpentine Proteaceae. Ann Bot 2005;95:609-18.
    • (2005) Ann Bot , vol.95 , pp. 609-618
    • Leon, V.1    Rabier, J.2    Notonier, R.3
  • 139
    • 4644241550 scopus 로고    scopus 로고
    • Feature-oriented scanning methodology for probe microscopy and nanotechnology
    • Lapshin RV. Feature-oriented scanning methodology for probe microscopy and nanotechnology. Nanotechnology 2004;15: 1135-51.
    • (2004) Nanotechnology , vol.15 , pp. 1135-1151
    • Lapshin, R.V.1
  • 140
    • 0031000858 scopus 로고    scopus 로고
    • Sterilization and freezedrying of drug-free and drug-loaded solid lipid nanoparticles
    • Cavalli R, Caputo O, Eugenia M, et al. Sterilization and freezedrying of drug-free and drug-loaded solid lipid nanoparticles. J Pharm 1997;148:47-54.
    • (1997) J Pharm , vol.148 , pp. 47-54
    • Cavalli, R.1    Caputo, O.2    Eugenia, M.3
  • 141
    • 0037190052 scopus 로고    scopus 로고
    • Formulation parameters determining the physicochemical characteristics of solid lipid nanoparticles loaded with all-Trans retinoic acid
    • Lim S-J, Kim C-K. Formulation parameters determining the physicochemical characteristics of solid lipid nanoparticles loaded with all-Trans retinoic acid. Int J Pharm 2002;243:135-46.
    • (2002) Int J Pharm , vol.243 , pp. 135-146
    • Lim, S.-J.1    Kim, C.-K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.