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Volumn 53, Issue 3, 2013, Pages 309-318

Role of phospholipase C in cell invasion and metastasis

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPASE C GAMMA; PLCG1 PROTEIN, HUMAN;

EID: 84885734781     PISSN: 22124926     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.jbior.2013.07.006     Document Type: Review
Times cited : (66)

References (95)
  • 1
    • 84879859652 scopus 로고    scopus 로고
    • Targeting FGFR with dovitinib (TKI258): preclinical and clinical data in breast cancer
    • DOI: 10.1158/1078-0432.CCR-13-0190
    • Andre F., Bachelot T., Campone M., Dalenc F., Perez-Garcia J.M., Hurvitz S.A., et al. Targeting FGFR with dovitinib (TKI258): preclinical and clinical data in breast cancer. Clin Cancer Res 2013, DOI: 10.1158/1078-0432.CCR-13-0190.
    • (2013) Clin Cancer Res
    • Andre, F.1    Bachelot, T.2    Campone, M.3    Dalenc, F.4    Perez-Garcia, J.M.5    Hurvitz, S.A.6
  • 2
    • 0025880895 scopus 로고
    • Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas
    • Arteaga C.L., Johnson M.D., Todderud G., Coffey R.J., Carpenter G., Page D.L. Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas. Proc Natl Acad Sci U S A 1991, 88:10435-10439.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 10435-10439
    • Arteaga, C.L.1    Johnson, M.D.2    Todderud, G.3    Coffey, R.J.4    Carpenter, G.5    Page, D.L.6
  • 3
    • 84860668033 scopus 로고    scopus 로고
    • The interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-gamma1 signalling in breast cancer cell migration and dissemination
    • Balz L.M., Bartkowiak K., Andreas A., Pantel K., Niggemann B., Zanker K.S., et al. The interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-gamma1 signalling in breast cancer cell migration and dissemination. J Pathol 2012, 227:234-244.
    • (2012) J Pathol , vol.227 , pp. 234-244
    • Balz, L.M.1    Bartkowiak, K.2    Andreas, A.3    Pantel, K.4    Niggemann, B.5    Zanker, K.S.6
  • 4
    • 27144480288 scopus 로고    scopus 로고
    • Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice
    • Bayascas J.R., Leslie N.R., Parsons R., Fleming S., Alessi D.R. Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice. Curr Biol 2005, 15:1839-1846.
    • (2005) Curr Biol , vol.15 , pp. 1839-1846
    • Bayascas, J.R.1    Leslie, N.R.2    Parsons, R.3    Fleming, S.4    Alessi, D.R.5
  • 5
    • 79956132815 scopus 로고    scopus 로고
    • LKB1 regulates TCR-mediated PLCgamma1 activation and thymocyte positive selection
    • Cao Y., Li H., Liu H., Zhang M., Hua Z., Ji H., et al. LKB1 regulates TCR-mediated PLCgamma1 activation and thymocyte positive selection. Embo J 2011, 30:2083-2093.
    • (2011) Embo J , vol.30 , pp. 2083-2093
    • Cao, Y.1    Li, H.2    Liu, H.3    Zhang, M.4    Hua, Z.5    Ji, H.6
  • 6
    • 0033604513 scopus 로고    scopus 로고
    • Phospholipase C-gamma as a signal-transducing element
    • Carpenter G., Ji Q. Phospholipase C-gamma as a signal-transducing element. Exp Cell Res 1999, 253:15-24.
    • (1999) Exp Cell Res , vol.253 , pp. 15-24
    • Carpenter, G.1    Ji, Q.2
  • 7
    • 60549111070 scopus 로고    scopus 로고
    • Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
    • Charafe-Jauffret E., Ginestier C., Iovino F., Wicinski J., Cervera N., Finetti P., et al. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res 2009, 69:1302-1313.
    • (2009) Cancer Res , vol.69 , pp. 1302-1313
    • Charafe-Jauffret, E.1    Ginestier, C.2    Iovino, F.3    Wicinski, J.4    Cervera, N.5    Finetti, P.6
  • 8
    • 0028089832 scopus 로고
    • Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement
    • Chen P., Xie H., Sekar M.C., Gupta K., Wells A. Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement. J Cell Biol 1994, 127:847-857.
    • (1994) J Cell Biol , vol.127 , pp. 847-857
    • Chen, P.1    Xie, H.2    Sekar, M.C.3    Gupta, K.4    Wells, A.5
  • 9
    • 69549131213 scopus 로고    scopus 로고
    • Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
    • Creighton C.J., Li X., Landis M., Dixon J.M., Neumeister V.M., Sjolund A., et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci U S A 2009, 106:13820-13825.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13820-13825
    • Creighton, C.J.1    Li, X.2    Landis, M.3    Dixon, J.M.4    Neumeister, V.M.5    Sjolund, A.6
  • 10
    • 45849104623 scopus 로고    scopus 로고
    • Phospholipase-C gamma-1 (PLCgamma-1) is critical in hepatocyte growth factor induced invitro invasion and migration without affecting the growth of prostate cancer cells
    • Davies G., Martin T.A., Ye L., Lewis-Russell J.M., Mason M.D., Jiang W.G. Phospholipase-C gamma-1 (PLCgamma-1) is critical in hepatocyte growth factor induced invitro invasion and migration without affecting the growth of prostate cancer cells. Urol Oncol 2008, 26:386-391.
    • (2008) Urol Oncol , vol.26 , pp. 386-391
    • Davies, G.1    Martin, T.A.2    Ye, L.3    Lewis-Russell, J.M.4    Mason, M.D.5    Jiang, W.G.6
  • 11
    • 77952828838 scopus 로고    scopus 로고
    • Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis
    • Dey J.H., Bianchi F., Voshol J., Bonenfant D., Oakeley E.J., Hynes N.E. Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis. Cancer Res 2010, 70:4151-4162.
    • (2010) Cancer Res , vol.70 , pp. 4151-4162
    • Dey, J.H.1    Bianchi, F.2    Voshol, J.3    Bonenfant, D.4    Oakeley, E.J.5    Hynes, N.E.6
  • 12
    • 14544277088 scopus 로고    scopus 로고
    • Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patients
    • DiGiovanna M.P., Stern D.F., Edgerton S.M., Whalen S.G., Moore D., Thor A.D. Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patients. J Clin Oncol 2005, 23:1152-1160.
    • (2005) J Clin Oncol , vol.23 , pp. 1152-1160
    • DiGiovanna, M.P.1    Stern, D.F.2    Edgerton, S.M.3    Whalen, S.G.4    Moore, D.5    Thor, A.D.6
  • 13
    • 0035496541 scopus 로고    scopus 로고
    • The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis
    • Eccles S.A. The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis. J Mammary Gland Biol Neoplasia 2001, 6:393-406.
    • (2001) J Mammary Gland Biol Neoplasia , vol.6 , pp. 393-406
    • Eccles, S.A.1
  • 15
    • 77950914672 scopus 로고    scopus 로고
    • PI3K/Akt signalling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs
    • Falasca M. PI3K/Akt signalling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs. Curr Pharm Des 2010, 16:1410-1416.
    • (2010) Curr Pharm Des , vol.16 , pp. 1410-1416
    • Falasca, M.1
  • 16
    • 0032518666 scopus 로고    scopus 로고
    • Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting
    • Falasca M., Logan S.K., Lehto V.P., Baccante G., Lemmon M.A., Schlessinger J. Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. Embo J 1998, 17:414-422.
    • (1998) Embo J , vol.17 , pp. 414-422
    • Falasca, M.1    Logan, S.K.2    Lehto, V.P.3    Baccante, G.4    Lemmon, M.A.5    Schlessinger, J.6
  • 17
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
    • Fillmore C.M., Kuperwasser C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 2008, 10:R25.
    • (2008) Breast Cancer Res , vol.10
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 18
    • 70449471819 scopus 로고    scopus 로고
    • Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes
    • Finlay D.K., Sinclair L.V., Feijoo C., Waugh C.M., Hagenbeek T.J., Spits H., et al. Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes. J Exp Med 2009, 206:2441-2454.
    • (2009) J Exp Med , vol.206 , pp. 2441-2454
    • Finlay, D.K.1    Sinclair, L.V.2    Feijoo, C.3    Waugh, C.M.4    Hagenbeek, T.J.5    Spits, H.6
  • 20
    • 77149154686 scopus 로고    scopus 로고
    • Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance
    • Fu G., Chen Y., Yu M., Podd A., Schuman J., He Y., et al. Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance. J Exp Med 2010, 207:309-318.
    • (2010) J Exp Med , vol.207 , pp. 309-318
    • Fu, G.1    Chen, Y.2    Yu, M.3    Podd, A.4    Schuman, J.5    He, Y.6
  • 21
    • 84875421249 scopus 로고    scopus 로고
    • Exploring mechanisms of FGF signalling through the lens of structural biology
    • Goetz R., Mohammadi M. Exploring mechanisms of FGF signalling through the lens of structural biology. Nat Rev Mol Cell Biol 2013, 14:166-180.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 166-180
    • Goetz, R.1    Mohammadi, M.2
  • 22
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 23
    • 55549119209 scopus 로고    scopus 로고
    • Scaffolding function of PAK in the PDK1-Akt pathway
    • Higuchi M., Onishi K., Kikuchi C., Gotoh Y. Scaffolding function of PAK in the PDK1-Akt pathway. Nat Cell Biol 2008, 10:1356-1364.
    • (2008) Nat Cell Biol , vol.10 , pp. 1356-1364
    • Higuchi, M.1    Onishi, K.2    Kikuchi, C.3    Gotoh, Y.4
  • 24
    • 0042307325 scopus 로고    scopus 로고
    • The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
    • Holbro T., Beerli R.R., Maurer F., Koziczak M., Barbas C.F., Hynes N.E. The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci U S A 2003, 100:8933-8938.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8933-8938
    • Holbro, T.1    Beerli, R.R.2    Maurer, F.3    Koziczak, M.4    Barbas, C.F.5    Hynes, N.E.6
  • 25
    • 34547871259 scopus 로고    scopus 로고
    • Targeting HER proteins in cancer therapy and the role of the non-target HER3
    • Hsieh A.C., Moasser M.M. Targeting HER proteins in cancer therapy and the role of the non-target HER3. Br J Cancer 2007, 97:453-457.
    • (2007) Br J Cancer , vol.97 , pp. 453-457
    • Hsieh, A.C.1    Moasser, M.M.2
  • 26
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • Huang J., Manning B.D. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 2009, 37:217-222.
    • (2009) Biochem Soc Trans , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2
  • 27
    • 84874336095 scopus 로고    scopus 로고
    • Small molecule inhibitors of phospholipase C from a novel high-throughput screen
    • Huang W., Barrett M., Hajicek N., Hicks S., Harden T.K., Sondek J., et al. Small molecule inhibitors of phospholipase C from a novel high-throughput screen. J Biol Chem 2009, 288:5840-5848.
    • (2009) J Biol Chem , vol.288 , pp. 5840-5848
    • Huang, W.1    Barrett, M.2    Hajicek, N.3    Hicks, S.4    Harden, T.K.5    Sondek, J.6
  • 28
    • 79251501315 scopus 로고    scopus 로고
    • Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
    • Itoh N., Ornitz D.M. Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. JBiochem 2011, 149:121-130.
    • (2011) JBiochem , vol.149 , pp. 121-130
    • Itoh, N.1    Ornitz, D.M.2
  • 29
    • 84862775159 scopus 로고    scopus 로고
    • Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer
    • Jain V.K., Turner N.C. Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer. Breast Cancer Res 2012, 14:208.
    • (2012) Breast Cancer Res , vol.14 , pp. 208
    • Jain, V.K.1    Turner, N.C.2
  • 31
    • 0030967648 scopus 로고    scopus 로고
    • Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development
    • Ji Q.S., Winnier G.E., Niswender K.D., Horstman D., Wisdom R., Magnuson M.A., et al. Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proc Natl Acad Sci U S A 1997, 94:2999-3003.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 2999-3003
    • Ji, Q.S.1    Winnier, G.E.2    Niswender, K.D.3    Horstman, D.4    Wisdom, R.5    Magnuson, M.A.6
  • 32
    • 34547866453 scopus 로고    scopus 로고
    • Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1
    • Jones N.P., Katan M. Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1. Mol Cell Biol 2007, 27:5790-5805.
    • (2007) Mol Cell Biol , vol.27 , pp. 5790-5805
    • Jones, N.P.1    Katan, M.2
  • 33
    • 84873657250 scopus 로고    scopus 로고
    • Mammalian phospholipase C
    • Kadamur G., Ross E.M. Mammalian phospholipase C. Annu Rev Physiol 2013, 75:127-154.
    • (2013) Annu Rev Physiol , vol.75 , pp. 127-154
    • Kadamur, G.1    Ross, E.M.2
  • 35
    • 0032497846 scopus 로고    scopus 로고
    • Families of phosphoinositide-specific phospholipase C: structure and function
    • Katan M. Families of phosphoinositide-specific phospholipase C: structure and function. Biochim Biophys Acta 1998, 1436:5-17.
    • (1998) Biochim Biophys Acta , vol.1436 , pp. 5-17
    • Katan, M.1
  • 37
    • 0025805394 scopus 로고
    • PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254
    • Kim H.K., Kim J.W., Zilberstein A., Margolis B., Kim J.G., Schlessinger J., et al. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254. Cell 1991, 65:435-441.
    • (1991) Cell , vol.65 , pp. 435-441
    • Kim, H.K.1    Kim, J.W.2    Zilberstein, A.3    Margolis, B.4    Kim, J.G.5    Schlessinger, J.6
  • 38
    • 0001550680 scopus 로고    scopus 로고
    • Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1
    • Kim M.J., Chang J.S., Park S.K., Hwang J.I., Ryu S.H., Suh P.G. Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1. Biochemistry 2000, 39:8674-8682.
    • (2000) Biochemistry , vol.39 , pp. 8674-8682
    • Kim, M.J.1    Chang, J.S.2    Park, S.K.3    Hwang, J.I.4    Ryu, S.H.5    Suh, P.G.6
  • 39
    • 77950628416 scopus 로고    scopus 로고
    • Mechanisms of resistance to HER family targeting antibodies
    • Kruser T.J., Wheeler D.L. Mechanisms of resistance to HER family targeting antibodies. Exp Cell Res 2010, 316:1083-1100.
    • (2010) Exp Cell Res , vol.316 , pp. 1083-1100
    • Kruser, T.J.1    Wheeler, D.L.2
  • 40
    • 84872856962 scopus 로고    scopus 로고
    • Overexpression of activated phospholipase Cgamma1 is a risk factor for distant metastases in T1-T2, N0 breast cancer patients undergoing adjuvant chemotherapy
    • Lattanzio R., Marchisio M., La Sorda R., Tinari N., Falasca M., Alberti S., et al. Overexpression of activated phospholipase Cgamma1 is a risk factor for distant metastases in T1-T2, N0 breast cancer patients undergoing adjuvant chemotherapy. Int J Cancer 2013, 132:1022-1031.
    • (2013) Int J Cancer , vol.132 , pp. 1022-1031
    • Lattanzio, R.1    Marchisio, M.2    La Sorda, R.3    Tinari, N.4    Falasca, M.5    Alberti, S.6
  • 41
    • 66449127175 scopus 로고    scopus 로고
    • PLC-gamma1 and Rac1 coregulate EGF-induced cytoskeleton remodeling and cell migration
    • Li S., Wang Q., Wang Y., Chen X., Wang Z. PLC-gamma1 and Rac1 coregulate EGF-induced cytoskeleton remodeling and cell migration. Mol Endocrinol 2009, 23:901-913.
    • (2009) Mol Endocrinol , vol.23 , pp. 901-913
    • Li, S.1    Wang, Q.2    Wang, Y.3    Chen, X.4    Wang, Z.5
  • 42
    • 0037088684 scopus 로고    scopus 로고
    • Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice
    • Liao H.J., Kume T., McKay C., Xu M.J., Ihle J.N., Carpenter G. Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. J Biol Chem 2002, 277:9335-9341.
    • (2002) J Biol Chem , vol.277 , pp. 9335-9341
    • Liao, H.J.1    Kume, T.2    McKay, C.3    Xu, M.J.4    Ihle, J.N.5    Carpenter, G.6
  • 43
    • 11244306450 scopus 로고    scopus 로고
    • Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells
    • Lim M.A., Yang L., Zheng Y., Wu H., Dong L.Q., Liu F. Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells. Oncogene 2004, 23:9348-9358.
    • (2004) Oncogene , vol.23 , pp. 9348-9358
    • Lim, M.A.1    Yang, L.2    Zheng, Y.3    Wu, H.4    Dong, L.Q.5    Liu, F.6
  • 44
    • 67649604297 scopus 로고    scopus 로고
    • Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells
    • Liu Y., Wang J., Wu M., Wan W., Sun R., Yang D., et al. Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells. Mol Cancer Res 2009, 7:944-954.
    • (2009) Mol Cancer Res , vol.7 , pp. 944-954
    • Liu, Y.1    Wang, J.2    Wu, M.3    Wan, W.4    Sun, R.5    Yang, D.6
  • 45
    • 34247152035 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase-dependent regulation of phospholipase Cgamma
    • Maffucci T., Falasca M. Phosphoinositide 3-kinase-dependent regulation of phospholipase Cgamma. Biochem Soc Trans 2007, 35:229-230.
    • (2007) Biochem Soc Trans , vol.35 , pp. 229-230
    • Maffucci, T.1    Falasca, M.2
  • 46
    • 77949507235 scopus 로고    scopus 로고
    • A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation
    • Maffucci T., Raimondi C., Abu-Hayyeh S., Dominguez V., Sala G., Zachary I., et al. A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation. PLoS One 2009, 4:e8285.
    • (2009) PLoS One , vol.4
    • Maffucci, T.1    Raimondi, C.2    Abu-Hayyeh, S.3    Dominguez, V.4    Sala, G.5    Zachary, I.6
  • 47
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: navigating downstream
    • Manning B.D., Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 49
    • 68049117229 scopus 로고    scopus 로고
    • 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma
    • Maurer M., Su T., Saal L.H., Koujak S., Hopkins B.D., Barkley C.R., et al. 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma. Cancer Res 2009, 69:6299-6306.
    • (2009) Cancer Res , vol.69 , pp. 6299-6306
    • Maurer, M.1    Su, T.2    Saal, L.H.3    Koujak, S.4    Hopkins, B.D.5    Barkley, C.R.6
  • 51
    • 4444296491 scopus 로고    scopus 로고
    • Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation
    • Mouneimne G., Soon L., DesMarais V., Sidani M., Song X., Yip S.C., et al. Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. J Cell Biol 2004, 166:697-708.
    • (2004) J Cell Biol , vol.166 , pp. 697-708
    • Mouneimne, G.1    Soon, L.2    DesMarais, V.3    Sidani, M.4    Song, X.5    Yip, S.C.6
  • 52
    • 0037304478 scopus 로고    scopus 로고
    • Fibroblast growth factors and their receptors in transitional cell carcinoma
    • Munro N.P., Knowles M.A. Fibroblast growth factors and their receptors in transitional cell carcinoma. J Urol 2003, 169:675-682.
    • (2003) J Urol , vol.169 , pp. 675-682
    • Munro, N.P.1    Knowles, M.A.2
  • 53
    • 0026848355 scopus 로고
    • Altered distribution of phospholipase C-gamma 1 in benign hyperproliferative epidermal diseases
    • Nanney L.B., Gates R.E., Todderud G., King L.E., Carpenter G. Altered distribution of phospholipase C-gamma 1 in benign hyperproliferative epidermal diseases. Cell Growth Differ 1992, 3:233-239.
    • (1992) Cell Growth Differ , vol.3 , pp. 233-239
    • Nanney, L.B.1    Gates, R.E.2    Todderud, G.3    King, L.E.4    Carpenter, G.5
  • 54
    • 34247269026 scopus 로고    scopus 로고
    • Genetic determinants of cancer metastasis
    • Nguyen D.X., Massague J. Genetic determinants of cancer metastasis. Nat Rev Genet 2007, 8:341-352.
    • (2007) Nat Rev Genet , vol.8 , pp. 341-352
    • Nguyen, D.X.1    Massague, J.2
  • 56
    • 0028069363 scopus 로고
    • Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues
    • Noh D.Y., Lee Y.H., Kim S.S., Kim Y.I., Ryu S.H., Suh P.G., et al. Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues. Cancer 1994, 73:36-41.
    • (1994) Cancer , vol.73 , pp. 36-41
    • Noh, D.Y.1    Lee, Y.H.2    Kim, S.S.3    Kim, Y.I.4    Ryu, S.H.5    Suh, P.G.6
  • 57
    • 48249100529 scopus 로고    scopus 로고
    • Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion
    • Nozawa H., Howell G., Suzuki S., Zhang Q., Qi Y., Klein-Seetharaman J., et al. Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion. Clin Cancer Res 2008, 14:4336-4344.
    • (2008) Clin Cancer Res , vol.14 , pp. 4336-4344
    • Nozawa, H.1    Howell, G.2    Suzuki, S.3    Zhang, Q.4    Qi, Y.5    Klein-Seetharaman, J.6
  • 58
    • 84866544994 scopus 로고    scopus 로고
    • Migfilin protein promotes migration and invasion in human glioma through epidermal growth factor receptor-mediated phospholipase C-gamma and STAT3 protein signaling pathways
    • Ou Y., Ma L., Dong L., Ma L., Zhao Z., Ma L., et al. Migfilin protein promotes migration and invasion in human glioma through epidermal growth factor receptor-mediated phospholipase C-gamma and STAT3 protein signaling pathways. J Biol Chem 2012, 287:32394-32405.
    • (2012) J Biol Chem , vol.287 , pp. 32394-32405
    • Ou, Y.1    Ma, L.2    Dong, L.3    Ma, L.4    Zhao, Z.5    Ma, L.6
  • 60
    • 0028083941 scopus 로고
    • Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis
    • Park J.G., Lee Y.H., Kim S.S., Park K.J., Noh D.Y., Ryu S.H., et al. Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis. Cancer Res 1994, 54:2240-2244.
    • (1994) Cancer Res , vol.54 , pp. 2240-2244
    • Park, J.G.1    Lee, Y.H.2    Kim, S.S.3    Park, K.J.4    Noh, D.Y.5    Ryu, S.H.6
  • 61
    • 76049114936 scopus 로고    scopus 로고
    • Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer
    • Park S.Y., Lee H.E., Li H., Shipitsin M., Gelman R., Polyak K. Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer. Clin Cancer Res 2010, 16:876-887.
    • (2010) Clin Cancer Res , vol.16 , pp. 876-887
    • Park, S.Y.1    Lee, H.E.2    Li, H.3    Shipitsin, M.4    Gelman, R.5    Polyak, K.6
  • 62
    • 84864300658 scopus 로고    scopus 로고
    • Two distinct mechanisms by which phospholipase C-gamma1 mediates epidermal growth factor-induced keratinocyte migration and proliferation
    • Peng J., Liao L., Chen Y., Pennypacker S.D., Gao X., Zhou S.H., et al. Two distinct mechanisms by which phospholipase C-gamma1 mediates epidermal growth factor-induced keratinocyte migration and proliferation. J Dermatol Sci 2012, 67:199-202.
    • (2012) J Dermatol Sci , vol.67 , pp. 199-202
    • Peng, J.1    Liao, L.2    Chen, Y.3    Pennypacker, S.D.4    Gao, X.5    Zhou, S.H.6
  • 63
    • 0037136701 scopus 로고    scopus 로고
    • The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migration
    • Piccolo E., Innominato P.F., Mariggio M.A., Maffucci T., Iacobelli S., Falasca M. The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migration. Oncogene 2002, 21:6520-6529.
    • (2002) Oncogene , vol.21 , pp. 6520-6529
    • Piccolo, E.1    Innominato, P.F.2    Mariggio, M.A.3    Maffucci, T.4    Iacobelli, S.5    Falasca, M.6
  • 64
    • 38849185196 scopus 로고    scopus 로고
    • PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE
    • Pinner S., Sahai E. PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. Nat Cell Biol 2008, 10:127-137.
    • (2008) Nat Cell Biol , vol.10 , pp. 127-137
    • Pinner, S.1    Sahai, E.2
  • 65
    • 15444377640 scopus 로고    scopus 로고
    • Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-gamma1
    • Poulin B., Sekiya F., Rhee S.G. Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-gamma1. Proc Natl Acad Sci U S A 2005, 102:4276-4281.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4276-4281
    • Poulin, B.1    Sekiya, F.2    Rhee, S.G.3
  • 67
    • 84865654433 scopus 로고    scopus 로고
    • Phosphoinositides signalling in cancer: focus on PI3K and PLC
    • Raimondi C., Falasca M. Phosphoinositides signalling in cancer: focus on PI3K and PLC. Adv Biol Regul 2012, 52:166-182.
    • (2012) Adv Biol Regul , vol.52 , pp. 166-182
    • Raimondi, C.1    Falasca, M.2
  • 69
    • 79959365543 scopus 로고    scopus 로고
    • Targeting PDK1 in cancer
    • Raimondi C., Falasca M. Targeting PDK1 in cancer. Curr Med Chem 2011, 18:2763-2769.
    • (2011) Curr Med Chem , vol.18 , pp. 2763-2769
    • Raimondi, C.1    Falasca, M.2
  • 70
    • 0033779101 scopus 로고    scopus 로고
    • Structure, function, and control of phosphoinositide-specific phospholipase C
    • Rebecchi M.J., Pentyala S.N. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol Rev 2000, 80:1291-1335.
    • (2000) Physiol Rev , vol.80 , pp. 1291-1335
    • Rebecchi, M.J.1    Pentyala, S.N.2
  • 71
    • 57749118818 scopus 로고    scopus 로고
    • Phospholipase Cgamma1 is required for metastasis development and progression
    • Sala G., Dituri F., Raimondi C., Previdi S., Maffucci T., Mazzoletti M., et al. Phospholipase Cgamma1 is required for metastasis development and progression. Cancer Res 2008, 68:10187-10196.
    • (2008) Cancer Res , vol.68 , pp. 10187-10196
    • Sala, G.1    Dituri, F.2    Raimondi, C.3    Previdi, S.4    Maffucci, T.5    Mazzoletti, M.6
  • 72
    • 3543026271 scopus 로고    scopus 로고
    • Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation
    • Sekiya F., Poulin B., Kim Y.J., Rhee S.G. Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation. J Biol Chem 2004, 279:32181-32190.
    • (2004) J Biol Chem , vol.279 , pp. 32181-32190
    • Sekiya, F.1    Poulin, B.2    Kim, Y.J.3    Rhee, S.G.4
  • 73
    • 33846552656 scopus 로고    scopus 로고
    • Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
    • Sergina N.V., Rausch M., Wang D., Blair J., Hann B., Shokat K.M., et al. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 2007, 445:437-441.
    • (2007) Nature , vol.445 , pp. 437-441
    • Sergina, N.V.1    Rausch, M.2    Wang, D.3    Blair, J.4    Hann, B.5    Shokat, K.M.6
  • 74
    • 34248358157 scopus 로고    scopus 로고
    • PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors
    • Shepard C.R., Kassis J., Whaley D.L., Kim H.G., Wells A. PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors. Oncogene 2007, 26:3020-3026.
    • (2007) Oncogene , vol.26 , pp. 3020-3026
    • Shepard, C.R.1    Kassis, J.2    Whaley, D.L.3    Kim, H.G.4    Wells, A.5
  • 75
    • 18844371753 scopus 로고    scopus 로고
    • PLC and PI3K pathways are important in the inhibition of EGF-induced cell migration by gefitinib ('Iressa', ZD1839)
    • Shien T., Doihara H., Hara H., Takahashi H., Yoshitomi S., Taira N., et al. PLC and PI3K pathways are important in the inhibition of EGF-induced cell migration by gefitinib ('Iressa', ZD1839). Breast Cancer 2004, 11:367-373.
    • (2004) Breast Cancer , vol.11 , pp. 367-373
    • Shien, T.1    Doihara, H.2    Hara, H.3    Takahashi, H.4    Yoshitomi, S.5    Taira, N.6
  • 76
    • 0035697162 scopus 로고    scopus 로고
    • Deficiency of phospholipase C-gamma1 impairs renal development and hematopoiesis
    • Shirane M., Sawa H., Kobayashi Y., Nakano T., Kitajima K., Shinkai Y., et al. Deficiency of phospholipase C-gamma1 impairs renal development and hematopoiesis. Development 2001, 128:5173-5180.
    • (2001) Development , vol.128 , pp. 5173-5180
    • Shirane, M.1    Sawa, H.2    Kobayashi, Y.3    Nakano, T.4    Kitajima, K.5    Shinkai, Y.6
  • 77
    • 84864401436 scopus 로고    scopus 로고
    • Fibroblast growth factor receptors in breast cancer: expression, downstream effects, and possible drug targets
    • Tenhagen M., van Diest P.J., Ivanova I.A., van der Wall E., van der Groep P. Fibroblast growth factor receptors in breast cancer: expression, downstream effects, and possible drug targets. Endocr Relat Cancer 2012, 19:R115-R129.
    • (2012) Endocr Relat Cancer , vol.19
    • Tenhagen, M.1    van Diest, P.J.2    Ivanova, I.A.3    van der Wall, E.4    van der Groep, P.5
  • 78
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 79
    • 84858396997 scopus 로고    scopus 로고
    • Mechanisms of FGFR3 actions in endocrine resistant breast cancer
    • Tomlinson D.C., Knowles M.A., Speirs V. Mechanisms of FGFR3 actions in endocrine resistant breast cancer. Int J Cancer 2012, 130:2857-2866.
    • (2012) Int J Cancer , vol.130 , pp. 2857-2866
    • Tomlinson, D.C.1    Knowles, M.A.2    Speirs, V.3
  • 80
    • 84862203852 scopus 로고    scopus 로고
    • FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCgamma/COX-2-mediated mechanisms
    • Tomlinson D.C., Baxter E.W., Loadman P.M., Hull M.A., Knowles M.A. FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCgamma/COX-2-mediated mechanisms. PLoS One 2012, 7:e38972.
    • (2012) PLoS One , vol.7
    • Tomlinson, D.C.1    Baxter, E.W.2    Loadman, P.M.3    Hull, M.A.4    Knowles, M.A.5
  • 81
    • 66349120144 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer
    • Tomlinson D.C., Lamont F.R., Shnyder S.D., Knowles M.A. Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer. Cancer Res 2009, 69:4613-4620.
    • (2009) Cancer Res , vol.69 , pp. 4613-4620
    • Tomlinson, D.C.1    Lamont, F.R.2    Shnyder, S.D.3    Knowles, M.A.4
  • 82
    • 75149170979 scopus 로고    scopus 로고
    • Fibroblast growth factor signalling: from development to cancer
    • Turner N., Grose R. Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer 2010, 10:116-129.
    • (2010) Nat Rev Cancer , vol.10 , pp. 116-129
    • Turner, N.1    Grose, R.2
  • 83
    • 77950278598 scopus 로고    scopus 로고
    • FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
    • Turner N., Pearson A., Sharpe R., Lambros M., Geyer F., Lopez-Garcia M.A., et al. FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer. Cancer Res 2010, 70:2085-2094.
    • (2010) Cancer Res , vol.70 , pp. 2085-2094
    • Turner, N.1    Pearson, A.2    Sharpe, R.3    Lambros, M.4    Geyer, F.5    Lopez-Garcia, M.A.6
  • 84
    • 77955172153 scopus 로고    scopus 로고
    • MiR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer
    • Uhlmann S., Zhang J.D., Schwager A., Mannsperger H., Riazalhosseini Y., Burmester S., et al. miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. Oncogene 2010, 29:4297-4306.
    • (2010) Oncogene , vol.29 , pp. 4297-4306
    • Uhlmann, S.1    Zhang, J.D.2    Schwager, A.3    Mannsperger, H.4    Riazalhosseini, Y.5    Burmester, S.6
  • 85
    • 34249281332 scopus 로고    scopus 로고
    • The cofilin pathway in breast cancer invasion and metastasis
    • Wang W., Eddy R., Condeelis J. The cofilin pathway in breast cancer invasion and metastasis. Nat Rev Cancer 2007, 7:429-440.
    • (2007) Nat Rev Cancer , vol.7 , pp. 429-440
    • Wang, W.1    Eddy, R.2    Condeelis, J.3
  • 86
    • 0037862104 scopus 로고    scopus 로고
    • Phospholipase C-gamma1 in tumor progression
    • Wells A., Grandis J.R. Phospholipase C-gamma1 in tumor progression. Clin Exp Metastasis 2003, 20:285-290.
    • (2003) Clin Exp Metastasis , vol.20 , pp. 285-290
    • Wells, A.1    Grandis, J.R.2
  • 87
    • 77955431465 scopus 로고    scopus 로고
    • Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis
    • Xie Z., Chen Y., Liao E.Y., Jiang Y., Liu F.Y., Pennypacker S.D. Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis. Biochem Biophys Res Commun 2010, 397:296-300.
    • (2010) Biochem Biophys Res Commun , vol.397 , pp. 296-300
    • Xie, Z.1    Chen, Y.2    Liao, E.Y.3    Jiang, Y.4    Liu, F.Y.5    Pennypacker, S.D.6
  • 88
    • 77955432031 scopus 로고    scopus 로고
    • The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis
    • Xie Z., Chen Y., Pennypacker S.D., Zhou Z., Peng D. The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis. Biochem Biophys Res Commun 2010, 398:719-722.
    • (2010) Biochem Biophys Res Commun , vol.398 , pp. 719-722
    • Xie, Z.1    Chen, Y.2    Pennypacker, S.D.3    Zhou, Z.4    Peng, D.5
  • 89
    • 77956173049 scopus 로고    scopus 로고
    • Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration
    • Xie Z., Peng J., Pennypacker S.D., Chen Y. Critical role for the catalytic activity of phospholipase C-gamma1 in epidermal growth factor-induced cell migration. Biochem Biophys Res Commun 2010, 399:425-428.
    • (2010) Biochem Biophys Res Commun , vol.399 , pp. 425-428
    • Xie, Z.1    Peng, J.2    Pennypacker, S.D.3    Chen, Y.4
  • 90
    • 84870853914 scopus 로고    scopus 로고
    • PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells
    • Xie Z., Jiang Y., Liao E.Y., Chen Y., Pennypacker S.D., Peng J., et al. PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells. Oncogene 2012, 31:5090-5098.
    • (2012) Oncogene , vol.31 , pp. 5090-5098
    • Xie, Z.1    Jiang, Y.2    Liao, E.Y.3    Chen, Y.4    Pennypacker, S.D.5    Peng, J.6
  • 91
    • 34247468876 scopus 로고    scopus 로고
    • Regulation of the actin cytoskeleton in cancer cell migration and invasion
    • Yamaguchi H., Condeelis J. Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta 2007, 1773:642-652.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 642-652
    • Yamaguchi, H.1    Condeelis, J.2
  • 93
    • 0037203868 scopus 로고    scopus 로고
    • Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE
    • Ye K., Aghdasi B., Luo H.R., Moriarity J.L., Wu F.Y., Hong J.J., et al. Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature 2002, 415:541-544.
    • (2002) Nature , vol.415 , pp. 541-544
    • Ye, K.1    Aghdasi, B.2    Luo, H.R.3    Moriarity, J.L.4    Wu, F.Y.5    Hong, J.J.6
  • 94
    • 38449109575 scopus 로고    scopus 로고
    • Nuclear phosphoinositide signaling
    • Ye K., Ahn J.Y. Nuclear phosphoinositide signaling. Front Biosci 2008, 13:540-548.
    • (2008) Front Biosci , vol.13 , pp. 540-548
    • Ye, K.1    Ahn, J.Y.2
  • 95
    • 0033637979 scopus 로고    scopus 로고
    • Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
    • Ye K., Hurt K.J., Wu F.Y., Fang M., Luo H.R., Hong J.J., et al. Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. Cell 2000, 103:919-930.
    • (2000) Cell , vol.103 , pp. 919-930
    • Ye, K.1    Hurt, K.J.2    Wu, F.Y.3    Fang, M.4    Luo, H.R.5    Hong, J.J.6


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