3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells

Journal of Biological Chemistry

Volumn 287, Issue 1, 2012, Pages 245-256

  Yadav, Vivek R ^a   Prasad, Sahdeo ^a   Gupta, Subash C ^a   Sung, Bokyung ^a   Phatak, Sharangdhar S ^a   Zhang, Shuxing ^a   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION PATHWAY; ANTICANCER POTENTIALS; CHROMONES; CYSTEINE RESIDUES; CYTOKINES; DOWN-REGULATION; GENE PRODUCTS; NUCLEAR FACTORS; NUCLEAR TRANSLOCATIONS; OKADAIC ACID; PHORBOL ESTERS; REGULATED GENES; REPORTER-GENE EXPRESSION; SURVIVIN; TUMOR CELLS; TUMORIGENESIS;

AMINO ACIDS; CELL DEATH; ENZYMES; PHOSPHORYLATION; PLANTS (BOTANY); TUMORS;

GENE EXPRESSION;

3 FORMYLCHROMONE; CHROMONE DERIVATIVE; CYCLIN D1; CYCLOOXYGENASE 2; CYSTEINE; CYSTEINE 179; CYSTEINE 38; ENDOTOXIN; GELATINASE B; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; OKADAIC ACID; PHORBOL ESTER; PROTEIN BCL 2; PROTEIN BCL XL; SERINE; SURVIVIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME REGULATION; GENE MUTATION; GENE PRODUCT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SENSITIZATION; TUMOR CELL;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOGENS; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CHROMONES; CYCLOOXYGENASE 2; CYSTEINE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HUMANS; I-KAPPA B KINASE; MAP KINASE KINASE KINASES; MODELS, MOLECULAR; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEOLYSIS; TIME FACTORS; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84855262939     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.274613     Document Type: Article

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