Altered cell cycle response of drug-resistant lung carcinoma cells to doxorubicin

European Journal of Cancer

Volumn 36, Issue 9, 2000, Pages 1149-1160

  O'Loughlin, C ^a   Heenan, M ^a   Coyle, S ^a   Clynes, M ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

Author keywords

Cell cycle; Doxorubicin; G2 M arrest; Genetic instability; Multiple drug resistance

Indexed keywords

CAFFEINE; CYCLIN B; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; GLYCOPROTEIN P; PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; DNA DAMAGE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG CARCINOMA; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; WESTERN BLOTTING;

ANTIBIOTICS, ANTINEOPLASTIC; BLOTTING, WESTERN; CAFFEINE; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASE; CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN B; DNA TOPOISOMERASES, TYPE II; DOXORUBICIN; DRUG COMBINATIONS; DRUG RESISTANCE, NEOPLASM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; LUNG NEOPLASMS; MITOSIS; P-GLYCOPROTEIN; TUMOR CELLS, CULTURED;

EID: 0034027695     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(00)00071-X     Document Type: Article

References (31)

1. Bradshaw D.M., Arceci R.J. Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance. J. Clin. Oncol. 16:1998;3674-3690.
2. Barlogie B. The effect of Adriamycin on the cell cycle traverse of a human lymphoid cell line. Cancer Res. 36:1976;1975-1979.
3. Elledge S.J. Cell cycle checkpoints. preventing an identity crisis Science. 274:1996;1664-1672.
4. Sanchez Y., Wong C., Thomas R.S.et al. Conservation of the Chk1 checkpoint pathway in mammals. linkage of DNA damage to Cdk regulation through Cdc25 Science. 277:1997;1497-1501.
5. Lopez-Gironal A., Furnari B., Mondesert O., Russell P. Nuclear localisation of cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature. 397:1999;172-175.
6. Hoffmann I., Karenti E. The role of cdc25 in checkpoints and feedback controls in the eukaryotic cell cycle. J. Cell Sci. Suppl. 18:1994;75-79.
7. Lock R.B., Ross W.E. Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells. Cancer Res. 50:1990;3761-3766.
8. Lock R.B. Inhibition of p34cdc2 kinase activation, p34 tyrosine dephosphorylation, and mitotic progression on Chinese hamster ovary cells exposed to etoposide. Cancer Res. 52:1992;1817-1822.
9. Tsao Y.P., D'Arpa P., Liu L.F. The involvement of active DNA synthesis in camptothecin-induced G2 arrest. altered regulation of p34cdc2/cyclin B Cancer Res. 52:1992;1823-1829.
10. Ling Y.H., El-Naggar A.K., Priebe W., Perez-Soler R. Cell cycle dependent cytotoxicity, G2/M phase arrest, and disruption of p34cdc2/cyclin B1 activity induced by Doxorubicin in synchronised p388 cells. Mol. Pharmacol. 49:1996;832-841.
11. Hoffmann I., Clarke P.R., Marcote M.J., Karsenti E., Draetta G. Phosphorylation and activation of human cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J. 12:1993;53-63.
12. O'Connor P.M., Ferris D.F., Hoffmann I., Jackman J., Draetta G., Kohn K.W. Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard. Proc. Natl. Acad. Sci. USA. 91:1994;9480-9484.
13. McBride S., Meleady P., Baird A., Dinsdale D., Clynes M. Human lung carcinoma cell line DLKP contains 3 distinct subpopulations with different growth and attachment properties. Tumour Biol. 19:1998;88-103.
14. Heenan M., O'Driscoll L., Cleary I., Connolly L., Clynes M. Isolation from a human MDR lung cell line of multiple clonal subpopulations which exhibit significantly different drug resistance. Int. J. Cancer. 71:1997;907-915.
15. NicAmhlaoibh R., Heenan M., Cleary I.et al. Altered expression of mRNAs for apoptosis-modulating proteins in a low level multidrug resistant variant of a human lung carcinoma cell line that also expresses mdr1 mRNA. Int. J. Cancer. 82:1999;368-376.
16. O'Connor P.M., Ferris D.K., Pagano M.et al. G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J. Biol. Chem. 268:1993;8298-8308.
17. Downes C.S., Clarke D.J., Mullinger A.M., Gimenez-Ablan J.F., Creighton A.M, Johnson R.T. A topoisomerase II-dependent G2 cycle checkpoint in mammalian cells. Nature. 372:1994;467-470.
18. Cleary I., Doherty G., Moran E., Clynes M. The mutli-drug resistant lung tumour cell line, DLKP-A10, express novel drug accumulation and sequestration systems. Biochem. Pharmacol. 53:1997;1493-1502.
19. Musk S.R., Steel G.G. Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity. Int. J. Radiat. Biol. 57:1990;1105-1112.
20. Traganos F., Kapuscinski J., Darzynkiewicz Z. Caffeine modulates the effects of DNA-intercalating drugs in vitro. A flow cytometric and spectrophotometric analysis of caffeine interaction with novantrone, doxorubicin, ellipticine and the doxorubicin analogue AD198 Cancer Res. 51:1991;3682-3689.
21. Traganos F., Kapuscinski J., Gong J., Ardelt B., Darzynkiewicz R., Darzynkiewicz Z. Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells. Cancer Res. 53:1993;4613-4618.
22. Germain D., Hendley J., Futcher B. DNA damage inhibits proteolysis of the B-type cyclin Clb5 in S. cerevisiae. J. Cell Sci. 110:1997;1813-1820.
23. Shimizu T., O'Connor P.M., Kohn K.W., Pommier Y. Unscheduled activation of cyclin B1/cdc2 kinase in human promyelocytic leukemia cell line HL-60 cells undergoing apoptosis induced by DNA damage. Cancer Res. 55:1995;228-231.
24. Metting N.F., Little J.B. Transient failure to dephosphorylate the cdc2-cyclin B1 complex accompanies radiation-induced G2-phase arrest in HeLa cells. Radiat. Res. 143:1995;286-292.
25. Lammer C., Wagerer S., Saffrich R., Mertens D., Ansgorge W., Hoffmann I. The cdc25B phosphatase is essential for the G2/M phase transition in human cells. J. Cell Sci. 111:1998;2445-2453.
26. Strausfeld U., Labbe J.C., Fesquet D.et al. Dephosphorylation and activation of p34cdc2/cyclin B complex in vitro by human cdc25 protein. Nature. 351:1991;242-245.
27. Jin P., Hardy S., Morgan D.O. Nuclear localisation of cyclin B1 controls mitotic entry after DNA damage. J. Cell Biol. 141:1998;875-885.
28. Toyoshima F., Moriguchi T., Wada A., Fukuda M., Nishida E. Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint. EMBO J. 17:1998;2728-2735.
29. McGowan C.H., Russell P. Cell cycle regulation of human wee1. EMBO J. 14:1995;2166-2175.
30. Kaufmann W.K. Cell cycle checkpoints and DNA repair preserve the stability of the human genome. Cancer Metast. Rev. 14:1995;31-41.
31. Paules R.S., Levedakou E.N., Wilson S.J.et al. Defective G2 checkpoint in cells from individuals with familial cancer syndromes. Cancer Res. 55:1995;1763-1773.