Modification of cysteine 179 of IκBα kinase by nimbolide leads to down-regulation of NF-κB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents

Journal of Biological Chemistry

Volumn 285, Issue 46, 2010, Pages 35406-35417

  Gupta, Subash C ^a   Prasad, Sahdeo ^a   Reuter, Simone ^a   Kannappan, Ramaswamy ^a   Yadav, Vivek R ^a   Ravindran, Jayaraj ^a   Hema, Padmanabhan S ^b   Chaturvedi, Madan M ^a,c   Nair, Mangalam ^b   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b REGIONAL RESEARCH LABORATORY CSIR   (India)

^c UNIVERSITY OF DELHI   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; APOPTOSIS; AZADIRACHTA INDICA; CANCER DRUG; CELL SURVIVAL; CHEMOTHERAPEUTIC AGENTS; CONSTITUTIVELY ACTIVES; CYCLIND1; CYSTEINE RESIDUES; DNA BINDING; DOWN-REGULATION; GENE TRANSCRIPTIONS; INFLAMMATORY CYTOKINES; INFLAMMATORY STIMULI; MOLECULAR ENTITIES; NUCLEAR FACTORS; NUCLEAR TRANSLOCATIONS; PROLIFERATIVE PROTEINS; TRITERPENOIDS; TUMOR CELLS;

AMINO ACIDS; CELL DEATH; PHOSPHORYLATION; PROTEINS; TRANSCRIPTION;

TUMORS;

ALANINE; ANTINEOPLASTIC AGENT; CARCINOGEN; CYCLIN D1; CYSTEINE; CYTOKINE; FLUOROURACIL; GELATINASE B; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; NIMBOLIDE; PROTEIN BCL 2; PROTEIN BCL XL; THALIDOMIDE; VASCULOTROPIN;

ANGIOGENESIS; APOPTOSIS; ARTICLE; AZADIRACHTA INDICA; CANCER CELL; CANCER CELL CULTURE; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENTIATION; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

AMINO ACID SUBSTITUTION; APOPTOSIS; AZADIRACHTA; BLOTTING, WESTERN; CASPASES; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN D1; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HEK293 CELLS; HL-60 CELLS; HUMANS; I-KAPPA B KINASE; JURKAT CELLS; K562 CELLS; LIMONINS; MOLECULAR STRUCTURE; NEOPLASMS; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

AZADIRACHTA INDICA;

EID: 78149259518     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.161984     Document Type: Article

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