All-encomPASsing regulation of β-cells: PAS domain proteins in β-cell dysfunction and diabetes

Trends in Endocrinology and Metabolism

Volumn 26, Issue 1, 2015, Pages 49-57

  Sabatini, Paul V ^a,b   Lynn, Francis C ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Arnt; Bmal1; Circadian; Clock; Diabetes; Hif1 ; Hypoxia; Insulin secretion; Npas4; PAS domain; Pask; Per; Sim; Vhl; cells

Indexed keywords

ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR PROTEIN; EXENDIN 4; GLUCOKINASE; GLUCOSE TRANSPORTER 2; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INCRETIN; PERIOD CIRCADIAN PROTEIN ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR PROTEIN SINGLE MINDED PROTEIN; PROTEIN; PROTEIN BMAL1; TRANSCRIPTION FACTOR CLOCK; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CIRCADIAN RHYTHM SIGNALING PROTEIN; DROSOPHILA PROTEIN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1BETA; NUCLEAR PROTEIN; PAS DOMAIN KINASES; PROTEIN SERINE THREONINE KINASE; SIM PROTEIN, DROSOPHILA; TRANSCRIPTION FACTOR;

APOPTOSIS; CELL PROLIFERATION; CIRCADIAN RHYTHM; DIABETES MELLITUS; DNA RESPONSIVE ELEMENT; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE STIMULATED INSULIN SECRETION; GLUCOSE TOLERANCE; GLYCEMIC CONTROL; GLYCOLYSIS; HUMAN; HYDROXYLATION; HYPOXIA RESPONSE ELEMENT; IMMUNOFLUORESCENCE; INSULIN RELEASE; INSULIN SENSITIVITY; MIN6 CELL LINE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; OXYGEN TENSION; PANCREAS BLOOD FLOW; PANCREAS ISLET BETA CELL; REVIEW; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DIABETES MELLITUS; DROSOPHILA PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INSULIN-SECRETING CELLS; NUCLEAR PROTEINS; PERIOD CIRCADIAN PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 84920569019     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2014.11.002     Document Type: Review

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