Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion

Diabetologia

Volumn 54, Issue 4, 2011, Pages 819-827

  Da Silva Xavier, G ^a   Farhan, H ^a   Kim, H ^a   Caxaria, S ^a   Johnson, P ^b   Hughes, S ^b   Bugliani, M ^c   Marselli, L ^c   Marchetti, P ^c   Birzele, F ^d   Sun, G ^a   Scharfmann, R ^e   Rutter, J ^f   Siniakowicz, K ^g   Weir, G ^g   Parker, H ^h   Reimann, F ^h   Gribble, F M ^h   Rutter, G A ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF PISA   (Italy)

^d BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

^h ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Alpha cells; Glucagon secretion; Human islets of Langerhans; Knockout mouse; PASK

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; GLUCAGON; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA 2; INSULIN; PER ARNT SIM DOMAIN CONTAINING PROTEIN KINASE; PREPROGLUCAGON; PROTEIN KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; EPITHELIUM; GENE; GENE CONTROL; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; GLUCAGON RELEASE; GLUCOSE TOLERANCE; HOMOZYGOTE; HORMONE BLOOD LEVEL; KNOCKOUT MOUSE; LASER CAPTURE MICRODISSECTION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS EPITHELIUM; PANCREAS ISLET BETA CELL; PASK GENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE STUDY; RAT; WILD TYPE;

ANIMALS; CELL LINE; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; GLUCAGON; GLUCAGON-SECRETING CELLS; GLUCOSE; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, MUTANT STRAINS; MODELS, BIOLOGICAL; POLYMERASE CHAIN REACTION; PROTEIN-SERINE-THREONINE KINASES; RATS;

EID: 79953823344     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-2010-7     Document Type: Article

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