메뉴 건너뛰기




Volumn 57, Issue , 2015, Pages 75-101

Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis

Author keywords

Breast cancer; Cancer stem cells; EGFR; ER; HER2; Hormonal therapy; Targeted therapy; Therapy resistance

Indexed keywords

TUMOR PROTEIN;

EID: 84920836558     PISSN: 22124926     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.jbior.2014.09.016     Document Type: Review
Times cited : (107)

References (141)
  • 1
    • 7944221151 scopus 로고    scopus 로고
    • Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma
    • Abd El-Rehim D.M., Pinder S.E., Paish C.E., Bell J.A., Rampaul R.S., Blamey R.W. Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma. Br J Cancer 2004, 91:1532-1542.
    • (2004) Br J Cancer , vol.91 , pp. 1532-1542
    • Abd El-Rehim, D.M.1    Pinder, S.E.2    Paish, C.E.3    Bell, J.A.4    Rampaul, R.S.5    Blamey, R.W.6
  • 4
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
    • the CLEOPATRA Study Group
    • Baselga J., Cortés J., Kim S.B. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. NEngl J Med 2012, 366:109-119. the CLEOPATRA Study Group.
    • (2012) NEngl J Med , vol.366 , pp. 109-119
    • Baselga, J.1    Cortés, J.2    Kim, S.B.3
  • 5
    • 35148885729 scopus 로고    scopus 로고
    • Afunctional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    • Berns K., Horlings H.M., Hennessy B.T., Madiredjo M., Hijmans E.M., Beelen K., et al. Afunctional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 2007, 12:395-402.
    • (2007) Cancer Cell , vol.12 , pp. 395-402
    • Berns, K.1    Horlings, H.M.2    Hennessy, B.T.3    Madiredjo, M.4    Hijmans, E.M.5    Beelen, K.6
  • 7
    • 24044520039 scopus 로고    scopus 로고
    • EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations
    • Bhargava R., Gerald W.L., Li A.R., Pan Q., Lal P., Ladanyi M., et al. EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations. Mod Pathol 2005, 18:1027-1033.
    • (2005) Mod Pathol , vol.18 , pp. 1027-1033
    • Bhargava, R.1    Gerald, W.L.2    Li, A.R.3    Pan, Q.4    Lal, P.5    Ladanyi, M.6
  • 8
    • 84884564646 scopus 로고    scopus 로고
    • First FDA approval of dual anti-HER2 regimen: pertuzumab in combination with trastuzumab and docetaxel for HER2-positive metastatic breast cancer
    • Blumenthal G.M., Scher N.S., Cortazar P., Chattopadhyay S., Tang S., Song P., et al. First FDA approval of dual anti-HER2 regimen: pertuzumab in combination with trastuzumab and docetaxel for HER2-positive metastatic breast cancer. Clin Cancer Res 2013, 19:4911-4916.
    • (2013) Clin Cancer Res , vol.19 , pp. 4911-4916
    • Blumenthal, G.M.1    Scher, N.S.2    Cortazar, P.3    Chattopadhyay, S.4    Tang, S.5    Song, P.6
  • 9
    • 84874010025 scopus 로고    scopus 로고
    • Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q-syndrome and other ribosomopathies
    • Boultwood J., Yip B.H., Vuppusetty C., Pellagatti A., Wainscoat J.S. Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q-syndrome and other ribosomopathies. Adv Biol Regul 2013, 53:8-17.
    • (2013) Adv Biol Regul , vol.53 , pp. 8-17
    • Boultwood, J.1    Yip, B.H.2    Vuppusetty, C.3    Pellagatti, A.4    Wainscoat, J.S.5
  • 10
    • 0037429722 scopus 로고    scopus 로고
    • ErbB-4: mechanism of action and biology
    • Carpenter G. ErbB-4: mechanism of action and biology. Exp Cell Res 2003, 284:66-77.
    • (2003) Exp Cell Res , vol.284 , pp. 66-77
    • Carpenter, G.1
  • 11
    • 77949716267 scopus 로고    scopus 로고
    • PIKing the right isoform: the emergent role of the p110beta subunit in breast cancer
    • Carvalho S., Milanezi F., Costa J.L., Amendoeira I., Schmitt F. PIKing the right isoform: the emergent role of the p110beta subunit in breast cancer. Virchows Arch 2010, 456:235-243.
    • (2010) Virchows Arch , vol.456 , pp. 235-243
    • Carvalho, S.1    Milanezi, F.2    Costa, J.L.3    Amendoeira, I.4    Schmitt, F.5
  • 12
    • 84873445750 scopus 로고    scopus 로고
    • Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors
    • Chakrabarty A., Bhola N.E., Sutton C., Ghosh R., Kuba M.G., Dave B., et al. Trastuzumab-resistant cells rely on a HER2-PI3K-FoxO-survivin axis and are sensitive to PI3K inhibitors. Cancer Res 2013, 73:1190-1200.
    • (2013) Cancer Res , vol.73 , pp. 1190-1200
    • Chakrabarty, A.1    Bhola, N.E.2    Sutton, C.3    Ghosh, R.4    Kuba, M.G.5    Dave, B.6
  • 14
    • 84885831339 scopus 로고    scopus 로고
    • PLCe and the RASSF family in tumour suppression and other functions
    • Chan J.J., Katan M. PLCe and the RASSF family in tumour suppression and other functions. Adv Biol Regul 2013, 53:258-279.
    • (2013) Adv Biol Regul , vol.53 , pp. 258-279
    • Chan, J.J.1    Katan, M.2
  • 16
    • 84856767715 scopus 로고    scopus 로고
    • PIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups
    • R28
    • Cizkova M., Susini A., Vacher S., Cizeron-Clairac G., Andrieu C., Driouch K., et al. PIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups. Breast Cancer Res 2012, 14:R28.
    • (2012) Breast Cancer Res , vol.14
    • Cizkova, M.1    Susini, A.2    Vacher, S.3    Cizeron-Clairac, G.4    Andrieu, C.5    Driouch, K.6
  • 17
    • 84878532044 scopus 로고    scopus 로고
    • Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab
    • Cizkova M., Dujaric M.E., Lehmann-Che J., Scott V., Tembo O., Asselain B., et al. Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab. Br J Cancer 2013, 108:1807-1809.
    • (2013) Br J Cancer , vol.108 , pp. 1807-1809
    • Cizkova, M.1    Dujaric, M.E.2    Lehmann-Che, J.3    Scott, V.4    Tembo, O.5    Asselain, B.6
  • 18
    • 78149473552 scopus 로고    scopus 로고
    • Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer
    • R40
    • Creighton C.J., Fu X., Hennessy B.T., Casa A.J., Zhang Y., Gonzalez-Angulo A.M., et al. Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer. Breast Cancer Res 2010, 12:R40. 10.1186/bcr2594.
    • (2010) Breast Cancer Res , vol.12
    • Creighton, C.J.1    Fu, X.2    Hennessy, B.T.3    Casa, A.J.4    Zhang, Y.5    Gonzalez-Angulo, A.M.6
  • 19
    • 84864536555 scopus 로고    scopus 로고
    • Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts
    • Cufi S., Corominas-Faja B., Vazquez-Martin A., Oliveras-Ferraros C., Dorca J., Bosch-Barrera J., et al. Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts. Oncotarget 2012, 3:395-398.
    • (2012) Oncotarget , vol.3 , pp. 395-398
    • Cufi, S.1    Corominas-Faja, B.2    Vazquez-Martin, A.3    Oliveras-Ferraros, C.4    Dorca, J.5    Bosch-Barrera, J.6
  • 20
    • 84904968175 scopus 로고    scopus 로고
    • Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention
    • Davis N.M., Sokolosky M., Stadelman K., Abrams S.L., Libra M., Candido S., et al. Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention. Oncotarget 2014, 5:4603-4650.
    • (2014) Oncotarget , vol.5 , pp. 4603-4650
    • Davis, N.M.1    Sokolosky, M.2    Stadelman, K.3    Abrams, S.L.4    Libra, M.5    Candido, S.6
  • 21
    • 84861120119 scopus 로고    scopus 로고
    • Epidermal growth factor receptor variant III contributes to cancer stem cell phenotypes in invasive breast carcinoma
    • Del Vecchio C.A., Jensen K.C., Nitta R.T., Shain A.H., Giacomini C., Wong A.J. Epidermal growth factor receptor variant III contributes to cancer stem cell phenotypes in invasive breast carcinoma. Cancer Res 2012, 72:2657-2671.
    • (2012) Cancer Res , vol.72 , pp. 2657-2671
    • Del Vecchio, C.A.1    Jensen, K.C.2    Nitta, R.T.3    Shain, A.H.4    Giacomini, C.5    Wong, A.J.6
  • 22
    • 84862908866 scopus 로고    scopus 로고
    • Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers
    • Deng X.S., Wang S., Deng A., Liu B., Edgerton S.M., Lind S.E., et al. Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Cell Cycle 2012, 11:367-376.
    • (2012) Cell Cycle , vol.11 , pp. 367-376
    • Deng, X.S.1    Wang, S.2    Deng, A.3    Liu, B.4    Edgerton, S.M.5    Lind, S.E.6
  • 23
    • 84893767633 scopus 로고    scopus 로고
    • STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention
    • Dorritie K.A., McCubrey J.A., Johnson D.E. STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention. Leukemia 2014, 28:248-257.
    • (2014) Leukemia , vol.28 , pp. 248-257
    • Dorritie, K.A.1    McCubrey, J.A.2    Johnson, D.E.3
  • 24
    • 84906748715 scopus 로고    scopus 로고
    • STAT transcription factors in normal and cancer stem cells
    • Dorritie K.A., Redner R.L., Johnson D.E. STAT transcription factors in normal and cancer stem cells. Adv Biol Regul 2014, pii: S2212-4926(14) 00025-6.
    • (2014) Adv Biol Regul
    • Dorritie, K.A.1    Redner, R.L.2    Johnson, D.E.3
  • 25
    • 3042742432 scopus 로고    scopus 로고
    • Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis
    • Eckert L.B., Repasky G.A., Ulkü A.S., McFall A., Zhou H., Sartor C.I., et al. Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer Res 2004, 64:4585-4592.
    • (2004) Cancer Res , vol.64 , pp. 4585-4592
    • Eckert, L.B.1    Repasky, G.A.2    Ulkü, A.S.3    McFall, A.4    Zhou, H.5    Sartor, C.I.6
  • 27
    • 84893407807 scopus 로고    scopus 로고
    • SHIP2 signaling in normal and pathological situations: its impact on cell proliferation
    • Elong Edimo W., Schurmans S., Roger P.P., Erneux C. SHIP2 signaling in normal and pathological situations: its impact on cell proliferation. Adv Biol Regul 2014, 54:142-151.
    • (2014) Adv Biol Regul , vol.54 , pp. 142-151
    • Elong, E.W.1    Schurmans, S.2    Roger, P.P.3    Erneux, C.4
  • 28
    • 84874002628 scopus 로고    scopus 로고
    • SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts
    • Elong Edimo W., Vanderwinden J.M., Erneux C. SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts. Adv Biol Regul 2013, 53:28-37.
    • (2013) Adv Biol Regul , vol.53 , pp. 28-37
    • Elong Edimo, W.1    Vanderwinden, J.M.2    Erneux, C.3
  • 29
    • 84879491743 scopus 로고    scopus 로고
    • An open-label safety study of lapatinib plus trastuzumab plus paclitaxel in first-line HER2-positive metastatic breast cancer
    • Esteva F.J., Franco S.X., Hagan M.K., Brewster A.M., Somer R.A., Williams W., et al. An open-label safety study of lapatinib plus trastuzumab plus paclitaxel in first-line HER2-positive metastatic breast cancer. Oncologist 2013, 18:661-666.
    • (2013) Oncologist , vol.18 , pp. 661-666
    • Esteva, F.J.1    Franco, S.X.2    Hagan, M.K.3    Brewster, A.M.4    Somer, R.A.5    Williams, W.6
  • 30
    • 84906726390 scopus 로고    scopus 로고
    • Pancreatic cancer stem cells: association with cell surface markers, prognosis, resistance, metastasis and treatment
    • Fitzgerald T.L., McCubrey J.A. Pancreatic cancer stem cells: association with cell surface markers, prognosis, resistance, metastasis and treatment. Adv Biol Regul 2014, 56:45-50. pii: S2212-4926(14)00007-4. 10.1016/j.jbior.2014.05.001.
    • (2014) Adv Biol Regul , vol.56 , pp. 45-50
    • Fitzgerald, T.L.1    McCubrey, J.A.2
  • 31
    • 84906761458 scopus 로고    scopus 로고
    • PTEN and leukemia stem cells
    • Fragoso R., Barata J.T. PTEN and leukemia stem cells. Adv Biol Regul 2014, 56:22-29. pii: S2212-4926(14)00026-8. 10.1016/j.jbior.2014.05.005.
    • (2014) Adv Biol Regul , vol.56 , pp. 22-29
    • Fragoso, R.1    Barata, J.T.2
  • 32
    • 0037139416 scopus 로고    scopus 로고
    • Evidence of high incidence of EGFRvIII expression and coexpression with EGFR in human invasive breast cancer by laser capture microdissection and immunohistochemical analysis
    • Ge H., Gong X., Tang C.K. Evidence of high incidence of EGFRvIII expression and coexpression with EGFR in human invasive breast cancer by laser capture microdissection and immunohistochemical analysis. Int J Cancer 2002, 98:357-361.
    • (2002) Int J Cancer , vol.98 , pp. 357-361
    • Ge, H.1    Gong, X.2    Tang, C.K.3
  • 33
    • 52049094848 scopus 로고    scopus 로고
    • Down-regulation of phosphatidylinositol 3'-kinase/AKT/molecular target of rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer
    • Generali D., Fox S.B., Brizzi M.P., Allevi G., Bonardi S., Aguggini S., et al. Down-regulation of phosphatidylinositol 3'-kinase/AKT/molecular target of rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer. Clin Cancer Res 2008, 14:2673-2680.
    • (2008) Clin Cancer Res , vol.14 , pp. 2673-2680
    • Generali, D.1    Fox, S.B.2    Brizzi, M.P.3    Allevi, G.4    Bonardi, S.5    Aguggini, S.6
  • 36
    • 84862638243 scopus 로고    scopus 로고
    • Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN
    • Han M., Liu M., Wang Y., Chen X., Xu J., Sun Y., et al. Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN. PLoS One 2012, 7:e39520.
    • (2012) PLoS One , vol.7 , pp. e39520
    • Han, M.1    Liu, M.2    Wang, Y.3    Chen, X.4    Xu, J.5    Sun, Y.6
  • 37
    • 66249109653 scopus 로고    scopus 로고
    • Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics
    • Hennessy B.T., Gonzalez-Angulo A.M., Stemke-Hale K., Gilcrease M.Z., Krishnamurthy S., Lee J.S., et al. Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res 2009, 69:4116-4124.
    • (2009) Cancer Res , vol.69 , pp. 4116-4124
    • Hennessy, B.T.1    Gonzalez-Angulo, A.M.2    Stemke-Hale, K.3    Gilcrease, M.Z.4    Krishnamurthy, S.5    Lee, J.S.6
  • 38
    • 0042307325 scopus 로고    scopus 로고
    • The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
    • Holbro T., Beerli R.R., Maurer F., Koziczak M., Barbas C.F., Hynes N.E. The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci U S A 2003, 100:8933-8938.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8933-8938
    • Holbro, T.1    Beerli, R.R.2    Maurer, F.3    Koziczak, M.4    Barbas, C.F.5    Hynes, N.E.6
  • 39
    • 33947230755 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines
    • Hollestelle A., Elstrodt F., Nagel J.H., Kallemeijn W.W., Schutte M. Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines. Mol Cancer Res 2007, 5:195-201.
    • (2007) Mol Cancer Res , vol.5 , pp. 195-201
    • Hollestelle, A.1    Elstrodt, F.2    Nagel, J.H.3    Kallemeijn, W.W.4    Schutte, M.5
  • 40
    • 84893344687 scopus 로고    scopus 로고
    • Activation machinery of the small GTPase Arf6
    • Hongu T., Kanaho Y. Activation machinery of the small GTPase Arf6. Adv Biol Regul 2014, 54:59-66.
    • (2014) Adv Biol Regul , vol.54 , pp. 59-66
    • Hongu, T.1    Kanaho, Y.2
  • 41
    • 34547871259 scopus 로고    scopus 로고
    • Targeting HER proteins in cancer therapy and the role of the non-target HER3
    • Hsieh A.C., Moasser M.M. Targeting HER proteins in cancer therapy and the role of the non-target HER3. Br J Cancer 2007, 97:453-457.
    • (2007) Br J Cancer , vol.97 , pp. 453-457
    • Hsieh, A.C.1    Moasser, M.M.2
  • 42
    • 84878559365 scopus 로고    scopus 로고
    • On the regulation of protein phosphatase 2A and its role in controlling entry into and exit from mitosis
    • Hunt T. On the regulation of protein phosphatase 2A and its role in controlling entry into and exit from mitosis. Adv Biol Regul 2013, 53:173-178.
    • (2013) Adv Biol Regul , vol.53 , pp. 173-178
    • Hunt, T.1
  • 43
    • 84874857331 scopus 로고    scopus 로고
    • HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab
    • Ithimakin S., Day K.C., Malik F., Zen Q., Dawsey S.J., Bersano-Begey T.F., et al. HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab. Cancer Res 2013, 73:1635-1646.
    • (2013) Cancer Res , vol.73 , pp. 1635-1646
    • Ithimakin, S.1    Day, K.C.2    Malik, F.3    Zen, Q.4    Dawsey, S.J.5    Bersano-Begey, T.F.6
  • 44
    • 84880868333 scopus 로고    scopus 로고
    • Clinical significance of HER-2 splice variants in breast cancer progression and drug resistance
    • Epub 2013 Jul 1
    • Jackson C., Browell D., Gautrey H., Tyson-Capper A. Clinical significance of HER-2 splice variants in breast cancer progression and drug resistance. Int J Cell Biol 2013, 973584. Epub 2013 Jul 1. 10.1155/2013/973584.
    • (2013) Int J Cell Biol , pp. 973584
    • Jackson, C.1    Browell, D.2    Gautrey, H.3    Tyson-Capper, A.4
  • 45
    • 84878612879 scopus 로고    scopus 로고
    • Deconstructing mTOR complexes in regulation of glioblastoma multiforme and its stem cells
    • Jhanwar-Uniyal M., Jeevan D., Neil J., Shannon C., Albert L., Murali R. Deconstructing mTOR complexes in regulation of glioblastoma multiforme and its stem cells. Adv Biol Regul 2013, 53:202-210.
    • (2013) Adv Biol Regul , vol.53 , pp. 202-210
    • Jhanwar-Uniyal, M.1    Jeevan, D.2    Neil, J.3    Shannon, C.4    Albert, L.5    Murali, R.6
  • 46
    • 44149120446 scopus 로고    scopus 로고
    • HER4 intracellular domain (4ICD) activity in the developing mammary gland and breast cancer
    • Jones F.E. HER4 intracellular domain (4ICD) activity in the developing mammary gland and breast cancer. JMammary Gland Biol Neoplasia 2008, 13:247-258.
    • (2008) JMammary Gland Biol Neoplasia , vol.13 , pp. 247-258
    • Jones, F.E.1
  • 47
    • 84888066704 scopus 로고    scopus 로고
    • Targeted cancer therapy - are the days of systemic chemotherapy numbered?
    • Joo W.D., Visintin I., Mor G. Targeted cancer therapy - are the days of systemic chemotherapy numbered?. Maturitas 2013, pii: S0378-5122(13) 00292-2.
    • (2013) Maturitas
    • Joo, W.D.1    Visintin, I.2    Mor, G.3
  • 48
    • 81755184076 scopus 로고    scopus 로고
    • Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression
    • Jung J.W., Park S.B., Lee S.J., Seo M.S., Trosko J.E., Kang K.S. Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression. PLoS ONE 2011, 6:e28068.
    • (2011) PLoS ONE , vol.6 , pp. e28068
    • Jung, J.W.1    Park, S.B.2    Lee, S.J.3    Seo, M.S.4    Trosko, J.E.5    Kang, K.S.6
  • 49
    • 80055032877 scopus 로고    scopus 로고
    • Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib
    • Epub 2011 Oct 28
    • Kancha R.K., von Bubnoff N., Bartosch N., Peschel C., Engh R.A., Duyster J. Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib. PLoS One 2011, 6:e26760. Epub 2011 Oct 28. 10.1371/journal.pone.0026760.
    • (2011) PLoS One , vol.6 , pp. e26760
    • Kancha, R.K.1    von Bubnoff, N.2    Bartosch, N.3    Peschel, C.4    Engh, R.A.5    Duyster, J.6
  • 50
    • 84856716249 scopus 로고    scopus 로고
    • Pertuzumab: in the first-line treatment of HER2-positive metastatic breast cancer
    • Keating G.M. Pertuzumab: in the first-line treatment of HER2-positive metastatic breast cancer. Drugs 2012, 72:353-360.
    • (2012) Drugs , vol.72 , pp. 353-360
    • Keating, G.M.1
  • 51
    • 84901463783 scopus 로고    scopus 로고
    • Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles
    • Kenney J.W., Moore C.E., Wang X., Proud C.G. Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles. Adv Biol Regul 2014, 55:15-27.
    • (2014) Adv Biol Regul , vol.55 , pp. 15-27
    • Kenney, J.W.1    Moore, C.E.2    Wang, X.3    Proud, C.G.4
  • 52
    • 34948837444 scopus 로고    scopus 로고
    • Selective targeting of cancer stem cells: a new concept in cancer therapeutics
    • Korkaya H., Wicha M.S. Selective targeting of cancer stem cells: a new concept in cancer therapeutics. BioDrugs 2007, 21:299-310.
    • (2007) BioDrugs , vol.21 , pp. 299-310
    • Korkaya, H.1    Wicha, M.S.2
  • 53
    • 54049096261 scopus 로고    scopus 로고
    • HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion
    • Korkaya H., Paulson A., Iovino F., Wicha M.S. HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene 2008, 27:6120-6130.
    • (2008) Oncogene , vol.27 , pp. 6120-6130
    • Korkaya, H.1    Paulson, A.2    Iovino, F.3    Wicha, M.S.4
  • 54
    • 67649969473 scopus 로고    scopus 로고
    • Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling
    • Korkaya H., Paulson A., Charafe-Jauffret E., Ginestier C., Brown M., Dutcher J., et al. Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol 2009, 7(6):e1000121. 10.1371/journal.pbio.1000121.
    • (2009) PLoS Biol , vol.7 , Issue.6 , pp. e1000121
    • Korkaya, H.1    Paulson, A.2    Charafe-Jauffret, E.3    Ginestier, C.4    Brown, M.5    Dutcher, J.6
  • 55
    • 63449116164 scopus 로고    scopus 로고
    • HER-2, notch, and breast cancer stem cells: targeting an axis of evil
    • Korkaya H., Wicha M.S. HER-2, notch, and breast cancer stem cells: targeting an axis of evil. Clin Cancer Res 2009, 15:1845-1847.
    • (2009) Clin Cancer Res , vol.15 , pp. 1845-1847
    • Korkaya, H.1    Wicha, M.S.2
  • 56
    • 84873391501 scopus 로고    scopus 로고
    • Breast cancer stem cells: we've got them surrounded
    • Korkaya H., Wicha M.S. Breast cancer stem cells: we've got them surrounded. Clin Cancer Res 2013, 19:511-513.
    • (2013) Clin Cancer Res , vol.19 , pp. 511-513
    • Korkaya, H.1    Wicha, M.S.2
  • 57
    • 84879092200 scopus 로고    scopus 로고
    • HER2 and breast cancer stem cells: more than meets the eye
    • Korkaya H., Wicha M.S. HER2 and breast cancer stem cells: more than meets the eye. Cancer Res 2013, 73:3489-3493.
    • (2013) Cancer Res , vol.73 , pp. 3489-3493
    • Korkaya, H.1    Wicha, M.S.2
  • 58
    • 84904981108 scopus 로고    scopus 로고
    • Asystematic review of dual targeting in HER2-positive breast cancer
    • Kümler I., Tuxen M.K., Nielsen D.L. Asystematic review of dual targeting in HER2-positive breast cancer. Cancer Treat Rev 2013, pii: S0305-7372(13) 00191-6.
    • (2013) Cancer Treat Rev
    • Kümler, I.1    Tuxen, M.K.2    Nielsen, D.L.3
  • 59
    • 84885734781 scopus 로고    scopus 로고
    • Role of phospholipase C in cell invasion and metastasis
    • Lattanzio R., Piantelli M., Falasca M. Role of phospholipase C in cell invasion and metastasis. Adv Biol Regul 2013, 53:309-318.
    • (2013) Adv Biol Regul , vol.53 , pp. 309-318
    • Lattanzio, R.1    Piantelli, M.2    Falasca, M.3
  • 60
    • 84893357888 scopus 로고    scopus 로고
    • Class I PI 3-kinases signaling in platelet activation and thrombosis: PDK1/Akt/GSK3 axis and impact of PTEN and SHIP1
    • Laurent P.A., Severin S., Gratacap M.P., Payrastre B. Class I PI 3-kinases signaling in platelet activation and thrombosis: PDK1/Akt/GSK3 axis and impact of PTEN and SHIP1. Adv Biol Regul 2014, 54:162-174.
    • (2014) Adv Biol Regul , vol.54 , pp. 162-174
    • Laurent, P.A.1    Severin, S.2    Gratacap, M.P.3    Payrastre, B.4
  • 61
    • 27144469023 scopus 로고    scopus 로고
    • Correlation between human epidermal growth factor receptor family (EGFR, HER2, HER3, HER4), phosphorylated Akt (P-Akt), and clinical outcomes after radiation therapy in carcinoma of the cervix
    • Lee C.M., Shrieve D.C., Zempolich K.A., Lee R.J., Hammond E., Handrahan D.L., et al. Correlation between human epidermal growth factor receptor family (EGFR, HER2, HER3, HER4), phosphorylated Akt (P-Akt), and clinical outcomes after radiation therapy in carcinoma of the cervix. Gynecol Oncol 2005, 99:415-421.
    • (2005) Gynecol Oncol , vol.99 , pp. 415-421
    • Lee, C.M.1    Shrieve, D.C.2    Zempolich, K.A.3    Lee, R.J.4    Hammond, E.5    Handrahan, D.L.6
  • 62
    • 77953422867 scopus 로고    scopus 로고
    • PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer
    • Loi S., Haibe-Kains B., Majjaj S., Lallemand F., Durbecq V., Larsimont D., et al. PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer. Proc Natl Acad Sci U S A 2010, 107:10208-10213.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 10208-10213
    • Loi, S.1    Haibe-Kains, B.2    Majjaj, S.3    Lallemand, F.4    Durbecq, V.5    Larsimont, D.6
  • 63
    • 84901433444 scopus 로고    scopus 로고
    • An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer
    • Maertens O., Cichowski K. An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer. Adv Biol Regul 2014, 55.
    • (2014) Adv Biol Regul , vol.55
    • Maertens, O.1    Cichowski, K.2
  • 64
    • 84864568178 scopus 로고    scopus 로고
    • Lin28 and HER2: two stem cell regulators conspire to drive aggressive breast cancer
    • Malik F., Korkaya H., Clouthier S.G., Wicha M.S. Lin28 and HER2: two stem cell regulators conspire to drive aggressive breast cancer. Cell Cycle 2012, 11:2780-2781.
    • (2012) Cell Cycle , vol.11 , pp. 2780-2781
    • Malik, F.1    Korkaya, H.2    Clouthier, S.G.3    Wicha, M.S.4
  • 65
    • 79960271775 scopus 로고    scopus 로고
    • Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway
    • Martelli A.M., Evangelisti C., Chappell W., Abrams S.L., Bäsecke J., Stivala F., et al. Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway. Leukemia 2011, 25:1064-1079.
    • (2011) Leukemia , vol.25 , pp. 1064-1079
    • Martelli, A.M.1    Evangelisti, C.2    Chappell, W.3    Abrams, S.L.4    Bäsecke, J.5    Stivala, F.6
  • 66
    • 84897993008 scopus 로고    scopus 로고
    • GSK-3β: a key regulator of breast cancer drug resistance
    • Martelli A.M., Buontempo F., Evangelisti C. GSK-3β: a key regulator of breast cancer drug resistance. Cell Cycle 2014, 13:697-698.
    • (2014) Cell Cycle , vol.13 , pp. 697-698
    • Martelli, A.M.1    Buontempo, F.2    Evangelisti, C.3
  • 67
    • 84906729585 scopus 로고    scopus 로고
    • Targeting signaling pathways in T-cell acute lymphoblastic leukemia initiating cells
    • Martelli A.M., Lonetti A., Buontempo F., Ricci F., Tazzari P.L., Evangelisti C., et al. Targeting signaling pathways in T-cell acute lymphoblastic leukemia initiating cells. Adv Biol Regul 2014, 56:6-21. pii: S2212-4926(14)00006-2. 10.1016/j.jbior.2014.04.004.
    • (2014) Adv Biol Regul , vol.56 , pp. 6-21
    • Martelli, A.M.1    Lonetti, A.2    Buontempo, F.3    Ricci, F.4    Tazzari, P.L.5    Evangelisti, C.6
  • 68
    • 84873659904 scopus 로고    scopus 로고
    • Basal/HER2 breast carcinomas: integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin)
    • Martin-Castillo B., Oliveras-Ferraros C., Vazquez-Martin A., Cufí S., Moreno J.M., Corominas-Faja B., et al. Basal/HER2 breast carcinomas: integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin). Cell Cycle 2013, 15(12):225-245.
    • (2013) Cell Cycle , vol.15 , Issue.12 , pp. 225-245
    • Martin-Castillo, B.1    Oliveras-Ferraros, C.2    Vazquez-Martin, A.3    Cufí, S.4    Moreno, J.M.5    Corominas-Faja, B.6
  • 69
    • 84884655057 scopus 로고    scopus 로고
    • Pertuzumab: a review of its use for first-line combination treatment of HER2-positive metastatic breast cancer
    • McCormack P.L. Pertuzumab: a review of its use for first-line combination treatment of HER2-positive metastatic breast cancer. Drugs 2013, 73:1491-1502.
    • (2013) Drugs , vol.73 , pp. 1491-1502
    • McCormack, P.L.1
  • 70
    • 0029030083 scopus 로고
    • Differential-effects of viral and cellular oncogenes on the growth factor-dependency of hematopoietic-cells
    • McCubrey J., Steelman L., Wang X., Algate P., Hoyle P., White C., et al. Differential-effects of viral and cellular oncogenes on the growth factor-dependency of hematopoietic-cells. Int J Oncol 1995, 7:295-310.
    • (1995) Int J Oncol , vol.7 , pp. 295-310
    • McCubrey, J.1    Steelman, L.2    Wang, X.3    Algate, P.4    Hoyle, P.5    White, C.6
  • 71
    • 7644229154 scopus 로고    scopus 로고
    • Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells
    • McCubrey J.A., Shelton J.G., Steelman L.S., Franklin R.A., Sreevalsan T., McMahon M. Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells. Oncogene 2004, 23:7810-7820.
    • (2004) Oncogene , vol.23 , pp. 7810-7820
    • McCubrey, J.A.1    Shelton, J.G.2    Steelman, L.S.3    Franklin, R.A.4    Sreevalsan, T.5    McMahon, M.6
  • 72
    • 51349105331 scopus 로고    scopus 로고
    • Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an Achilles heel by sensitization to targeted therapy
    • McCubrey J.A., Sokolosky M.L., Lehmann B.D., Taylor J.R., Navolanic P.M., Chappell W.H., et al. Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an Achilles heel by sensitization to targeted therapy. Adv Enzyme Regul 2008, 48:113-135.
    • (2008) Adv Enzyme Regul , vol.48 , pp. 113-135
    • McCubrey, J.A.1    Sokolosky, M.L.2    Lehmann, B.D.3    Taylor, J.R.4    Navolanic, P.M.5    Chappell, W.H.6
  • 73
    • 79960237399 scopus 로고    scopus 로고
    • Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways
    • McCubrey J.A., Steelman L.S., Kempf C.R., Chappell W.H., Abrams S.L., Stivala F., et al. Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways. JCell Physiol 2011, 226:2762-2781.
    • (2011) JCell Physiol , vol.226 , pp. 2762-2781
    • McCubrey, J.A.1    Steelman, L.S.2    Kempf, C.R.3    Chappell, W.H.4    Abrams, S.L.5    Stivala, F.6
  • 74
    • 84906770195 scopus 로고    scopus 로고
    • Foreword: "targeting signaling pathways in stem cells"
    • McCubrey J.A., Cocco L. Foreword: "targeting signaling pathways in stem cells". Adv Biol Regul 2014, 56:1-5. pii: S2212-4926(14)00028-1. 10.1016/j.jbior.2014.07.001.
    • (2014) Adv Biol Regul , vol.56 , pp. 1-5
    • McCubrey, J.A.1    Cocco, L.2
  • 77
    • 84906766048 scopus 로고    scopus 로고
    • Targeting breast cancer initiating cells: advances in breast cancer research and therapy
    • McCubrey J.A., Davis N.M., Abrams S.L., Montalto G., Cervello M., Libra M., et al. Targeting breast cancer initiating cells: advances in breast cancer research and therapy. Adv Biol Regul 2014, 56:81-107. pii: S2212-4926(14)00009-8. 10.1016/j.jbior.2014.05.003.
    • (2014) Adv Biol Regul , vol.56 , pp. 81-107
    • McCubrey, J.A.1    Davis, N.M.2    Abrams, S.L.3    Montalto, G.4    Cervello, M.5    Libra, M.6
  • 78
    • 84891841884 scopus 로고    scopus 로고
    • Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention
    • McCubrey J.A., Steelman L.S., Bertrand F.E., Davis N.M., Abrams S.L., Montalto G., et al. Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention. Leukemia 2014, 28:15-33.
    • (2014) Leukemia , vol.28 , pp. 15-33
    • McCubrey, J.A.1    Steelman, L.S.2    Bertrand, F.E.3    Davis, N.M.4    Abrams, S.L.5    Montalto, G.6
  • 79
    • 84867787383 scopus 로고    scopus 로고
    • Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer
    • R138
    • Meric-Bernstam F., Chen H., Akcakanat A., Do K.A., Lluch A., Hennessy B.T., et al. Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer. Breast Cancer Res 2012, 14:R138.
    • (2012) Breast Cancer Res , vol.14
    • Meric-Bernstam, F.1    Chen, H.2    Akcakanat, A.3    Do, K.A.4    Lluch, A.5    Hennessy, B.T.6
  • 81
    • 46949101939 scopus 로고    scopus 로고
    • EGFR/HER2 in breast cancer: a biological approach for molecular diagnosis and therapy
    • Milanezi F., Carvalho S., Schmitt F.C. EGFR/HER2 in breast cancer: a biological approach for molecular diagnosis and therapy. Expert Rev Mol Diagn 2008, 8:417-434.
    • (2008) Expert Rev Mol Diagn , vol.8 , pp. 417-434
    • Milanezi, F.1    Carvalho, S.2    Schmitt, F.C.3
  • 82
    • 84858299509 scopus 로고    scopus 로고
    • ErbB2 is necessary for ErbB4 ligands to stimulate oncogenic activities in models of human breast cancer
    • Mill C.P., Zordan M.D., Rothenberg S.M., Settleman J., Leary J.F., Riese D.J. ErbB2 is necessary for ErbB4 ligands to stimulate oncogenic activities in models of human breast cancer. Genes Cancer 2011, 2:792-804.
    • (2011) Genes Cancer , vol.2 , pp. 792-804
    • Mill, C.P.1    Zordan, M.D.2    Rothenberg, S.M.3    Settleman, J.4    Leary, J.F.5    Riese, D.J.6
  • 83
    • 78651427805 scopus 로고    scopus 로고
    • II Ligand stimulation of ErbB4 and A constitutively-active ErbB4 mutant result in different biological responses in human pancreatic tumor cell lines
    • Mill C.P., Gettinger K.L., Riese D.J. II Ligand stimulation of ErbB4 and A constitutively-active ErbB4 mutant result in different biological responses in human pancreatic tumor cell lines. Exp Cell Res 2011, 317:392-404.
    • (2011) Exp Cell Res , vol.317 , pp. 392-404
    • Mill, C.P.1    Gettinger, K.L.2    Riese, D.J.3
  • 84
    • 77954974573 scopus 로고    scopus 로고
    • Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer
    • Miller T.W., Hennessy B.T., González-Angulo A.M., Fox E.M., Mills G.B., Chen H., et al. Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer. JClin Invest 2010, 120:2406-2413.
    • (2010) JClin Invest , vol.120 , pp. 2406-2413
    • Miller, T.W.1    Hennessy, B.T.2    González-Angulo, A.M.3    Fox, E.M.4    Mills, G.B.5    Chen, H.6
  • 85
    • 66249119060 scopus 로고    scopus 로고
    • Loss of phosphatase and tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer
    • Miller T.W., Pérez-Torres M., Narasanna A., Guix M., Stål O., Pérez-Tenorio G., et al. Loss of phosphatase and tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer. Cancer Res 2009, 69:4192-4201.
    • (2009) Cancer Res , vol.69 , pp. 4192-4201
    • Miller, T.W.1    Pérez-Torres, M.2    Narasanna, A.3    Guix, M.4    Stål, O.5    Pérez-Tenorio, G.6
  • 86
    • 80755127903 scopus 로고    scopus 로고
    • Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer
    • Miller T.W., Rexer B.N., Garrett J.T., Arteaga C.L. Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer. Breast Cancer Res 2011, 13:224. 10.1186/bcr3039.
    • (2011) Breast Cancer Res , vol.13 , pp. 224
    • Miller, T.W.1    Rexer, B.N.2    Garrett, J.T.3    Arteaga, C.L.4
  • 87
    • 84883171439 scopus 로고    scopus 로고
    • The role of chemokine receptor CXCR4 in breast cancer metastasis
    • Mukherjee D., Zhao J. The role of chemokine receptor CXCR4 in breast cancer metastasis. Am J Cancer Res 2013, 3:46-57.
    • (2013) Am J Cancer Res , vol.3 , pp. 46-57
    • Mukherjee, D.1    Zhao, J.2
  • 88
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Müller A., Homey B., Soto H., Ge N., Catron D., Buchanan M.E., et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001, 410:50-56.
    • (2001) Nature , vol.410 , pp. 50-56
    • Müller, A.1    Homey, B.2    Soto, H.3    Ge, N.4    Catron, D.5    Buchanan, M.E.6
  • 89
    • 0242694519 scopus 로고    scopus 로고
    • HER-2-targeted therapy - lessons learned and future directions
    • Nahta R., Esteva F.J. HER-2-targeted therapy - lessons learned and future directions. Clin Cancer Res 2003, 9:5078-5084.
    • (2003) Clin Cancer Res , vol.9 , pp. 5078-5084
    • Nahta, R.1    Esteva, F.J.2
  • 90
    • 35348848403 scopus 로고    scopus 로고
    • Prognostic significance of overexpression and phosphorylation of epidermal growth factor receptor (EGFR) and the presence of truncated EGFRvIII in locoregionally advanced breast cancer
    • Nieto Y., Nawaz F., Jones R.B., Shpall E.J., Nawaz S. Prognostic significance of overexpression and phosphorylation of epidermal growth factor receptor (EGFR) and the presence of truncated EGFRvIII in locoregionally advanced breast cancer. JClin Oncol 2007, 25:4405-4413.
    • (2007) JClin Oncol , vol.25 , pp. 4405-4413
    • Nieto, Y.1    Nawaz, F.2    Jones, R.B.3    Shpall, E.J.4    Nawaz, S.5
  • 92
    • 0034027695 scopus 로고    scopus 로고
    • Altered cell cycle response of drug-resistant lung carcinoma cells to doxorubicin
    • O'Loughlin C., Heenan M., Coyle S., Clynes M. Altered cell cycle response of drug-resistant lung carcinoma cells to doxorubicin. Eur J Cancer 2000, 36:1149-1160.
    • (2000) Eur J Cancer , vol.36 , pp. 1149-1160
    • O'Loughlin, C.1    Heenan, M.2    Coyle, S.3    Clynes, M.4
  • 93
    • 41449105551 scopus 로고    scopus 로고
    • HER2 status and benefit from adjuvant trastuzumab in breast cancer
    • Paik S., Kim C., Wolmark N. HER2 status and benefit from adjuvant trastuzumab in breast cancer. NEngl J Med 2008, 358:1409-1411.
    • (2008) NEngl J Med , vol.358 , pp. 1409-1411
    • Paik, S.1    Kim, C.2    Wolmark, N.3
  • 94
    • 0033747558 scopus 로고    scopus 로고
    • Prognostic value of the type I growth factor receptors in a large series of human primary breast cancers quantified with a real-time reverse transcription-polymerase chain reaction assay
    • Pawlowski V., Révillion F., Hebbar M., Hornez L., Peyrat J.P. Prognostic value of the type I growth factor receptors in a large series of human primary breast cancers quantified with a real-time reverse transcription-polymerase chain reaction assay. Clin Cancer Res 2000, 6:4217-4225.
    • (2000) Clin Cancer Res , vol.6 , pp. 4217-4225
    • Pawlowski, V.1    Révillion, F.2    Hebbar, M.3    Hornez, L.4    Peyrat, J.P.5
  • 95
    • 33750997293 scopus 로고    scopus 로고
    • Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines
    • Pitfield S.E., Bryant I., Penington D.J., Park G., Riese D.J. Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines. Oncol Res 2006, 16:179-193.
    • (2006) Oncol Res , vol.16 , pp. 179-193
    • Pitfield, S.E.1    Bryant, I.2    Penington, D.J.3    Park, G.4    Riese, D.J.5
  • 96
    • 84874013459 scopus 로고    scopus 로고
    • Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells
    • Pouillon V., Marechal Y., Frippiat C., Erneux C., Schurmans S. Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells. Adv Biol Regul 2013, 53:39-50.
    • (2013) Adv Biol Regul , vol.53 , pp. 39-50
    • Pouillon, V.1    Marechal, Y.2    Frippiat, C.3    Erneux, C.4    Schurmans, S.5
  • 98
    • 77949887005 scopus 로고    scopus 로고
    • EGFR variant-mediated invasion by enhanced CXCR4 expression through transcriptional and post-translational mechanisms
    • Rahimi M., George J., Tang C. EGFR variant-mediated invasion by enhanced CXCR4 expression through transcriptional and post-translational mechanisms. Int J Cancer 2010, 126:1850-1860.
    • (2010) Int J Cancer , vol.126 , pp. 1850-1860
    • Rahimi, M.1    George, J.2    Tang, C.3
  • 99
    • 79955472668 scopus 로고    scopus 로고
    • CXCR4 suppression attenuates EGFRvIII-mediated invasion and induces p38 MAPK-dependent protein trafficking and degradation of EGFRvIII in breast cancer cells
    • Rahimi M., Toth T.A., Tang C.K. CXCR4 suppression attenuates EGFRvIII-mediated invasion and induces p38 MAPK-dependent protein trafficking and degradation of EGFRvIII in breast cancer cells. Cancer Lett 2011, 306:43-51.
    • (2011) Cancer Lett , vol.306 , pp. 43-51
    • Rahimi, M.1    Toth, T.A.2    Tang, C.K.3
  • 100
    • 79952344515 scopus 로고    scopus 로고
    • Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation
    • Raven J.F., Williams V., Wang S., Tremblay M.L., Muller W.J., Durbin J.E., et al. Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation. Cell Cycle 2011, 10:794-804.
    • (2011) Cell Cycle , vol.10 , pp. 794-804
    • Raven, J.F.1    Williams, V.2    Wang, S.3    Tremblay, M.L.4    Muller, W.J.5    Durbin, J.E.6
  • 101
    • 84925550146 scopus 로고    scopus 로고
    • Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis
    • R1028-R1035
    • Reis-Filho J.S., Milanezi F., Carvalho S., Simpson P.T., Steele D., Savage K., et al. Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis. Breast Cancer Res 2005, 7:R1028-R1035.
    • (2005) Breast Cancer Res , vol.7
    • Reis-Filho, J.S.1    Milanezi, F.2    Carvalho, S.3    Simpson, P.T.4    Steele, D.5    Savage, K.6
  • 102
    • 33746911642 scopus 로고    scopus 로고
    • EGFR amplification and lack of activating mutations in metaplastic breast carcinomas
    • Reis-Filho J.S., Pinheiro C., Lambros M.B., Milanezi F., Carvalho S., Savage K., et al. EGFR amplification and lack of activating mutations in metaplastic breast carcinomas. JPathol 2006, 209:445-453.
    • (2006) JPathol , vol.209 , pp. 445-453
    • Reis-Filho, J.S.1    Pinheiro, C.2    Lambros, M.B.3    Milanezi, F.4    Carvalho, S.5    Savage, K.6
  • 103
    • 85027940454 scopus 로고    scopus 로고
    • Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition
    • Rexer B.N., Ham A.J., Rinehart C., Hill S., Granja-Ingram Nde M., Gonzalez-Angulo A.B., et al. Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition. Oncogene 2011, 30:4163-4174.
    • (2011) Oncogene , vol.30 , pp. 4163-4174
    • Rexer, B.N.1    Ham, A.J.2    Rinehart, C.3    Hill, S.4    Granja-Ingram Nde, M.5    Gonzalez-Angulo, A.B.6
  • 104
    • 84890506215 scopus 로고    scopus 로고
    • Phosphatase and tensin homolog deficiency and resistance to trastuzumab and chemotherapy
    • Rexer B.N., Shyr Y., Arteaga C.L. Phosphatase and tensin homolog deficiency and resistance to trastuzumab and chemotherapy. JClin Oncol 2013, 31:2073-2075.
    • (2013) JClin Oncol , vol.31 , pp. 2073-2075
    • Rexer, B.N.1    Shyr, Y.2    Arteaga, C.L.3
  • 105
    • 84878596429 scopus 로고    scopus 로고
    • IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia
    • Ribeiro D., Melao A., Barata J.T. IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia. Adv Biol Regul 2013, 53:211-222.
    • (2013) Adv Biol Regul , vol.53 , pp. 211-222
    • Ribeiro, D.1    Melao, A.2    Barata, J.T.3
  • 106
    • 36649016921 scopus 로고    scopus 로고
    • Molecular differentiation of early and late stage laryngeal squamous cell carcinoma: an exploratory analysis
    • Saglam O., Shah V., Worsham M.J. Molecular differentiation of early and late stage laryngeal squamous cell carcinoma: an exploratory analysis. Diagn Mol Pathol 2007, 16:218-221.
    • (2007) Diagn Mol Pathol , vol.16 , pp. 218-221
    • Saglam, O.1    Shah, V.2    Worsham, M.J.3
  • 107
    • 84872326962 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin
    • Sanchez-Alvarez R., Martinez-Outschoorn U.E., Lamb R., Hulit J., Howell A., Gandara R., et al. Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin. Cell Cycle 2013, 12:172-182.
    • (2013) Cell Cycle , vol.12 , pp. 172-182
    • Sanchez-Alvarez, R.1    Martinez-Outschoorn, U.E.2    Lamb, R.3    Hulit, J.4    Howell, A.5    Gandara, R.6
  • 108
    • 84863983915 scopus 로고    scopus 로고
    • Mutation profiling identifies numerous rare drug targets and distinct mutation patterns in different clinical subtypes of breast cancers
    • Santarpia L., Qi Y., Stemke-Hale K., Wang B., Young E.J., Booser D.J., et al. Mutation profiling identifies numerous rare drug targets and distinct mutation patterns in different clinical subtypes of breast cancers. Breast Cancer Res Treat 2012, 134:333-343.
    • (2012) Breast Cancer Res Treat , vol.134 , pp. 333-343
    • Santarpia, L.1    Qi, Y.2    Stemke-Hale, K.3    Wang, B.4    Young, E.J.5    Booser, D.J.6
  • 110
    • 0141502211 scopus 로고    scopus 로고
    • Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation
    • Shelton J.G., Moye P.W., Steelman L.S., Blalock W.L., Lee J.T., Franklin R.A., et al. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia 2003, 17:1765-1782.
    • (2003) Leukemia , vol.17 , pp. 1765-1782
    • Shelton, J.G.1    Moye, P.W.2    Steelman, L.S.3    Blalock, W.L.4    Lee, J.T.5    Franklin, R.A.6
  • 111
    • 25144481913 scopus 로고    scopus 로고
    • Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines
    • Shelton J.G., Steelman L.S., Abrams S.L., White E.R., Akula S.M., Franklin R.A., et al. Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines. Cell Cycle 2005, 4:822-830.
    • (2005) Cell Cycle , vol.4 , pp. 822-830
    • Shelton, J.G.1    Steelman, L.S.2    Abrams, S.L.3    White, E.R.4    Akula, S.M.5    Franklin, R.A.6
  • 112
    • 84874005088 scopus 로고    scopus 로고
    • Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling
    • Shiizaki S., Naguro I., Ichijo H. Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling. Adv Biol Regul 2013, 53:135-144.
    • (2013) Adv Biol Regul , vol.53 , pp. 135-144
    • Shiizaki, S.1    Naguro, I.2    Ichijo, H.3
  • 113
    • 84860864158 scopus 로고    scopus 로고
    • NF-κB, stem cells and breast cancer: the links get stronger
    • Shostak K., Chariot A. NF-κB, stem cells and breast cancer: the links get stronger. Breast Cancer Res 2011, 13:214.
    • (2011) Breast Cancer Res , vol.13 , pp. 214
    • Shostak, K.1    Chariot, A.2
  • 114
    • 33749010330 scopus 로고    scopus 로고
    • Molecular detection of EGFRvIII-positive cells in the peripheral blood of breast cancer patients
    • Silva H.A., Abraul E., Raimundo D., Dias M.F., Marques C., Guerra C., et al. Molecular detection of EGFRvIII-positive cells in the peripheral blood of breast cancer patients. Eur J Cancer 2006, 42:2617-2622.
    • (2006) Eur J Cancer , vol.42 , pp. 2617-2622
    • Silva, H.A.1    Abraul, E.2    Raimundo, D.3    Dias, M.F.4    Marques, C.5    Guerra, C.6
  • 116
    • 84897984334 scopus 로고    scopus 로고
    • Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells
    • Sokolosky M., Chappell W.H., Stadelman K., Abrams S.L., Davis N.M., Steelman L.S., et al. Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells. Cell Cycle 2014, 13:820-833.
    • (2014) Cell Cycle , vol.13 , pp. 820-833
    • Sokolosky, M.1    Chappell, W.H.2    Stadelman, K.3    Abrams, S.L.4    Davis, N.M.5    Steelman, L.S.6
  • 117
    • 42449107999 scopus 로고    scopus 로고
    • Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors
    • Steelman L.S., Navolanic P.M., Sokolosky M.L., Taylor J.R., Lehmann B.D., Chappell W.H., et al. Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors. Oncogene 2008, 27:4086-4095.
    • (2008) Oncogene , vol.27 , pp. 4086-4095
    • Steelman, L.S.1    Navolanic, P.M.2    Sokolosky, M.L.3    Taylor, J.R.4    Lehmann, B.D.5    Chappell, W.H.6
  • 118
    • 80052398902 scopus 로고    scopus 로고
    • Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells
    • Steelman L.S., Navolanic P., Chappell W.H., Abrams S.L., Wong E.W.T., Martelli A.M., et al. Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells. Cell Cycle 2011, 10:3003-3015.
    • (2011) Cell Cycle , vol.10 , pp. 3003-3015
    • Steelman, L.S.1    Navolanic, P.2    Chappell, W.H.3    Abrams, S.L.4    Wong, E.W.T.5    Martelli, A.M.6
  • 119
    • 51049118140 scopus 로고    scopus 로고
    • An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
    • Stemke-Hale K., Gonzalez-Angulo A.M., Lluch A., Neve R.M., Kuo W.L., Davies M., et al. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 2008, 68:6084-6091.
    • (2008) Cancer Res , vol.68 , pp. 6084-6091
    • Stemke-Hale, K.1    Gonzalez-Angulo, A.M.2    Lluch, A.3    Neve, R.M.4    Kuo, W.L.5    Davies, M.6
  • 123
    • 0032718015 scopus 로고    scopus 로고
    • Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both invitro and invivo
    • Tang C.K., Concepcion X.Z., Milan M., Gong X., Montgomery E., Lippman M.E. Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both invitro and invivo. Cancer Res 1999, 59:5315-5322.
    • (1999) Cancer Res , vol.59 , pp. 5315-5322
    • Tang, C.K.1    Concepcion, X.Z.2    Milan, M.3    Gong, X.4    Montgomery, E.5    Lippman, M.E.6
  • 124
    • 0034214087 scopus 로고    scopus 로고
    • Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer
    • Tang C.K., Gong X.Q., Moscatello D.K., Wong A.J., Lippman M.E. Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer. Cancer Res 2000, 60:3081-3087.
    • (2000) Cancer Res , vol.60 , pp. 3081-3087
    • Tang, C.K.1    Gong, X.Q.2    Moscatello, D.K.3    Wong, A.J.4    Lippman, M.E.5
  • 125
    • 84868595258 scopus 로고    scopus 로고
    • The promise of antibody-drug conjugates
    • Teicher B.A., Doroshow J.H. The promise of antibody-drug conjugates. NEngl J Med 2012, 367:1847-1848.
    • (2012) NEngl J Med , vol.367 , pp. 1847-1848
    • Teicher, B.A.1    Doroshow, J.H.2
  • 126
    • 84860389233 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy
    • R35
    • Teng Y.H., Tan W.J., Thike A.A., Cheok P.Y., Tse G.M., Wong N.S., et al. Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy. Breast Cancer Res 2011, 13:R35.
    • (2011) Breast Cancer Res , vol.13
    • Teng, Y.H.1    Tan, W.J.2    Thike, A.A.3    Cheok, P.Y.4    Tse, G.M.5    Wong, N.S.6
  • 127
    • 79952996052 scopus 로고    scopus 로고
    • Areview of an unfavorable subset of breast cancer: estrogen receptor positive progesterone receptor negative
    • Thakkar J.P., Mehta D.G. Areview of an unfavorable subset of breast cancer: estrogen receptor positive progesterone receptor negative. Oncologist 2011, 16:276-285.
    • (2011) Oncologist , vol.16 , pp. 276-285
    • Thakkar, J.P.1    Mehta, D.G.2
  • 128
    • 0004345993 scopus 로고    scopus 로고
    • Comparative analysis of the EGF-receptor family in pancreatic cancer: expression of HER-4 correlates with a favourable tumor stage
    • Thybusch-Bernhardt A., Beckmann S., Juhl H. Comparative analysis of the EGF-receptor family in pancreatic cancer: expression of HER-4 correlates with a favourable tumor stage. Int J Surg Investig 2001, 2:393-400.
    • (2001) Int J Surg Investig , vol.2 , pp. 393-400
    • Thybusch-Bernhardt, A.1    Beckmann, S.2    Juhl, H.3
  • 129
    • 84901437003 scopus 로고    scopus 로고
    • Signaling specificity in the Akt pathway in biology and disease
    • Toker A., Marmiroli S. Signaling specificity in the Akt pathway in biology and disease. Adv Biol Regul 2014, 55:28-38.
    • (2014) Adv Biol Regul , vol.55 , pp. 28-38
    • Toker, A.1    Marmiroli, S.2
  • 131
  • 132
    • 84885434409 scopus 로고    scopus 로고
    • New strategies to overcome resistance to mammalian target of rapamycin inhibitors in breast cancer
    • Vicier C., Dieci M.V., Andre F. New strategies to overcome resistance to mammalian target of rapamycin inhibitors in breast cancer. Curr Opin Oncol 2013, 25:587-593.
    • (2013) Curr Opin Oncol , vol.25 , pp. 587-593
    • Vicier, C.1    Dieci, M.V.2    Andre, F.3
  • 133
    • 33846296953 scopus 로고    scopus 로고
    • Aconstitutively active ERBB4/HER4 allele with enhanced transcriptional coactivation and cell-killing activities
    • Vidal G.A., Clark D.E., Marrero L., Jones F.E. Aconstitutively active ERBB4/HER4 allele with enhanced transcriptional coactivation and cell-killing activities. Oncogene 2007, 26:462-466.
    • (2007) Oncogene , vol.26 , pp. 462-466
    • Vidal, G.A.1    Clark, D.E.2    Marrero, L.3    Jones, F.E.4
  • 134
    • 84874601173 scopus 로고    scopus 로고
    • MTOR inhibitors in the treatment of breast cancer
    • Vinayak S., Carlson R.W. mTOR inhibitors in the treatment of breast cancer. Oncology 2013, 27:38-44.
    • (2013) Oncology , vol.27 , pp. 38-44
    • Vinayak, S.1    Carlson, R.W.2
  • 135
    • 48049092377 scopus 로고    scopus 로고
    • Abrogation of G2/M arrest sensitizes curcumin-resistant hepatoma cells to apoptosis
    • Wang W.Z., Cheng J., Luo J., Zhuang S.M. Abrogation of G2/M arrest sensitizes curcumin-resistant hepatoma cells to apoptosis. FEBS Lett 2008, 582:2689-2695.
    • (2008) FEBS Lett , vol.582 , pp. 2689-2695
    • Wang, W.Z.1    Cheng, J.2    Luo, J.3    Zhuang, S.M.4
  • 137
    • 0037456676 scopus 로고    scopus 로고
    • Aconstitutively active ErbB4 mutant inhibits drug-resistant colony formation by the DU-145 and PC-3 human prostate tumor cell lines
    • Williams E.E., Trout L.J., Gallo R.M., Pitfield S.E., Bryant I., Penington D.J., et al. Aconstitutively active ErbB4 mutant inhibits drug-resistant colony formation by the DU-145 and PC-3 human prostate tumor cell lines. Cancer Lett 2003, 192:67-74.
    • (2003) Cancer Lett , vol.192 , pp. 67-74
    • Williams, E.E.1    Trout, L.J.2    Gallo, R.M.3    Pitfield, S.E.4    Bryant, I.5    Penington, D.J.6
  • 138
    • 0038575385 scopus 로고    scopus 로고
    • Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer
    • Witton C.J., Reeves J.R., Going J.J., Cooke T.G., Bartlett J.M. Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer. JPathol 2003, 200:290-297.
    • (2003) JPathol , vol.200 , pp. 290-297
    • Witton, C.J.1    Reeves, J.R.2    Going, J.J.3    Cooke, T.G.4    Bartlett, J.M.5
  • 139
    • 77954617702 scopus 로고    scopus 로고
    • Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer
    • Yang S.X., Costantino J.P., Kim C., Mamounas E.P., Nguyen D., Jeong J.H., et al. Akt phosphorylation at Ser473 predicts benefit of paclitaxel chemotherapy in node-positive breast cancer. JClin Oncol 2010, 28:2974-2981.
    • (2010) JClin Oncol , vol.28 , pp. 2974-2981
    • Yang, S.X.1    Costantino, J.P.2    Kim, C.3    Mamounas, E.P.4    Nguyen, D.5    Jeong, J.H.6
  • 140
    • 56449102243 scopus 로고    scopus 로고
    • Co-expression of EGFRvIII with ErbB-2 enhances tumorigenesis: EGFRvIII mediated constitutively activated and sustained signaling pathways, whereas EGF-induced a transient effect on EGFR-mediated signaling pathways
    • Yu H., Gong X., Luo X., Han W., Hong G., Singh B., et al. Co-expression of EGFRvIII with ErbB-2 enhances tumorigenesis: EGFRvIII mediated constitutively activated and sustained signaling pathways, whereas EGF-induced a transient effect on EGFR-mediated signaling pathways. Cancer Biol Ther 2008, 7:1818-1828.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1818-1828
    • Yu, H.1    Gong, X.2    Luo, X.3    Han, W.4    Hong, G.5    Singh, B.6
  • 141
    • 70249145117 scopus 로고    scopus 로고
    • EGFRvIII-induced estrogen-independence, tamoxifen-resistance phenotype correlates with PgR expression and modulation of apoptotic molecules in breast cancer
    • Zhang Y., Su H., Rahimi M., Tochihara R., Tang C. EGFRvIII-induced estrogen-independence, tamoxifen-resistance phenotype correlates with PgR expression and modulation of apoptotic molecules in breast cancer. Int J Cancer 2009, 125:2021-2028.
    • (2009) Int J Cancer , vol.125 , pp. 2021-2028
    • Zhang, Y.1    Su, H.2    Rahimi, M.3    Tochihara, R.4    Tang, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.