Zebrafish as a systems toxicology model for developmental neurotoxicity testing

Congenital Anomalies

Volumn 55, Issue 1, 2015, Pages 1-16

  Nishimura, Yuhei ^a,b,c   Murakami, Soichiro ^a   Ashikawa, Yoshifumi ^a   Sasagawa, Shota ^a   Umemoto, Noriko ^a,b,c   Shimada, Yasuhito ^a,b,c   Tanaka, Toshio ^a,b,c  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c MIE UNIVERSITY   (Japan)

Author keywords

ADME; Autism; Developmental neurotoxicity; Systems toxicology; Zebrafish

Indexed keywords

ABSORPTION; AXONOGENESIS; BEHAVIOR; BLOOD BRAIN BARRIER; BRAIN METABOLISM; CHEMICAL REACTION KINETICS; COGNITION; DEVELOPMENTAL TOXICITY; EXCRETION; GENE EXPRESSION PROFILING; KINETICS; LEARNING; MEMORY; MOLECULAR DYNAMICS; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEUROIMAGING; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SENSORIMOTOR FUNCTION; TOXICITY TESTING; TOXICOKINETICS; ZEBRA FISH; ANIMAL; CENTRAL NERVOUS SYSTEM; DRUG EFFECTS; DRUG SCREENING; EMBRYOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; NEUROTOXICITY SYNDROMES;

ANIMALIA; DANIO RERIO; MAMMALIA; RODENTIA;

ZEBRAFISH PROTEIN;

ANIMALS; CENTRAL NERVOUS SYSTEM; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION PROFILING; HUMANS; NEUROGENESIS; NEUROTOXICITY SYNDROMES; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84920983678     PISSN: 09143505     EISSN: 17414520     Source Type: Journal    
DOI: 10.1111/cga.12079     Document Type: Review

References (260)

1. Ahrens MB, Orger MB, Robson DN, Li JM, Keller PJ. 2013. Whole-brain functional imaging at cellular resolution using light-sheet microscopy. Nat Methods 10:413-420.
2. Alfonso-Loeches S, Pascual M, Guerri C. 2013. Gender differences in alcohol-induced neurotoxicity and brain damage. Toxicology 311:27-34.
3. Ali S, Champagne DL, Richardson MK. 2012. Behavioral profiling of zebrafish embryos exposed to a panel of 60 water-soluble compounds. Behav Brain Res 228:272-283.
4. Al-Jaberi N, Lindsay S, Sarma S, Bayatti N, Clowry GJ. 2013. The early fetal development of human neocortical GABAergic interneurons. Cereb Cortex.
5. Allende ML, Weinberg ES. 1994. The expression pattern of two zebrafish achaete-scute homolog (ash) genes is altered in the embryonic brain of the cyclops mutant. Dev Biol 166:509-530.
6. Annilo T, Chen ZQ, Shulenin S etal. 2006. Evolution of the vertebrate ABC gene family: analysis of gene birth and death. Genomics 88:1-11.
7. Aoyama H. 2012. Developmental neurotoxicity testing: scientific approaches towards the next generation to protect the developing nervous system of children. An overview of the Developmental Neurotoxicity Symposium in 2011. Congenit Anom Kyoto 52:119-121.
8. Appel B. 2000. Zebrafish neural induction and patterning. Dev Dyn 219:155-168.
9. Arenzana FJ, Clemente D, Sanchez-Gonzalez R, Porteros A, Aijon J, Arevalo R. 2005. Development of the cholinergic system in the brain and retina of the zebrafish. Brain Res Bull 66:421-425.
10. Arrenberg AB, Driever W. 2013. Integrating anatomy and function for zebrafish circuit analysis. Front Neural Circuits 7:74.
11. Auer TO, Duroure K, De Cian A, Concordet JP, Del Bene F. 2014. Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair. Genome Res 24:142-153.
12. Bailey J, Oliveri A, Levin ED. 2013. Zebrafish model systems for developmental neurobehavioral toxicology. Birth Defects Res C Embryo Today 99:14-23.
13. Bal-Price AK, Coecke S, Costa L etal. 2012. Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. ALTEX 29:202-215.
14. Barlow BK, Cory-Slechta DA, Richfield EK, Thiruchelvam M. 2007. The gestational environment and Parkinson's disease: evidence for neurodevelopmental origins of a neurodegenerative disorder. Reprod Toxicol 23:457-470.
15. Barresi MJ, Burton S, Dipietrantonio K, Amsterdam A, Hopkins N, Karlstrom RO. 2010. Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Dev Dyn 239:2603-2618.
16. Barros TP, Alderton WK, Reynolds HM, Roach AG, Berghmans S. 2008. Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery. Br J Pharmacol 154:1400-1413.
17. Bauer M, Szulc J, Meyer M etal. 2008. Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons. J Neurochem 104:1101-1115.
18. Benner MJ, Drew RE, Hardy RW, Robison BD. 2010. Zebrafish (Danio rerio) vary by strain and sex in their behavioral and transcriptional responses to selenium supplementation. Comp Biochem Physiol A Mol Integr Physiol 157:310-318.
19. Birnbaum LS. 2012. Environmental chemicals: evaluating low-dose effects. Environ Health Perspect 120:A143-A144.
20. Blader P, Fischer N, Gradwohl G, Guillemot F, Strahle U. 1997. The activity of neurogenin1 is controlled by local cues in the zebrafish embryo. Development 124:4557-4569.
21. Bogdanovic O, Gomez-Skarmeta JL. 2014. Embryonic DNA methylation: insights from the genomics era. Brief Funct Genomics 13:121-130.
22. Braubach OR, Wood HD, Gadbois S, Fine A, Croll RP. 2009. Olfactory conditioning in the zebrafish (Danio rerio). Behav Brain Res 198:190-198.
23. Brosamle C, Halpern ME. 2002. Characterization of myelination in the developing zebrafish. Glia 39:47-57.
24. Brown AS. 2011. The environment and susceptibility to schizophrenia. Prog Neurobiol 93:23-58.
25. Buckley CE, Marguerie A, Alderton WK, Franklin RJ. 2010. Temporal dynamics of myelination in the zebrafish spinal cord. Glia 58:802-812.
26. Burgess HA, Granato M. 2007. Sensorimotor gating in larval zebrafish. J Neurosci 27:4984-4994.
27. Burgess HA, Granato M. 2008. The neurogenetic frontier-lessons from misbehaving zebrafish. Brief Funct Genomic Proteomic 7:474-482.
28. Burnison BK, Meinelt T, Playle R, Pietrock M, Wienke A, Steinberg CE. 2006. Cadmium accumulation in zebrafish (Danio rerio) eggs is modulated by dissolved organic matter (DOM). Aquat Toxicol 79:185-191.
29. Buske C, Gerlai R. 2011. Shoaling develops with age in Zebrafish (Danio rerio). Prog Neuropsychopharmacol Biol Psychiatry 35:1409-1415.
30. Cameron IL, Hunter KE. 1984. Regulation of the permeability of the medaka fish embryo chorion by exogeneous sodium and calcium ions. J Exp Zool 231:447-454.
31. Campagna R, Brunelli L, Airoldi L etal. 2011. Cerebellum proteomics addressing the cognitive deficit of rats perinatally exposed to the food-relevant polychlorinated biphenyl 138. Toxicol Sci 123:170-179.
32. Castillo J, Crespo D, Capilla E etal. 2009. Evolutionary structural and functional conservation of an ortholog of the GLUT2 glucose transporter gene (SLC2A2) in zebrafish. Am J Physiol Regul Integr Comp Physiol 297:R1570-R1581.
33. Chapouton P, Godinho L. 2010. Neurogenesis. Methods Cell Biol 100:73-126.
34. Chedotal A, Richards LJ. 2010. Wiring the brain: the biology of neuronal guidance. Cold Spring Harb Perspect Biol 2:a001917.
35. Cheesman SE, Layden MJ, Von Ohlen T, Doe CQ, Eisen JS. 2004. Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation. Development 131:5221-5232.
36. Chen L, Yu K, Huang C etal. 2012. Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae. Environ Sci Technol 46:9727-9734.
37. Chiu CN, Prober DA. 2013. Regulation of zebrafish sleep and arousal states: current and prospective approaches. Front Neural Circuits 7:58.
38. Chng HT, Ho HK, Yap CW, Lam SH, Chan EC. 2012. An investigation of the bioactivation potential and metabolism profile of Zebrafish versus human. J Biomol Screen 17:974-986.
39. Colwill RM, Creton R. 2011. Locomotor behaviors in zebrafish (Danio rerio) larvae. Behav Processes 86:222-229.
40. Cornide-Petronio ME, Barreiro-Iglesias A. 2013. Role of Slit and Robo proteins in the development of dopaminergic neurons. Dev Neurosci 35:285-292.
41. Costa LG, Steardo L, Cuomo V. 2004. Structural effects and neurofunctional sequelae of developmental exposure to psychotherapeutic drugs: experimental and clinical aspects. Pharmacol Rev 56:103-147.
42. Cowden J, Padnos B, Hunter D, Macphail R, Jensen K, Padilla S. 2012. Developmental exposure to valproate and ethanol alters locomotor activity and retino-tectal projection area in zebrafish embryos. Reprod Toxicol 33:165-173.
43. Crofton KM, Mundy WR, Shafer TJ. 2012. Developmental neurotoxicity testing: a path forward. Congenit Anom Kyoto 52:140-146.
44. Cutler C, Multani P, Robbins D etal. 2013. Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood 122:3074-3081.
45. Danesin C, Houart C. 2012. A Fox stops the Wnt: implications for forebrain development and diseases. Curr Opin Genet Dev 22:323-330.
46. Danesin C, Peres JN, Johansson M etal. 2009. Integration of telencephalic Wnt and hedgehog signaling center activities by Foxg1. Dev Cell 16:576-587.
47. Davis AP, Murphy CG, Rosenstein MC, Wiegers TC, Mattingly CJ. 2008. The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study. BMC Med Genomics 1:48.
48. Davis AP, Wiegers TC, Roberts PM etal. 2013. A CTD-Pfizer collaboration: manual curation of 88, 000 scientific articles text mined for drug-disease and drug-phenotype interactions. Database (Oxford) 2013:bat080.
49. De Esch C, Slieker R, Wolterbeek A, Woutersen R, De Groot D. 2012. Zebrafish as potential model for developmental neurotoxicity testing: a mini review. Neurotoxicol Teratol 34:545-553.
50. Delgado L, Schmachtenberg O. 2008. Immunohistochemical localization of GABA, GAD65, and the receptor subunits GABAAalpha1 and GABAB1 in the zebrafish cerebellum. Cerebellum 7:444-450.
51. Diekmann H, Hill A. 2013. ADMETox in zebrafish. Drug Discov Today 10:e31.
52. Dietert RR, Dietert JM, Dewitt JC. 2011. Environmental risk factors for autism. Emerg Health Threats J 4:7111.
53. Dougherty KJ, Kiehn O. 2010. Functional organization of V2a-related locomotor circuits in the rodent spinal cord. Ann N Y Acad Sci 1198:85-93.
54. Driscoll CD, Streissguth AP, Riley EP. 1990. Prenatal alcohol exposure: comparability of effects in humans and animal models. Neurotoxicol Teratol 12:231-237.
55. Drummond I. 2003. Making a zebrafish kidney: a tale of two tubes. Trends Cell Biol 13:357-365.
56. Dufour-Rainfray D, Vourc'h P, Tourlet S, Guilloteau D, Chalon S, Andres CR. 2011. Fetal exposure to teratogens: evidence of genes involved in autism. Neurosci Biobehav Rev 35:1254-1265.
57. Easter SS, Jr, Burrill J, Marcus RC, Ross LS, Taylor JS, Wilson SW. 1994. Initial tract formation in the vertebrate brain. Prog Brain Res 102:79-93.
58. Ek CJ, Dziegielewska KM, Habgood MD, Saunders NR. 2012. Barriers in the developing brain and Neurotoxicology. Neurotoxicology 33:586-604.
59. Engeszer RE, Barbiano LA, Ryan MJ, Parichy DM. 2007. Timing and plasticity of shoaling behaviour in the zebrafish, Danio rerio. Anim Behav 74:1269-1275.
60. Engeszer RE, Ryan MJ, Parichy DM. 2004. Learned social preference in zebrafish. Curr Biol 14:881-884.
61. Esbenshade TA, Estvander BR, Miller TR etal. 2007. Pharmacological classification of histamine H3 receptor agents across species is attributable to transmembrane 3 sequence differences. Inflamm Res 56(Suppl 1):S45-S46.
62. Esterberg R, Coffin AB, Ou H, Simon JA, Raible DW, Rubel EW. 2013. Fish in a dish: drug discovery for hearing habilitation. Drug Discov Today Dis Models.
63. Estudante M, Morais JG, Soveral G, Benet LZ. 2013. Intestinal drug transporters: an overview. Adv Drug Deliv Rev 65:1340-1356.
64. Fadool JM, Dowling JE. 2008. Zebrafish: a model system for the study of eye genetics. Prog Retin Eye Res 27:89-110.
65. Fan CY, Cowden J, Simmons SO, Padilla S, Ramabhadran R. 2010. Gene expression changes in developing zebrafish as potential markers for rapid developmental neurotoxicity screening. Neurotoxicol Teratol 32:91-98.
66. Farrell TC, Cario CL, Milanese C, Vogt A, Jeong JH, Burton EA. 2011. Evaluation of spontaneous propulsive movement as a screening tool to detect rescue of Parkinsonism phenotypes in zebrafish models. Neurobiol Dis 44:9-18.
67. Fay RR, Simmons AM. 1999. The sense of hearing in fishes and amphibians. Comparative Hearing: Fish and Amphibians 269-318.
68. Field HA, Ober EA, Roeser T, Stainier DY. 2003. Formation of the digestive system in zebrafish. I. Liver morphogenesis. Dev Biol 253:279-290.
69. Fischer S, Kluver N, Burkhardt-Medicke K etal. 2013. Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos. BMC Biol 11:69.
70. Fleming A, Diekmann H, Goldsmith P. 2013. Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS ONE 8:e77548.
71. Fox DA, Grandjean P, De Groot D, Paule MG. 2012. Developmental origins of adult diseases and neurotoxicity: epidemiological and experimental studies. Neurotoxicology 33:810-816.
72. Fremeau RT, Jr, Troyer MD, Pahner I etal. 2001. The expression of vesicular glutamate transporters defines two classes of excitatory synapse. Neuron 31:247-260.
73. Friedrich RW, Genoud C, Wanner AA. 2013. Analyzing the structure and function of neuronal circuits in zebrafish. Front Neural Circuits 7:71.
74. Friedrich RW, Jacobson GA, Zhu P. 2010. Circuit neuroscience in zebrafish. Curr Biol 20:R371-R381.
75. Fu C, Cawthon B, Clinkscales W, Bruce A, Winzenburger P, Ess KC. 2012. GABAergic interneuron development and function is modulated by the Tsc1 gene. Cereb Cortex 22:2111-2119.
76. Gahtan E, Baier H. 2004. Of lasers, mutants, and see-through brains: functional neuroanatomy in zebrafish. J Neurobiol 59:147-161.
77. Gatzidou ET, Zira AN, Theocharis SE. 2007. Toxicogenomics: a pivotal piece in the puzzle of toxicological research. J Appl Toxicol 27:302-309.
78. Gerlai R. 2013. Antipredatory behavior of zebrafish: adaptive function and a tool for translational research. Evol Psychol 11:591-605.
79. Geschwind DH, Levitt P. 2007. Autism spectrum disorders: developmental disconnection syndromes. Curr Opin Neurobiol 17:103-111.
80. Goldsmith P, Harris WA. 2003. The zebrafish as a tool for understanding the biology of visual disorders. Semin Cell Dev Biol 14:11-18.
81. Goldstone JV, McArthur AG, Kubota A etal. 2010. Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish. BMC Genomics 11:643.
82. Gonzalez A, Pariente JA, Salido GM. 2007. Ethanol stimulates ROS generation by mitochondria through Ca2+ mobilization and increases GFAP content in rat hippocampal astrocytes. Brain Res 1178:28-37.
83. Gorski JA, Talley T, Qiu M, Puelles L, Rubenstein JL, Jones KR. 2002. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci 22:6309-6314.
84. Guengerich FP. 2001. Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem Res Toxicol 14:611-650.
85. Gunnarsson L, Jauhiainen A, Kristiansson E, Nerman O, Larsson DG. 2008. Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environ Sci Technol 42:5807-5813.
86. Guo S. 2004. Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish? Genes Brain Behav 3:63-74.
87. Guo S. 2009. Using zebrafish to assess the impact of drugs on neural development and function. Expert Opin Drug Discov 4:715-726.
88. Harper SL, Carriere JL, Miller JM, Hutchison JE, Maddux BL, Tanguay RL. 2011. Systematic evaluation of nanomaterial toxicity: utility of standardized materials and rapid assays. ACS Nano 5:4688-4697.
89. Hartung T, Van Vliet E, Jaworska J, Bonilla L, Skinner N, Thomas R. 2012. Food for thought... systems toxicology. ALTEX 29:119-128.
90. Hawkes C. 2003. Olfaction in neurodegenerative disorder. Mov Disord 18:364-372.
91. Helenius IT, Yeh JR. 2012. Small zebrafish in a big chemical pond. J Cell Biochem 113:2208-2216.
92. Herbert MR, Ziegler DA. 2005. Volumetric neuroimaging and low-dose early-life exposures: loose coupling of pathogenesis-brain-behavior links. Neurotoxicology 26:565-572.
93. Hevner RF, Hodge RD, Daza RA, Englund C. 2006. Transcription factors in glutamatergic neurogenesis: conserved programs in neocortex, cerebellum, and adult hippocampus. Neurosci Res 55:223-233.
94. Higashijima S. 2008. Transgenic zebrafish expressing fluorescent proteins in central nervous system neurons. Dev Growth Differ 50:407-413.
95. Higashijima S, Mandel G, Fetcho JR. 2004. Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish. J Comp Neurol 480:1-18.
96. Hitchcock SA, Pennington LD. 2006. Structure-brain exposure relationships. J Med Chem 49:7559-7583.
97. Hjorth J, Key B. 2002. Development of axon pathways in the zebrafish central nervous system. Int J Dev Biol 46:609-619.
98. Ho NY, Yang L, Legradi J etal. 2013. Gene responses in the central nervous system of zebrafish embryos exposed to the neurotoxicant methyl mercury. Environ Sci Technol 47:3316-3325.
99. Howe K, Clark MD, Torroja CF etal. 2013. The zebrafish reference genome sequence and its relationship to the human genome. Nature 496:498-503.
100. Huang SM, Xu F, Lam SH, Gong Z, Ong CN. 2013. Metabolomics of developing zebrafish embryos using gas chromatography- and liquid chromatography-mass spectrometry. Mol Biosyst 9:1372-1380.
101. Huang YY, Neuhauss SC. 2008. The optokinetic response in zebrafish and its applications. Front Biosci 13:1899-1916.
102. Ingebretson JJ, Masino MA. 2013. Quantification of locomotor activity in larval zebrafish: considerations for the design of high-throughput behavioral studies. Front Neural Circuits 7:109.
103. Irons TD, Macphail RC, Hunter DL, Padilla S. 2009. Acute neuroactive drug exposures alter locomotor activity in larval zebrafish. Neurotoxicol Teratol 32:84-90.
104. Ito K, Nguyen HT, Kato Y etal. 2008. P-glycoprotein (Abcb1) is involved in absorptive drug transport in skin. J Control Release 131:198-204.
105. Jacob J, Ribes V, Moore S etal. 2014. Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome. Dis Model Mech 7:107-117.
106. Jen JC, Chan WM, Bosley TM etal. 2004. Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis. Science 304:1509-1513.
107. Jeong JY, Kwon HB, Ahn JC etal. 2008. Functional and developmental analysis of the blood-brain barrier in zebrafish. Brain Res Bull 75:619-628.
108. Jonz MG, Nurse CA. 2005. Development of oxygen sensing in the gills of zebrafish. J Exp Biol 208:1537-1549.
109. Jung KH, Das ND, Park JH etal. 2010. Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro 24:1696-1704.
110. Kalberg WO, Provost B, Tollison SJ etal. 2006. Comparison of motor delays in young children with fetal alcohol syndrome to those with prenatal alcohol exposure and with no prenatal alcohol exposure. Alcohol Clin Exp Res 30:2037-2045.
111. Kalueff AV, Gebhardt M, Stewart AM etal. 2013. Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond. Zebrafish 10:70-86.
112. Kalueff AV, Stewart AM, Gerlai R. 2014. Zebrafish as an emerging model for studying complex brain disorders. Trends Pharmacol Sci 35:63-75.
113. Kanungo J, Lantz S, Paule MG. 2011. In vivo imaging and quantitative analysis of changes in axon length using transgenic zebrafish embryos. Neurotoxicol Teratol 33:618-623.
114. Kastenhuber E, Kratochwil CF, Ryu S, Schweitzer J, Driever W. 2010. Genetic dissection of dopaminergic and noradrenergic contributions to catecholaminergic tracts in early larval zebrafish. J Comp Neurol 518:439-458.
115. Kennedy B, Malicki J. 2009. What drives cell morphogenesis: a look inside the vertebrate photoreceptor. Dev Dyn 238:2115-2138.
116. Kessaris N, Pringle N, Richardson WD. 2008. Specification of CNS glia from neural stem cells in the embryonic neuroepithelium. Philos Trans R Soc Lond B Biol Sci 363:71-85.
117. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF. 1995. Stages of embryonic development of the zebrafish. Dev Dyn 203:253-310.
118. Klee EW, Schneider H, Clark KJ etal. 2012. Zebrafish: a model for the study of addiction genetics. Hum Genet 131:977-1008.
119. Koch M. 1999. The neurobiology of startle. Prog Neurobiol 59:107-128.
120. Kokel D, Bryan J, Laggner C etal. 2010. Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat Chem Biol 6:231-237.
121. Kokel D, Peterson RT. 2008. Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish. Brief Funct Genomic Proteomic 7:483-490.
122. Kortum F, Das S, Flindt M etal. 2011. The core FOXG1 syndrome phenotype consists of postnatal microcephaly, severe mental retardation, absent language, dyskinesia, and corpus callosum hypogenesis. J Med Genet 48:396-406.
123. Korzh V, Strähle U. 2002. Proneural, prosensory, antiglial: the many faces of neurogenins. Trends Neurosci 25:603-605.
124. Kucenas S, Snell H, Appel B. 2008. nkx2.2a promotes specification and differentiation of a myelinating subset of oligodendrocyte lineage cells in zebrafish. Neuron Glia Biol 4:71-81.
125. Kullander K. 2005. Genetics moving to neuronal networks. Trends Neurosci 28:239-247.
126. Kuwada JY. 1986. Cell recognition by neuronal growth cones in a simple vertebrate embryo. Science 233:740-746.
127. Kuwagata M. 2012. Current problems of in vivo developmental neurotoxicity tests and a new in vivo approach focusing on each step of the developing central nervous system. Congenit Anom Kyoto 52:129-139.
128. Kuwagata M, Ogawa T, Shioda S, Nagata T. 2009. Observation of fetal brain in a rat valproate-induced autism model: a developmental neurotoxicity study. Int J Dev Neurosci 27:399-405.
129. Kyzar E, Zapolsky I, Green J etal. 2012. The Zebrafish Neurophenome Database (ZND): a dynamic open-access resource for zebrafish neurophenotypic data. Zebrafish 9:8-14.
130. Landrigan PJ, Lambertini L, Birnbaum LS. 2012. A research strategy to discover the environmental causes of autism and neurodevelopmental disabilities. Environ Health Perspect 120:a258-a260.
131. Lange M, Neuzeret F, Fabreges B etal. 2013. Inter-individual and inter-strain variations in zebrafish locomotor ontogeny. PLoS ONE 8:e70172.
132. Lee KJ, Nallathamby PD, Browning LM, Osgood CJ, Xu XH. 2007. In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos. ACS Nano 1:133-143.
133. Li H, Arber S, Jessell TM, Edlund H. 1999. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet 23:67-70.
134. Lillesaar C. 2011. The serotonergic system in fish. J Chem Neuroanat 41:294-308.
135. Lindsay SM, Vogt RG. 2004. Behavioral responses of newly hatched zebrafish (Danio rerio) to amino acid chemostimulants. Chem Senses 29:93-100.
136. Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein JL. 2009. Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol 512:556-572.
137. Long Y, Li Q, Zhong S, Wang Y, Cui Z. 2011. Molecular characterization and functions of zebrafish ABCC2 in cellular efflux of heavy metals. Comp Biochem Physiol C Toxicol Pharmacol 153:381-391.
138. Loscher W, Potschka H. 2005. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog Neurobiol 76:22-76.
139. Lovenberg TW, Pyati J, Chang H, Wilson SJ, Erlander MG. 2000. Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles. J Pharmacol Exp Ther 293:771-778.
140. Lucas ME, Muller F, Rudiger R, Henion PD, Rohrer H. 2006. The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons. Development 133:4015-4024.
141. Macphail RC, Brooks J, Hunter DL, Padnos B, Irons TD, Padilla S. 2009. Locomotion in larval zebrafish: Influence of time of day, lighting and ethanol. Neurotoxicology 30:52-58.
142. Martin SC, Heinrich G, Sandell JH. 1998. Sequence and expression of glutamic acid decarboxylase isoforms in the developing zebrafish. J Comp Neurol 396:253-266.
143. Martyniuk CJ, Popesku JT, Chown B, Denslow ND, Trudeau VL. 2012. Quantitative proteomics in teleost fish: insights and challenges for neuroendocrine and neurotoxicology research. Gen Comp Endocrinol 176:314-320.
144. Mathias JR, Saxena MT, Mumm JS. 2012. Advances in zebrafish chemical screening technologies. Future Med Chem 4:1811-1822.
145. Mattingly CJ, Hampton TH, Brothers KM, Griffin NE, Planchart A. 2009. Perturbation of defense pathways by low-dose arsenic exposure in zebrafish embryos. Environ Health Perspect 117:981-987.
146. Matz CJ, Treble RG, Krone PH. 2007. Accumulation and elimination of cadmium in larval stage zebrafish following acute exposure. Ecotoxicol Environ Saf 66:44-48.
147. Maximino C, De Brito TM, Da Silva Batista AW, Herculano AM, Morato S, Gouveia A, Jr. 2010. Measuring anxiety in zebrafish: a critical review. Behav Brain Res 214:157-171.
148. Mazaheri A, Coffey-Corina S, Mangun GR, Bekker EM, Berry AS, Corbett BA. 2010. Functional disconnection of frontal cortex and visual cortex in attention-deficit/hyperactivity disorder. Biol Psychiatry 67:617-623.
149. Mazumdar M, Xia W, Hofmann O etal. 2012. Prenatal lead levels, plasma amyloid beta levels, and gene expression in young adulthood. Environ Health Perspect 120:702-707.
150. McCollum CW, Ducharme NA, Bondesson M, Gustafsson JA. 2011. Developmental toxicity screening in zebrafish. Birth Defects Res C Embryo Today 93:67-114.
151. McLean DL, Fetcho JR. 2004. Ontogeny and innervation patterns of dopaminergic, noradrenergic, and serotonergic neurons in larval zebrafish. J Comp Neurol 480:38-56.
152. Mikut R, Dickmeis T, Driever W etal. 2013. Automated processing of zebrafish imaging data: a survey. Zebrafish 10:401-421.
153. Miyasaka N, Wanner AA, Li J etal. 2013. Functional development of the olfactory system in zebrafish. Mech Dev 130:336-346.
154. Miyazaki K, Narita N, Narita M. 2005. Maternal administration of thalidomide or valproic acid causes abnormal serotonergic neurons in the offspring: implication for pathogenesis of autism. Int J Dev Neurosci 23:287-297.
155. Morikawa Y, D'autreaux F, Gershon MD, Cserjesi P. 2007. Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Dev Biol 307:114-126.
156. Mu Y, Li XQ, Zhang B, Du JL. 2012. Visual input modulates audiomotor function via hypothalamic dopaminergic neurons through a cooperative mechanism. Neuron 75:688-699.
157. Mueller T, Wullimann MF, Guo S. 2008. Early teleostean basal ganglia development visualized by zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression. J Comp Neurol 507:1245-1257.
158. Muth-Köhne E, Wichmann A, Delov V, Fenske M. 2012. The classification of motor neuron defects in the zebrafish embryo toxicity test (ZFET) as an animal alternative approach to assess developmental neurotoxicity. Neurotoxicol Teratol 34:413-424.
159. Muto A, Kawakami K. 2013. Prey capture in zebrafish larvae serves as a model to study cognitive functions. Front Neural Circuits 7:110.
160. Ndubaku U, De Bellard ME. 2008. Glial cells: old cells with new twists. Acta Histochem 110:182-195.
161. Neuhauss SC. 2003. Behavioral genetic approaches to visual system development and function in zebrafish. J Neurobiol 54:148-160.
162. Ni B, Wu X, Yan GM, Wang J, Paul SM. 1995. Regional expression and cellular localization of the Na(+)-dependent inorganic phosphate cotransporter of rat brain. J Neurosci 15:5789-5799.
163. Nielsen AL, Jorgensen AL. 2003. Structural and functional characterization of the zebrafish gene for glial fibrillary acidic protein, GFAP. Gene 310:123-132.
164. Nishimura M, Koeda A, Suganuma Y etal. 2007. Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes. Drug Metab Pharmacokinet 22:178-186.
165. Nishimura Y, Yata K, Nomoto T etal. 2013. Identification of a novel indoline derivative for in vivo fluorescent imaging of blood-brain barrier disruption in animal models. ACS Chem Neurosci 4:1183-1193.
166. North TE, Goessling W, Walkley CR etal. 2007. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 447:1007-1011.
167. Norton WH. 2013. Toward developmental models of psychiatric disorders in zebrafish. Front Neural Circuits 7:79.
168. Norton WH, Mangoli M, Lele Z etal. 2005. Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones. Development 132:645-658.
169. O'malley DM, Sankrithi NS, Borla MA etal. 2004. Optical physiology and locomotor behaviors of wild-type and nacre zebrafish. Methods Cell Biol 76:261-284.
170. Oka T, Nishimura Y, Zang L etal. 2010. Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. BMC Physiol 10:21.
171. Oliveira RF. 2013. Mind the fish: zebrafish as a model in cognitive social neuroscience. Front Neural Circuits 7:131.
172. Oswald M, Robison BD. 2008. Strain-specific alteration of zebrafish feeding behavior in response to aversive stimuli. Can J Zool 86:1085-1094.
173. Ota S, Kawahara A. 2014. Zebrafish: a model vertebrate suitable for the analysis of human genetic disorders. Congenit Anom Kyoto 54:8-11.
174. Otte JC, Schmidt AD, Hollert H, Braunbeck T. 2010. Spatio-temporal development of CYP1 activity in early life-stages of zebrafish (Danio rerio). Aquat Toxicol 100:38-50.
175. Ou H, Simon JA, Rubel EW, Raible DW. 2012. Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line. Hear Res 288:58-66.
176. Oyabu A, Narita M, Tashiro Y. 2013. The effects of prenatal exposure to valproic acid on the initial development of serotonergic neurons. Int J Dev Neurosci 31:202-208.
177. Padilla S, Corum D, Padnos B etal. 2012. Zebrafish developmental screening of the ToxCast Phase I chemical library. Reprod Toxicol 33:174-187.
178. Pan YA, Freundlich T, Weissman TA etal. 2013. Zebrabow: multispectral cell labeling for cell tracing and lineage analysis in zebrafish. Development 140:2835-2846.
179. Panula P, Chen YC, Priyadarshini M etal. 2010. The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases. Neurobiol Dis 40:46-57.
180. Park HC, Hong SK, Kim HS etal. 2000. Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis. Neurosci Lett 279:81-84.
181. Park HC, Mehta A, Richardson JS, Appel B. 2002. olig2 is required for zebrafish primary motor neuron and oligodendrocyte development. Dev Biol 248:356-368.
182. Pauls S, Zecchin E, Tiso N, Bortolussi M, Argenton F. 2007. Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts. Dev Biol 304:875-890.
183. Perkins EJ, Ankley GT, Crofton KM etal. 2013. Current perspectives on the use of alternative species in human health and ecological hazard assessments. Environ Health Perspect 121:1002-1010.
184. Peterson RT, Macrae CA. 2012. Systematic approaches to toxicology in the zebrafish. Annu Rev Pharmacol Toxicol 52:433-453.
185. Peterson RT, Nass R, Boyd WA, Freedman JH, Dong K, Narahashi T. 2008. Use of non-mammalian alternative models for neurotoxicological study. Neurotoxicology 29:546-555.
186. Pettersson-Yeo W, Allen P, Benetti S, McGuire P, Mechelli A. 2011. Dysconnectivity in schizophrenia: where are we now? Neurosci Biobehav Rev 35:1110-1124.
187. Petzold AM, Balciunas D, Sivasubbu S etal. 2009. Nicotine response genetics in the zebrafish. Proc Natl Acad Sci U S A 106:18662-18667.
188. Polanska K, Jurewicz J, Hanke W. 2013. Review of current evidence on the impact of pesticides, polychlorinated biphenyls and selected metals on attention deficit / hyperactivity disorder in children. Int J Occup Med Environ Health 26:16-38.
189. Prykhozhij SV, Marsico A, Meijsing SH. 2013. Zebrafish Expression Ontology of Gene Sets (ZEOGS): a tool to analyze enrichment of zebrafish anatomical terms in large gene sets. Zebrafish 10:303-315.
190. Raftery TD, Isales GM, Yozzo KL, Volz DC. 2014. High-content screening assay for identification of chemicals impacting spontaneous activity in zebrafish embryos. Environ Sci Technol 48:804-810.
191. Raper J, Mason C. 2010. Cellular strategies of axonal pathfinding. Cold Spring Harb Perspect Biol 2:a001933.
192. Rawson DM, Zhang T, Kalicharan D, Jongebloed WL. 2000. Field emission scanning electron microscopy and transmission electron microscopy studies of the chorion, plasma membrane and syncytial layers of the gastrula-stage embryo of the zebrafish Brachydanio rerio: a consideration of the structural and functional relationships with respect to cryoprotectant penetration. Aquac Res 31:325-336.
193. Rihel J, Prober DA, Arvanites A etal. 2010. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science 327:348-351.
194. Rihel J, Schier AF. 2012. Behavioral screening for neuroactive drugs in zebrafish. Dev Neurobiol 72:373-385.
195. Roberts AC, Bill BR, Glanzman DL. 2013. Learning and memory in zebrafish larvae. Front Neural Circuits 7:126.
196. Roberts AC, Reichl J, Song MY etal. 2011. Habituation of the C-start response in larval zebrafish exhibits several distinct phases and sensitivity to NMDA receptor blockade. PLoS ONE 6:e29132.
197. Rombough P. 2002. Gills are needed for ionoregulation before they are needed for O(2) uptake in developing zebrafish, Danio rerio. J Exp Biol 205:1787-1794.
198. Ronneberger O, Liu K, Rath M etal. 2012. ViBE-Z: a framework for 3D virtual colocalization analysis in zebrafish larval brains. Nat Methods 9:735-742.
199. Roth FC, Draguhn A. 2012. GABA metabolism and transport: effects on synaptic efficacy. Neural Plast 2012:805830.
200. Rubinstein AL. 2006. Zebrafish assays for drug toxicity screening. Expert Opin Drug Metab Toxicol 2:231-240.
201. Sackerman J, Donegan JJ, Cunningham CS etal. 2010. Zebrafish behavior in novel environments: effects of acute exposure to anxiolytic compounds and choice of danio rerio line. Int J Comp Psychol 23:43-61.
202. Sallinen V, Torkko V, Sundvik M etal. 2009. MPTP and MPP+ target specific aminergic cell populations in larval zebrafish. J Neurochem 108:719-731.
203. Sato T, Takahoko M, Okamoto H. 2006. HuC:Kaede, a useful tool to label neural morphologies in networks in vivo. Genesis 44:136-142.
204. Saverino C, Gerlai R. 2008. The social zebrafish: behavioral responses to conspecific, heterospecific, and computer animated fish. Behav Brain Res 191:77-87.
205. Schmidt R, Strahle U, Scholpp S. 2013. Neurogenesis in zebrafish - from embryo to adult. Neural Dev 8:3.
206. Schnorr SJ, Steenbergen PJ, Richardson MK, Champagne DL. 2012. Measuring thigmotaxis in larval zebrafish. Behav Brain Res 228:367-374.
207. Scholz S, Fischer S, Gundel U, Kuster E, Luckenbach T, Voelker D. 2008. The zebrafish embryo model in environmental risk assessment-applications beyond acute toxicity testing. Environ Sci Pollut Res Int 15:394-404.
208. Schreiber R, Altenburger R, Paschke A, Schuurmann G, Kuster E. 2009. A novel in vitro system for the determination of bioconcentration factors and the internal dose in zebrafish (Danio rerio) eggs. Chemosphere 77:928-933.
209. Schweitzer J, Lohr H, Filippi A, Driever W. 2012. Dopaminergic and noradrenergic circuit development in zebrafish. Dev Neurobiol 72:256-268.
210. Selderslaghs IW, Hooyberghs J, De Coen W, Witters HE. 2010. Locomotor activity in zebrafish embryos: a new method to assess developmental neurotoxicity. Neurotoxicol Teratol 32:460-471.
211. Shelton JF, Hertz-Picciotto I, Pessah IN. 2012. Tipping the balance of autism risk: potential mechanisms linking pesticides and autism. Environ Health Perspect 120:944-951.
212. Shimada Y, Hirano M, Nishimura Y, Tanaka T. 2012. A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening. PLoS ONE 7:e52549.
213. Sipes NS, Padilla S, Knudsen TB. 2011. Zebrafish: as an integrative model for twenty-first century toxicity testing. Birth Defects Res C Embryo Today 93:256-267.
214. Smidt MP, Van Hooft JA. 2013. Subset specification of central serotonergic neurons. Front Cell Neurosci 7:200.
215. Spence SJ, Schneider MT. 2009. The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatr Res 65:599-606.
216. Sprague J, Bayraktaroglu L, Bradford Y etal. 2008. The Zebrafish Information Network: the zebrafish model organism database provides expanded support for genotypes and phenotypes. Nucleic Acids Res 36:D768-D772.
217. Spurgeon DJ, Jones OA, Dorne JL, Svendsen C, Swain S, Sturzenbaum SR. 2010. Systems toxicology approaches for understanding the joint effects of environmental chemical mixtures. Sci Total Environ 408:3725-3734.
218. Steenbergen PJ, Richardson MK, Champagne DL. 2011. The use of the zebrafish model in stress research. Prog Neuropsychopharmacol Biol Psychiatry 35:1432-1451.
219. Sukardi H, Ung CY, Gong Z, Lam SH. 2010. Incorporating zebrafish omics into chemical biology and toxicology. Zebrafish 7:41-52.
220. Szyf M. 2011. The implications of DNA methylation for toxicology: toward toxicomethylomics, the toxicology of DNA methylation. Toxicol Sci 120:235-255.
221. Takada N, Kucenas S, Appel B. 2010. Sox10 is necessary for oligodendrocyte survival following axon wrapping. Glia 58:996-1006.
222. Thompson BL, Levitt P, Stanwood GD. 2009. Prenatal exposure to drugs: effects on brain development and implications for policy and education. Nat Rev Neurosci 10:303-312.
223. Tiedeken JA, Ramsdell JS. 2007. Embryonic exposure to domoic Acid increases the susceptibility of zebrafish larvae to the chemical convulsant pentylenetetrazole. Environ Health Perspect 115:1547-1552.
224. Tierney KB. 2011. Behavioural assessments of neurotoxic effects and neurodegeneration in zebrafish. Biochim Biophys Acta 1812:381-389.
225. Tierney KB, Baldwin DH, Hara TJ, Ross PS, Scholz NL, Kennedy CJ. 2010. Olfactory toxicity in fishes. Aquat Toxicol 96:2-26.
226. Ton C, Parng C. 2005. The use of zebrafish for assessing ototoxic and otoprotective agents. Hear Res 208:79-88.
227. Trampus M, Ferri N, Adami M, Ongini E. 1993. The dopamine D1 receptor agonists, A68930 and SKF 38393, induce arousal and suppress REM sleep in the rat. Eur J Pharmacol 235:83-87.
228. Tropepe V, Sive HL. 2003. Can zebrafish be used as a model to study the neurodevelopmental causes of autism? Genes Brain Behav 2:268-281.
229. Tseng HP, Hseu TH, Buhler DR, Wang WD, Hu CH. 2005. Constitutive and xenobiotics-induced expression of a novel CYP3A gene from zebrafish larva. Toxicol Appl Pharmacol 205:247-258.
230. Tsuji R, Crofton KM. 2012. Developmental neurotoxicity guideline study: issues with methodology, evaluation and regulation. Congenit Anom Kyoto 52:122-128.
231. Umemoto N, Nishimura Y, Shimada Y etal. 2013. Fluorescent-based methods for gene knockdown and functional cardiac imaging in zebrafish. Mol Biotechnol 55:131-142.
232. Van Thriel C, Westerink RH, Beste C, Bale AS, Lein PJ, Leist M. 2012. Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts. Neurotoxicology 33:911-924.
233. Van Vliet E. 2011. Current standing and future prospects for the technologies proposed to transform toxicity testing in the 21st century. ALTEX 28:17-44.
234. Vatine G, Vallone D, Gothilf Y, Foulkes NS. 2011. It's time to swim! Zebrafish and the circadian clock. FEBS Lett 585:1485-1494.
235. Vignet C, Begout ML, Pean S, Lyphout L, Leguay D, Cousin X. 2013. Systematic screening of behavioral responses in two zebrafish strains. Zebrafish 10:365-375.
236. Vitebsky A, Reyes R, Sanderson MJ, Michel WC, Whitlock KE. 2005. Isolation and characterization of the laure olfactory behavioral mutant in the zebrafish, Danio rerio. Dev Dyn 234:229-242.
237. Wallace KN, Pack M. 2003. Unique and conserved aspects of gut development in zebrafish. Dev Biol 255:12-29.
238. Warp E, Agarwal G, Wyart C etal. 2012. Emergence of patterned activity in the developing zebrafish spinal cord. Curr Biol 22:93-102.
239. Watanabe K, Nishimura Y, Nomoto T etal. 2012. In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish. BMC Neurosci 13:101.
240. Watanabe K, Nishimura Y, Oka T etal. 2010. In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives. BMC Neurosci 11:116.
241. Weigt S, Huebler N, Braunbeck T, Von Landenberg F, Broschard TH. 2010. Zebrafish teratogenicity test with metabolic activation (mDarT): effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos. Toxicology 275:36-49.
242. Weigt S, Huebler N, Strecker R, Braunbeck T, Broschard TH. 2011. Zebrafish (Danio rerio) embryos as a model for testing proteratogens. Toxicology 281:25-36.
243. Wendik B, Maier E, Meyer D. 2004. Zebrafish mnx genes in endocrine and exocrine pancreas formation. Dev Biol 268:372-383.
244. Wiegand C, Pflugmacher S, Giese M, Frank H, Steinberg C. 2000. Uptake, toxicity, and effects on detoxication enzymes of atrazine and trifluoroacetate in embryos of zebrafish. Ecotoxicol Environ Saf 45:122-131.
245. William CM, Tanabe Y, Jessell TM. 2003. Regulation of motor neuron subtype identity by repressor activity of Mnx class homeodomain proteins. Development 130:1523-1536.
246. Wilson SW, Houart C. 2004. Early steps in the development of the forebrain. Dev Cell 6:167-181.
247. Winneke G. 2011. Developmental aspects of environmental neurotoxicology: lessons from lead and polychlorinated biphenyls. J Neurol Sci 308:9-15.
248. Wolman M, Granato M. 2012. Behavioral genetics in larval zebrafish: learning from the young. Dev Neurobiol 72:366-372.
249. Wolman MA, Jain RA, Liss L, Granato M. 2011. Chemical modulation of memory formation in larval zebrafish. Proc Natl Acad Sci U S A 108:15468-15473.
250. Wolman MA, Liu Y, Tawarayama H, Shoji W, Halloran MC. 2004. Repulsion and attraction of axons by semaphorin3D are mediated by different neuropilins in vivo. J Neurosci 24:8428-8435.
251. Wullimann MF. 2009. Secondary neurogenesis and telencephalic organization in zebrafish and mice: a brief review. Integr Zool 4:123-133.
252. Wullimann MF, Mueller T. 2004. Teleostean and mammalian forebrains contrasted: evidence from genes to behavior. J Comp Neurol 475:143-162.
253. Xie J, Farage E, Sugimoto M, Anand-Apte B. 2010. A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development. BMC Dev Biol 10:76.
254. Yang D, Lauridsen H, Buels K etal. 2011. Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior. Toxicol Sci 121:146-159.
255. Yang L, Kemadjou JR, Zinsmeister C etal. 2007. Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo. Genome Biol 8:R227.
256. Zellner D, Padnos B, Hunter DL, Macphail RC, Padilla S. 2011. Rearing conditions differentially affect the locomotor behavior of larval zebrafish, but not their response to valproate-induced developmental neurotoxicity. Neurotoxicol Teratol 33:674-679.
257. Zhang B, Shimada Y, Kuroyanagi J, Umemoto N, Nishimura Y, Tanaka T. 2014. Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation. PLoS ONE 9:e85439.
258. Zhang X, Gong Z. 2013. Fluorescent transgenic zebrafish Tg(nkx2.2a:mEGFP) provides a highly sensitive monitoring tool for neurotoxins. PLoS ONE 8:e55474.
259. Zhao Y, Marin O, Hermesz E etal. 2003. The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain. Proc Natl Acad Sci U S A 100:9005-9010.
260. Zu Y, Tong X, Wang Z etal. 2013. TALEN-mediated precise genome modification by homologous recombination in zebrafish. Nat Methods 10:329-331.