Perturbation of defense pathways by low-dose Arsenic exposure in zebrafish embryos

Environmental Health Perspectives

Volumn 117, Issue 6, 2009, Pages 981-987

  Mattingly, Carolyn J ^a   Hampton, Thomas H ^b   Brothers, Kimberly M ^c   Griffin, Nina E ^a   Planchart, Antonio ^a  

^a MOUNT DESERT ISLAND BIOLOGICAL LABORATORY   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MAINE   (United States)

Author keywords

Comparative toxicogenomics database; Embryonic development; Gene regulatory networks; Immunity; Microarray; Toxicogenomics; Transcriptional profiling; Zebrafish

Indexed keywords

ARGININOSUCCINATE SYNTHASE; ARSENIC; CD28 ANTIGEN; COMPLEMENT COMPONENT C3; FIBRONECTIN; FORKHEAD BOX 05 PROTEIN; GENE PRODUCT; GENOMIC DNA; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; NOTCH1A RECEPTOR; NOTCH1B RECEPTOR; NUCLEAR FACTOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELL 2 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLASMINOGEN; PROTEIN KINASE B BETA; RNA; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; UNCLASSIFIED DRUG;

ANIMAL EMBRYO; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DNA MICROARRAY; DOWN REGULATION; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; IMMUNE RESPONSE; IMMUNOREGULATION; NEOPLASM; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ZEBRA FISH;

ANIMALS; ARSENIC; EMBRYO, NONMAMMALIAN; GENE EXPRESSION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; WATER POLLUTANTS, CHEMICAL; ZEBRAFISH;

DANIO RERIO; VERTEBRATA;

EID: 67449114068     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.0900555     Document Type: Article

References (57)

1. Aggarwal M, Naraharisetti SB, Dandapat S, Degen GH, Malik JK. 2008. Perturbations in immune responses induced by concurrent subchronic exposure to arsenic and endosulfan. Toxicology 251(1-3):51-60.
2. Andrew AS, Bernardo V, Warnke LA, Davey JC, Hampton T, Mason RA, et al. 2007. Exposure to arsenic at levels found in U.S. drinking water modifies expression in the mouse lung. Toxicol Sci 100(1):75-87.
3. Andrew AS, Burgess JL, Meza MM, Demidenko E, Waugh MG, Hamilton JW, et al. 2006. Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic. Environ Health Perspect 114:1193-1198.
4. Andrew AS, Jewell DA, Mason RA, Whitfield ML, Moore JH, Karagas MR. 2008. Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. Population. Environ Health Perspect 116:524-531.
5. Andrew AS, Warren AJ, Barchowsky A, Temple KA, Klei L, Soucy NV, et al. 2003. Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect 111:825-835.
6. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, et al. 2000. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25(1):25-29.
7. Birnbaum LS, Fenton SR. 2003. Cancer and developmental exposure to endocrine disruptors. Environ Health Perspect 111:389-394.
8. Biswas R, Ghosh P, Banerjee N, Das JK, Sau T, Banerjee A, et al. 2008. Analysis of T-cell proliferation and cytokine secretion in the individuals exposed to arsenic. Hum Exp Toxicol 27(5):381-386.
9. Bodwell JE, Kingsley LA, Hamilton JW. 2004. Arsenic at very low concentrations alters glucocorticoid receptor (GR)-mediated gene activation but not GR-mediated gene repression: complex dose-response effects are closely correlated with levels of activated GR and require a functional GR DNA binding domain. Chem Res Toxicol 17(8):1064-1076.
10. Concha G, Vogler G, Lezcano D, Nermell B, Vahter M. 1998. Exposure to inorganic arsenic metabolites during early human development. Toxicol Sci 44(2):185-190.
11. CTD. 2009. Comparative Toxicogenomics Database. Available: http:// ctd.mdibl.org/ [accessed 1 May 2009].
12. Davey JC, Bodwell JE, Gosse JA, Hamilton JW. 2007. Arsenic as an endocrine disruptor: effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture. Toxicol Sci 98(1):75-86.
13. Davis AP, Murphy CG, Rosenstein MC, Wiegers TC, Mattingly CJ. 2008. The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study. BMC Med Genomics 1:48; doi:10.1186/1755-8794-1-48 [Online 9 October 2008].
14. Davis AP, Murphy CG, Saraceni-Richards CA, Rosenstein MC, Wiegers TC, Mattingly CJ. 2009. Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks. Nucleic Acids Res 37:D786-D792.
15. Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, et al. 2003. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4(5):P3; doi:10.1186/gb-2003-4-5-p3 [Online 3 April 2003].
16. Eisen MB, Spellman PT, Brown PO, Botstein D. 1998. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95(25):14863-14868.
17. Fry RC, Navasumrit P, Valiathan C, Svensson JP, Hogan BJ, Luo M, et al. 2007. Activation of inflammation/NF-κB signaling in infants born to arsenic-exposed mothers. PLoS Genet 3(11):e207; doi:10.1371/ journal.pgen.0030207 [Online 23 November 2007].
18. Goessling W, North TE, Zon LI. 2007. New waves of discovery: modeling cancer in zebrafish. J Clin Oncol 25(17):2473-2479.
19. Gosse JA, Hampton TH, Davey JC, Hamilton JW. 2008. A new approach to analysis and interpretation of toxicogenomic gene expression data and its importance in examining biological responses to low, environmentally-relevant doses of toxicants. In: Toxicogenomics: A Powerful Tool for Toxicity Assessment (Sahu SC, ed). Hoboken, NJ:John Wiley & Sons, 27-57.
20. Guo L, Lobenhofer EK, Wang C, Shippy R, Harris SC, Zhang L, et al. 2006. Rat toxicogenomic study reveals analytical consistency across microarray platforms. Nat Biotechnol 24:1162-1169.
21. Hales CN, Barker DJ. 2001. The thrifty phenotype hypothesis. Br Med Bull 60:5-20.
22. He W, Greenwell RJ, Brooks DM, Calderon-Garciduenas L, Beall HD, Coffin JD. 2007. Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion. Toxicol Sci 99(1):244-253.
23. Hill DS, Wlodarczyk BJ, Finnell RH. 2008. Reproductive consequences of oral arsenate exposure during pregnancy in a mouse model. Birth Defects Res B Dev Reprod Toxicol 83(1):40-47.
24. Ho SM, Tang WY, Belmonte de Frausto J, Prins GS. 2006. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res 66(11):5624-5632.
25. Hughes MF. 2006. Biomarkers of exposure: a case study with inorganic arsenic. Environ Health Perspect 114:1790-1796.
26. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. 2003. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31(4):e15.
27. Lahiri DK, Maloney B, Basha MR, Ge YW, Zawia NH. 2007. How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the "LEARN" model (latent early-life associated regulation) may explain the triggering of AD. Curr Alzheimer Res 4(2):219-228.
28. Lieschke GJ, Currie PD. 2007. Animal models of human disease: zebrafish swim into view. Nat Rev Genet 8(5):353-367.
29. Liu J, Yu L, Tokar EJ, Bortner C, Sifre MI, Sun Y, et al. 2008. Arsenic-induced aberrant gene expression in fetal mouse primary liver-cell cultures. Ann NY Acad Sci 1140:368-375.
30. Marsit CJ, Karagas MR, Danaee H, Liu M, Andrew A, Schned A, et al. 2006. Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Carcinogenesis 27(1):112-116.
31. Mattingly CJ, McLachlan JA, Toscano WA Jr. 2001. Green fluorescent protein (GFP) as a marker of aryl hydrocarbon receptor (AhR) function in developing zebrafish (Danio rerio). Environ Health Perspect 109:845-849.
32. Mattingly CJ, Rosenstein MC, Davis AP, Colby GT, Forrest JN Jr, Boyer JL. 2006. The comparative toxicogenomics database: a cross-species resource for building chemical-gene interaction networks. Toxicol Sci 92(2):587-595.
33. Mead MN. 2005. Arsenic: in search of an antidote to a global poison. Environ Health Perspect 113:A378-A386.
34. NCBI (National Center for Biotechnology Information). 2009. Available: http://www.ncbi.nlm.nih.gov/ [accessed 1 May 2009].
35. Nayak AS, Lage CR, Kim CH. 2007. Effects of low concentrations of arsenic on the innate immune system of the zebrafish (Danio rerio). Toxicol Sci 98(1):118-124.
36. Newbold RR. 2004. Lessons learned from perinatal exposure to diethylstilbestrol. Toxicol Appl Pharmacol 199(2):142-150.
37. Newbold RR, Padilla-Banks E, Jefferson WN. 2006. Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinology 147(6 suppl):S11-S17.
38. Olsen CE, Liguori AE, Zong Y, Lantz RC, Burgess JL, Boitano S. 2008. Arsenic upregulates mmp-9 and inhibits wound repair in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 295(2):L293-L302.
39. Pichler FB, Laurenson S, Williams LC, Dodd A, Copp BR, Love DR. 2003. Chemical discovery and global gene expression analysis in zebrafish. Nat Biotechnol 21(8):879-883.
40. R Development Core Team. 2009. R: A Language and Environment for Statistical Computing. Vienna:R Foundation for Statistical Computing.
41. Ravelli AC, van der Meulen JH, Michels RP, Osmond C, Barker DJ, Hales CN, et al. 1998. Glucose tolerance in adults after prenatal exposure to famine. Lancet 351(9097):173-177.
42. Rossman TG, Uddin AN, Burns FJ. 2004. Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol Appl Pharmacol 198(3):394-404.
43. Sakurai T, Ohta T, Tomita N, Kojima C, Hariya Y, Mizukami A, et al. 2006. Evaluation of immunotoxic and immunodisruptive effects of inorganic arsenite on human monocytes/macrophages. Int Immunopharmacol 6(2):304-315.
44. Shen J, Liu J, Xie Y, Diwan BA, Waalkes MP. 2007. Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure. Toxicol Sci 95(2):313-320.
45. Shi L, Reid LH, Jones WD, Shippy R, Warrington JA, Baker SC, et al. 2006. The Microarray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol 24(9):1151-1161.
46. Speirs K, Lieberman L, Caamano J, Hunter CA, Scott P. 2004. Cutting edge: NF-κB2 is a negative regulator of dendritic cell function. J Immunol 172(2):752-756.
47. Straub AC, Stolz DB, Vin H, Ross MA, Soucy NV, Klei LR, et al. 2007. Low level arsenic promotes progressive inflammatory angiogenesis and liver blood vessel remodeling in mice. Toxicol Appl Pharmacol 222(3):327-336.
48. Tenorio EP, Saavedra R. 2005. Differential effect of sodium arsenite during the activation of human CD4+ and CD8+ T lymphocytes. Int Immunopharmacol 5(13-14):1853-1869.
49. The Gene Ontology. 2009. Gene Ontology Home. Available: http:// www.geneontology.org/ [accessed 1 May 2009].
50. U.S. EPA (U.S. Environmental Protection Agency). 2006. Arsenic in Drinking Water. Available: http://www.epa.gov/safewater/arsenic/ index.html [accessed 1 May 2009].
51. Vahidnia A, van der Voet GB, de Wolff FA. 2007. Arsenic neurotoxicity - a review. Hum Exp Toxicol 26(10):823-832.
52. Vickers MH, Krechowec SO, Breier BH. 2007. Is later obesity programmed in utero? Curr Drug Targets 8(8):923-934.
53. Waalkes MP, Liu J, Diwan BA. 2007. Transplacental arsenic carcinogenesis in mice. Toxicol Appl Pharmacol 222(3):271-280.
54. Weidman JR, Dolinoy DC, Murphy SK, Jirtle RL. 2007. Cancer susceptibility: epigenetic manifestation of environmental exposures. Cancer J 13(1):9-16.
55. Wu MM, Chiou HY, Ho IC, Chen CJ, Lee TC. 2003. Gene expression of inflammatory molecules in circulating lymphocytes from arsenic-exposed human subjects. Environ Health Perspect 111:1429-1438.
56. Xie Y, Liu J, Benbrahim-Tallaa L, Ward JM, Logsdon D, Diwan BA, et al. 2007. Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic. Toxicology 236(1-2):7-15.
57. Yu X, Robinson JF, Gribble E, Hong SW, Sidhu JS, Faustman EM. 2008. Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways. Toxicol Appl Pharmacol 233(3):389-403.