메뉴 건너뛰기




Volumn 39, Issue 5, 2013, Pages 770-779

Preparation, characterization, cellular uptake and evaluation in vivo of solid lipid nanoparticles loaded with cucurbitacin B

Author keywords

Anti tumor efficacy; Cellular uptake; Cucurbitacin B; Cytotoxicity; Solid lipid nanoparticles; Tissues distribution

Indexed keywords

ANTINEOPLASTIC AGENT; CUCURBITACIN; CUCURBITACIN B; PHOSPHATIDYLCHOLINE; POLOXAMER; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG;

EID: 84875911854     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2012.702348     Document Type: Article
Times cited : (34)

References (51)
  • 1
    • 21244470815 scopus 로고    scopus 로고
    • Cucurbitacins and cucurbitane glycosides: Structures and biological activities
    • Chen JC, Chiu MH, Nie RL, Cordell GA, Qiu SX. (2005). Cucurbitacins and cucurbitane glycosides: Structures and biological activities. Nat Prod Rep, 22:386-399.
    • (2005) Nat Prod Rep , vol.22 , pp. 386-399
    • Chen, J.C.1    Chiu, M.H.2    Nie, R.L.3    Cordell, G.A.4    Qiu, S.X.5
  • 2
    • 0032603225 scopus 로고    scopus 로고
    • Anti-inflammatory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice
    • Peters RR, Saleh TF, Lora M, Patry C, de Brum-Fernandes AJ, Farias MR et al. (1999). Anti-inflammatory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice. Life Sci, 64:2429-2437.
    • (1999) Life Sci , vol.64 , pp. 2429-2437
    • Peters, R.R.1    Saleh, T.F.2    Lora, M.3    Patry, C.4    De Brum-Fernandes, A.J.5    Farias, M.R.6
  • 3
    • 0023911699 scopus 로고
    • Isolation of an antiinflammatory principle from the fruit juice of Ecballium elaterium
    • Yesilada E, Tanaka S, Sezik E, Tabata M. (1988). Isolation of an antiinflammatory principle from the fruit juice of Ecballium elaterium. J Nat Prod, 51:504-508.
    • (1988) J Nat Prod , vol.51 , pp. 504-508
    • Yesilada, E.1    Tanaka, S.2    Sezik, E.3    Tabata, M.4
  • 5
    • 0036747181 scopus 로고    scopus 로고
    • Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells
    • Oh H, Mun YJ, Im SJ, Lee SY, Song HJ, Lee HS et al. (2002). Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells. Planta Med, 68:832-833.
    • (2002) Planta Med , vol.68 , pp. 832-833
    • Oh, H.1    Mun, Y.J.2    Im, S.J.3    Lee, S.Y.4    Song, H.J.5    Lee, H.S.6
  • 6
    • 0036177350 scopus 로고    scopus 로고
    • Anti-inflammatory and anti-tumor-promoting effects of cucurbitane glycosides from the roots of Bryonia dioica
    • Ukiya M, Akihisa T, Yasukawa K, Tokuda H, Toriumi M, Koike K et al. (2002). Anti-inflammatory and anti-tumor-promoting effects of cucurbitane glycosides from the roots of Bryonia dioica. J Nat Prod, 65:179-183.
    • (2002) J Nat Prod , vol.65 , pp. 179-183
    • Ukiya, M.1    Akihisa, T.2    Yasukawa, K.3    Tokuda, H.4    Toriumi, M.5    Koike, K.6
  • 7
    • 33845225917 scopus 로고    scopus 로고
    • Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells
    • Tannin-Spitz T, Grossman S, Dovrat S, Gottlieb HE, Bergman M. (2007). Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells. Biochem Pharmacol, 73:56-67.
    • (2007) Biochem Pharmacol , vol.73 , pp. 56-67
    • Tannin-Spitz, T.1    Grossman, S.2    Dovrat, S.3    Gottlieb, H.E.4    Bergman, M.5
  • 8
    • 14744287772 scopus 로고    scopus 로고
    • Relationship between cucurbitacins reversed-phase high-performance liquid chromatography hydrophobicity index and basal cytotoxicity on HepG2 cells
    • Bartalis J, Halaweish FT. (2005). Relationship between cucurbitacins reversed-phase high-performance liquid chromatography hydrophobicity index and basal cytotoxicity on HepG2 cells. J Chromatogr B Analyt Technol Biomed Life Sci, 818:159-166.
    • (2005) J Chromatogr B Analyt Technol Biomed Life Sci , vol.818 , pp. 159-166
    • Bartalis, J.1    Halaweish, F.T.2
  • 9
    • 0034665504 scopus 로고    scopus 로고
    • Scale-up of the preparation process of solid lipid nanospheres. Part I
    • Marengo E, Cavalli R, Caputo O, Rodriguez L, Gasco MR. (2000). Scale-up of the preparation process of solid lipid nanospheres. Part I. Int J Pharm, 205:3-13.
    • (2000) Int J Pharm , vol.205 , pp. 3-13
    • Marengo, E.1    Cavalli, R.2    Caputo, O.3    Rodriguez, L.4    Gasco, M.R.5
  • 10
    • 0038032150 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery - A review of the state of the art
    • Muller RH, Mader K, Gohla S. (2000). Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Eur J Pharm Biopharm, 50:161-177.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 161-177
    • Muller, R.H.1    Mader, K.2    Gohla, S.3
  • 11
    • 0034996764 scopus 로고    scopus 로고
    • Long-circulating and target-specific nanoparticles: Theory to practice
    • Moghimi SM, Hunter AC, Murray JC. (2001). Long-circulating and target-specific nanoparticles: Theory to practice. Pharmacol Rev, 53:283-318.
    • (2001) Pharmacol Rev , vol.53 , pp. 283-318
    • Moghimi, S.M.1    Hunter, A.C.2    Murray, J.C.3
  • 12
    • 0035291191 scopus 로고    scopus 로고
    • SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy
    • Maeda H. (2001). SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy. Adv Drug Deliv Rev, 46:169-185.
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 169-185
    • Maeda, H.1
  • 13
    • 0032900507 scopus 로고    scopus 로고
    • Doxorubicin-polymer conjugates: Further demonstration of the concept of enhanced permeability and retention
    • Muggia FM. (1999). Doxorubicin-polymer conjugates: Further demonstration of the concept of enhanced permeability and retention. Clin Cancer Res, 5:7-8.
    • (1999) Clin Cancer Res , vol.5 , pp. 7-8
    • Muggia, F.M.1
  • 14
    • 0024839642 scopus 로고
    • Tumoritropic and lymphotropic principles of macromolecular drugs
    • Maeda H, Matsumura Y. (1989). Tumoritropic and lymphotropic principles of macromolecular drugs. Crit Rev Ther Drug Carrier Syst, 6:193-210.
    • (1989) Crit Rev Ther Drug Carrier Syst , vol.6 , pp. 193-210
    • Maeda, H.1    Matsumura, Y.2
  • 15
    • 70350244685 scopus 로고    scopus 로고
    • PLGA nanoparticles stabilized with cationic surfactant: Safety studies and application in oral delivery of paclitaxel to treat chemical-induced breast cancer in rat
    • Bhardwaj V, Ankola DD, Gupta SC, Schneider M, Lehr CM, Kumar MN. (2009). PLGA nanoparticles stabilized with cationic surfactant: Safety studies and application in oral delivery of paclitaxel to treat chemical-induced breast cancer in rat. Pharm Res, 26:2495-2503.
    • (2009) Pharm Res , vol.26 , pp. 2495-2503
    • Bhardwaj, V.1    Ankola, D.D.2    Gupta, S.C.3    Schneider, M.4    Lehr, C.M.5    Kumar, M.N.6
  • 16
    • 0036848464 scopus 로고    scopus 로고
    • Enhanced brain targeting by synthesis of 3',5'-dioctanoyl-5-fluoro-2'- deoxyuridine and incorporation into solid lipid nanoparticles
    • Wang JX, Sun X, Zhang ZR. (2002). Enhanced brain targeting by synthesis of 3',5'-dioctanoyl-5-fluoro-2'-deoxyuridine and incorporation into solid lipid nanoparticles. Eur J Pharm Biopharm, 54:285-290.
    • (2002) Eur J Pharm Biopharm , vol.54 , pp. 285-290
    • Wang, J.X.1    Sun, X.2    Zhang, Z.R.3
  • 17
    • 34248545518 scopus 로고    scopus 로고
    • Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application
    • Weyenberg W, Filev P, Van den Plas D, Vandervoort J, De Smet K, Sollie P et al. (2007). Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application. Int J Pharm, 337:291-298.
    • (2007) Int J Pharm , vol.337 , pp. 291-298
    • Weyenberg, W.1    Filev, P.2    Van Den Plas, D.3    Vandervoort, J.4    De Smet, K.5    Sollie, P.6
  • 18
    • 0028883318 scopus 로고
    • Application of an original process for obtaining colloidal dispersions of some coats polymers. Preparation, characterization, industrial scaling up
    • Labouret A, Thioune O, Fessi H, Devissaguet JP, Puisieux F. (1995). Application of an original process for obtaining colloidal dispersions of some coats polymers. Preparation, characterization, industrial scaling up. Drug Dev Ind Pharm, 21:229-241.
    • (1995) Drug Dev Ind Pharm , vol.21 , pp. 229-241
    • Labouret, A.1    Thioune, O.2    Fessi, H.3    Devissaguet, J.P.4    Puisieux, F.5
  • 19
    • 77953257877 scopus 로고    scopus 로고
    • Passive and active drug targeting: Drug delivery to tumors as an example
    • Torchilin VP. (2010). Passive and active drug targeting: Drug delivery to tumors as an example. Handb Exp Pharmacol, 197:3-53.
    • (2010) Handb Exp Pharmacol , vol.197 , pp. 3-53
    • Torchilin, V.P.1
  • 20
    • 0031889196 scopus 로고    scopus 로고
    • Effect of particle size and charge on the disposition of lipid carriers after intratumoral injection into tissue-isolated tumors
    • Nomura T, Koreeda N, Yamashita F, Takakura Y, Hashida M. (1998). Effect of particle size and charge on the disposition of lipid carriers after intratumoral injection into tissue-isolated tumors. Pharm Res, 15:128-132.
    • (1998) Pharm Res , vol.15 , pp. 128-132
    • Nomura, T.1    Koreeda, N.2    Yamashita, F.3    Takakura, Y.4    Hashida, M.5
  • 21
    • 0028285718 scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization
    • Schwarz C, Mehnert W, Lucks JS, Muller RH. (1994). Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization. J Control Release, 30:83-96.
    • (1994) J Control Release , Issue.30 , pp. 83-96
    • Schwarz, C.1    Mehnert, W.2    Lucks, J.S.3    Muller, R.H.4
  • 22
    • 77954385672 scopus 로고    scopus 로고
    • The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation
    • Kedmi R, Ben-Arie N, Peer D. (2010). The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation. Biomaterials, 31:6867-6875.
    • (2010) Biomaterials , vol.31 , pp. 6867-6875
    • Kedmi, R.1    Ben-Arie, N.2    Peer, D.3
  • 23
    • 11944265265 scopus 로고    scopus 로고
    • Nanoparticle surface charges alter blood-brain barrier integrity and permeability
    • Lockman PR, Koziara JM, Mumper RJ, Allen DD. (2004). Nanoparticle surface charges alter blood-brain barrier integrity and permeability. J Drug Target, 12:635-641.
    • (2004) J Drug Target , vol.12 , pp. 635-641
    • Lockman, P.R.1    Koziara, J.M.2    Mumper, R.J.3    Allen, D.D.4
  • 24
    • 34547905035 scopus 로고    scopus 로고
    • Lipid nanoparticles for improved topical application of drugs for skin diseases
    • Schafer-Korting M, Mehnert W, Korting HC. (2007). Lipid nanoparticles for improved topical application of drugs for skin diseases. Adv Drug Deliv Rev, 59:427-443.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 427-443
    • Schafer-Korting, M.1    Mehnert, W.2    Korting, H.C.3
  • 25
    • 79954422645 scopus 로고    scopus 로고
    • In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines
    • Bartalis J, Halaweish FT. (2011). In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines. Bioorg Med Chem, 19:2757-2766.
    • (2011) Bioorg Med Chem , vol.19 , pp. 2757-2766
    • Bartalis, J.1    Halaweish, F.T.2
  • 26
    • 0032743565 scopus 로고    scopus 로고
    • Pharmacokinetics and organ distribution of cyclosporin A incorporated in liposomes and mixed micelles
    • Lee MK, Choi L, Kim MH, Kim CK. (1999). Pharmacokinetics and organ distribution of cyclosporin A incorporated in liposomes and mixed micelles. Int J Pharm, 191:87-93.
    • (1999) Int J Pharm , vol.191 , pp. 87-93
    • Lee, M.K.1    Choi, L.2    Kim, M.H.3    Kim, C.K.4
  • 27
    • 0033030870 scopus 로고    scopus 로고
    • Phospholipid-based microemulsions of flurbiprofen by the spontaneous emulsification process
    • Park KM, Lee MK, Hwang KJ, Kim CK. (1999). Phospholipid-based microemulsions of flurbiprofen by the spontaneous emulsification process. Int J Pharm, 183:145-154.
    • (1999) Int J Pharm , vol.183 , pp. 145-154
    • Park, K.M.1    Lee, M.K.2    Hwang, K.J.3    Kim, C.K.4
  • 28
    • 0037345462 scopus 로고    scopus 로고
    • The effect of buffer concentration, pH and buffer ions on the degradation and drug release from polyglycolide
    • Hurrell S, Cameron RE. (2003). The effect of buffer concentration, pH and buffer ions on the degradation and drug release from polyglycolide. Polym Int, 52:358-366.
    • (2003) Polym Int , vol.52 , pp. 358-366
    • Hurrell, S.1    Cameron, R.E.2
  • 29
    • 24644463195 scopus 로고    scopus 로고
    • Preparation and pharmacokinetic evaluation of Tashinone IIA solid lipid nanoparticles
    • Liu J, Zhu J, Du Z, Qin B. (2005). Preparation and pharmacokinetic evaluation of Tashinone IIA solid lipid nanoparticles. Drug Dev Ind Pharm, 31:551-556.
    • (2005) Drug Dev Ind Pharm , vol.31 , pp. 551-556
    • Liu, J.1    Zhu, J.2    Du, Z.3    Qin, B.4
  • 30
    • 1942453805 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for parenteral drug delivery
    • Wissing SA, Kayser O, Muller RH. (2004). Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev, 56:1257-1272.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1257-1272
    • Wissing, S.A.1    Kayser, O.2    Muller, R.H.3
  • 31
    • 34548418880 scopus 로고    scopus 로고
    • Uptake and metabolism of novel biodegradable poly (glycerol-adipate) nanoparticles in DAOY monolayer
    • Meng W, Parker TL, Kallinteri P, Walker DA, Higgins S, Hutcheon GA et al. (2006). Uptake and metabolism of novel biodegradable poly (glycerol-adipate) nanoparticles in DAOY monolayer. J Control Release, 116:314-321.
    • (2006) J Control Release , vol.116 , pp. 314-321
    • Meng, W.1    Parker, T.L.2    Kallinteri, P.3    Walker, D.A.4    Higgins, S.5    Hutcheon, G.A.6
  • 33
    • 0037331856 scopus 로고    scopus 로고
    • Dynamics of endocytosis and exocytosis of poly(D,L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells
    • Panyam J, Labhasetwar V. (2003). Dynamics of endocytosis and exocytosis of poly(D,L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells. Pharm Res, 20:212-220.
    • (2003) Pharm Res , vol.20 , pp. 212-220
    • Panyam, J.1    Labhasetwar, V.2
  • 34
    • 33750073484 scopus 로고    scopus 로고
    • Nanoparticles for cellular drug delivery: Mechanisms and factors influencing delivery
    • Chavanpatil MD, Khdair A, Panyam J. (2006). Nanoparticles for cellular drug delivery: Mechanisms and factors influencing delivery. J Nanosci Nanotechnol, 6:2651-2663.
    • (2006) J Nanosci Nanotechnol , vol.6 , pp. 2651-2663
    • Chavanpatil, M.D.1    Khdair, A.2    Panyam, J.3
  • 35
    • 34548623990 scopus 로고    scopus 로고
    • Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles
    • Park K, Kim JH, Nam YS, Lee S, Nam HY, Kim K et al. (2007). Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles. J Control Release, 122:305-314.
    • (2007) J Control Release , vol.122 , pp. 305-314
    • Park, K.1    Kim, J.H.2    Nam, Y.S.3    Lee, S.4    Nam, H.Y.5    Kim, K.6
  • 36
    • 33847095924 scopus 로고    scopus 로고
    • Effect of PEG conformation and particle size on the cellular uptake efficiency of nanoparticles with the HepG2 cells
    • Hu Y, Xie J, Tong YW, Wang CH. (2007). Effect of PEG conformation and particle size on the cellular uptake efficiency of nanoparticles with the HepG2 cells. J Control Release, 118:7-17.
    • (2007) J Control Release , vol.118 , pp. 7-17
    • Hu, Y.1    Xie, J.2    Tong, Y.W.3    Wang, C.H.4
  • 37
    • 0037130209 scopus 로고    scopus 로고
    • Residual polyvinyl alcohol associated with poly (D,L-lactide-co- glycolide) nanoparticles affects their physical properties and cellular uptake
    • Sahoo SK, Panyam J, Prabha S, Labhasetwar V. (2002). Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. J Control Release, 82:105-114.
    • (2002) J Control Release , vol.82 , pp. 105-114
    • Sahoo, S.K.1    Panyam, J.2    Prabha, S.3    Labhasetwar, V.4
  • 39
    • 37249078585 scopus 로고    scopus 로고
    • Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells
    • Yuan H, Miao J, Du YZ, You J, Hu FQ, Zeng S. (2008). Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells. Int J Pharm, 348:137-145.
    • (2008) Int J Pharm , vol.348 , pp. 137-145
    • Yuan, H.1    Miao, J.2    Du, Y.Z.3    You, J.4    Hu, F.Q.5    Zeng, S.6
  • 40
    • 77952896692 scopus 로고    scopus 로고
    • A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung
    • Nassimi M, Schleh C, Lauenstein HD, Hussein R, Hoymann HG, Koch W et al. (2010). A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung. Eur J Pharm Biopharm, 75:107-116.
    • (2010) Eur J Pharm Biopharm , vol.75 , pp. 107-116
    • Nassimi, M.1    Schleh, C.2    Lauenstein, H.D.3    Hussein, R.4    Hoymann, H.G.5    Koch, W.6
  • 41
    • 79955794727 scopus 로고    scopus 로고
    • Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): High pressure homogenization versus ultrasound
    • Silva AC, Gonzalez-Mira E, Garcia ML, Egea MA, Fonseca J, Silva R et al. (2011). Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): high pressure homogenization versus ultrasound. Colloids Surf B Biointerfaces, 86:158-165.
    • (2011) Colloids Surf B Biointerfaces , vol.86 , pp. 158-165
    • Silva, A.C.1    Gonzalez-Mira, E.2    Garcia, M.L.3    Egea, M.A.4    Fonseca, J.5    Silva, R.6
  • 42
    • 24944496710 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration
    • Manjunath K, Venkateswarlu V. (2005). Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration. J Control Release, 107:215-228.
    • (2005) J Control Release , vol.107 , pp. 215-228
    • Manjunath, K.1    Venkateswarlu, V.2
  • 43
    • 40449122796 scopus 로고    scopus 로고
    • Nanoparticlemediated cellular response is size-dependent
    • Jiang W, Kim BY, Rutka JT, Chan WC. (2008). Nanoparticlemediated cellular response is size-dependent. Nat Nanotechnol, 3:145-150.
    • (2008) Nat Nanotechnol , vol.3 , pp. 145-150
    • Jiang, W.1    Kim, B.Y.2    Rutka, J.T.3    Chan, W.C.4
  • 44
    • 0029360711 scopus 로고
    • Long circulating microparticulate drug carriers
    • Stolnik S, Illum L, Davis SS. (1995). Long circulating microparticulate drug carriers. Adv Drug Deliv Rev, 16:195-214.
    • (1995) Adv Drug Deliv Rev , vol.16 , pp. 195-214
    • Stolnik, S.1    Illum, L.2    Davis, S.S.3
  • 46
    • 29544448116 scopus 로고    scopus 로고
    • Polymer conjugates: Nanosized medicines for treating cancer
    • Vicent MJ, Duncan R. (2006). Polymer conjugates: Nanosized medicines for treating cancer. Trends Biotechnol, 24:39-47.
    • (2006) Trends Biotechnol , vol.24 , pp. 39-47
    • Vicent, M.J.1    Duncan, R.2
  • 47
    • 0034993240 scopus 로고    scopus 로고
    • The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor-selective macromolecular drug targeting
    • Maeda H. (2001). The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor-selective macromolecular drug targeting. Adv Enzyme Regul, 41:189-207.
    • (2001) Adv Enzyme Regul , vol.41 , pp. 189-207
    • Maeda, H.1
  • 48
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
    • Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. (2000). Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review. J Control Release, 65:271-284.
    • (2000) J Control Release , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 49
    • 41549123975 scopus 로고    scopus 로고
    • Nanoparticles for drug delivery: The need for precision in reporting particle size parameters
    • Gaumet M, Vargas A, Gurny R, Delie F. (2008). Nanoparticles for drug delivery: The need for precision in reporting particle size parameters. Eur J Pharm Biopharm, 69:1-9.
    • (2008) Eur J Pharm Biopharm , vol.69 , pp. 1-9
    • Gaumet, M.1    Vargas, A.2    Gurny, R.3    Delie, F.4
  • 51
    • 0032950389 scopus 로고    scopus 로고
    • Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain
    • Yang SC, Lu LF, Cai Y, Zhu JB, Liang BW, Yang CZ. (1999). Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. J Control Release, 59:299-307.
    • (1999) J Control Release , vol.59 , pp. 299-307
    • Yang, S.C.1    Lu, L.F.2    Cai, Y.3    Zhu, J.B.4    Liang, B.W.5    Yang, C.Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.