mTOR links incretin signaling to HIF induction in pancreatic beta cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 41, 2011, Pages 16876-16882

  Van De Velde, Sam ^a   Hogan, Meghan F ^a   Montminy, Marc ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Insulin; Islet cell

Indexed keywords

CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCAGON LIKE PEPTIDE 1; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INCRETIN; MAMMALIAN TARGET OF RAPAMYCIN;

ANIMAL EXPERIMENT; ARTICLE; CELL FUNCTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; HORMONE ACTION; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; CELL LINE; CELL SURVIVAL; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GLUCAGON-LIKE PEPTIDE 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INCRETINS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-SECRETING CELLS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 80054772950     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114228108     Document Type: Article

References (29)

1. Drucker DJ (2006) The biology of incretin hormones. Cell Metab 3:153-65.
2. Drucker DJ, Nauck MA (2006) The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368:1696-705. (Pubitemid 46048557)
3. Jhala US, et al. (2003) cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev 17:1575-80. (Pubitemid 36828785)
4. Inada A, et al. (2004) Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells. Mol Cell Biol 24:2831-41. (Pubitemid 38381273)
5. Park S, et al. (2006) Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. J Biol Chem 281:1159-68.
6. Norquay LD, et al. (2009) Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice. Endocrinology 150:4531-40.
7. Altarejos JY, Montminy M (2011) CREB and the CRTC co-activators: Sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol 12:141-51.
8. Buse JB, et al. (2010) DURATION-1: Exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks. Diabetes Care 33:1255-61.
9. Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: From growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12:21-35.
10. Polak P, Hall MN (2009) mTOR and the control of whole body metabolism. Curr Opin Cell Biol 21:209-18.
11. Zhang X, et al. (2005) Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci USA 102:4459-64. (Pubitemid 40397134)
12. Koo SH, et al. (2005) The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437:1109-11.
13. Semenza GL (2010) HIF-1: Upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20:51-6.
14. Sengupta S, Peterson TR, Sabatini DM (2010) Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 40:310-22.
15. Screaton RA, et al. (2004) The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 119:61-74. (Pubitemid 39349320)
16. Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J (2008) Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci USA 105:17414-9.
17. Mantovani G, et al. (2005) Effect of cyclic adenosine 3′,5′-monophosphate/protein kinase a pathway on markers of cell proliferation in nonfunctioning pituitary adenomas. J Clin Endocrinol Metab 90:6721-4. (Pubitemid 41759338)
18. Ringel MD, Schwindinger WF, Levine MA (1996) Clinical implications of genetic defects in G proteins. The molecular basis of McCune-Albright syndrome and Albright hereditary osteodystrophy. Medicine (Baltimore) 75:171-84. (Pubitemid 26260235)
19. Ruvinsky I, et al. (2005) Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev 19:2199-211. (Pubitemid 41330321)
20. Granot Z, et al. (2009) LKB1 regulates pancreatic beta cell size, polarity, and function. Cell Metab 10:296-308.
21. Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324:1029-33.
22. Zehetner J, et al. (2008) PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes Dev 22:3135-46.
23. Gunton JE, et al. (2005) Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 122:337-49. (Pubitemid 41127137)
24. Cheng K, et al. (2010) Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest 120:2171-83.
25. Porat S, et al. (2011) Control of pancreatic beta cell regeneration by glucose metabolism. Cell Metab 13:440-9.
26. Cantley J, et al. (2009) Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice. J Clin Invest 119:125-35.
27. Dentin R, Hedrick S, Xie J, Yates J, 3rd, Montminy M (2008) Hepatic glucose sensing via the CREB coactivator CRTC2. Science 319:1402-5. (Pubitemid 351354877)
28. Ravnskjaer K, et al. (2007) Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J 26:2880-9. (Pubitemid 46975772)
29. Parsons GB, et al. (2007) Ectopic expression of glucagon-like peptide 1 for gene therapy of type II diabetes. Gene Ther 14:38-48. (Pubitemid 44942864)