Repositioning of an existing drug for the neglected tropical disease Onchocerciasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 8, 2010, Pages 3424-3429

  Gloeckner, Christian ^a   Garner, Amanda L ^a   Mersha, Fana ^b   Oksov, Yelena ^c   Tricoche, Nancy ^c   Eubanks, Lisa M ^a   Lustigman, Sara ^c   Kaufmann, Gunnar F ^a   Janda, Kim D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NEW ENGLAND BIOLABS   (United States)

^c NEW YORK BLOOD CENTER   (United States)

Author keywords

Chitinase; Closantel; Filarial parasite; Molting; River blindness

Indexed keywords

CLOSANTEL;

ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DRUG SYNTHESIS; INFECTION; LARVA; NONHUMAN; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PRIORITY JOURNAL; TROPICAL DISEASE;

ANIMALS; ANTHELMINTICS; CHITIN; CHITINASE; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MOLTING; ONCHOCERCA; ONCHOCERCIASIS; SALICYLANILIDES; SMALL MOLECULE LIBRARIES;

INVERTEBRATA; MAMMALIA; ONCHOCERCA VOLVULUS;

EID: 77649268555     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0915125107     Document Type: Article

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