Inhibition of NFB by the natural product withaferin a in cellular models of cystic fibrosis inflammation

Journal of Inflammation

Volumn 6, Issue , 2009, Pages

  Maitra, Rangan ^a   Porter, Melissa A ^a   Huang, Shan ^b   Gilmour, Brian P ^a  

^a RTI INTERNATIONAL   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; WITHAFERIN A;

ARTICLE; BACTERIUM ISOLATE; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG SCREENING; FLUORESCENCE; GENE TRANSLOCATION; HUMAN; HUMAN CELL; RESPIRATORY TRACT DISEASE; WITHANIA SOMNIFERA;

BACTERIA (MICROORGANISMS); HAEMOPHILUS INFLUENZAE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; WITHANIA SOMNIFERA;

EID: 67651171596     PISSN: None     EISSN: 14769255     Source Type: Journal    
DOI: 10.1186/1476-9255-6-15     Document Type: Article

References (26)

1. What we know and what we do not know about cystic fibrosis transmembrane conductance regulator. J Ma PB Davis, Clinics in Chest Medicine 1998 19 459 471 10.1016/S0272-5231(05)70093-9 9759549 (Pubitemid 28421621)
2. Genotype-phenotype correlation in cystic fibrosis patients. M Ferrari L Cremonesi, Annales de Biologie Clinique 1996 54 235 241 8949420
3. Role of CFTR in airway disease. JM Pilewski RA Frizzell, Physiol Rev 1999 79 S215 255 9922383
4. Inflammation and CFTR: might neutrophils be the key in cystic fibrosis? V Witko-Sarsat I Sermet-Gaudelus G Lenoir B Descamps-Latscha, Mediators Inflamm 1999 8 8 7 11 10704083 10.1080/09629359990658
5. The role of inflammation in the pathophysiology of CF lung disease. JF Chmiel M Berger MW Konstan, Clin Rev Allergy Immunol 2002 23 5 27 10.1385/CRIAI:23:1:005 12162106
6. TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells. CM Greene TP Carroll SG Smith CC Taggart J Devaney S Griffin SJ O'Neill NG McElvaney, J Immunol 2005 174 1638 1646 15661927
7. Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis. N Aldallal EE McNaughton LJ Manzel AM Richards J Zabner TW Ferkol DC Look, Am J Respir Crit Care Med 2002 166 1248 1256 10.1164/rccm.200206-627OC 12403695 (Pubitemid 35222603)
8. TNF-alpha, IL-8, soluble ICAM-1, and neutrophils in sputum of cystic fibrosis patients. PS Salva NA Doyle L Graham H Eigen CM Doerschuk, Pediatr Pulmonol 1996 21 11 19 10.1002/(SICI)1099-0496(199601)21:1<11::AID- PPUL2>3.0.CO;2-T 8776260
9. Pathophysiology and management of pulmonary infections in cystic fibrosis. RL Gibson JL Burns BW Ramsey, Am J Respir Crit Care Med 2003 168 918 951 10.1164/rccm.200304-505SO 14555458 (Pubitemid 37267172)
10. TLR signaling. T Kawai S Akira, Cell Death Differ 2006 13 816 825 10.1038/sj.cdd.4401850 16410796
11. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. LC Mishra BB Singh S Dagenais, Altern Med Rev 2000 5 334 346 10956379
12. Small molecule anti-angiogenic probes of the ubiquitin proteasome pathway: potential application to choroidal neovascularization. P Bargagna-Mohan PP Ravindranath R Mohan, Invest Ophthalmol Vis Sci 2006 47 4138 4145 10.1167/iovs.05-1452 16936134 (Pubitemid 46044333)
13. Withaferin A is a potent inhibitor of angiogenesis. R Mohan HJ Hammers P Bargagna-Mohan XH Zhan CJ Herbstritt A Ruiz L Zhang AD Hanson BP Conner J Rougas VS Pribluda, Angiogenesis 2004 7 115 122 10.1007/s10456-004-1026-3 15516832 (Pubitemid 39491728)
14. Cytokine secretion by cystic fibrosis airway epithelial cells. MN Becker MS Sauer MS Muhlebach AJ Hirsh Q Wu MW Verghese SH Randell, Am J Respir Crit Care Med 2004 169 645 653 10.1164/rccm.200207-765OC 14670800
15. Airway epithelial cell tolerance to Pseudomonas aeruginosa. Q Wu Z Lu MW Verghese SH Randell, Respir Res 2005 6 26 15804356 10.1186/1465-9921-6-26 (Pubitemid 41358043)
16. Infection and inflammation in cystic fibrosis: A short review. H Heijerman, J Cyst Fibros 2005 4 Suppl 2 3 5 10.1016/j.jcf.2005.05.005 15970469 (Pubitemid 41131322)
17. The role of airway epithelium and blood neutrophils in the inflammatory response in cystic fibrosis. SW Terheggen-Lagro GT Rijkers CK van der Ent, J Cyst Fibros 2005 4 Suppl 2 15 23 10.1016/j.jcf.2005.05.007 15967736 (Pubitemid 41131324)
18. Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide. R MacRedmond C Greene CC Taggart N McElvaney S O'Neill, Respir Res 2005 6 116 16219107 10.1186/1465-9921-6-116 (Pubitemid 41554936)
19. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. V Hornung S Rothenfusser S Britsch A Krug B Jahrsdorfer T Giese S Endres G Hartmann, J Immunol 2002 168 4531 4537 11970999
20. The role of nuclear factor kappa B in the pathogenesis of pulmonary diseases: implications for therapy. JG Wright JW Christman, Am J Respir Med 2003 2 211 219 14720003
21. Nuclear factor kappa B is a promising therapeutic target in inflammatory lung disease. GY Park JW Christman, Curr Drug Targets 2006 7 661 668 10.2174/138945006777435317 16787168 (Pubitemid 43827261)
22. The role of nuclear factor-kappa B in pulmonary diseases. JW Christman RT Sadikot TS Blackwell, Chest 2000 117 1482 1487 10.1378/chest.117.5.1482 10807839
23. The use of complementary and alternative medicine in children with chronic medical conditions. DZ Samdup RG Smith S Il Song, Am J Phys Med Rehabil 2006 85 842 846 10.1097/01.phm.0000233183.17059.b9 16998432 (Pubitemid 44450609)
24. Actin microfilament aggregation induced by withaferin A is mediated by annexin II. RR Falsey MT Marron GM Gunaherath N Shirahatti D Mahadevan AA Gunatilaka L Whitesell, Nat Chem Biol 2006 2 33 38 10.1038/nchembio755 16408090
25. Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves. B Jayaprakasam Y Zhang NP Seeram MG Nair, Life Sci 2003 74 125 132 10.1016/j.lfs.2003.07.007 14575818 (Pubitemid 37324225)
26. Antiinflammatory therapies for cystic fibrosis: past, present, and future. WA Prescott Jr CE Johnson, Pharmacotherapy 2005 25 555 573 10.1592/phco.25.4.555.61025 15977917 (Pubitemid 40471498)