BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis

PLoS Biology

Volumn 2, Issue 11, 2004, Pages

  Rudic, R Daniel ^a   McNamara, Peter ^b   Curtis, Anne Maria ^a   Boston, Raymond C ^a   Panda, Satchidananda ^c   Hogenesch, John B ^c   FitzGerald, Garret A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Phenomix Corporation   (United States)

^c GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; CORTICOSTERONE; GLUCAGON; GLUCOSE; INSULIN; PROTEIN BMAL1; TRANSCRIPTION FACTOR CLOCK; TRIACYLGLYCEROL; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CARBOHYDRATE METABOLISM; CIRCADIAN RHYTHM; CONTROLLED STUDY; DELETION MUTANT; GENE FUNCTION; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HYPOGLYCEMIA; LIPID DIET; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ANALYSIS OF VARIANCE; ANIMAL; ANIMAL FOOD; BODY MASS; DIET; GENE DELETION; GENETICS; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; TIME; TRANSGENIC MOUSE;

ANALYSIS OF VARIANCE; ANIMAL FEED; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BODY MASS INDEX; CIRCADIAN RHYTHM; CORTICOSTERONE; DIET; GENE DELETION; GLUCAGON; GLUCONEOGENESIS; GLUCOSE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HYPOGLYCEMIA; INSULIN; MICE; MICE, TRANSGENIC; MUTATION; PHENOTYPE; TIME FACTORS; TRANS-ACTIVATORS; TRIGLYCERIDES;

EID: 14044264801     PISSN: 15449173     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pbio.0020377     Document Type: Article

References (50)

1. Akhtar RA, Reddy AB, Maywood ES, Clayton JD, King VM, et al. (2002) Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus. Curr Biol 12: 540-550.
2. Albrecht U, Eichele G (2003) The mammalian circadian clock. Curr Opin Genet Dev 13: 271-277.
3. Bergman RN, Ider YZ, Bowden CR, Cobelli C (1979) Quantitative estimation of insulin sensitivity. Am J Physiol 236: E667-677.
4. Boston RC, Stefanovski D, Moate PJ, Sumner AE, Watanabe RM, et al. (2003) MINMOD millennium: A computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test. Diabetes Technol Ther 5: 1003-1015.
5. Brotman DJ, Girod JP (2002) The metabolic syndrome: A tug-of-war with no winner. Cleve Clin J Med 69: 990-994.
6. Bunger MK, Wilsbacher LD, Moran SM, Clendenin C, Radcliffe LA, et al. (2000) Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 103: 1009-1017.
7. Castex C, Hoo-Paris R (1987) Regulation of endocrine pancreas secretions (insulin and glucagon) during the periodic lethargy-waking cycle of the hibernating mammal. Diabete Metab 13: 176-181.
8. Coulston AM, Liu GC, Reaven GM (1983) Plasma glucose, insulin and lipid responses to high-carbohydrate low-fat diets in normal humans. Metabolism 32: 52-56.
9. Cryer PE (1993) Glucose counterregulation: Prevention and correction of hypoglycemia in humans. Am J Physiol 264: E149-155.
10. Damiola F, Le Minh N, Preitner N, Kornmann B, Fleury-Olela F, et al. (2000) Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev 14: 2950-2961.
11. Deboer T, Vansteensel MJ, Detari L, Meijer JH (2003) Sleep states alter activity of suprachiasmatic nucleus neurons. Nat Neurosci 6: 1086-1090.
12. Gagliardino JJ, Hernandez RE (1971) Circadian variation of the serum glucose and immunoreactive insulin levels. Endocrinology 88: 1532-1534.
13. Grundleger ML, Thenen SW (1982) Decreased insulin binding, glucose transport, and glucose metabolism in soleus muscle of rats fed a high fat diet. Diabetes 31: 232-237.
14. Hastings MH, Reddy AB, Maywood ES (2003) A clockwork web: Circadian timing in brain and periphery, in health and disease. Nat Rev Neurosci 4: 649-661.
15. Herzog ED, Takahashi JS, Block GD (1998) Clock controls circadian period in isolated suprachiasmatic nucleus neurons. Nat Neurosci 1: 708-713.
16. Hirota T, Okano T, Kokame K, Shirotani-Ikejima H, Miyata T, et al. (2002) Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts. J Biol Chem 277: 44244-44251.
17. Hochgeschwender U, Costa JL, Reed P, Bui S, Brennan MB (2003) Altered glucose homeostasis in POMC null mouse mutants lacking central and peripheral melanocortin. Endocrinology 144: 5194-5202.
18. Ibuka N, Inouye SI, Kawamura H (1977) Analysis of sleep-wakefulness rhythms in male rats after suprachiasmatic nucleus lesions and ocular enucleation. Brain Res 122: 33-47.
19. Ibuka N, Nihonmatsu I, Sekiguchi S (1980) Sleep-wakefulness rhythms in mice after suprachiasmatic nucleus lesions. Waking Sleeping 4: 167-173.
20. Johnson JH, Ogawa A, Chen L, Orci L, Newgard CB, et al. (1990) Underexpression of beta cell high Km glucose transporters in noninsulindependent diabetes. Science 250: 546-549.
21. King DP, Zhao Y, Sangoram AM, Wilsbacher LD, Tanaka M, et al. (1997) Positional cloning of the mouse circadian clock gene. Cell 89: 641-653.
22. Kita Y, Shiozawa M, Jin W, Majewski RR, Besharse JC, et al. (2002) Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies. Pharmacogenetics 12: 55-65.
23. Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, et al. (2000) Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol 20: 5479-5489.
24. la Fleur SE, Kalsbeek A, Wortel J, Fekkes ML, Buijs RM (2001) A daily rhythm in glucose tolerance: A role for the suprachiasmatic nucleus. Diabetes 50: 1237-1243.
25. Linn T, Strate C, Schneider K (1999) Diet promotes beta-cell loss by apoptosis in prediabetic nonobese diabetic mice. Endocrinology 140: 3767-3773.
26. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8: 731-737.
27. Malherbe C, De Gasparo M, De Hertogh R, Hoet JJ (1969) Circadian variations of blood sugar and plasma insulin levels in man. Diabetologia 5: 397-404.
28. Marquez S, Crespo P, Carlini V, Garbarino-Pico E, Baler R, et al. (2004) The metabolism of phospholipids oscillates rhythmically in cultures of fibroblasts and is regulated by the clock protein PERIOD 1. FASEB J 18: 519-521.
29. Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, et al. (2003) Control mechanism of the circadian clock for timing of cell division in vivo. Science 302: 255-259.
30. McNamara P, Seo SP, Rudic RD, Sehgal A, Chakravarti D, et al. (2001) Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: A humoral mechanism to reset a peripheral clock. Cell 105: 877-889.
31. Miller BH, Olson SL, Turek FW, Levine JE, Horton TH, et al. (2004) Circadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy. Curr Biol 14: 1367-1373.
32. Miyake K, Ogawa W, Matsumoto M, Nakamura T, Sakaue H, et al. (2002) Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver. J Clin Invest 110: 1483-1491.
33. Mosko S, Moore RY (1979) Retinohypothalamic tract development: Alteration by suprachiasmatic lesions in the neonatal rat. Brain Res 164: 1-15.
34. Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW (1997) Mechanisms of liver and muscle insulin resistance induced by chronic highfat feeding. Diabetes 46: 1768-1774.
35. Oishi K, Miyazaki K, Kadota K, Kikuno R, Nagase T, et al. (2003) Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes. J Biol Chem 278: 41519-41527.
36. Pacini G, Thomaseth K, Ahren B (2001) Contribution to glucose tolerance of insulin-independent vs. insulin-dependent mechanisms in mice. Am J Physiol Endocrinol Metab 281: E693-703.
37. Panda S, Antoch MP, Miller BH, Su AI, Schook AB, et al. (2002) Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109: 307-320.
38. Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418: 935-941.
39. Schlierf G, Dorow E (1973) Diurnal patterns of triglycerides, free fatty acids, blood sugar, and insulin during carbohydrate-induction in man and their modification by nocturnal suppression of lipolysis. J Clin Invest 52: 732-740.
40. Seaman GV, Engel R, Swank RL, Hissen W (1965) Circadian periodicity in some physicochemical parameters of circulating blood. Nature 207: 833-835.
41. Stokkan KA, Yamazaki S, Tei H, Sakaki Y, Menaker M (2001) Entrainment of the circadian clock in the liver by feeding. Science 291: 490-493.
42. Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, et al. (2002) Extensive and divergent circadian gene expression in liver and heart. Nature 417: 78-83.
43. Surwit RS, Schneider MS, Feinglos MN (1992) Stress and diabetes mellitus. Diabetes Care 15: 1413-1422.
44. Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, et al. (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264: 719-725.
45. Welsh D, Richardson GS, Dement WC (1988) Effect of running wheel availability on circadian patterns of sleep and wakefulness in mice. Physiol Behav 43: 771-777.
46. Wimmer M (1988) A bioluminescent assay for the determination of phosphoenolpyruvate carboxykinase activity in nanogram-sized tissue samples. Anal Biochem 170: 376-381.
47. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7: 941-946.
48. Young ME, Razeghi P, Cedars AM, Guthrie PH, Taegtmeyer H (2001) Intrinsic diurnal variations in cardiac metabolism and contractile function. Circ Res 89: 1199-1208.
49. Young MW, Kay SA (2001) Time zones: A comparative genetics of circadian clocks. Nat Rev Genet 2: 702-715.
50. Zimmet P, Alberti KG, Shaw J (2001) Global and societal implications of the diabetes epidemic. Nature 414: 782-787.