Gambogic acid covalently modifies IκB kinase-β subunit to mediate suppression of lipopolysaccharide-induced activation of NF-κB in macrophages

Biochemical Journal

Volumn 419, Issue 2, 2009, Pages 401-409

  Palempall, Umamaheshwari D ^a   Gandhi, Ujjawal ^a   Kalantari, Parisa ^a   Vunta, Hema ^a   Arner, Ryan J ^a   Narayan, Vivek ^a   Ravindran, Anand ^a   Prabhu, K Sandeep ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Anti inflammatory activity; Cyclo oxygenase 2 (COX 2); Gambogic acid; Inhibitory B (I B) kinase (IKK ); Plant derived bioactive; Polyprenylated xanthone

Indexed keywords

ANTI-INFLAMMATORY ACTIVITY; CYCLO-OXYGENASE-2 (COX-2); GAMBOGIC ACID; PLANT-DERIVED BIOACTIVE; POLYPRENYLATED XANTHONE;

ACIDS; GELATION; GENES; MACROPHAGES; NUCLEIC ACIDS; POLYSACCHARIDES; RESINS; RNA;

GENETIC ALGORITHMS;

CD71 ANTIGEN; CYCLOOXYGENASE 2 INHIBITOR; CYSTEINE; GAMBOGIC ACID; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; I KAPPA B KINASE; TRANSCRIPTION FACTOR RELA; XANTHONE DERIVATIVE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DNA BINDING; DOWN REGULATION; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN TRANSPORT; PROTEOMICS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; IMMUNOPRECIPITATION; METABOLISM;

GARCINIA HANBURYI; GARCINIA MORELLA;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLOW CYTOMETRY; HUMANS; I-KAPPA B KINASE; IMMUNOPRECIPITATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; XANTHONES;

EID: 64249171904     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081482     Document Type: Article

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