메뉴 건너뛰기




Volumn 53, Issue 1, 2013, Pages 8-17

Activation of the mTOR pathway by the amino acid l-leucine in the 5q- syndrome and other ribosomopathies

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84874010025     PISSN: 22124926     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.jbior.2012.09.002     Document Type: Review
Times cited : (33)

References (65)
  • 1
    • 0033808169 scopus 로고    scopus 로고
    • Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway
    • Anthony J.C., Yoshizawa F., Anthony T.G., Vary T.C., Jefferson L.S., Kimball S.R. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr 2000, 130:2413-2419.
    • (2000) J Nutr , vol.130 , pp. 2413-2419
    • Anthony, J.C.1    Yoshizawa, F.2    Anthony, T.G.3    Vary, T.C.4    Jefferson, L.S.5    Kimball, S.R.6
  • 3
    • 34047095297 scopus 로고    scopus 로고
    • The two TORCs and Akt
    • Bhaskar P.T., Hay N. The two TORCs and Akt. Dev Cell 2007, 12:487-502.
    • (2007) Dev Cell , vol.12 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 5
    • 84865636769 scopus 로고    scopus 로고
    • Haploinsufficiency of ribosomal proteins and p53 activation in anemia: Diamond-Blackfan anemia and the 5q- syndrome
    • Boultwood J., Pellagatti A., Wainscoat J.S. Haploinsufficiency of ribosomal proteins and p53 activation in anemia: Diamond-Blackfan anemia and the 5q- syndrome. Adv Biol Regul 2012, 52:196-203.
    • (2012) Adv Biol Regul , vol.52 , pp. 196-203
    • Boultwood, J.1    Pellagatti, A.2    Wainscoat, J.S.3
  • 6
    • 0028360374 scopus 로고
    • A mammalian protein targeted by G1-arresting rapamycin-receptor complex
    • Brown E.J., Albers M.W., Shin T.B., Ichikawa K., Keith C.T., Lane W.S., et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 1994, 369:756-758.
    • (1994) Nature , vol.369 , pp. 756-758
    • Brown, E.J.1    Albers, M.W.2    Shin, T.B.3    Ichikawa, K.4    Keith, C.T.5    Lane, W.S.6
  • 8
    • 59049100116 scopus 로고    scopus 로고
    • An amino acid shuffle activates mTORC1
    • Cohen A., Hall M.N. An amino acid shuffle activates mTORC1. Cell 2009, 136:399-400.
    • (2009) Cell , vol.136 , pp. 399-400
    • Cohen, A.1    Hall, M.N.2
  • 9
    • 14944341734 scopus 로고    scopus 로고
    • Oral leucine administration stimulates protein synthesis in rat skeletal muscle
    • Crozier S.J., Kimball S.R., Emmert S.W., Anthony J.C., Jefferson L.S. Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J Nutr 2005, 135:376-382.
    • (2005) J Nutr , vol.135 , pp. 376-382
    • Crozier, S.J.1    Kimball, S.R.2    Emmert, S.W.3    Anthony, J.C.4    Jefferson, L.S.5
  • 11
    • 64849110053 scopus 로고    scopus 로고
    • Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma
    • Drakos E., Atsaves V., Li J., Leventaki V., Andreeff M., Medeiros L.J., et al. Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma. Leukemia 2009, 23:784-790.
    • (2009) Leukemia , vol.23 , pp. 784-790
    • Drakos, E.1    Atsaves, V.2    Li, J.3    Leventaki, V.4    Andreeff, M.5    Medeiros, L.J.6
  • 12
    • 79953117045 scopus 로고    scopus 로고
    • Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells
    • Dutt S., Narla A., Lin K., Mullally A., Abayasekara N., Megerdichian C., et al. Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells. Blood 2011, 117:2567-2576.
    • (2011) Blood , vol.117 , pp. 2567-2576
    • Dutt, S.1    Narla, A.2    Lin, K.3    Mullally, A.4    Abayasekara, N.5    Megerdichian, C.6
  • 13
    • 38349088899 scopus 로고    scopus 로고
    • Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
    • Ebert B.L., Pretz J., Bosco J., Chang C.Y., Tamayo P., Galili N., et al. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature 2008, 451:335-339.
    • (2008) Nature , vol.451 , pp. 335-339
    • Ebert, B.L.1    Pretz, J.2    Bosco, J.3    Chang, C.Y.4    Tamayo, P.5    Galili, N.6
  • 14
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman J.A., Luo J., Cantley L.C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006, 7:606-619.
    • (2006) Nat Rev Genet , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 15
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S., Kroemer G., Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 2006, 5:671-688.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 16
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z., Zhang H., Levine A.J., Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A 2005, 102:8204-8209.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 17
    • 77952007543 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony
    • Foster K.G., Fingar D.C. Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony. J Biol Chem 2010, 285:14071-14077.
    • (2010) J Biol Chem , vol.285 , pp. 14071-14077
    • Foster, K.G.1    Fingar, D.C.2
  • 18
    • 23044474905 scopus 로고    scopus 로고
    • Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
    • Fuchs B.C., Bode B.P. Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?. Semin Cancer Biol 2005, 15:254-266.
    • (2005) Semin Cancer Biol , vol.15 , pp. 254-266
    • Fuchs, B.C.1    Bode, B.P.2
  • 19
    • 33748744175 scopus 로고    scopus 로고
    • Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia
    • Gazda H.T., Kho A.T., Sanoudou D., Zaucha J.M., Kohane I.S., Sieff C.A., et al. Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia. Stem Cells 2006, 24:2034-2044.
    • (2006) Stem Cells , vol.24 , pp. 2034-2044
    • Gazda, H.T.1    Kho, A.T.2    Sanoudou, D.3    Zaucha, J.M.4    Kohane, I.S.5    Sieff, C.A.6
  • 20
    • 84862777407 scopus 로고    scopus 로고
    • Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
    • Han J.M., Jeong S.J., Park M.C., Kim G., Kwon N.H., Kim H.K., et al. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 2012, 149:410-424.
    • (2012) Cell , vol.149 , pp. 410-424
    • Han, J.M.1    Jeong, S.J.2    Park, M.C.3    Kim, G.4    Kwon, N.H.5    Kim, H.K.6
  • 21
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • Hara K., Yonezawa K., Weng Q.P., Kozlowski M.T., Belham C., Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 1998, 273:14484-14494.
    • (1998) J Biol Chem , vol.273 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng, Q.P.3    Kozlowski, M.T.4    Belham, C.5    Avruch, J.6
  • 22
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N., Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004, 18:1926-1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 23
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman J., Movva N.R., Hall M.N. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 1991, 253:905-909.
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 24
    • 27744569843 scopus 로고    scopus 로고
    • MTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    • Holz M.K., Ballif B.A., Gygi S.P., Blenis J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 2005, 123:569-580.
    • (2005) Cell , vol.123 , pp. 569-580
    • Holz, M.K.1    Ballif, B.A.2    Gygi, S.P.3    Blenis, J.4
  • 25
    • 0037043851 scopus 로고    scopus 로고
    • P53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation
    • Horton L.E., Bushell M., Barth-Baus D., Tilleray V.J., Clemens M.J., Hensold J.O. p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation. Oncogene 2002, 21:5325-5334.
    • (2002) Oncogene , vol.21 , pp. 5325-5334
    • Horton, L.E.1    Bushell, M.2    Barth-Baus, D.3    Tilleray, V.J.4    Clemens, M.J.5    Hensold, J.O.6
  • 26
    • 84866314916 scopus 로고    scopus 로고
    • Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia
    • Jaako P., Debnath S., Olsson K., Bryder D., Flygare J., Karlsson S. Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia. Blood 2012, 120:2225-2228.
    • (2012) Blood , vol.120 , pp. 2225-2228
    • Jaako, P.1    Debnath, S.2    Olsson, K.3    Bryder, D.4    Flygare, J.5    Karlsson, S.6
  • 27
    • 37549028779 scopus 로고    scopus 로고
    • Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
    • Jastrzebski K., Hannan K.M., Tchoubrieva E.B., Hannan R.D., Pearson R.B. Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function. Growth Factors 2007, 25:209-226.
    • (2007) Growth Factors , vol.25 , pp. 209-226
    • Jastrzebski, K.1    Hannan, K.M.2    Tchoubrieva, E.B.3    Hannan, R.D.4    Pearson, R.B.5
  • 29
    • 0038458489 scopus 로고    scopus 로고
    • The role of mRNA 5'-noncoding and 3'-end sequences on 40S ribosomal subunit recruitment, and how RNA viruses successfully compete with cellular mRNAs to ensure their own protein synthesis
    • Kean K.M. The role of mRNA 5'-noncoding and 3'-end sequences on 40S ribosomal subunit recruitment, and how RNA viruses successfully compete with cellular mRNAs to ensure their own protein synthesis. Biol Cell 2003, 95:129-139.
    • (2003) Biol Cell , vol.95 , pp. 129-139
    • Kean, K.M.1
  • 31
    • 0242496906 scopus 로고    scopus 로고
    • Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway
    • Lim H.K., Choi Y.A., Park W., Lee T., Ryu S.H., Kim S.Y., et al. Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway. J Biol Chem 2003, 278:45117-45127.
    • (2003) J Biol Chem , vol.278 , pp. 45117-45127
    • Lim, H.K.1    Choi, Y.A.2    Park, W.3    Lee, T.4    Ryu, S.H.5    Kim, S.Y.6
  • 32
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma X.M., Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 2009, 10:307-318.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 33
    • 41949101770 scopus 로고    scopus 로고
    • SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs
    • Ma X.M., Yoon S.O., Richardson C.J., Julich K., Blenis J. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell 2008, 133:303-313.
    • (2008) Cell , vol.133 , pp. 303-313
    • Ma, X.M.1    Yoon, S.O.2    Richardson, C.J.3    Julich, K.4    Blenis, J.5
  • 34
    • 84055178474 scopus 로고    scopus 로고
    • Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
    • Magnuson B., Ekim B., Fingar D.C. Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J 2012, 441:1-21.
    • (2012) Biochem J , vol.441 , pp. 1-21
    • Magnuson, B.1    Ekim, B.2    Fingar, D.C.3
  • 35
    • 0033761629 scopus 로고    scopus 로고
    • Synthesis of the translational apparatus is regulated at the translational level
    • Meyuhas O. Synthesis of the translational apparatus is regulated at the translational level. Eur J Biochem 2000, 267:6321-6330.
    • (2000) Eur J Biochem , vol.267 , pp. 6321-6330
    • Meyuhas, O.1
  • 36
    • 77957075353 scopus 로고    scopus 로고
    • Ribosomal protein S6 kinase from TOP mRNAs to cell size
    • Meyuhas O., Dreazen A. Ribosomal protein S6 kinase from TOP mRNAs to cell size. Prog Mol Biol Transl Sci 2009, 90:109-153.
    • (2009) Prog Mol Biol Transl Sci , vol.90 , pp. 109-153
    • Meyuhas, O.1    Dreazen, A.2
  • 37
    • 77951431225 scopus 로고    scopus 로고
    • Ribosomopathies: human disorders of ribosome dysfunction
    • Narla A., Ebert B.L. Ribosomopathies: human disorders of ribosome dysfunction. Blood 2010, 115:3196-3205.
    • (2010) Blood , vol.115 , pp. 3196-3205
    • Narla, A.1    Ebert, B.L.2
  • 38
    • 80054839638 scopus 로고    scopus 로고
    • Translational medicine: ribosomopathies
    • Narla A., Ebert B.L. Translational medicine: ribosomopathies. Blood 2011, 118:4300-4301.
    • (2011) Blood , vol.118 , pp. 4300-4301
    • Narla, A.1    Ebert, B.L.2
  • 39
    • 59049087460 scopus 로고    scopus 로고
    • Bidirectional transport of amino acids regulates mTOR and autophagy
    • Nicklin P., Bergman P., Zhang B., Triantafellow E., Wang H., Nyfeler B., et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 2009, 136:521-534.
    • (2009) Cell , vol.136 , pp. 521-534
    • Nicklin, P.1    Bergman, P.2    Zhang, B.3    Triantafellow, E.4    Wang, H.5    Nyfeler, B.6
  • 40
    • 0028034233 scopus 로고
    • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
    • Pause A., Belsham G.J., Gingras A.C., Donze O., Lin T.A., Lawrence J.C., et al. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature 1994, 371:762-767.
    • (1994) Nature , vol.371 , pp. 762-767
    • Pause, A.1    Belsham, G.J.2    Gingras, A.C.3    Donze, O.4    Lin, T.A.5    Lawrence, J.C.6
  • 41
    • 84866315615 scopus 로고    scopus 로고
    • L-Leucine improves anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q)MDS by activating the mTOR pathway
    • Payne E., Virgilio M., Narla A., Sun H., Levine M., Paw B.H., et al. L-Leucine improves anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q)MDS by activating the mTOR pathway. Blood 2012, 120:2214-2224.
    • (2012) Blood , vol.120 , pp. 2214-2224
    • Payne, E.1    Virgilio, M.2    Narla, A.3    Sun, H.4    Levine, M.5    Paw, B.H.6
  • 42
    • 44649092154 scopus 로고    scopus 로고
    • Haploinsufficiency of RPS14 in 5q- syndrome is associated with deregulation of ribosomal- and translation-related genes
    • Pellagatti A., Hellstrom-Lindberg E., Giagounidis A., Perry J., Malcovati L., Della Porta M.G., et al. Haploinsufficiency of RPS14 in 5q- syndrome is associated with deregulation of ribosomal- and translation-related genes. Br J Haematol 2008, 142:57-64.
    • (2008) Br J Haematol , vol.142 , pp. 57-64
    • Pellagatti, A.1    Hellstrom-Lindberg, E.2    Giagounidis, A.3    Perry, J.4    Malcovati, L.5    Della Porta, M.G.6
  • 43
    • 84857675728 scopus 로고    scopus 로고
    • The mTOR signalling pathway in human cancer
    • Populo H., Lopes J.M., Soares P. The mTOR signalling pathway in human cancer. Int J Mol Sci 2012, 13:1886-1918.
    • (2012) Int J Mol Sci , vol.13 , pp. 1886-1918
    • Populo, H.1    Lopes, J.M.2    Soares, P.3
  • 44
    • 34548817330 scopus 로고    scopus 로고
    • Successful treatment of a Diamond-Blackfan anemia patient with amino acid leucine
    • Pospisilova D., Cmejlova J., Hak J., Adam T., Cmejla R. Successful treatment of a Diamond-Blackfan anemia patient with amino acid leucine. Haematologica 2007, 92:e66-e67.
    • (2007) Haematologica , vol.92
    • Pospisilova, D.1    Cmejlova, J.2    Hak, J.3    Adam, T.4    Cmejla, R.5
  • 45
    • 0033521535 scopus 로고    scopus 로고
    • Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E
    • Pyronnet S., Imataka H., Gingras A.C., Fukunaga R., Hunter T., Sonenberg N. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J 1999, 18:270-279.
    • (1999) EMBO J , vol.18 , pp. 270-279
    • Pyronnet, S.1    Imataka, H.2    Gingras, A.C.3    Fukunaga, R.4    Hunter, T.5    Sonenberg, N.6
  • 47
    • 32244435285 scopus 로고    scopus 로고
    • Regulation of the small GTPase Rheb by amino acids
    • Roccio M., Bos J.L., Zwartkruis F.J. Regulation of the small GTPase Rheb by amino acids. Oncogene 2006, 25:657-664.
    • (2006) Oncogene , vol.25 , pp. 657-664
    • Roccio, M.1    Bos, J.L.2    Zwartkruis, F.J.3
  • 49
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak Y., Bar-Peled L., Zoncu R., Markhard A.L., Nada S., Sabatini D.M. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010, 141:290-303.
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 51
    • 0037117409 scopus 로고    scopus 로고
    • Identification of a conserved motif required for mTOR signaling
    • Schalm S.S., Blenis J. Identification of a conserved motif required for mTOR signaling. Curr Biol 2002, 12:632-639.
    • (2002) Curr Biol , vol.12 , pp. 632-639
    • Schalm, S.S.1    Blenis, J.2
  • 52
    • 0037718389 scopus 로고    scopus 로고
    • TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
    • Schalm S.S., Fingar D.C., Sabatini D.M., Blenis J. TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol 2003, 13:797-806.
    • (2003) Curr Biol , vol.13 , pp. 797-806
    • Schalm, S.S.1    Fingar, D.C.2    Sabatini, D.M.3    Blenis, J.4
  • 53
    • 84859707963 scopus 로고    scopus 로고
    • Hijacking leucyl-tRNA synthetase for amino acid-dependent regulation of TORC1
    • Segev N., Hay N. Hijacking leucyl-tRNA synthetase for amino acid-dependent regulation of TORC1. Mol Cell 2012, 46:4-6.
    • (2012) Mol Cell , vol.46 , pp. 4-6
    • Segev, N.1    Hay, N.2
  • 54
    • 83455195454 scopus 로고    scopus 로고
    • The ribosome-related protein, SBDS, is critical for normal erythropoiesis
    • Sen S., Wang H., Nghiem C.L., Zhou K., Yau J., Tailor C.S., et al. The ribosome-related protein, SBDS, is critical for normal erythropoiesis. Blood 2011, 118:6407-6417.
    • (2011) Blood , vol.118 , pp. 6407-6417
    • Sen, S.1    Wang, H.2    Nghiem, C.L.3    Zhou, K.4    Yau, J.5    Tailor, C.S.6
  • 55
    • 21244480367 scopus 로고    scopus 로고
    • The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
    • Smith E.M., Finn S.G., Tee A.R., Browne G.J., Proud C.G. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J Biol Chem 2005, 280:18717-18727.
    • (2005) J Biol Chem , vol.280 , pp. 18717-18727
    • Smith, E.M.1    Finn, S.G.2    Tee, A.R.3    Browne, G.J.4    Proud, C.G.5
  • 56
    • 0032054816 scopus 로고    scopus 로고
    • The mRNA 5' cap-binding protein eIF4E and control of cell growth
    • Sonenberg N., Gingras A.C. The mRNA 5' cap-binding protein eIF4E and control of cell growth. Curr Opin Cell Biol 1998, 10:268-275.
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 268-275
    • Sonenberg, N.1    Gingras, A.C.2
  • 57
    • 34247573364 scopus 로고    scopus 로고
    • Leucine and protein synthesis: mTOR and beyond
    • Stipanuk M.H. Leucine and protein synthesis: mTOR and beyond. Nutr Rev 2007, 65:122-129.
    • (2007) Nutr Rev , vol.65 , pp. 122-129
    • Stipanuk, M.H.1
  • 58
    • 0035200856 scopus 로고    scopus 로고
    • Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation
    • Tang H., Hornstein E., Stolovich M., Levy G., Livingstone M., Templeton D., et al. Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. Mol Cell Biol 2001, 21:8671-8683.
    • (2001) Mol Cell Biol , vol.21 , pp. 8671-8683
    • Tang, H.1    Hornstein, E.2    Stolovich, M.3    Levy, G.4    Livingstone, M.5    Templeton, D.6
  • 59
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • Tee A.R., Manning B.D., Roux P.P., Cantley L.C., Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 2003, 13:1259-1268.
    • (2003) Curr Biol , vol.13 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 62
    • 0035881470 scopus 로고    scopus 로고
    • Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase
    • Wang X., Li W., Williams M., Terada N., Alessi D.R., Proud C.G. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J 2001, 20:4370-4379.
    • (2001) EMBO J , vol.20 , pp. 4370-4379
    • Wang, X.1    Li, W.2    Williams, M.3    Terada, N.4    Alessi, D.R.5    Proud, C.G.6
  • 63
    • 0034535175 scopus 로고    scopus 로고
    • Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex
    • Wilson K.F., Wu W.J., Cerione R.A. Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex. J Biol Chem 2000, 275:37307-37310.
    • (2000) J Biol Chem , vol.275 , pp. 37307-37310
    • Wilson, K.F.1    Wu, W.J.2    Cerione, R.A.3
  • 65
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: from growth signal integration to cancer, diabetes and ageing
    • Zoncu R., Efeyan A., Sabatini D.M. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011, 12:21-35.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.