Behavioral screening for neuroactive drugs in zebrafish

Developmental Neurobiology

Volumn 72, Issue 3, 2012, Pages 373-385

  Rihel, Jason ^a   Schier, Alexander F ^a,b,c  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

Behavior; Chemical genetics; Sleep; Small molecule screen; Zebrafish

Indexed keywords

6 NITROQUIPAZINE; ALCOHOL; ALPHA FLUOROMETHYLHISTIDINE; AMPHETAMINE; ANTIHISTAMINIC AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; BUSPIRONE; CAFFEINE; CENTRAL NERVOUS SYSTEM AGENTS; CHLORPHENIRAMINE; CLOZAPINE; COCAINE; DIAZEPAM; DIZOCILPINE; FLUOXETINE; FLUPHENAZINE; FLUVOXAMINE; HALOPERIDOL; MELATONIN; NICOTINE; SCOPOLAMINE; ZIMELDINE;

ANIMAL BEHAVIOR; AROUSAL; ARTICLE; BEHAVIOR; BEHAVIORAL SCREENING; BLOOD BRAIN BARRIER; CELL COUNT; DRUG ADSORPTION; DRUG COST; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXCRETION; DRUG MECHANISM; DRUG METABOLISM; DRUG RESPONSE; DRUG SCREENING; DRUG TOLERANCE; GENE EXPRESSION; GENE MUTATION; GENETICS; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; IN VIVO STUDY; LOCOMOTION; NEUROTRANSMISSION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SLEEP TIME; SLEEP WAKING CYCLE; TREATMENT INDICATION; ZEBRA FISH;

ANIMALS; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM STIMULANTS; DRUG EVALUATION, PRECLINICAL; HUMANS; PHARMACEUTICAL PREPARATIONS; SLEEP; WAKEFULNESS; ZEBRAFISH;

EID: 84856972043     PISSN: 19328451     EISSN: 10974695     Source Type: Journal    
DOI: 10.1002/dneu.20910     Document Type: Article

References (143)

1. Adriani W, Felici A, Sargolini F, Roullet P, Usiello A, Oliverio AMele A. 1998. N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes. Exp Brain Res 123: 52-59.
2. Agid Y, Buzsaki G, Diamond DM, Frackowiak R, Giedd J, Girault JA, Grace A, et al. 2007. How can drug discovery for psychiatric disorders be improved? Nat Rev Drug Discov 6: 189-201.
3. Appelbaum L, Wang GX, Maro GS, Mori R, Tovin A, Marin W, Yokogawa T, et al. 2009. Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish. Proc Natl Acad Sci USA 106: 21942-21947.
4. Bajgar J. 2004. Organophosphates/nerve agent poisoning: Mechanism of action, diagnosis, prophylaxis, and treatment. Adv Clin Chem 38: 151-216.
5. Ban TA. 2006. The role of serendipity in drug discovery. Dialogues Clin Neurosci 8: 335-344.
6. Baraban SC, Dinday MT, Castro PA, Chege S, Guyenet S, Taylor MR. 2007. A large-scale mutagenesis screen to identify seizure-resistant zebrafish. Epilepsia 48: 1151-1157.
7. Baraban SC, Taylor MR, Castro PA, Baier H. 2005. Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. Neuroscience 131: 759-768.
8. Bencan Z, Levin ED. 2008. The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish. Physiol Behav 95: 408-412.
9. Bencan Z, Sledge D, Levin ED. 2009. Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety. Pharmacol Biochem Behav 94: 75-80.
10. Best JD, Alderton WK. 2008. Zebrafish: An in vivo model for the study of neurological diseases. Neuropsychiatr Dis Treat 4: 567-576.
11. Best JD, Berghmans S, Hunt JJ, Clarke SC, Fleming A, Goldsmith P, Roach AG. 2008. Non-associative learning in larval zebrafish. Neuropsychopharmacology 33: 1206-1215.
12. Bilotta J, Saszik S, Givin CM, Hardesty HR, Sutherland SE. 2002. Effects of embryonic exposure to ethanol on zebrafish visual function. Neurotoxicol Teratol 24: 759-766.
13. Blank M, Guerim LD, Cordeiro RF, Vianna MR. 2009. A one-trial inhibitory avoidance task to zebrafish: Rapid acquisition of an NMDA-dependent long-term memory. Neurobiol Learn Mem 92: 529-534.
14. Blaser RE, Koid A, Poliner RM. 2010. Context-dependent sensitization to ethanol in zebrafish (Danio rerio). Pharmacol Biochem Behav 95: 278-284.
15. Bo P, Ongini E, Giorgetti A, Savoldi F. 1988. Synchronization of the EEG and sedation induced by neuroleptics depend upon blockade of both D1 and D2 dopamine receptors. Neuropharmacology 27: 799-805.
16. Boehmler W, Carr T, Thisse C, Thisse B, Canfield VA, Levenson R. 2007. D4 Dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour. Genes Brain Behav 6: 155-166.
17. Borla MA, Palecek B, Budick S, O'Malley DM. 2002. Prey capture by larval zebrafish: Evidence for fine axial motor control. Brain Behav Evol 60: 207-229.
18. Braff DL, Geyer MA, Light GA, Sprock J, Perry W, Cadenhead KS, Swerdlow NR. 2001. Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia. Schizophr Res 49: 171-178.
19. Bretaud S, Lee S, Guo S. 2004. Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease. Neurotoxicol Teratol 26: 857-864.
20. Brisbare-Roch C, Dingemanse J, Koberstein R, Hoever P, Aissaoui H, Flores S, Mueller C, et al. 2007. Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat Med 13: 150-155.
21. Brockerhoff SE, Hurley JB, Janssen-Bienhold U, Neuhauss SC, Driever W, Dowling JE. 1995. A behavioral screen for isolating zebrafish mutants with visual system defects. Proc Natl Acad Sci USA 92: 10545-10549.
22. Bromee T, Kukkonen JP, Andersson P, Conlon JM, Larhammar D. 2005. Pharmacological characterization of ligand-receptor interactions at the zebrafish bradykinin receptor. Br J Pharmacol 144: 11-16.
23. Budi EH, Patterson LB, Parichy DM. 2008. Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation. Development 135: 2603-2614.
24. Budick SA, O'Malley DM. 2000. Locomotor repertoire of the larval zebrafish: Swimming, turning and prey capture. J Exp Biol 203: 2565-2579.
25. Burgess HA, Granato, M. 2007. Sensorimotor gating in larval zebrafish. J Neurosci 27: 4984-4994.
26. Cachat J, Canavello P, Elegante M, Bartels B, Hart P, Bergner C, Egan R, et al. 2010. Modeling withdrawal syndrome in zebrafish. Behav Brain Res 208: 371-376.
27. Campillos M, Kuhn M, Gavin AC, Jensen LJ, Bork P. 2008. Drug target identification using side-effect similarity. Science 321: 263-266.
28. Chen J, Patel R, Friedman TC, Jones KS. 2010. The behavioral and pharmacological actions of NMDA receptor antagonism are conserved in zebrafish larvae. Int J Comp Psychol 23: 82-90.
29. Clifton JD, Lucumi E, Myers MC, Napper A, Hama K, Farber SA, Smith ABIII, et al. 2010. Identification of novel inhibitors of dietary lipid absorption using zebrafish. PLoS One 5: e12386.
30. Culebras A. 1996. Clinical Handbook of Sleep Disorders. Boston: Butterworth-Heinemann.
31. Darland T, Dowling JE. 2001. Behavioral screening for cocaine sensitivity in mutagenized zebrafish. Proc Natl Acad Sci USA 98: 11691-11696.
32. de Velasco EM, Law PY, Rodriguez RE. 2009. Mu opioid receptor from the zebrafish exhibits functional characteristics as those of mammalian mu opioid receptor. Zebrafish 6: 259-268.
33. Dlugos CA, Brown SJ, Rabin RA. 2011. Gender differences in ethanol-induced behavioral sensitivity in zebrafish. Alcohol 45: 11-18.
34. Dlugos CA, Rabin RA. 2003. Ethanol effects on three strains of zebrafish: Model system for genetic investigations. Pharmacol Biochem Behav 74: 471-480.
35. Duner T, Conlon JM, Kukkonen JP, Akerman KE, Yan YL, Postlethwait JH, Larhammar D. 2002. Cloning, structural characterization and functional expression of a zebrafish bradykinin B2-related receptor. Biochem J 364: 817-824.
36. Egan RJ, Bergner CL, Hart PC, Cachat JM, Canavello PR, Elegante MF, Elkhayat SI, et al. 2009. Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish. Behav Brain Res 205: 38-44.
37. Eliceiri BP, Gonzalez AM, Baird A. 2011. Zebrafish model of the blood-brain barrier: Morphological and permeability studies. Methods Mol Biol 686: 371-378.
38. Emran F, Rihel J, Adolph AR, Dowling JE. 2010. Larval zebrafish lose vision at night. Proc Natl Acad Sci USA 107: 6034-6039.
39. Emran F, Rihel J, Adolph AR, Wong KY, Kraves S, Dowling JE. 2007. OFF ganglion cells cannot drive the optokinetic reflex in zebrafish. Proc Natl Acad Sci USA 104: 19126-19131.
40. Esbenshade TA, Estvander BR, Miller TR, Baranowski JL, Sharma R, Hancock AA, Krueger KM. 2007. Pharmacological classification of histamine H3 receptor agents across species is attributable to transmembrane 3 sequence differences. Inflamm Res 56 ( Suppl 1): S45-46.
41. Faraco JH, Appelbaum L, Marin W, Gaus SE, Mourrain P, Mignot E. 2006. Regulation of hypocretin (orexin) expression in embryonic zebrafish. J Biol Chem 281: 29753-29761.
42. Fernandes Y, Gerlai R. 2009. Long-term behavioral changes in response to early developmental exposure to ethanol in zebrafish. Alcohol Clin Exp Res 33: 601-609.
43. Fischer-Barnicol D, Lanquillon S, Haen E, Zofel P, Koch HJ, Dose M, Klein HE. 2008. Typical and atypical antipsychotics-The misleading dichotomy. Results from the Working Group "Drugs in Psychiatry" (AGATE). Neuropsychobiology 57: 80-87.
44. Gahtan E, Tanger P, Baier H. 2005. Visual prey capture in larval zebrafish is controlled by identified reticulospinal neurons downstream of the tectum. J Neurosci 25: 9294-9303.
45. Geddes J, Freemantle N, Harrison P, Bebbington P. 2000. Atypical antipsychotics in the treatment of schizophrenia: Systematic overview and meta-regression analysis. Br Med J 321: 1371-1376.
46. Gerlai R, Ahmad F, Prajapati S. 2008. Differences in acute alcohol-induced behavioral responses among zebrafish populations. Alcohol Clin Exp Res 32: 1763-1773.
47. Gerlai R, Chatterjee D, Pereira T, Sawashima T, Krishnannair R. 2009. Acute and chronic alcohol dose: Population differences in behavior and neurochemistry of zebrafish. Genes Brain Behav 8: 586-599.
48. Gerlai R, Lahav M, Guo S, Rosenthal A. 2000. Drinks like a fish: Zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects. Pharmacol Biochem Behav 67: 773-782.
49. Gerlai R, Lee V, Blaser R. 2006. Effects of acute and chronic ethanol exposure on the behavior of adult zebrafish (Danio rerio). Pharmacol Biochem Behav 85: 752-761.
50. Giacomini NJ, Rose B, Kobayashi K, Guo S. 2006. Antipsychotics produce locomotor impairment in larval zebrafish. Neurotoxicol Teratol 28: 245-250.
51. Gonzalez-Nunez V, Marron Fernandez de Velasco E, Arsequell G, Valencia G, Rodriguez RE. 2007. Identification of dynorphin a from zebrafish: A comparative study with mammalian dynorphin A. Neuroscience 144: 675-684.
52. Grossman L, Utterback E, Stewart A, Gaikwad S, Chung KM, Suciu C, Wong K, et al. 2010. Characterization of behavioral and endocrine effects of LSD on zebrafish. Behav Brain Res 214: 277-284.
53. Hirayama J, Kaneko M, Cardone L, Cahill G, Sassone-Corsi P. 2005. Analysis of circadian rhythms in zebrafish. Methods Enzymol 393: 186-204.
54. Hopkins AL. 2008. Network pharmacology: The next paradigm in drug discovery. Nat Chem Biol 4: 682-690.
55. Hossain MS, Larsson A, Scherbak N, Olsson PE, Orban L. 2008. Zebrafish androgen receptor: Isolation, molecular, and biochemical characterization. Biol Reprod 78: 361-369.
56. Hsieh DJ, Liao CF. 2002. Zebrafish M2 muscarinic acetylcholine receptor: Cloning, pharmacological characterization, expression patterns and roles in embryonic bradycardia. Br J Pharmacol 137: 782-792.
57. Hultman KA, Scott AW, Johnson SL. 2008. Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes. Zebrafish 5: 279-287.
58. Irons TD, MacPhail RC, Hunter DL, Padilla S. 2010. Acute neuroactive drug exposures alter locomotor activity in larval zebrafish. Neurotoxicol Teratol 32: 84-90.
59. Jeong JY, Kwon HB, Ahn JC, Kang D, Kwon SH, Park JA, Kim KW. 2008. Functional and developmental analysis of the blood-brain barrier in zebrafish. Brain Res Bull 75: 619-628.
60. Kabashi E, Champagne N, Brustein E, Drapeau P. 2010. In the swim of things: Recent insights to neurogenetic disorders from zebrafish. Trends Genet 26: 373-381.
61. Kaslin J, Nystedt JM, Ostergard M, Peitsaro N, Panula P. 2004. The orexin/hypocretin system in zebrafish is connected to the aminergic and cholinergic systems. J Neurosci 24: 2678-2689.
62. Kily LJ, Cowe YC, Hussain O, Patel S, McElwaine S, Cotter FE, Brennan CH. 2008. Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways. J Exp Biol 211: 1623-1634.
63. Kim YH, Lee Y, Kim D, Jung MW, Lee CJ. 2010. Scopolamine-induced learning impairment reversed by physostigmine in zebrafish. Neurosci Res 67: 156-161.
64. Kitambi SS, McCulloch KJ, Peterson RT, Malicki JJ. 2009. Small molecule screen for compounds that affect vascular development in the zebrafish retina. Mech Dev 126: 464-477.
65. Kokel D, Bryan J, Laggner C, White R, Cheung CY, Mateus R, Healey D, et al. 2010. Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat Chem Biol 6: 231-237.
66. Kokel D, Peterson RT. 2008. Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish. Brief Funct Genomic Proteomic 7: 483-490.
67. Lam CS, Korzh V, Strahle U. 2005. Zebrafish embryos are susceptible to the dopaminergic neurotoxin MPTP. Eur J Neurosci 21: 1758-1762.
68. Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, et al. 2006. The Connectivity Map: Using gene-expression signatures to connect small molecules, genes, and disease. Science 313: 1929-1935.
69. Lau BY, Bretaud S, Huang Y, Lin E, Guo S. 2006. Dissociation of food and opiate preference by a genetic mutation in zebrafish. Genes Brain Behav 5: 497-505.
70. Lau BY, Mathur P, Gould GG, Guo S. 2011. Identification of a brain center whose activity discriminates a choice behavior in zebrafish. Proc Natl Acad Sci USA 108: 2581-2586.
71. Levin ED, Bencan Z, Cerutti DT. 2007. Anxiolytic effects of nicotine in zebrafish. Physiol Behav 90: 54-58.
72. Levin ED, Chen E. 2004. Nicotinic involvement in memory function in zebrafish. Neurotoxicol Teratol 26: 731-735.
73. Levin ED, Limpuangthip J, Rachakonda T, Peterson M. 2006. Timing of nicotine effects on learning in zebrafish. Psychopharmacology (Berl) 184: 547-552.
74. Lockwood B, Bjerke S, Kobayashi K, Guo S. 2004. Acute effects of alcohol on larval zebrafish: A genetic system for large-scale screening. Pharmacol Biochem Behav 77: 647-654.
75. Lopez-Patino MA, Yu L, Cabral H, Zhdanova IV. 2008a. Anxiogenic effects of cocaine withdrawal in zebrafish. Physiol Behav 93: 160-171.
76. Lopez Patino MA, Yu L, Yamamoto BK, Zhdanova IV. 2008b. Gender differences in zebrafish responses to cocaine withdrawal. Physiol Behav 95: 36-47.
77. Lord AM, North TE, Zon LI. 2007. Prostaglandin E2: Making more of your marrow. Cell Cycle 6: 3054-3057.
78. Lovenberg TW, Pyati J, Chang H, Wilson SJ, Erlander MG. 2000. Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles. J Pharmacol Exp Ther 293: 771-778.
79. MacPhail RC, Brooks J, Hunter DL, Padnos B, Irons TD, Padilla S. 2009. Locomotion in larval zebrafish: Influence of time of day, lighting and ethanol. Neurotoxicology 30: 52-58.
80. MacRae CA, Peterson RT. 2003. Zebrafish-based small molecule discovery. Chem Biol 10: 901-908.
81. Mathew LK, Sengupta S, Kawakami A, Andreasen EA, Lohr CV, Loynes CA, Renshaw SA, et al. 2007. Unraveling tissue regeneration pathways using chemical genetics. J Biol Chem 282: 35202-35210.
82. Mathur P, Guo S. 2010. Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes. Neurobiol Dis 40: 66-72.
83. Mathur P, Guo S. 2011. Differences of acute versus chronic ethanol exposure on anxiety-like behavioral responses in zebrafish. Behav Brain Res 219: 234-239.
84. Maximino C, da Silva AW, Gouveia AJr, Herculano AM. 2011. Pharmacological analysis of zebrafish (Danio rerio) scototaxis. Prog Neuropsychopharmacol Biol Psychiatry 35: 624-631.
85. McKinley ET, Baranowski TC, Blavo DO, Cato C, Doan TN, Rubinstein AL. 2005. Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons. Brain Res Mol Brain Res 141: 128-137.
86. Miller G. 2010. Is pharma running out of brainy ideas? Science 329: 502-504.
87. Molina G, Vogt A, Bakan A, Dai W, Queiroz de Oliveira P, Znosko W, Smithgall TE, et al. 2009. Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nat Chem Biol 5: 680-687.
88. Mori S, Chang JT, Andrechek ER, Potti A, Nevins JR. 2009 Utilization of genomic signatures to identify phenotype-specific drugs. PLoS One 4: e6772.
89. Murphey RD, Stern HM, Straub CT, Zon LI. 2006. A chemical genetic screen for cell cycle inhibitors in zebrafish embryos. Chem Biol Drug Des 68: 213-219.
90. Neubauer DN. 2010. Almorexant, a dual orexin receptor antagonist for the treatment of insomnia. Curr Opin Investig Drugs 11: 101-110.
91. Neuhauss SC, Biehlmaier O, Seeliger MW, Das T, Kohler K, Harris WA, Baier H. 1999. Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. J Neurosci 19: 8603-8615.
92. North TE, Goessling W, Peeters M, Li P, Ceol C, Lord AM, Weber GJ, et al. 2009. Hematopoietic stem cell development is dependent on blood flow. Cell 137: 736-748.
93. North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, et al. 2007. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 447: 1007-1011.
94. Olney JW, Newcomer JW, Farber NB. 1999. NMDA receptor hypofunction model of schizophrenia. J Psychiatr Res 33: 523-533.
95. Ongini E, Caporali MG, Longo VG. 1987. Blockade of D-1 dopamine receptors by SCH 23390 prevents EEG and behavioral activation induced by L-dopa. Neurosci Lett 82: 206-210.
96. Oppedal D, Goldsmith MI. 2010. A chemical screen to identify novel inhibitors of fin regeneration in zebrafish. Zebrafish 7: 53-60.
97. Ou HC, Cunningham LL, Francis SP, Brandon CS, Simon JA, Raible DW, Rubel EW. 2009. Identification of FDA-approved drugs and bioactives that protect hair cells in the zebrafish (Danio rerio) lateral line and mouse (Mus musculus) utricle. J Assoc Res Otolaryngol 10: 191-203.
98. Owens KN, Santos F, Roberts B, Linbo T, Coffin AB, Knisely AJ, Simon JA, et al. 2008. Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death. PLoS Genet 4, e1000020.
99. Pangalos MN, Schechter LE, Hurko O. 2007. Drug development for CNS disorders: Strategies for balancing risk and reducing attrition. Nat Rev Drug Discov 6: 521-532.
100. Panula P, Chen YC, Priyadarshini M, Kudo H, Semenova S, Sundvik M, Sallinen V. 2010. The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases. Neurobiol Dis 40: 46-57.
101. Pardo-Martin C, Chang TY, Koo BK, Gilleland CL, Wasserman SC, Yanik MF. 2010. High-throughput in vivo vertebrate screening. Nat Methods 7: 634-636.
102. Peal DS, Mills RW, Lynch SN, Mosley JM, Lim E, Ellinor PT, January CT, et al. 2011. Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen. Circulation 123: 23-30.
103. Peal DS, Peterson RT, Milan D. 2010. Small molecule screening in zebrafish. J Cardiovasc Transl Res 3: 454-460.
104. Peitsaro N, Anichtchik OV, Panula P. 2000. Identification of a histamine H(3)-like receptor in the zebrafish (Danio rerio) brain. J Neurochem 75: 718-724.
105. Peitsaro N, Kaslin J, Anichtchik OV, Panula P. 2003. Modulation of the histaminergic system and behaviour by alpha-fluoromethylhistidine in zebrafish. J Neurochem 86: 432-441.
106. Peitsaro N, Sundvik M, Anichtchik OV, Kaslin J, Panula P. 2007. Identification of zebrafish histamine H1, H2, and H3 receptors and effects of histaminergic ligands on behavior. Biochem Pharmacol 73: 1205-1214.
107. Peterson RT, Link BA, Dowling JE, Schreiber SL. 2000. Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc Natl Acad Sci USA 97: 12965-12969.
108. Peterson RT, Shaw SY, Peterson TA, Milan DJ, Zhong TP, Schreiber SL, MacRae CA, etal. 2004. Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotechnol 22: 595-599.
109. Petzold AM, Balciunas D, Sivasubbu S, Clark KJ, Bedell VM, Westcot SE, Myers SR, et al. 2009. Nicotine response genetics in the zebrafish. Proc Natl Acad Sci USA 106: 18662-18667.
110. Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, Nagle A, et al. 2008. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci USA 105: 9059-9064.
111. Prober DA, Rihel J, Onah AA, Sung RJ, Schier AF. 2006. Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish. J Neurosci 26: 13400-13410.
112. Prober DA, Zimmerman S, Myers BR, McDermott BMJr, Kim SH, Caron S, Rihel J, et al. 2008. Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. JNeurosci 28: 10102-10110.
113. Rawashdeh O, de Borsetti NH, Roman G, Cahill GM. 2007. Melatonin suppresses nighttime memory formation in zebrafish. Science 318: 1144-1146.
114. Renier C, Faraco JH, Bourgin P, Motley T, Bonaventure P, Rosa F, Mignot E. 2007. Genomic and functional conservation of sedative-hypnotic targets in the zebrafish. Pharmacogenet Genomics 17: 237-253.
115. Richetti SK, Blank M, Capiotti KM, Piato AL, Bogo MR, Vianna MR, Bonan CD. 2011. Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish. Behav Brain Res 217: 10-15.
116. Rihel J, Prober DA, Arvanites A, Lam K, Zimmerman S, Jang S, Haggarty SJ, et al. 2010a. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science 327: 348-351.
117. Rihel J, Prober DA, Schier AF. 2010b. Monitoring sleep and arousal in zebrafish. Methods Cell Biol 100: 281-294.
118. Ringholm A, Fredriksson R, Poliakova N, Yan YL, Postlethwait JH, Larhammar D, Schioth HB. 2002. One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology. J Neurochem 82: 6-18.
119. Rivas-Boyero AA, Herrero-Turrion MJ, Gonzalez-Nunez V, Sanchez-Simon FM, Barreto-Valer K, Rodriguez RE. 2011. Pharmacological characterization of a nociceptin receptor from zebrafish (Danio rerio). J Mol Endocrinol 46: 111-123.
120. Ruuskanen JO, Peitsaro N, Kaslin JV, Panula P, Scheinin M. 2005. Expression and function of alpha-adrenoceptors in zebrafish: Drug effects, mRNA and receptor distributions. J Neurochem 94: 1559-1569.
121. Sackerman J, Donegan JJ, Cunningham CS, Nguyen NN, Lawless K, Long A, Benno RH, et al. 2010. Zebrafish behavior in novel environments: effects of acute exposure to anxiolytic compounds and choice of Danio rerio line. Int J Comp Psychol 23: 43-61.
122. Seibt KJ, Oliveira Rda L, Zimmermann FF, Capiotti KM, Bogo MR, Ghisleni G, Bonan CD. 2010. Antipsychotic drugs prevent the motor hyperactivity induced by psychotomimetic MK-801 in zebrafish (Danio rerio). Behav Brain Res 214: 417-422.
123. Seifert R, Wenzel-Seifert K, Burckstummer T, Pertz HH, Schunack W, Dove S, Buschauer A, et al. 2003. Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther 305: 1104-1115.
124. Smith LE, Carvan MJIII, Dellinger JA, Ghorai JK, White DB, Williams FE, Weber DN. 2010. Developmental selenomethionine and methylmercury exposures affect zebrafish learning. Neurotoxicol Teratol 32: 246-255.
125. Strahle U, Grabher C. 2010. The zebrafish embryo as a model for assessing off-target drug effects. Dis Model Mech 3: 689-692.
126. Swain HA, Sigstad C, Scalzo FM. 2004. Effects of dizocilpine (MK-801) on circling behavior, swimming activity, and place preference in zebrafish (Danio rerio). Neurotoxicol Teratol 26: 725-729.
127. Taylor KL, Grant NJ, Temperley ND, Patton EE. 2010. Small molecule screening in zebrafish: An in vivo approach to identifying new chemical tools and drug leads. Cell Commun Signal 8: 11.
128. Thirumalai V, Cline HT. 2008. Endogenous dopamine suppresses initiation of swimming in prefeeding zebrafish larvae. J Neurophysiol 100: 1635-1648.
129. Tierney KB. 2011. Behavioural assessments of neurotoxic effects and neurodegeneration in zebrafish. Biochim Biophys Acta 1812: 381-389.
130. Trampus M, Ferri N, Adami M, Ongini E. 1993. The dopamine D1 receptor agonists, A68930 and SKF 38393, induce arousal and suppress REM sleep in the rat. Eur J Pharmacol 235: 83-87.
131. Webb KJ, Norton WH, Trumbach D, Meijer AH, Ninkovic J, Topp S, Heck D, et al. 2009. Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine. Genome Biol 10: R81.
132. Wheeler GN, Brandli AW. 2009. Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and Xenopus. Dev Dyn 238: 1287-1308.
133. Williams FE, Messer WSJr. 2004. Muscarinic acetylcholine receptors in the brain of the zebrafish (Danio rerio) measured by radioligand binding techniques. Comp Biochem Physiol C Toxicol Pharmacol 137: 349-353.
134. Wong DT, Perry KW, Bymaster FP. 2005. Case history: The discovery of fluoxetine hydrochloride (Prozac). Nat Rev Drug Discov 4: 764-774.
135. Wong K, Elegante M, Bartels B, Elkhayat S, Tien D, Roy S, Goodspeed J, et al. 2010. Analyzing habituation responses to novelty in zebrafish (Danio rerio). Behav Brain Res 208: 450-457.
136. Xie J, Farage E, Sugimoto M, Anand-Apte B. 2010. A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development. BMC Dev Biol 10: 76.
137. Yeh JR, Munson KM, Elagib KE, Goldfarb AN, Sweetser DA, Peterson RT. 2009. Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation. Nat Chem Biol 5: 236-243.
138. Yokogawa T, Marin W, Faraco J, Pezeron G, Appelbaum L, Zhang J, Rosa F, etal. 2007. Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol 5: e277.
139. Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA, Lin HY, etal. 2008. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol 4: 33-41.
140. Zhang J, Piontek J, Wolburg H, Piehl C, Liss M, Otten C, Christ A, et al. 2010. Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion. Proc Natl Acad Sci USA 107: 1425-1430.
141. Zhdanova IV. 2006. Sleep in zebrafish. Zebrafish 3: 215-226.
142. Zhdanova IV, Wang SY, Leclair OU, Danilova NP. 2001. Melatonin promotes sleep-like state in zebrafish. Brain Res 903: 263-268.
143. Zon LI, Peterson RT. 2005. In vivo drug discovery in the zebrafish. Nat Rev Drug Discov 4: 35-44.