IPF fibroblasts are desensitized to type i collagen matrix-induced cell death by suppressing low autophagy via aberrant Akt/mTOR kinases

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Nho, Richard Seonghun ^a   Hergert, Polla ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; COLLAGEN TYPE 1; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN LC3 2; RAPAMYCIN; UNCLASSIFIED DRUG; 3-METHYLADENINE; ADENINE; CHLOROQUINE; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL ADHESION; CELL DESENSITIZATION; CELL PROLIFERATION; CELL STRESS; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROSING ALVEOLITIS; HEK293 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG FIBROBLAST; MOLECULAR DYNAMICS; MYOFIBROBLAST; PHENOTYPE; PHYSICAL SENSITIVITY; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; CELL LINE; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; FIBROBLAST; METABOLISM; PHAGOSOME; PROTEIN MULTIMERIZATION;

ADENINE; AUTOPHAGY; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHLOROQUINE; COLLAGEN TYPE I; ENZYME ACTIVATION; FIBROBLASTS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; PHAGOSOMES; PROTEIN MULTIMERIZATION; PROTO-ONCOGENE PROTEINS C-AKT; TOR SERINE-THREONINE KINASES;

EID: 84899639570     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094616     Document Type: Article

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