-
1
-
-
4344668661
-
Drug Repositioning: Identifying and Developing New Uses for Existing Drugs
-
Ashburn T. T., Thor K. B. Drug Repositioning: Identifying and Developing New Uses for Existing Drugs. Nat. Rev. Drug Disc. 2004 ; 3: 673-683
-
(2004)
Nat. Rev. Drug Disc
, vol.3
, pp. 673-683
-
-
Ashburn, T.T.1
Thor, K.B.2
-
3
-
-
84867445885
-
NCATS Launches Drug Repurposing Program
-
Allison M. NCATS Launches Drug Repurposing Program. Nature Biotechnology. 2012 ; 30: 571-572
-
(2012)
Nature Biotechnology
, vol.30
, pp. 571-572
-
-
Allison, M.1
-
4
-
-
79961166537
-
Finding Promiscuous Old Drugs for New Uses
-
Ekins S., Williams A. J. Finding Promiscuous Old Drugs for New Uses. Pharm. Res 28. 2011 ;: 1785-1791
-
(2011)
Pharm. Res 28
, pp. 1785-1791
-
-
Ekins, S.1
Williams, A.J.2
-
5
-
-
84863204946
-
Drug Repurposing Programmes Get Lift off
-
Mullard A. Drug Repurposing Programmes Get Lift Off. Nat. Rev. Drug Disc. 2012 ; 11: 505-506
-
(2012)
Nat. Rev. Drug Disc
, vol.11
, pp. 505-506
-
-
Mullard, A.1
-
6
-
-
84921482380
-
AstraZeneca's Compound Interest
-
Osherovich L. AstraZeneca's Compound Interest. SciBX. 2012 ; 5 ( 1 ):
-
(2012)
SciBX
, vol.5
, Issue.1
-
-
Osherovich, L.1
-
7
-
-
75949093281
-
Is Open Innovation the Way Forward for Big Pharma?
-
Hunter J., Stephens S. Is Open Innovation the Way Forward for Big Pharma?. Nat. Rev. Drug Disc. 2010 ; 9: 87-88
-
(2010)
Nat. Rev. Drug Disc
, vol.9
, pp. 87-88
-
-
Hunter, J.1
Stephens, S.2
-
9
-
-
77955114844
-
Is Pharma Running out of Brainy Ideas?
-
Miller G. Is Pharma Running Out of Brainy Ideas?. Science. 2010 ; 329: 502-504
-
(2010)
Science
, vol.329
, pp. 502-504
-
-
Miller, G.1
-
10
-
-
84879459828
-
Innovating by Developing New Uses of Already-Approved Drugs: Trends in the Marketing Approval of Supplemental Indications
-
DiMasi J. A. Innovating by Developing New Uses of Already-Approved Drugs: Trends in the Marketing Approval of Supplemental Indications. Clin. Ther. 2013 ; 35: 808-818
-
(2013)
Clin. Ther
, vol.35
, pp. 808-818
-
-
Dimasi, J.A.1
-
12
-
-
84858978535
-
Drug Repositioning for Personalized Medicine
-
Li Y. Y., Jones S. J. Drug Repositioning for Personalized Medicine. Genome Med. 2012 ; 4: 27
-
(2012)
Genome Med
, vol.4
, pp. 27
-
-
Li, Y.Y.1
Jones, S.J.2
-
13
-
-
48049086591
-
Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases
-
Brenk R., Schipani A., James D., et al. Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases. Chem. Med. Chem. 2008 ; 3: 435-444
-
(2008)
Chem. Med. Chem
, vol.3
, pp. 435-444
-
-
Brenk, R.1
Schipani, A.2
James, D.3
-
14
-
-
79961001524
-
Partnering between Pharma Peers on the Rise
-
Mullard A. Partnering between Pharma Peers on the Rise. Nat. Rev. Drug Disc. 2011 ; 10: 561-562
-
(2011)
Nat. Rev. Drug Disc
, vol.10
, pp. 561-562
-
-
Mullard, A.1
-
15
-
-
79955428497
-
The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics
-
Huang R., Southall N., Wang Y., et al. The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics. Sci. Transl. Med. 2011 ; 27: 80
-
(2011)
Sci. Transl. Med
, vol.27
, pp. 80
-
-
Huang, R.1
Southall, N.2
Wang, Y.3
-
16
-
-
33746381549
-
A Clinical Drug Library Screen Identifies Astemizole as an Antimalarial Agent
-
Chong C. R., Chen X., Shi L., et al. A Clinical Drug Library Screen Identifies Astemizole as an Antimalarial Agent. Nat. Chem. Biol. 2006 ; 2: 415-416
-
(2006)
Nat. Chem. Biol
, vol.2
, pp. 415-416
-
-
Chong, C.R.1
Chen, X.2
Shi, L.3
-
17
-
-
84878888598
-
Predictive Methods in Drug Repurposing: Gold Mine or Just a Bigger Haystack?
-
Cavalla D. Predictive Methods in Drug Repurposing: Gold Mine or Just a Bigger Haystack?. Drug Discov. Today. 2013 ; 18: 523-532
-
(2013)
Drug Discov. Today
, vol.18
, pp. 523-532
-
-
Cavalla, D.1
-
18
-
-
84901357361
-
Toward Better Drug Repositioning: Prioritizing and Integrating Existing Methods into Efficient Pipelines
-
Jin G., Wong S. T. C. Toward Better Drug Repositioning: Prioritizing and Integrating Existing Methods into Efficient Pipelines. Drug Disc. Today. 2014 ; 9: 637-644
-
(2014)
Drug Disc. Today
, vol.9
, pp. 637-644
-
-
Jin, G.1
Wong, S.T.C.2
-
19
-
-
84875459651
-
Computational Drug Repositioning: From Data to Therapeutics
-
Hurle M. R., Yang L., Xie Q., et al. Computational Drug Repositioning: From Data to Therapeutics. Clin. Pharmacol. Ther. 2013 ; 93: 335-341
-
(2013)
Clin. Pharmacol. Ther
, vol.93
, pp. 335-341
-
-
Hurle, M.R.1
Yang, L.2
Xie, Q.3
-
20
-
-
84875718672
-
Transcriptional Data: A New Gateway to Drug Repositioning?
-
Iorio F., Rittman T., Ge H., et al. Transcriptional Data: A New Gateway to Drug Repositioning?. Drug Discov. Today. 2013 ; 18: 350-357
-
(2013)
Drug Discov. Today
, vol.18
, pp. 350-357
-
-
Iorio, F.1
Rittman, T.2
Ge, H.3
-
21
-
-
84894660885
-
Pathway Analysis for Drug Repositioning Based on Public Database Mining
-
Pan Y., Cheng T., Wang Y., et al. Pathway Analysis for Drug Repositioning Based on Public Database Mining. J. Chem. Inf. Model. 2014 ; 54: 407-418
-
(2014)
J. Chem. Inf. Model
, vol.54
, pp. 407-418
-
-
Pan, Y.1
Cheng, T.2
Wang, Y.3
-
22
-
-
80052026293
-
Repositioning Chloroquine and Metformin to Eliminate Cancer Stem Cell Traits in Pre-malignant Lesions
-
Vazquez-Martin A., López-Bonetc E., Cufí S., et al. Repositioning Chloroquine and Metformin to Eliminate Cancer Stem Cell Traits in Pre-malignant Lesions. Drug Resist. Update. 2011 ; 14: 212-223
-
(2011)
Drug Resist. Update
, vol.14
, pp. 212-223
-
-
Vazquez-Martin, A.1
López-Bonetc, E.2
Cufí, S.3
-
23
-
-
84867338003
-
Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data
-
Sirota M., Dudley J. T., Kim J., et al. Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data. Sci. Transl. Med. 2011 ; 3 ( 96 ):
-
(2011)
Sci. Transl. Med
, vol.3
, Issue.96
-
-
Sirota, M.1
Dudley, J.T.2
Kim, J.3
-
24
-
-
80051831092
-
Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease
-
Dudley J. T., Sirota M., Shenoy M., et al. Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease. Sci. Transl. Med. 2011 ; 3 ( 96 ):
-
(2011)
Sci. Transl. Med
, vol.3
, Issue.96
-
-
Dudley, J.T.1
Sirota, M.2
Shenoy, M.3
-
25
-
-
84867332154
-
Linking PharmGKB to Phenotype Studies and Animal Models of Disease for Drug Repurposing
-
Hoehndorf R., Oellrich A., Rebholz-Schuhmann D., et al. Linking PharmGKB to Phenotype Studies and Animal Models of Disease for Drug Repurposing. Pac. Symp. Biocomput. 2012: 388-399
-
Pac. Symp. Biocomput
, vol.2012
, pp. 388-399
-
-
Hoehndorf, R.1
Oellrich, A.2
Rebholz-Schuhmann, D.3
-
26
-
-
84862218504
-
Drug Repurposing through Nonhypothesis Driven Phenotypic Screening
-
Reaume A. Drug Repurposing through Nonhypothesis Driven Phenotypic Screening. Drug Disc. Today. 2011 ; 8: 85-88
-
(2011)
Drug Disc. Today
, vol.8
, pp. 85-88
-
-
Reaume, A.1
-
28
-
-
77649220176
-
Phenotypic Screening: Zebrafish Behavior in Profile
-
Whalley K. Phenotypic Screening: Zebrafish Behavior in Profile. Nature Rev. Drug Disc. 2010 ; 9: 192-193
-
(2010)
Nature Rev. Drug Disc
, vol.9
, pp. 192-193
-
-
Whalley, K.1
-
30
-
-
33745223646
-
Finding Function in Novel Targets: C. Elegans as a Model Organism
-
Kaletta T., Hengartner M. O. Finding Function in Novel Targets: C. elegans as a Model Organism. Nat. Rev. Drug Disc. 2006 ; 5: 387-399
-
(2006)
Nat. Rev. Drug Disc
, vol.5
, pp. 387-399
-
-
Kaletta, T.1
Hengartner, M.O.2
-
31
-
-
85069278218
-
Zebrafish as a Platform for in Vivo Drug Discovery
-
McRae C. A., Peterson R. T. Zebrafish as a Platform for In Vivo Drug Discovery. Drug Disc. Today Dis. Mod. 2013 ; 10: e1 -e56
-
(2013)
Drug Disc. Today Dis. Mod
, vol.10
, pp. e1-e56
-
-
McRae, C.A.1
Peterson, R.T.2
-
32
-
-
33644824638
-
High-Throughput Assay for Small Molecules That Modulate Zebrafish Embryonic Heart Rate
-
Burns C. G., Milan D. J., Grande E. J., et al. High-Throughput Assay for Small Molecules That Modulate Zebrafish Embryonic Heart Rate. Nat. Chem. Biol. 2005 ; 1: 263-264
-
(2005)
Nat. Chem. Biol
, vol.1
, pp. 263-264
-
-
Burns, C.G.1
Milan, D.J.2
Grande, E.J.3
-
33
-
-
0037453021
-
Drugs That Induce Repolarization Abnormalities Cause Bradycardia in Zebrafish
-
Milan D. J., Peterson T. A., Ruskin J. N., et al. Drugs That Induce Repolarization Abnormalities Cause Bradycardia in Zebrafish. Circulation. 2003 ; 107: 1355-1358
-
(2003)
Circulation
, vol.107
, pp. 1355-1358
-
-
Milan, D.J.1
Peterson, T.A.2
Ruskin, J.N.3
-
34
-
-
84876798186
-
The Zebrafish Reference Genome Sequence and Its Relationship to the Human Genome
-
Howe K., Clark M. D., Torroja C. F., et al. The Zebrafish Reference Genome Sequence and Its Relationship to the Human Genome. Nature. 2013 ; 496: 498-503
-
(2013)
Nature
, vol.496
, pp. 498-503
-
-
Howe, K.1
Clark, M.D.2
Torroja, C.F.3
-
35
-
-
84883819705
-
High Throughput in Vivo Phenotyping: The Zebrafish as Tool for Drug Discovery for Hematopoietic Stem Cells and Cancer
-
Binder V., Zon L. I. High Throughput In Vivo Phenotyping: The Zebrafish as Tool for Drug Discovery for Hematopoietic Stem Cells and Cancer. Drug Disc. Today Dis. Mod. 2013 ; 10: e17 -e22
-
(2013)
Drug Disc. Today Dis. Mod
, vol.10
, pp. e17-e22
-
-
Binder, V.1
Zon, L.I.2
-
36
-
-
54449099444
-
Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology
-
Leung M. C. K., Williams P. L., Benedetto A., et al. Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology. Toxicol. Sci. 2008 ; 106: 5-28
-
(2008)
Toxicol. Sci
, vol.106
, pp. 5-28
-
-
Leung, M.C.K.1
Williams, P.L.2
Benedetto, A.3
-
37
-
-
33646933785
-
A Small-Molecule Screen in C. Elegans Yields a New Calcium Channel Antagonist
-
Kwok T. C. Y., Ricker N., Fraser R., et al. A Small-Molecule Screen in C. elegans Yields a New Calcium Channel Antagonist. Nature. 2006 ; 441: 91-95
-
(2006)
Nature
, vol.441
, pp. 91-95
-
-
Kwok, T.C.Y.1
Ricker, N.2
Fraser, R.3
-
38
-
-
34250697119
-
The Versatile Worm: Genetic and Genomic Resources for Caenorhabditis elegans Research
-
Antoshechkin I., Sternberg P. W. The Versatile Worm: Genetic and Genomic Resources for Caenorhabditis elegans Research. Nat. Rev. Genet. 2007 ; 8: 518-532
-
(2007)
Nat. Rev. Genet
, vol.8
, pp. 518-532
-
-
Antoshechkin, I.1
Sternberg, P.W.2
-
39
-
-
82755181551
-
Chemical Screen Identifies FDA Approved Drugs and Target Pathways That Induce Precocious Pancreatic Endocrine Differentiation
-
Rovira M., Huang W., Yusuff S., et al. Chemical Screen Identifies FDA Approved Drugs and Target Pathways That Induce Precocious Pancreatic Endocrine Differentiation. Proc. Natl. Acad. Sci. USA. 2011 ; 108: 19264-19269
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 19264-19269
-
-
Rovira, M.1
Huang, W.2
Yusuff, S.3
-
40
-
-
84899062886
-
Larval Zebrafish Model for FDA-Approved Drug Repositioning for Tobacco Dependence Treatment
-
Cousin M. A., Ebbert J. O., Wiinamaki A. R., et al. Larval Zebrafish Model for FDA-Approved Drug Repositioning for Tobacco Dependence Treatment. PLoS ONE. 2014 ; 9: e90467
-
(2014)
PLoS ONE
, vol.9
, pp. 90467
-
-
Cousin, M.A.1
Ebbert, J.O.2
Wiinamaki, A.R.3
-
41
-
-
84870543302
-
Screen of FDA-Approved Drug Library Reveals Compounds That Protect Hair Cells from Aminoglycosides and Cisplatin
-
Vlasits A. L., Simon J. A., Raible D. W., et al. Screen of FDA-Approved Drug Library Reveals Compounds That Protect Hair Cells from Aminoglycosides and Cisplatin. Hear. Res. 2012 ; 294: 153-165
-
(2012)
Hear. Res
, vol.294
, pp. 153-165
-
-
Vlasits, A.L.1
Simon, J.A.2
Raible, D.W.3
-
42
-
-
70349487183
-
Notch-Responsive Cells Initiate the Secondary Transition in Larval Zebrafish Pancreas
-
Parsons M. J., Pisharath H., Yusuff S., et al. Notch-Responsive Cells Initiate the Secondary Transition in Larval Zebrafish Pancreas. Mech. Dev. 2009 ; 126: 898-912
-
(2009)
Mech. Dev
, vol.126
, pp. 898-912
-
-
Parsons, M.J.1
Pisharath, H.2
Yusuff, S.3
-
43
-
-
84862675419
-
Zebrafish: A Model for the Study of Addiction Genetics
-
Klee E. W., Schneider H., Clark K. J., et al. Zebrafish: A Model for the Study of Addiction Genetics. Hum. Genet. 2012 ; 131: 977-1008
-
(2012)
Hum. Genet
, vol.131
, pp. 977-1008
-
-
Klee, E.W.1
Schneider, H.2
Clark, K.J.3
-
44
-
-
79956137330
-
Zebrafish for the Study of the Biological Effects of Nicotine
-
Klee E. W., Ebbert J. O., Schneider H., et al. Zebrafish for the Study of the Biological Effects of Nicotine. Nicotine Tob. Res. 2011 ; 13: 301-312
-
(2011)
Nicotine Tob. Res
, vol.13
, pp. 301-312
-
-
Klee, E.W.1
Ebbert, J.O.2
Schneider, H.3
-
46
-
-
29444440271
-
The Genetics of Hearing and Balance in Zebrafish
-
Nicolson T. The Genetics of Hearing and Balance in Zebrafish. Ann. Rev. Genet. 2005 ; 39: 9-22
-
(2005)
Ann. Rev. Genet
, vol.39
, pp. 9-22
-
-
Nicolson, T.1
-
47
-
-
77954142973
-
Drug Reprofiling Using Zebrafish Identifies Novel Compounds with Potential Promyelination Effects
-
Buckley C. E., Marguerie A., Roach A. G., et al. Drug Reprofiling Using Zebrafish Identifies Novel Compounds with Potential Promyelination Effects. Neuropharmacology. 2010 ; 59: 149-159
-
(2010)
Neuropharmacology
, vol.59
, pp. 149-159
-
-
Buckley, C.E.1
Marguerie, A.2
Roach, A.G.3
-
48
-
-
67349234898
-
Identification of FDA-Approved Drugs and Bioactives That Protect Hair Cells in the Zebrafish (Danio rerio) Lateral Line and Mouse (Mus musculus) Utricle
-
Ou H. C., Cunningham L. L., Francis S. P., et al. Identification of FDA-Approved Drugs and Bioactives That Protect Hair Cells in the Zebrafish (Danio rerio) Lateral Line and Mouse (Mus musculus) Utricle. J. Assoc. Res. Otolaryngol. 2009 ; 10: 191-203
-
(2009)
J. Assoc. Res. Otolaryngol
, vol.10
, pp. 191-203
-
-
Ou, H.C.1
Cunningham, L.L.2
Francis, S.P.3
-
49
-
-
81155134279
-
FDA-Approved Drugs That Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect against Proteotoxicity
-
Lublin A., Isoda F., Patel H., et al. FDA-Approved Drugs That Protect Mammalian Neurons from Glucose Toxicity Slow Aging Dependent on Cbp and Protect against Proteotoxicity. PLoS ONE. 2011 ; 6: e27762
-
(2011)
PLoS ONE
, vol.6
, pp. 27762
-
-
Lublin, A.1
Isoda, F.2
Patel, H.3
-
50
-
-
12244261636
-
Anticonvulsant Medications Extend Worm Life-Span
-
Evason K., Huang C., Yamben I., et al. Anticonvulsant Medications Extend Worm Life-Span. Science. 2005 ; 307: 258-262
-
(2005)
Science
, vol.307
, pp. 258-262
-
-
Evason, K.1
Huang, C.2
Yamben, I.3
-
52
-
-
84879189895
-
The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases
-
Spangenberg T., Burrows J. N., Kowalczyk P., et al. The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases. PLoS ONE. 2013 ; 8: e62906
-
(2013)
PLoS ONE
, vol.8
, pp. 62906
-
-
Spangenberg, T.1
Burrows, J.N.2
Kowalczyk, P.3
-
53
-
-
84863695210
-
Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference
-
Cheng F., Liu C., Jiang J., et al. Prediction of Drug-Target Interactions and Drug Repositioning via Network-Based Inference. PLoS Comput. Biol. 2012 ; 8: e1002503
-
(2012)
PLoS Comput. Biol
, vol.8
, pp. 1002503
-
-
Cheng, F.1
Liu, C.2
Jiang, J.3
-
54
-
-
80053453210
-
A Computational Approach to Finding Novel Targets for Existing Drugs
-
Li Y. Y., An J., Jones S. J. A Computational Approach to Finding Novel Targets for Existing Drugs. PLoS Comput. Biol. 2011 ; 7: e1002139
-
(2011)
PLoS Comput. Biol
, vol.7
, pp. 1002139
-
-
Li, Y.Y.1
An, J.2
Jones, S.J.3
-
55
-
-
0035986688
-
Cysteine Proteases of Malaria Parasites: Targets for Chemotherapy
-
Rosenthal P. J., Sijwali P. S., Singh A., et al. Cysteine Proteases of Malaria Parasites: Targets for Chemotherapy. Curr. Pharm. Des. 2002 ; 8: 1659-1672
-
(2002)
Curr. Pharm. des
, vol.8
, pp. 1659-1672
-
-
Rosenthal, P.J.1
Sijwali, P.S.2
Singh, A.3
-
56
-
-
84864577700
-
Cure of Hookworm Infection with a Cysteine Protease Inhibitor
-
Vermeire J. J., Lantz L. D., Caffrey C. R. Cure of Hookworm Infection with a Cysteine Protease Inhibitor. PLoS Negl. Trop. Dis. 2012 ; 6: e1680
-
(2012)
PLoS Negl. Trop. Dis
, vol.6
, pp. 1680
-
-
Vermeire, J.J.1
Lantz, L.D.2
Caffrey, C.R.3
-
57
-
-
0025103741
-
Antischistosomal Action of Mevinolin: Evidence That 3-Hydroxy-Methylglutaryl-Coenzyme a Reductase Activity in Schistosoma mansoni is Vital for Parasite Survival
-
Chen G. Z., Foster L., Bennett J. L. Antischistosomal Action of Mevinolin: Evidence That 3-Hydroxy-Methylglutaryl-Coenzyme a Reductase Activity in Schistosoma mansoni Is Vital for Parasite Survival. Naunyn. Schmiedebergs Arch. Pharmacol. 1990 ; 342: 477-482
-
(1990)
Naunyn. Schmiedebergs Arch. Pharmacol
, vol.342
, pp. 477-482
-
-
Chen, G.Z.1
Foster, L.2
Bennett, J.L.3
-
59
-
-
0036697233
-
Protein Kinases as Drug Targets in Parasitic Protozoa
-
Doerig C., Meijer L., Mottram J. C. Protein Kinases as Drug Targets in Parasitic Protozoa. Trends Parasitol. 2002 ; 18: 366-371
-
(2002)
Trends Parasitol
, vol.18
, pp. 366-371
-
-
Doerig, C.1
Meijer, L.2
Mottram, J.C.3
-
61
-
-
77649268555
-
Repositioning of an Existing Drug for the Neglected Tropical Disease Onchocerciasis
-
Gloeckner C., Garner A. L., Mersha F., et al. Repositioning of an Existing Drug for the Neglected Tropical Disease Onchocerciasis. Proc. Natl. Acad. Sci. USA. 2010 ; 107: 3424-3429
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 3424-3429
-
-
Gloeckner, C.1
Garner, A.L.2
Mersha, F.3
-
62
-
-
70449568249
-
Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening
-
Abdulla M-H., Ruelas D. S., Wolff B., et al. Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening. PLoS Negl. Trop. Dis. 2009 ; 3: e478
-
(2009)
PLoS Negl. Trop. Dis
, vol.3
, pp. 478
-
-
Abdulla, M.-H.1
Ruelas, D.S.2
Wolff, B.3
-
63
-
-
0034614334
-
A Long Twentieth Century of the Cell Cycle, and beyond
-
Nurse P. A Long Twentieth Century of the Cell Cycle, and Beyond. Cell. 2000 ; 100: 71-78
-
(2000)
Cell
, vol.100
, pp. 71-78
-
-
Nurse, P.1
-
64
-
-
64049108552
-
Side Effects of Benznidazole as a Treatment in Chronic Chagas Disease: Fears and Realities
-
Viotti R., Vigliano C., Lococo B., et al. Side Effects of Benznidazole as a Treatment in Chronic Chagas Disease: Fears and Realities. Exp. Rev. Anti-infect. Ther. 2009 ; 7: 157-163
-
(2009)
Exp. Rev. Anti-infect. Ther
, vol.7
, pp. 157-163
-
-
Viotti, R.1
Vigliano, C.2
Lococo, B.3
-
65
-
-
84871882795
-
Reprofiled Drug Targets Ancient Protozoans
-
Debnath A., Ndao M., Reed S. L. Reprofiled Drug Targets Ancient Protozoans. Gut Microbes. 2013 ; 4: 66-71
-
(2013)
Gut Microbes
, vol.4
, pp. 66-71
-
-
Debnath, A.1
Ndao, M.2
Reed, S.L.3
-
66
-
-
84875625471
-
A Reprofiled Drug, Auranofin, is Effective against Metronidazole-Resistant Giardia lamblia
-
Tejman-Yarden N., Miyamoto Y., Leitsch D., et al. A Reprofiled Drug, Auranofin, Is Effective against Metronidazole-Resistant Giardia lamblia. Antimicrob. Agents Chemother. 2013 ; 57: 2029-2035
-
(2013)
Antimicrob. Agents Chemother
, vol.57
, pp. 2029-2035
-
-
Tejman-Yarden, N.1
Miyamoto, Y.2
Leitsch, D.3
-
67
-
-
67649628133
-
Cathepsin K Inhibitors for Osteoporosis and Potential Off-Target Effects
-
Bromme D., Lacaille F. Cathepsin K Inhibitors for Osteoporosis and Potential Off-Target Effects. Exp. Opin. Invest. Drugs. 2009 ; 18: 585-600
-
(2009)
Exp. Opin. Invest. Drugs
, vol.18
, pp. 585-600
-
-
Bromme, D.1
Lacaille, F.2
-
68
-
-
0030824367
-
Avr-15 Encodes a Chloride Channel Subunit That Mediates Inhibitory Glutamatergic Neurotransmission and Ivermectin Sensitivity
-
Dent J. A., Davis M. W., Avery L. avr-15 Encodes a Chloride Channel Subunit That Mediates Inhibitory Glutamatergic Neurotransmission and Ivermectin Sensitivity. Caenorhabditis elegans. EMBO J. 1997 ; 16: 5867-5879
-
(1997)
Caenorhabditis Elegans. EMBO J
, vol.16
, pp. 5867-5879
-
-
Dent, J.A.1
Davis, M.W.2
Avery, L.3
-
69
-
-
58449137106
-
Brain Penetration of Ivermectin and Selamectin in mdr1a,b P-glycoprotein-and bcrp-Deficient Knockout Mice
-
Geyer J., Gavrilova O., Petzinger E. Brain Penetration of Ivermectin and Selamectin in mdr1a,b P-glycoprotein-and bcrp-Deficient Knockout Mice. J. Vet. Pharmacol. Ther. 2009 ; 32: 87-96
-
(2009)
J. Vet. Pharmacol. Ther
, vol.32
, pp. 87-96
-
-
Geyer, J.1
Gavrilova, O.2
Petzinger, E.3
-
70
-
-
84878042492
-
Kinase Scaffold Repurposing for Neglected Disease Drug Discovery: Discovery of an Efficacious, Lapatanib-Derived Lead Compound for Trypanosomiasis
-
Patel G., Karver C. E., Behera R., et al. Kinase Scaffold Repurposing for Neglected Disease Drug Discovery: Discovery of an Efficacious, Lapatanib-Derived Lead Compound for Trypanosomiasis. J. Med. Chem. 2013 ; 56: 3820-3832
-
(2013)
J. Med. Chem
, vol.56
, pp. 3820-3832
-
-
Patel, G.1
Karver, C.E.2
Behera, R.3
-
71
-
-
84876033143
-
The Human Aurora Kinase Inhibitor Danusertib is a Lead Compound for Anti-trypanosomal Drug Discovery via Target Repurposing
-
Ochiana S. O., Pandarinath V., Wang Z., et al. The Human Aurora Kinase Inhibitor Danusertib Is a Lead Compound for Anti-trypanosomal Drug Discovery via Target Repurposing. Eur. J. Med. Chem. 2013 ; 62: 777-784
-
(2013)
Eur. J. Med. Chem
, vol.62
, pp. 777-784
-
-
Ochiana, S.O.1
Pandarinath, V.2
Wang, Z.3
-
73
-
-
84860746711
-
Amantadine: The Journey from Fighting Flu to Treating Parkinson Disease
-
Hubsher G., Haider M., Okun M. S. Amantadine: The Journey from Fighting Flu to Treating Parkinson Disease. Neurology. 2012 ; 3: 1096-1099
-
(2012)
Neurology
, vol.3
, pp. 1096-1099
-
-
Hubsher, G.1
Haider, M.2
Okun, M.S.3
-
75
-
-
0037078312
-
The Prevention of Dementia with Antihypertensive Treatment
-
Forette F., Seux M. L., Staessen J. A., et al. The Prevention of Dementia with Antihypertensive Treatment. Arch. Intern. Med. 2002 ; 162: 2046-2052
-
(2002)
Arch. Intern. Med
, vol.162
, pp. 2046-2052
-
-
Forette, F.1
Seux, M.L.2
Staessen, J.A.3
-
76
-
-
79952860789
-
Selective Antihypertensive Dihydropyridines Lower Ab Accumulation by Targeting Both the Production and Clearance of Ab across the Blood-Brain Barrier
-
Paris D., Bachmeier C., Patel N., et al. Selective Antihypertensive Dihydropyridines Lower Ab Accumulation by Targeting Both the Production and Clearance of Ab across the Blood-Brain Barrier. Mol. Med. 2011 ; 17: 149-162
-
(2011)
Mol. Med
, vol.17
, pp. 149-162
-
-
Paris, D.1
Bachmeier, C.2
Patel, N.3
-
77
-
-
84875320351
-
Striking Reduction of Amyloid Plaque Burden in an Alzheimer's Mouse Model after Chronic Administration of Carmustine
-
Hayes C. D., Dey D., Palavicini J. P., et al. Striking Reduction of Amyloid Plaque Burden in an Alzheimer's Mouse Model after Chronic Administration of Carmustine. BMC Med. 2013 ; 26: 81
-
(2013)
BMC Med
, vol.26
, pp. 81
-
-
Hayes, C.D.1
Dey, D.2
Palavicini, J.P.3
-
79
-
-
77954721903
-
Drug Repurposing for Drug Development in Stroke
-
Fagan S. C. Drug Repurposing for Drug Development in Stroke. Pharmacotherapy. 2010 ; 30: 51S -54S
-
(2010)
Pharmacotherapy
, vol.30
, pp. 51S-54S
-
-
Fagan, S.C.1
-
80
-
-
77954699101
-
Repurposing an Old Drug to Improve the Safety and Use of Tissue Plasminogen Activator for Acute Ischemic Stroke: Minocycline
-
Hess D. C., Fagan S. Repurposing an Old Drug to Improve the Safety and Use of Tissue Plasminogen Activator for Acute Ischemic Stroke: Minocycline. Pharmacotherapy. 2010 ; 30 :
-
(2010)
Pharmacotherapy
, vol.30
-
-
Hess, D.C.1
Fagan, S.2
-
81
-
-
85019460426
-
An Open-Label Evaluator-Blinded Clinical Study of Minocycline Neuroprotection in Ischemic Stroke: Gender-Dependent Effect
-
Amiri-Nikpour M. R., Nazarbaghi S., Hamdi-Holasou M., et al. An Open-Label Evaluator-Blinded Clinical Study of Minocycline Neuroprotection in Ischemic Stroke: Gender-Dependent Effect. Acta Neurol. Scand. 2014 ;:
-
(2014)
Acta Neurol. Scand
-
-
Amiri-Nikpour, M.R.1
Nazarbaghi, S.2
Hamdi-Holasou, M.3
-
82
-
-
84879961743
-
Effects of Candesartan in Acute Stroke on Cognitive Function and Quality of Life: Results from the Scandinavian Candesartan Acute Stroke Trial
-
Hornslien A. G., Sandset E. C., Bath P. M., et al. Effects of Candesartan in Acute Stroke on Cognitive Function and Quality of Life: Results from the Scandinavian Candesartan Acute Stroke Trial. Stroke. 2013 ; 44: 2022-2024
-
(2013)
Stroke
, vol.44
, pp. 2022-2024
-
-
Hornslien, A.G.1
Sandset, E.C.2
Bath, P.M.3
-
83
-
-
84890027846
-
A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors
-
Jahchan N. S., Dudley J. T., Mazur P. K., et al. A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors. Cancer Discov. 2013 ; 3: 1364-1377
-
(2013)
Cancer Discov
, vol.3
, pp. 1364-1377
-
-
Jahchan, N.S.1
Dudley, J.T.2
Mazur, P.K.3
-
84
-
-
84880073554
-
Drug Repurposing for Gastrointestinal Stromal Tumor
-
Pessetto Z. Y., Weir S. J., Sethi G., et al. Drug Repurposing for Gastrointestinal Stromal Tumor. Mol. Cancer Ther. 2013 ; 12: 1299-1309
-
(2013)
Mol. Cancer Ther
, vol.12
, pp. 1299-1309
-
-
Pessetto, Z.Y.1
Weir, S.J.2
Sethi, G.3
-
85
-
-
80055050352
-
Parallel Screening of FDA-Approved Antineoplastic Drugs for Identifying Sensitizers of TRAIL-Induced Apoptosis in Cancer Cells
-
Taylor D. J. Parallel Screening of FDA-Approved Antineoplastic Drugs for Identifying Sensitizers of TRAIL-Induced Apoptosis in Cancer Cells. BMC Cancer. 2011 ; 11: 470
-
(2011)
BMC Cancer
, vol.11
, pp. 470
-
-
Taylor, D.J.1
-
86
-
-
84888405311
-
Repositioning of the Antihelmintic Drug Mebendazole for the Treatment for Colon Cancer
-
Nygren P., Fryknäs M., Agerup B., et al. Repositioning of the Antihelmintic Drug Mebendazole for the Treatment for Colon Cancer. J. Cancer Res. Clin. Oncol. 2013 ; 139: 2133-2140
-
(2013)
J. Cancer Res. Clin. Oncol
, vol.139
, pp. 2133-2140
-
-
Nygren, P.1
Fryknäs, M.2
Agerup, B.3
-
87
-
-
79959922456
-
A Novel Two-Stage, Transdisciplinary Study Identifies Digoxin as a Possible Drug for Prostate Cancer Treatment
-
Platz E. A., Yegnasubramanian S., Liu J. O., et al. A Novel Two-Stage, Transdisciplinary Study Identifies Digoxin as a Possible Drug for Prostate Cancer Treatment. Cancer Discov. 2011 ; 1: 68-77
-
(2011)
Cancer Discov
, vol.1
, pp. 68-77
-
-
Platz, E.A.1
Yegnasubramanian, S.2
Liu, J.O.3
-
88
-
-
84892455642
-
Novel Anti-glioblastoma Agents and Therapeutic Combinations Identified from a Collection of FDA Approved Drugs
-
Jiang P., Mukthavavam R., Chao Y., et al. Novel Anti-glioblastoma Agents and Therapeutic Combinations Identified from a Collection of FDA Approved Drugs. J. Trans. Med. 2014 ; 12: 13
-
(2014)
J. Trans. Med
, vol.12
, pp. 13
-
-
Jiang, P.1
Mukthavavam, R.2
Chao, Y.3
-
89
-
-
48249125791
-
Malignant Gliomas in Adults
-
Wen P. Y., Kesari S. Malignant Gliomas in Adults. N. Engl. J. Med. 2008 ; 359: 492-507
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 492-507
-
-
Wen, P.Y.1
Kesari, S.2
-
90
-
-
79960998860
-
Orphan Drug: Development Trends and Strategies
-
Sharma A., Jacob A., Tandon M., et al. Orphan Drug: Development Trends and Strategies. J. Pharm. Bioallied Sci. 2010 ; 2: 290-299
-
(2010)
J. Pharm. Bioallied Sci
, vol.2
, pp. 290-299
-
-
Sharma, A.1
Jacob, A.2
Tandon, M.3
-
92
-
-
79958241193
-
The Revival of Thalidomide: From Tragedy to Therapy
-
Greenstone G. The Revival of Thalidomide: From Tragedy to Therapy. Brit. Columb. Med. J. 2011 ; 53: 230-233
-
(2011)
Brit. Columb. Med. J
, vol.53
, pp. 230-233
-
-
Greenstone, G.1
-
93
-
-
0015189572
-
WHO Co-ordinated Short-Term Doubleblind Trial with Thalidomide in the Treatment of Acute Lepra Reactions in Male Lepromatous Patients
-
Iyer C. G. S., Languillon J., Ramanujam K., et al. WHO Co-ordinated Short-Term Doubleblind Trial with Thalidomide in the Treatment of Acute Lepra Reactions in Male Lepromatous Patients. Bull. Wld. Hlth. Org. 1971 ; 45: 719-732
-
(1971)
Bull. Wld. Hlth. Org
, vol.45
, pp. 719-732
-
-
Iyer, C.G.S.1
Languillon, J.2
Ramanujam, K.3
-
95
-
-
0032748385
-
Antitumor Activity of Thalidomide in Refractory Multiple Myeloma
-
Singhal S., Mehta J., Desikan R., et al. Antitumor Activity of Thalidomide in Refractory Multiple Myeloma. New Engl. J. Med. 1999 ; 341: 1565-1571
-
(1999)
New Engl. J. Med
, vol.341
, pp. 1565-1571
-
-
Singhal, S.1
Mehta, J.2
Desikan, R.3
-
96
-
-
20444461067
-
Metformin and the Reduced Risk of Cancer in Diabetic Patients
-
Evans J. M. M., Donnelly L. A., Emslie-Smith A. M., et al. Metformin and the Reduced Risk of Cancer in Diabetic Patients. Brit. Med. J. 2005 ; 330: 1304-1305
-
(2005)
Brit. Med. J
, vol.330
, pp. 1304-1305
-
-
Evans, J.M.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
-
98
-
-
67650514082
-
Metformin Induces Unique Biological and Molecular Responses in Triple Negative Breast Cancer Cells
-
Liu B., Fan Z., Edgerton S. M., et al. Metformin Induces Unique Biological and Molecular Responses in Triple Negative Breast Cancer Cells. Cell Cycle. 2009 ; 8: 2031-2040
-
(2009)
Cell Cycle
, vol.8
, pp. 2031-2040
-
-
Liu, B.1
Fan, Z.2
Edgerton, S.M.3
-
99
-
-
34547114031
-
Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth
-
Buzzai M., Jones R. G., Amaravadi R. K., et al. Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth. Cancer Res. 2007 ; 67: 6745-6752
-
(2007)
Cancer Res
, vol.67
, pp. 6745-6752
-
-
Buzzai, M.1
Jones, R.G.2
Amaravadi, R.K.3
-
100
-
-
70350236538
-
Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission
-
Hirsch H. A., Iliopoulos D., Tsichlis P. N., et al. Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission. Cancer Res. 2009 ; 69: 7507-7511
-
(2009)
Cancer Res
, vol.69
, pp. 7507-7511
-
-
Hirsch, H.A.1
Iliopoulos, D.2
Tsichlis, P.N.3
-
101
-
-
79960775459
-
Drug Repositioning for Orphan Diseases
-
Sardana D., Zhu C., Zhang M., et al. Drug Repositioning for Orphan Diseases. Brief. Bioinform. 2011 ; 12: 346-356
-
(2011)
Brief. Bioinform
, vol.12
, pp. 346-356
-
-
Sardana, D.1
Zhu, C.2
Zhang, M.3
-
102
-
-
79960830371
-
Database Identifies FDA-Approved Drugs with Potential to Be Repurposed for Treatment of Orphan Diseases
-
Xu K., Coté T. R. Database Identifies FDA-Approved Drugs with Potential to Be Repurposed for Treatment of Orphan Diseases. Brief. Bioinform. 2011 ; 12: 341-345
-
(2011)
Brief. Bioinform
, vol.12
, pp. 341-345
-
-
Xu, K.1
Coté, T.R.2
-
103
-
-
84855877059
-
Integrative Continuum: Accelerating Therapeutic Advances in Rare Autoimmune Diseases
-
Van Herle K., Behne J. M., Van Herle A., et al. Integrative Continuum: Accelerating Therapeutic Advances in Rare Autoimmune Diseases. Ann. Rev. Pharmacol. Toxicol. 2012 ; 52: 523-547
-
(2012)
Ann. Rev. Pharmacol. Toxicol
, vol.52
, pp. 523-547
-
-
Van Herle, K.1
Behne, J.M.2
Van Herle, A.3
-
104
-
-
84862173050
-
A Generalizable Pre-clinical Research Approach for Orphan Disease Therapy
-
Beaulieu C. L., Samuels M. E., Ekins S., et al. A Generalizable Pre-clinical Research Approach for Orphan Disease Therapy. Orphanet J Rare Dis. 2012 ; 15: 39
-
(2012)
Orphanet J Rare Dis
, vol.15
, pp. 39
-
-
Beaulieu, C.L.1
Samuels, M.E.2
Ekins, S.3
-
105
-
-
84863087650
-
Rational Drug Repositioning Guided by an Integrated Pharmacological Network of Protein, Disease and Drug
-
Lee H. S., Bae T., Lee J. H., et al. Rational Drug Repositioning Guided by an Integrated Pharmacological Network of Protein, Disease and Drug. BMC Syst. Biol. 2012 ; 6: 80
-
(2012)
BMC Syst. Biol
, vol.6
, pp. 80
-
-
Lee, H.S.1
Bae, T.2
Lee, J.H.3
|