1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes

British Journal of Pharmacology

Volumn 167, Issue 1, 2012, Pages 128-140

  Lee, Hwa Young ^a   Park, Sun Hong ^a   Lee, Misoon ^a   Kim, Hye Jin ^b   Ryu, Shi Yong ^b   Kim, Nam Doo ^c   Hwang, Bang Yeon ^a   Hong, Jin Tae ^a   Han, Sang Bae ^a   Kim, Youngsoo ^a  

^a Chungbuk National University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Daegu Gyeongbuk Medical Innovation Foundation   (South Korea)

Author keywords

1 dehydro 10 gingerdione; ginger (Zingiber officinale); inflammatory gene; inhibitory B kinase ; macrophages; NF B

Indexed keywords

1 DEHYDRO [10] GINGERDIONE; ANTIINFLAMMATORY AGENT; CYSTEINE; GINGER EXTRACT; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOMODULATING AGENT; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CATALYSIS; CONTROLLED STUDY; COX 2 GENE; CYTOPLASM; DRUG ISOLATION; DRUG TARGETING; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE; GENE EXPRESSION REGULATION; GINGER; IL 6 GENE; INDUCIBLE NOS GENE; INFLAMMATORY GENE; INNATE IMMUNITY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION;

ALKALINE PHOSPHATASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION; GINGER; GUAIACOL; I-KAPPA B KINASE; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER;

EID: 84864642665     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01980.x     Document Type: Article

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