Exendin-4 Increases the Expression of Hypoxia-Inducible Factor-1α in Rat Islets and Preserves the Endocrine Cell Volume of Both Free and Macroencapsulated Islet Grafts

Cell Transplantation

Volumn 21, Issue 6, 2012, Pages 1269-1283

  Jia, Xiaohui ^a   Sharma, Amit ^a,b   Kumagai Braesch, Makiko ^a   Wernerson, Annika M ^a   Sörenby, Anne K ^a   Yamamoto, Shinji ^a   Wang, Feng ^a   Tibell, Annika B ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

(HIF 1 ); Diabetes; Exendin 4; Hypoxia inducible factor 1 ; Islet transplantation; Macroencapsulation

Indexed keywords

ADENOSINE TRIPHOSPHATE; EXENDIN 4; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN ZINC SUSPENSION; MESSENGER RNA; NEUTRAL INSULIN; PROTEIN BCL 2; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL VOLUME; CONTROLLED STUDY; DRUG EFFECT; ENERGY YIELD; GLUCOSE BLOOD LEVEL; GRAFT NECROSIS; INSULINOMA; KIDNEY CAPSULE; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES; TREATMENT OUTCOME;

ADENOSINE TRIPHOSPHATE; ANIMALS; CASPASE 3; CELL HYPOXIA; CELL LINE, TUMOR; CELL SIZE; DIABETES MELLITUS, EXPERIMENTAL; ENDOCRINE SYSTEM; HOMEODOMAIN PROTEINS; HYPOGLYCEMIC AGENTS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; PEPTIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; TRANS-ACTIVATORS; VENOMS;

MUS; RATTUS; RODENTIA;

EID: 84865514635     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368911X627408     Document Type: Article

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