Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ

Biochemical Pharmacology

Volumn 91, Issue 4, 2014, Pages 501-509

  Heyninck, Karen ^a   Lahtela Kakkonen, Maija ^b   Van Der Veken, Pieter ^c   Haegeman, Guy ^a   Berghe, Wim Vanden ^a,c  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Cysteine; Inflammation; Kinase; Natural product; Signal transduction

Indexed keywords

AYURVEDIC DRUG; CYSTEINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NATURAL PRODUCT; PROTEIN KINASE; WITHAFERIN A; I KAPPA B KINASE; WITHANOLIDE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; AYURVEDA; CONTROLLED STUDY; ENZYME ACTIVITY; EXPRESSION VECTOR; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; LUCIFERASE ASSAY; MEDICINAL PLANT; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SIGNAL TRANSDUCTION; WITHANIA SOMNIFERA; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYME ACTIVE SITE; LIQUID CHROMATOGRAPHY; METABOLISM;

CATALYTIC DOMAIN; CHROMATOGRAPHY, LIQUID; CYSTEINE; HEK293 CELLS; HUMANS; I-KAPPA B KINASE; NF-KAPPA B; WITHANOLIDES;

EID: 84921643209     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.08.004     Document Type: Article

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