Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions

Drug Resistance Updates

Volumn 14, Issue 4-5, 2011, Pages 212-223

  Vazquez Martin, Alejandro ^a,b   López Bonetc, Eugeni ^b,c   Cufí, Sílvia ^a,b   Oliveras Ferraros, Cristina ^a,b   Del Barco, Sonia ^a,b   Martin Castillo, Begoña ^a,b   Menendez, Javier A ^a,b  

^a CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^b GIRONA BIOMEDICAL RESEARCH INSTITUTE IDIBGI   (Spain)

^c HOSPITAL JOSEP TRUETA   (Spain)

Author keywords

Autophagy; Breast cancer; Cancer stem cells; DCIS; EMT; Hypoxia; OIS; Oncogene induced senescence

Indexed keywords

CHLOROQUINE; METFORMIN; TAMOXIFEN;

ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL CULTURE; CANCER INVASION; CANCER PREVENTION; CANCER STEM CELL; CELL DIFFERENTIATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG TARGETING; EPITHELIAL MESENCHYMAL TRANSITION; HIGH RISK POPULATION; HUMAN; HUMAN CELL; HYPOXIA; INTRADUCTAL CARCINOMA; MALARIA; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ONCOGENE; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; SENESCENCE; STRESS;

AGING; ANIMALS; ANTIMALARIALS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; BREAST NEOPLASMS; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CHLOROQUINE; DRUG EVALUATION, PRECLINICAL; DRUG REPOSITIONING; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN; MOLECULAR TARGETED THERAPY; NEOPLASMS; NEOPLASTIC STEM CELLS; PHENOTYPE; SIGNAL TRANSDUCTION; TGF-BETA SUPERFAMILY PROTEINS;

EID: 80052026293     PISSN: 13687646     EISSN: 15322084     Source Type: Journal    
DOI: 10.1016/j.drup.2011.04.003     Document Type: Article

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