Prazosin induces p53-mediated autophagic cell death in H9C2 cells

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 384, Issue 2, 2011, Pages 209-216

  Yang, Yi Fan ^a,b   Wu, Chau Chung ^a,b   Chen, Wen Pin ^a   Chen, Yuh Lien ^a   Su, Ming Jai ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Autophagy; Doxazosin; p53; Prazosin; Quinazoline

Indexed keywords

3 METHYLADENINE; ADENYLATE KINASE; CASPASE 3; CELL PROTEIN; DOXAZOSIN; LIGHT CHAIN 3; MAMMALIAN TARGET OF RAPAMYCIN; PIFITHRIN ALPHA; PRAZOSIN; PROTEIN KINASE B; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL DEATH; CELL VACUOLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EXPOSURE; DRUG MECHANISM; ENZYME ACTIVATION; MICROTUBULE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ANIMALS; AUTOPHAGY; CASPASE 3; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; GREEN FLUORESCENT PROTEINS; HUMANS; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; MYOBLASTS, CARDIAC; PRAZOSIN; RATS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79961167902     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-011-0657-3     Document Type: Article

References (26)

1. ALLHAT Collaborative Research Group 2000 Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT) JAMA 283 1967 1975 10.1001/jama.283.15.1967
2. GM Balaburski RD Hontz ME Murphy 2010 p53 and ARF: unexpected players in autophagy Trends Cell Biol 20 363 369 20303758 10.1016/j.tcb.2010.02.007 1:CAS:528:DC%2BC3cXntVOrsLs%3D
3. S Caporali E Alvino G Starace M Ciomei MG Brasca L Levati A Garbin D Castiglia C Covaciu E Bonmassar, et al. 2010 The cyclin-dependent kinase inhibitor PHA-848125 suppresses the in vitro growth of human melanomas sensitive or resistant to temozolomide, and shows synergistic effects in combination with this triazene compound Pharmacol Res 61 437 448 20026273 10.1016/j.phrs.2009. 12.009 1:CAS:528:DC%2BC3cXktlCitL8%3D
4. N Chen V Karantza 2011 Autophagy as a therapeutic target in cancer Cancer Biol Ther 11 157 168 21228626 10.4161/cbt.11.2.14622 1:CAS:528: DC%2BC3MXislyhtbg%3D
5. JN Cohn DG Archibald S Ziesche JA Franciosa WE Harston FE Tristani WB Dunkman W Jacobs GS Francis KH Flohr, et al. 1986 Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study N Engl J Med 314 1547 1552 3520315 10.1056/NEJM198606123142404 1:STN:280:DyaL283jtVOjtw%3D%3D (Pubitemid 16114684)
6. S Eiras P Fernandez R Pineiro MJ Iglesias JR Gonzalez-Juanatey F Lago 2006 Doxazosin induces activation of GADD153 and cleavage of focal adhesion kinase in cardiomyocytes en route to apoptosis Cardiovasc Res 71 118 128 16631627 10.1016/j.cardiores.2006.03.014 1:CAS:528:DC%2BD28Xls1eisbs%3D (Pubitemid 43849671)
7. JR Gonzalez-Juanatey MJ Iglesias C Alcaide R Pineiro F Lago 2003 Doxazosin induces apoptosis in cardiomyocytes cultured in vitro by a mechanism that is independent of alpha1-adrenergic blockade Circulation 107 127 131 12515754 10.1161/01.CIR.0000043803.20822.D1 1:CAS:528:DC%2BD3sXhs1Q%3D (Pubitemid 36070944)
8. AB Gustafsson RA Gottlieb 2009 Autophagy in ischemic heart disease Circ Res 104 150 158 19179668 10.1161/CIRCRESAHA.108.187427 1:CAS:528: DC%2BD1MXntFahsA%3D%3D
9. C He DJ Klionsky 2009 Regulation mechanisms and signaling pathways of autophagy Annu Rev Genet 43 67 93 19653858 10.1146/annurev-genet-102808-114910 1:CAS:528:DC%2BD1MXhsF2qtrjK
10. AM Hussein OM Ahmed 2010 Regioselective one-pot synthesis and anti-proliferative and apoptotic effects of some novel tetrazolo[1,5-a] pyrimidine derivatives Bioorg Med Chem 18 2639 2644 20227281 10.1016/j.bmc.2010.02.028 1:CAS:528:DC%2BC3cXksVejtrg%3D
11. K Jastrzebski KM Hannan EB Tchoubrieva RD Hannan RB Pearson 2007 Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function Growth Factors 25 209 226 18092230 10.1080/08977190701779101 1:CAS:528:DC%2BD2sXhsVCgsbbN
12. DJ Klionsky H Abeliovich P Agostinis DK Agrawal G Aliev DS Askew M Baba EH Baehrecke BA Bahr A Ballabio, et al. 2008 Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes Autophagy 4 151 175 18188003 1:CAS:528:DC%2BD1cXksFGrtLg%3D (Pubitemid 351231180)
13. N Kyprianou TB Vaughan MC Michel 2009 Apoptosis induction by doxazosin and other quinazoline alpha1-adrenoceptor antagonists: a new mechanism for cancer treatment? Naunyn Schmiedebergs Arch Pharmacol 380 473 477 19904527 10.1007/s00210-009-0462-4 1:CAS:528:DC%2BD1MXhsVCrtLnF
14. SC Lin SC Chueh CJ Hsiao TK Li TH Chen CH Liao PC Lyu JH Guh 2007 Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle Neoplasia 9 830 839 17971903 10.1593/neo.07475 1:CAS:528:DC%2BD2sXhtl2rtr3M (Pubitemid 47623423)
15. N Mizushima T Yoshimori 2007 How to interpret LC3 immunoblotting Autophagy 3 542 545 17611390 1:CAS:528:DC%2BD2sXhtlOhs7jL (Pubitemid 350060049)
16. K Nishida S Kyoi O Yamaguchi J Sadoshima K Otsu 2009 The role of autophagy in the heart Cell Death Differ 16 31 38 19008922 10.1038/cdd.2008.163 1:CAS:528:DC%2BD1cXhsV2it7%2FP
17. F Schwartzenberg-Bar-Yoseph M Armoni E Karnieli 2004 The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression Cancer Res 64 2627 2633 15059920 10.1158/0008-5472.CAN-03-0846 1:CAS:528: DC%2BD2cXis1yju7o%3D (Pubitemid 38523921)
18. RJ Shaw 2009 LKB1 and AMP-activated protein kinase control of mTOR signalling and growth Acta Physiol (Oxf) 196 65 80 10.1111/j.1748-1716.2009. 01972.x 1:CAS:528:DC%2BD1MXlt1KrtL8%3D
19. Sui X, Jin L, Huang X, Geng S, He C, Hu X (2011) p53 signaling and autophagy in cancer: A revolutionary strategy could be developed for cancer treatment. Autophagy 7
20. F Traganos Z Darzynkiewicz 1994 Lysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulations Methods Cell Biol 41 185 194 7532261 10.1016/S0091-679X(08)61717- 3 1:CAS:528:DyaK2MXjvFaisL0%3D
21. K Tsuchihara S Fujii H Esumi 2009 Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues Cancer Lett 278 130 138 19004545 10.1016/j.canlet.2008.09.040 1:CAS:528:DC%2BD1MXltVCqsr4%3D
22. KH Vousden KM Ryan 2009 p53 and metabolism Nat Rev Cancer 9 691 700 19759539 10.1038/nrc2715 1:CAS:528:DC%2BD1MXhtFentb%2FM
23. PD Walden Y Globina A Nieder 2004 Induction of anoikis by doxazosin in prostate cancer cells is associated with activation of caspase-3 and a reduction of focal adhesion kinase Urol Res 32 261 265 15221243 10.1007/s00240-003-0365-7 1:CAS:528:DC%2BD2cXmslCiur4%3D (Pubitemid 39222602)
24. Z Xie DJ Klionsky 2007 Autophagosome formation: core machinery and adaptations Nat Cell Biol 9 1102 1109 17909521 10.1038/ncb1007-1102 1:CAS:528:DC%2BD2sXhtFSntbzJ (Pubitemid 47500484)
25. YF Yang CC Wu WP Chen MJ Su 2009 Transforming growth factor-beta type I receptor/ALK5 contributes to doxazosin-induced apoptosis in H9C2 cells Naunyn Schmiedebergs Arch Pharmacol 380 561 567 19727674 10.1007/s00210-009-0449-1 1:CAS:528:DC%2BD1MXhsVCrtLbM
26. XD Zhang ZH Qin J Wang 2010 The role of p53 in cell metabolism Acta Pharmacol Sin 31 1208 1212 20729871 10.1038/aps.2010.151 1:CAS:528: DC%2BC3cXhtFSntr7E