Predictive methods in drug repurposing: Gold mine or just a bigger haystack?

Drug Discovery Today

Volumn 18, Issue 11-12, 2013, Pages 523-532

  Cavalla, David ^a  

^a Numedicus Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ETANERCEPT; FUMARIC ACID DIMETHYL ESTER; GLYCOPYRRONIUM BROMIDE; INFLIXIMAB; MILNACIPRAN;

ANKYLOSING ARTHRITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPUTER ANALYSIS; CROHN DISEASE; DEPRESSION; DNA FINGERPRINTING; DRUG REPOSITIONING; DRUG TARGETING; FIBROMYALGIA; GENETIC SCREENING; HUMAN; IN VITRO STUDY; JUVENILE RHEUMATOID ARTHRITIS; MOLECULAR MODEL; MULTIPLE SCLEROSIS; PHENOTYPE; PSORIASIS; PSORIATIC ARTHRITIS; RETROSPECTIVE STUDY; REVIEW; RHEUMATOID ARTHRITIS; SIDE EFFECT; ULCER; ULCERATIVE COLITIS; VALIDITY;

ANIMALS; DRUG DISCOVERY; DRUG REPOSITIONING; HUMANS; PATENTS AS TOPIC;

EID: 84878888598     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.12.009     Document Type: Review

References (47)

1. D. Cavalla Therapeutic switching: a new strategic approach to enhance R&D productivity IDrugs 8 2005 914 918
2. M.J. Keiser Predicting new molecular targets for known drugs Nature 462 2009 175 181
3. L. Xie Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavir PLoS Comput. Biol. 7 2011 e1002037
4. F. Cheng Prediction of drug-target interactions and drug repositioning via network-based inference PLoS Comput. Biol. 8 2012 e1002503
5. B.T. Aftab Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer Cancer Res. 71 2011 6764 6772
6. C.C. Mandal Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44 J. Biol. Chem. 286 2011 11314 11327
7. M. Sirota Discovery and preclinical validation of drug indications using compendia of public gene expression data Sci. Transl. Med. 3 2011 96ra77
8. J.T. Dudley Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease Sci. Transl. Med. 3 2011 96ra76
9. J.O. Armitage, and R.D. Sidner Antitumour effect of cimetidine Lancet 1 1979 882 883
10. Shapira, N. et al. (2004) Treatments for Benign Tumors, Cancers, Neoplasias, and/or Other Inflammatory Disorders or Diseases. U.S. Patent WO/2004/050081
11. F. Iorio Discovery of drug mode of action and drug repositioning from transcriptional responses Proc. Natl. Acad. Sci. U. S. A. 107 2010 14621 14626
12. P.O. Bauer Inhibition of Rho kinases enhances the degradation of mutant huntingtin J. Biol. Chem. 284 2009 13153 13164
13. J.D. Rothstein Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression Nature 433 2005 73 77
14. Y. Li Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression Neuropharmacology 60 2011 1168 1175
15. D.C. Swinney, and J. Anthony How were new medicines discovered? Nat. Rev. Drug Discov. 10 2011 507 519
16. A.G. Reaume Drug repurposing through nonhypothesis driven phenotypic screening Drug Discov. Today: Ther. Strat. 8 2011 85 88
17. M.S. Saporito MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo J. Pharmacol. Exp. Ther. 342 2012 15 22
18. M. Campillos Drug target identification using side-effect similarity Science 321 2008 263 266
19. L. Yang, and P. Agarwal Systematic drug repositioning based on clinical side-effects PLoS ONE 6 2011 e28025
20. H. McMeekin Successful treatment of obsessive compulsive disorder with oxcarbazepine. A case report J. S. C. Med. Assoc. 98 2002 316 320
21. D. Cavalla, and C. Singal Retrospective clinical analysis for drug rescue: for new indications or stratified patient groups Drug Discov. Today 17 2012 104 109
22. E.A. Platz A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment Cancer Discov. 1 2011 68 77
23. I. Prassas, and E.P. Diamandis Novel therapeutic applications of cardiac glycosides Nat. Rev. Drug Discov. 7 2008 926 935
24. B. Chen Assessing drug target association using semantic linked data PLoS Comput. Biol. 8 2012 e1002574
25. Kranzler, J.D. and Rao, S.G. (2003) Methods of Treating Fibromyalgia. U.S. Patent 6602911
26. Kranzler, J.D. and Rao, S.G. (2006) Methods of Treating Fibromyalgia Syndrome, Chronic Fatigue Syndrome and Pain. U.S. Patent 6992110
27. Kranzler, J.D. and Rao, S.G. (2011) Methods of Treating Fibromyalgia Syndrome, Chronic Fatigue Syndrome and Pain. U.S. Patent 7888342
28. Bannister, R.M. et al. (2003) The Treatment Of Respiratory Diseases. U.S. Patent EP1267866 (A2)
29. Joshi, R.K. and Strebel, H.P. (2002) Use of Fumaric Acid Derivatives. U.S. Patent 6436992
30. Joshi, R.K. and Strebel, H.P. (2008) Dimethyl Fumarate for the Treatment of Multiple Sclerosis. U.S. Patent 7320999
31. V.M. Keatings Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma Am. J. Respir. Crit. Care Med. 153 1996 530 534
32. J.H. Vernooy Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum Am. J. Respir. Crit. Care Med. 166 2002 1218 1224
33. A. Churg Tumor necrosis factor-alpha drives 70% of cigarette smoke-induced emphysema in the mouse Am. J. Respir. Crit. Care Med. 170 2004 492 498
34. X.-Y. Zhang Infliximab protects against pulmonary emphysema in smoking rats Chin. Med. J. 124 2011 2502 2506
35. S.I. Rennard The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease Am. J. Respir. Crit. Care Med. 175 2007 926 934
36. A.P. Gregory TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis Nature 488 2012 508 511
37. M.Y. Kim Beneficial effects of candesartan, an angiotensin-blocking agent, on compensated alcoholic liver fibrosis-a randomized open-label controlled study Liver Int. 32 2012 977 987
38. W.F. Ward Radiation-induced endothelial dysfunction and fibrosis in rat lung: modification by the angiotensin converting enzyme inhibitor CL242817 Radiat. Res. 117 1989 342 350
39. J.P. Schanstra In vivo bradykinin B2 receptor activation reduces renal fibrosis J. Clin. Invest. 110 2002 371 379
40. R. Muthyala Orphan/rare drug discovery through drug repositioning Drug Discov. Today: Ther. Strat. 8 2011 71 76
41. S. Ekins In silico repositioning of approved drugs for rare and neglected diseases Drug Discov. Today 16 2011 298 310
42. I. Muir European Patent Law: Law and Procedure Under the EPC and PCT 2003 Oxford University Press
43. Campbell, J. (1992) Compositions and Methods of Treatment of Sympathetically Maintained Pain. U.S. Patent WO/1992/014453
44. Campbell, J. (2007) Treatment of Length Dependent Neuropathy. U.S. Patent WO/2007/056460
45. Campbell, J. and Michaelis, A. (2009) High Concentration Local Anesthetic Formulations. U.S. Patent WO/2009/026178
46. Campbell, J. (2012) Topical Treatment of Neuropathic Pain and Methods of Diagnosis. U.S. Patent WO/2012/012333
47. D. Cavalla APT drug R&D: the right active ingredient in the right presentation for the right therapeutic use Nat. Rev. Drug Discov. 8 2009 849 853