Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 48, 2011, Pages 19264-19269

  Rovira, Meritxell ^a   Huang, Wei ^a   Yusuff, Shamila ^a   Shim, Joong Sup ^b   Ferrante, Anthony A ^c   Liu, Jun O ^b   Parsons, Michael J ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c PHYSICAL SCIENCES INC   (United States)

Author keywords

Development; Embryogenesis; Notch signaling; Progenitor

Indexed keywords

DISULFIRAM; EPIRIZOLE; ESCULIN; GUANOSINE TRIPHOSPHATE; INOSINATE DEHYDROGENASE INHIBITOR; LEVALLORPHAN; MYCOPHENOLIC ACID; NOTCH RECEPTOR; RETINOIC ACID; SULFANILIC ACID; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LEVEL; CONTROLLED STUDY; DRUG APPROVAL; DRUG DETERMINATION; DRUG LIBRARY; DRUG MECHANISM; DRUG SCREENING; EMBRYO; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; LARVA; LIBRARY; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VITAMIN METABOLISM; ZEBRA FISH;

ACETANILIDES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAFFEIC ACIDS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; DIMETHYL SULFOXIDE; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; EPIRIZOLE; FLUORESCENT ANTIBODY TECHNIQUE; GREEN FLUORESCENT PROTEINS; GUANOSINE TRIPHOSPHATE; HMGB1 PROTEIN; INSULIN-SECRETING CELLS; LARVA; MICROSCOPY, CONFOCAL; MYCOPHENOLIC ACID; P-AMINOAZOBENZENE; PHARMACEUTICAL PREPARATIONS; REAL-TIME POLYMERASE CHAIN REACTION; SULFANILIC ACIDS; TRETINOIN; ZEBRAFISH;

EID: 82755181551     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1113081108     Document Type: Article

References (29)

1. Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC (2005) Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: Indirect evidence for islet regeneration? Diabetologia 48:2221-2228. (Pubitemid 41618910)
2. Chong AS, et al. (2006) Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration. Science 311:1774-1775.
3. Pisharath H, Rhee JM, Swanson MA, Leach SD, Parsons MJ (2007) Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase. Mech Dev 124:218-229. (Pubitemid 46274191)
4. Dong PD, et al. (2007) Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nat Genet 39:397-402. (Pubitemid 46328485)
5. Wang Y, Rovira M, Yusuff S, Parsons MJ (2011) Genetic inducible fate mapping in larval zebrafish reveals origins of adult insulin-producing β-cells. Development 138:609-617.
6. Parsons MJ, et al. (2009) Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas. Mech Dev 126:898-912.
7. Hesselson D, Anderson RM, Beinat M, Stainier DY (2009) Distinct populations of quiescent and proliferative pancreatic beta-cells identified by HOTcre mediated labeling. Proc Natl Acad Sci USA 106:14896-14901.
8. Kim J, et al. (2010) Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 17:388-399.
9. Chong CR, Chen X, Shi L, Liu JO, Sullivan DJ, Jr. (2006) A clinical drug library screen identifies astemizole as an antimalarial agent. Nat Chem Biol 2:415-416. (Pubitemid 44114918)
10. Chong CR, et al. (2006) Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target. J Med Chem 49:2677-2680.
11. Delporte FM, et al. (2008) Expression of zebrafish pax6b in pancreas is regulated by two enhancers containing highly conserved cis-elements bound by PDX1, PBX and PREP factors. BMC Dev Biol 8:53.
12. Wu X, et al. (2006) Mycophenolic acid is a potent inhibitor of angiogenesis. Arterioscler Thromb Vasc Biol 26:2414-2416. (Pubitemid 44465742)
13. Hedstrom L (2009) IMP dehydrogenase: Structure, mechanism, and inhibition. Chem Rev 109:2903-2928.
14. Lipsky JJ, Shen ML, Naylor S (2001) In vivo inhibition of aldehyde dehydrogenase by disulfiram. Chem Biol Interact 130-132:93-102. (Pubitemid 32295806)
15. Lin J, et al. (2011) Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth. Prostate 71:333-343.
16. O'Reilly-Pol T, Johnson SL (2008) Neocuproine ablates melanocytes in adult zebrafish. Zebrafish 5:257-264.
17. McCaffery P, Lee MO, Wagner MA, Sladek NE, Dräger UC (1992) Asymmetrical retinoic acid synthesis in the dorsoventral axis of the retina. Development 115:371-382.
18. Kinkel MD, et al. (2009) Cyp26 enzymes function in endoderm to regulate pancreatic field size. Proc Natl Acad Sci USA 106:7864-7869.
19. Russo JE, Hauguitz D, Hilton J (1988) Inhibition of mouse cytosolic aldehyde dehydrogenase by 4-(diethylamino)benzaldehyde. Biochem Pharmacol 37:1639-1642. (Pubitemid 18093362)
20. Lieber M, Mazzetta J, Nelson-Rees W, Kaplan M, Todaro G (1975) Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas. Int J Cancer 15:741-747.
21. Wu Y, et al. (2010) c-Kit and stem cell factor regulate PANC-1 cell differentiation into insulin- and glucagon-producing cells. Lab Invest 90:1373-1384.
22. Cen D, et al. (2002) Disulfiram induces apoptosis in human melanoma cells: A redoxrelated process. Mol Cancer Ther 1:197-204.
23. Zon LI, Peterson R (2010) The new age of chemical screening in zebrafish. Zebrafish 7:1.
24. Metz SA, Kowluru A (1999) Inosine monophosphate dehydrogenase: A molecular switch integrating pleiotropic GTP-dependent beta-cell functions. Proc Assoc Am Physicians 111:335-346. (Pubitemid 29331466)
25. Metz SA, Rabaglia ME, Pintar TJ (1992) Selective inhibitors of GTP synthesis impede exocytotic insulin release from intact rat islets. J Biol Chem 267:12517-12527.
26. Detimary P, Xiao C, Henquin JC (1997) Tight links between adenine and guanine nucleotide pools in mouse pancreatic islets: A study with mycophenolic acid. Biochem J 324:467-471. (Pubitemid 27267989)
27. Rovira M, et al. (2010) Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. Proc Natl Acad Sci USA 107:75-80.
28. Pauls S, Zecchin E, Tiso N, Bortolussi M, Argenton F (2007) Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts. Dev Biol 304:875-890. (Pubitemid 46527575)
29. Cross LM, Cook MA, Lin S, Chen JN, Rubinstein AL (2003) Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay. Arterioscler Thromb Vasc Biol 23:911-912. (Pubitemid 36566186)